4-Hydroxy-4-methylpentanoic acid

4-Hydroxy-4-methylpentanoic acid
Clinical data
Other names	4-Hydroxy-4-methylpentanoic acid
Identifiers
	IUPAC name 4-Hydroxy-4-methylpentanoic acid;
CAS Number	23327-19-7 ;
ChemSpider	10466768 ;
UNII	RBT229QVC5;
CompTox Dashboard (EPA)	DTXSID50633867 ;
Chemical and physical data
Formula	C6H12O3
Molar mass	132.159 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES OC(CCC(C)(O)C)=O;
	InChI InChI=1S/C6H12O3/c1-6(2,9)4-3-5(7)8/h9H,3-4H2,1-2H3,(H,7,8) ; Key:PQJUMPXLDAZULJ-UHFFFAOYSA-N ;
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4-Hydroxy-4-methylpentanoic acid (UMB68) is a tertiary alcohol, similar in structure to the drug GHB. The molecule has been synthesized and tested on animals in order to further research the effects of GHB. UMB68 has been shown to bind selectively to the GHB receptor ligand in binding assays, yet does not bind to GABAergic receptors. As such, it can provide a useful tool in studying the pharmacology of the GHB receptor in absence of GABAergic effects.^[1]

References

^ Wu H, Zink N, Carter LP, Mehta AK, Hernandez RJ, Ticku MK, Lamb R, France CP, Coop A (2003). "A Tertiary Alcohol Analog of γ-Hydroxybutyric Acid as a Specific γ-Hydroxybutyric Acid Receptor Ligand". Journal of Pharmacology and Experimental Therapeutics. 305 (2): 675–679. doi:10.1124/jpet.102.046797. PMID 12606613. S2CID 86191608.

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[1] Wu H, Zink N, Carter LP, Mehta AK, Hernandez RJ, Ticku MK, Lamb R, France CP, Coop A (2003). "A Tertiary Alcohol Analog of γ-Hydroxybutyric Acid as a Specific γ-Hydroxybutyric Acid Receptor Ligand". Journal of Pharmacology and Experimental Therapeutics. 305 (2): 675–679. doi:10.1124/jpet.102.046797. PMID 12606613. S2CID 86191608.

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References

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