The Carbon Cycle Greenhouse Gases (CCGG) research area operates the Global Greenhouse Gas Reference Network, measuring the atmospheric distribution and trends of the three main long-term drivers of climate change, carbon dioxide (CO₂), methane (CH₄), and nitrous oxide (N₂O), as well as carbon monoxide (CO) which is an important indicator of air pollution.

CCGG is also active in the development of a global model called 'CarbonTracker', a measurement and modeling system developed to keep track of sources (emissions to the atmosphere) and sinks (removal from the atmosphere) of carbon dioxide around the world. A version of CarbonTracker for methane (CH₄) has also been developed, as well as CarbonTracker-Lagrange (CT-L), a regional inverse modeling framework designed for estimating North American greenhouse gas emissions and uptake fluxes.