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AP-1

Dari Wikipedia bahasa Indonesia, ensiklopedia bebas

Dalam bidang studi genetika, AP-1 (bahasa Inggris: activator protein 1, AP-1) adalah protein di dalam inti sel berbentuk heterodimerik dari kompleks fos, jun[1] dan subgroup ATF,[2] yang merupakan faktor transkripsi yang memiliki peran penting dalam ekspresi genetik seluler seperti transformasi, proliferasi melalui represi ekspresi gen supresor tumor, diferensiasi, apoptosis, migrasi sel;[3] mengendalikan ekspresi dan fungsi regulator siklus sel seperti siklin D1, supresor tumor p53, p21(cip1/waf1), p19(ARF) dan p16; dan peradangan.

  1. ^ (Inggris) "A role for AP-1 in apoptosis: the case for and against". Department of Developmental Biology, Fernbach Building, Institut Pasteur; Ameyar M, Wisniewska M, Weitzman JB. Diakses tanggal 2010-09-18. 
  2. ^ (Inggris) "AP-1 in cell proliferation and survival". Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, University of California San Diego; Shaulian E, Karin M. Diakses tanggal 2010-09-18. 
  3. ^ (Inggris) "AP-1--The Jun proteins: Oncogenes or tumor suppressors in disguise?". Department of Biochemistry and Molecular Biology, The Institute for Medical Research-Israel-Canada, The Hebrew University-Hadassah Medical School; Shaulian E. Diakses tanggal 2010-09-18. 



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