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Protein-coding gene in the species Homo sapiens
Kinesin family member 4A is a protein that in humans is encoded by the KIF4A gene .[ 5] [ 6]
Kinesins , such as KIF4A, are microtubule -based motor proteins that generate directional movement along microtubules. They are involved in many crucial cellular processes, including cell division.[ 6]
KIF4A has been shown to interact with HMG20B [ 7] DNMT3B .[ 8]
Clinical significance [ edit ] NTCP is the entry receptor for both Hepatitis B (HBV ) and Hepatitis D viruses (HDV ).[ 9] HBV and HDV infection through its regulation of the retrograde transport of NTCP from the cytoplasm to the cell surface where it acts as a receptor for HBV /HDV infection.[ 10]
^ a b c GRCh38: Ensembl release 89: ENSG00000090889 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000034311 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Ha MJ, Yoon J, Moon E, Lee YM, Kim HJ, Kim W (Jun 2000). "Assignment of the kinesin family member 4 genes (KIF4A and KIF4B) to human chromosome bands Xq13.1 and 5q33.1 by in situ hybridization". Cytogenetics and Cell Genetics . 88 (1–2): 41–42. doi :10.1159/000015482 . PMID 10773663 . S2CID 46074226 . ^ a b "Entrez Gene: KIF4A kinesin family member 4A" .^ Lee YM, Kim W (September 2003). "Association of human kinesin superfamily protein member 4 with BRCA2-associated factor 35" . The Biochemical Journal . 374 (Pt 2): 497–503. doi :10.1042/BJ20030452 . PMC 1223617 PMID 12809554 . ^ Geiman TM, Sankpal UT, Robertson AK, Chen Y, Mazumdar M, Heale JT, et al. (2004). "Isolation and characterization of a novel DNA methyltransferase complex linking DNMT3B with components of the mitotic chromosome condensation machinery" . Nucleic Acids Research . 32 (9): 2716–2729. doi :10.1093/nar/gkh589 . PMC 419596 PMID 15148359 . ^ Yan H, Zhong G, Xu G, He W, Jing Z, Gao Z, et al. (November 2012). Chen ZJ (ed.). "Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus" . eLife . 1 : e00049. doi :10.7554/eLife.00049 PMC 3485615 PMID 23150796 . ^ Gad SA, Sugiyama M, Tsuge M, Wakae K, Fukano K, Oshima M, et al. (March 2022). "The kinesin KIF4 mediates HBV/HDV entry through the regulation of surface NTCP localization and can be targeted by RXR agonists in vitro" . PLOS Pathogens . 18 (3): e1009983. doi :10.1371/journal.ppat.1009983 PMC 8970526 PMID 35312737 .
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