MIB2 (gene)

MIB2
Identifiers
Aliases	MIB2, ZZANK1, ZZZ5, mindbomb E3 ubiquitin protein ligase 2, MIB E3 ubiquitin protein ligase 2
External IDs	OMIM: 611141; MGI: 2679684; HomoloGene: 16062; GeneCards: MIB2; OMA:MIB2 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	1,630,605 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	155,753,655 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; apex of heart; ; anterior pituitary; ; right ovary; ; left ovary; ; right hemisphere of cerebellum; ; right uterine tube; ; muscle of thigh; ; left uterine tube; ; skin of abdomen;
	Top expressed in
	granulocyte; ; primary visual cortex; ; superior frontal gyrus; ; internal carotid artery; ; external carotid artery; ; cerebellar cortex; ; dentate gyrus of hippocampal formation granule cell; ; subiculum; ; Rostral migratory stream; ; neural layer of retina;
	More reference expression data
	n/a
Gene ontology
Molecular function	signal transducer activity; zinc ion binding; ubiquitin protein ligase activity; metal ion binding; actin binding; protein binding; ubiquitin-protein transferase activity; transferase activity;
Cellular component	cytoplasm; endosome; early endosome; ubiquitin ligase complex; cytosol;
Biological process	Notch signaling pathway; positive regulation of I-kappaB kinase/NF-kappaB signaling; protein ubiquitination; protein polyubiquitination;
	Sources:Amigo / QuickGO
Orthologs
	142678
	76580
	ENSG00000197530
	ENSMUSG00000029060
	Q96AX9
	Q8R516
	NM_001170686; NM_001170687; NM_001170688; NM_001170689; NM_080875
NM_001256107; NM_001256108; NM_001256110; NM_145124; NM_001369161;
	NM_001369162; NM_001369163; NM_001369164; NM_001369165; NM_001369166; NM_001369167; NM_001369168
	NP_001164157; NP_001164158; NP_001164159; NP_001164160; NP_543151
NP_001243036; NP_001243037; NP_660106; NP_001356090; NP_001356091;
	NP_001356092; NP_001356093; NP_001356094; NP_001356095; NP_001356096; NP_001356097
	Wikidata
View/Edit Human	View/Edit Mouse

E3 ubiquitin-protein ligase MIB2 is an enzyme that in humans is encoded by the MIB2 gene.^[5]^[6]

Interactions

MIB2 (gene) has been shown to interact with Actin, alpha 1.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000197530 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029060 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Matsuda A, Suzuki Y, Honda G, Muramatsu S, Matsuzaki O, Nagano Y, Doi T, Shimotohno K, Harada T, Nishida E, Hayashi H, Sugano S (May 2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways". Oncogene. 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID 12761501. S2CID 38880905.
^ "Entrez Gene: MIB2 mindbomb homolog 2 (Drosophila)".
^ Takeuchi T, Heng Henry H Q, Ye Christine J, Liang Sheng-Ben, Iwata Jun, Sonobe Hiroshi, Ohtsuki Yuji (Oct 2003). "Down-regulation of a novel actin-binding molecule, skeletrophin, in malignant melanoma". Am. J. Pathol. 163 (4). United States: 1395–404. doi:10.1016/S0002-9440(10)63497-9. ISSN 0002-9440. PMC 1868282. PMID 14507647.

Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Takeuchi T, Heng HH, Ye CJ, et al. (2003). "Down-regulation of a novel actin-binding molecule, skeletrophin, in malignant melanoma". Am. J. Pathol. 163 (4): 1395–404. doi:10.1016/S0002-9440(10)63497-9. PMC 1868282. PMID 14507647.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Koo BK, Yoon KJ, Yoo KW, et al. (2005). "Mind bomb-2 is an E3 ligase for Notch ligand". J. Biol. Chem. 280 (23): 22335–42. doi:10.1074/jbc.M501631200. PMID 15824097.
Takeuchi T, Adachi Y, Ohtsuki Y (2005). "Skeletrophin, a novel RING molecule controlled by the chromatin remodeling complex, is downregulated in malignant melanoma". DNA Cell Biol. 24 (5): 339–44. doi:10.1089/dna.2005.24.339. PMID 15869411.
Takeuchi T, Adachi Y, Ohtsuki Y (2005). "Skeletrophin, a novel ubiquitin ligase to the intracellular region of Jagged-2, is aberrantly expressed in multiple myeloma". Am. J. Pathol. 166 (6): 1817–26. doi:10.1016/S0002-9440(10)62491-1. PMC 1602431. PMID 15920166.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
Takeuchi T, Adachi Y, Sonobe H, et al. (2006). "A ubiquitin ligase, skeletrophin, is a negative regulator of melanoma invasion". Oncogene. 25 (53): 7059–69. doi:10.1038/sj.onc.1209688. PMID 16715130. S2CID 22014056.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000197530 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029060 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12761501-5] Matsuda A, Suzuki Y, Honda G, Muramatsu S, Matsuzaki O, Nagano Y, Doi T, Shimotohno K, Harada T, Nishida E, Hayashi H, Sugano S (May 2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways". Oncogene. 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID 12761501. S2CID 38880905.

[entrez-6] "Entrez Gene: MIB2 mindbomb homolog 2 (Drosophila)".

[pmid14507647-7] Takeuchi T, Heng Henry H Q, Ye Christine J, Liang Sheng-Ben, Iwata Jun, Sonobe Hiroshi, Ohtsuki Yuji (Oct 2003). "Down-regulation of a novel actin-binding molecule, skeletrophin, in malignant melanoma". Am. J. Pathol. 163 (4). United States: 1395–404. doi:10.1016/S0002-9440(10)63497-9. ISSN 0002-9440. PMC 1868282. PMID 14507647.

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[6]

[7]

MIB2 (gene)

Interactions

References

Further reading

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