ANKRD15

KN motif and ankyrin repeat domain-containing protein 1 is a protein that in humans is encoded by the KANK1 gene.

KANK1
Identifiers
Aliases	KANK1, ANKRD15, CPSQ2, KANK, KN motif and ankyrin repeat domains 1
External IDs	OMIM: 607704; MGI: 2147707; HomoloGene: 17706; GeneCards: KANK1; OMA:KANK1 - orthologs
Gene location (Human) Chr. Chromosome 9 (human) Band 9p24.3 Start 470,291 bp End 746,105 bp
Gene location (Mouse) Chr. Chromosome 19 (mouse) Band 19|19 B Start 25,214,339 bp End 25,411,860 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cartilage tissue Descending thoracic aorta ascending aorta cardiac muscle tissue of right atrium popliteal artery tibial arteries gingival epithelium myocardium of left ventricle saphenous vein right auricle Top expressed in fourth ventricle choroid plexus of fourth ventricle hand interventricular septum Dermatocranium membranous bone basilar part of occipital bone ascending aorta aortic valve inner renal medulla More reference expression data BioGPS More reference expression data
Gene ontology Molecular function beta-catenin binding protein binding Cellular component cytoplasm cell projection membrane plasma membrane ruffle membrane nucleus Biological process negative regulation of neuron projection development regulation of transcription, DNA-templated negative regulation of actin filament polymerization negative regulation of ruffle assembly negative regulation of Rho protein signal transduction positive regulation of wound healing transcription, DNA-templated positive regulation of Wnt signaling pathway negative regulation of insulin receptor signaling pathway negative regulation of cell migration negative regulation of lamellipodium morphogenesis negative regulation of substrate adhesion-dependent cell spreading regulation of establishment of cell polarity positive regulation of canonical Wnt signaling pathway regulation of Rho protein signal transduction glomerular visceral epithelial cell migration cell population proliferation actin cytoskeleton organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23189 107351 Ensembl ENSG00000107104 ENSMUSG00000032702 UniProt Q14678 n/a RefSeq (mRNA) NM_001256876 NM_001256877 NM_015158 NM_153186 NM_001354331 NM_001354332 NM_001354333 NM_001354334 NM_001354335 NM_001354336 NM_001354337 NM_001354338 NM_001354339 NM_001354340 NM_001354341 NM_001354342 NM_001354343 NM_001354344 NM_181404 NM_001348180 RefSeq (protein) NP_001243805 NP_001243806 NP_055973 NP_694856 NP_001341260 NP_001341261 NP_001341262 NP_001341263 NP_001341264 NP_001341265 NP_001341266 NP_001341267 NP_001341268 NP_001341269 NP_001341270 NP_001341271 NP_001341272 NP_001341273 n/a Location (UCSC) Chr 9: 0.47 – 0.75 Mb Chr 19: 25.21 – 25.41 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a protein containing four ankyrin repeat domains in its C-terminus. The suggested role for this protein is in tumorigenesis of renal cell carcinoma. Two alternatively spliced transcript variants encoding different isoforms have been identified.

External links

• Human KANK1 genome location and KANK1 gene details page in the UCSC Genome Browser.

Further reading

• Nagase T, Seki N, Ishikawa K, et al. (1996). "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 3 (1): 17–24. doi:10.1093/dnares/3.1.17. PMID 8724849.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Roy BC, Aoyagi T, Sarkar S, et al. (2005). "Pathological characterization of Kank in renal cell carcinoma". Exp. Mol. Pathol. 78 (1): 41–8. doi:10.1016/j.yexmp.2004.08.012. PMID 15596059.
• Wang Y, Onishi Y, Kakinuma N, et al. (2005). "Alternative splicing of the human Kank gene produces two types of Kank protein". Biochem. Biophys. Res. Commun. 330 (4): 1247–53. doi:10.1016/j.bbrc.2005.03.106. PMID 15823577.
• Wang Y, Kakinuma N, Zhu Y, Kiyama R (2007). "Nucleo-cytoplasmic shuttling of human Kank protein accompanies intracellular translocation of beta-catenin". J. Cell Sci. 119 (Pt 19): 4002–10. doi:10.1242/jcs.03169. PMID 16968744. S2CID 14196261.