TUBG1

Tubulin, gamma 1 is a protein in humans that is encoded by the TUBG1 gene. This gene encodes a member of the tubulin superfamily. The encoded protein localizes to the centrosome where it binds to microtubules as part of a complex referred to as the gamma-tubulin ring complex. The protein mediates microtubule nucleation and is required for microtubule formation and progression of the cell cycle.

TUBG1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1Z5V, 1Z5W, 3CB2
Identifiers
Aliases	TUBG1, CDCBM4, GCP-1, TUBG, TUBGCP1, tubulin gamma 1
External IDs	OMIM: 191135; MGI: 101834; HomoloGene: 833; GeneCards: TUBG1; OMA:TUBG1 - orthologs
Gene location (Human) Chr. Chromosome 17 (human) Band 17q21.2 Start 42,609,641 bp End 42,615,238 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11 D|11 64.24 cM Start 101,010,764 bp End 101,017,245 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right testis left testis oocyte gonad gastrocnemius muscle stromal cell of endometrium trabecular bone left ventricle muscle of thigh prefrontal cortex Top expressed in tail of embryo abdominal wall perirhinal cortex entorhinal cortex otic vesicle yolk sac genital tubercle internal carotid artery CA3 field morula More reference expression data BioGPS n/a
Gene ontology Molecular function nucleotide binding GTP binding structural constituent of cytoskeleton protein binding GTPase activity identical protein binding Cellular component cytoplasm ciliary basal body recycling endosome cytosol centrosome pericentriolar material apical part of cell gamma-tubulin complex cilium microtubule organizing center condensed nuclear chromosome spindle microtubule polar microtubule cell leading edge centriole cytoplasmic microtubule microtubule cytoskeleton non-motile cilium nucleus spindle Biological process meiotic spindle organization G2/M transition of mitotic cell cycle cytoplasmic microtubule organization microtubule-based process microtubule cytoskeleton organization microtubule nucleation ciliary basal body-plasma membrane docking regulation of G2/M transition of mitotic cell cycle mitotic sister chromatid segregation mitotic cell cycle mitotic spindle organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7283 103733 Ensembl ENSG00000131462 ENSMUSG00000035198 UniProt P23258 P83887 RefSeq (mRNA) NM_001070 NM_134024 RefSeq (protein) NP_001061 NP_598785 Location (UCSC) Chr 17: 42.61 – 42.62 Mb Chr 11: 101.01 – 101.02 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Further reading

• Zhang X, Chen Q, Feng J, Hou J, Yang F, Liu J, Jiang Q, Zhang C (July 2009). "Sequential phosphorylation of Nedd1 by Cdk1 and Plk1 is required for targeting of the gammaTuRC to the centrosome". Journal of Cell Science. 122 (Pt 13): 2240–51. doi:10.1242/jcs.042747. PMID 19509060.
• Lau AS, Mruk DD (April 2003). "Rab8B GTPase and junction dynamics in the testis". Endocrinology. 144 (4): 1549–63. doi:10.1210/en.2002-220893. PMID 12639940.
• Feng Y, Olson EC, Stukenberg PT, Flanagan LA, Kirschner MW, Walsh CA (December 2000). "LIS1 regulates CNS lamination by interacting with mNudE, a central component of the centrosome". Neuron. 28 (3): 665–79. doi:10.1016/S0896-6273(00)00145-8. PMID 11163258. S2CID 15923472.
• Hsu LC, White RL (October 1998). "BRCA1 is associated with the centrosome during mitosis". Proceedings of the National Academy of Sciences of the United States of America. 95 (22): 12983–8. doi:10.1073/pnas.95.22.12983. PMC 23679. PMID 9789027.
• Manning JA, Shalini S, Risk JM, Day CL, Kumar S (March 2010). Hotchin NA (ed.). "A direct interaction with NEDD1 regulates gamma-tubulin recruitment to the centrosome". PLOS ONE. 5 (3): e9618. doi:10.1371/journal.pone.0009618. PMC 2835750. PMID 20224777.
• Aldaz H, Rice LM, Stearns T, Agard DA (May 2005). "Insights into microtubule nucleation from the crystal structure of human gamma-tubulin". Nature. 435 (7041): 523–7. doi:10.1038/nature03586. PMID 15917813. S2CID 4388646.
• Niu Y, Liu T, Tse GM, Sun B, Niu R, Li HM, Wang H, Yang Y, Ye X, Wang Y, Yu Q, Zhang F (April 2009). "Increased expression of centrosomal alpha, gamma-tubulin in atypical ductal hyperplasia and carcinoma of the breast". Cancer Science. 100 (4): 580–7. doi:10.1111/j.1349-7006.2008.01075.x. PMC 11158874. PMID 19215229. S2CID 205234685.
• Hampe C, Ardila-Osorio H, Fournier M, Brice A, Corti O (July 2006). "Biochemical analysis of Parkinson's disease-causing variants of Parkin, an E3 ubiquitin-protein ligase with monoubiquitylation capacity". Human Molecular Genetics. 15 (13): 2059–75. doi:10.1093/hmg/ddl131. PMID 16714300.
• Zyss D, Montcourrier P, Vidal B, Anguille C, Mérezègue F, Sahuquet A, Mangeat PH, Coopman PJ (December 2005). "The Syk tyrosine kinase localizes to the centrosomes and negatively affects mitotic progression". Cancer Research. 65 (23): 10872–80. doi:10.1158/0008-5472.CAN-05-1270. PMID 16322234.