Papers by Enrico Pezzarossa
Journal of the European Academy of Dermatology and Venereology : JEADV, Jan 2, 2014
Different lifestyle and dietetic factors have been linked with the onset and severity of acne. To... more Different lifestyle and dietetic factors have been linked with the onset and severity of acne. To assess the complex interconnection between dietetic variables and acne. This was a reanalysis of data from a case-control study by using a semantic connectivity map approach. 563 subjects, aged 10-24 years, involved in a case-control study of acne between March 2009 and February 2010, were considered in this study. The analysis evaluated the link between a moderate to severe acne and anthropometric variables, family history and dietetic factors. Analyses were conducted by relying on an artificial adaptive system, the Auto Semantic Connectivity Map (AutoCM). The AutoCM map showed that moderate-severe acne was closely associated with family history of acne in first degree relatives, obesity (BMI≥30), and high consumption of milk, in particular skim milk, cheese/yogurt, sweets/cakes, chocolate, and a low consumption of fish, and limited intake of fruits/vegetables. Our analyses confirm the...
Dermatology, 2014
in 61 (41.8%) of 146 subjects who underwent laboratory tests. Anti-thyroperoxidase (25.6%), anti-... more in 61 (41.8%) of 146 subjects who underwent laboratory tests. Anti-thyroperoxidase (25.6%), anti-thyroglobulin (23.4%), antinuclear antibodies (16.8%) and anti-gastric parietal cell antibodies (7.8%) were the most noticed autoantibodies. 74 (41.5%) autoimmune comorbidities, mainly autoimmune thyroiditis (37%), were reported. Conclusion: The prevalence of autoimmune comorbidities and circulating autoantibodies in this study was in agreement with other surveys conducted on Caucasian patients.
OBIETTIVO: Obiettivo del lavoro è stato quello di valutare l'efficacia delle Campagne di Educazio... more OBIETTIVO: Obiettivo del lavoro è stato quello di valutare l'efficacia delle Campagne di Educazione Sanitaria svolte nell'area di Cremona (Italia del nord) alla fine degli anni 90, prendendo come parametro di riferimento l'individuazione di melanomi con prognosi favorevole (spessore sec. Breslow <1 mm). METODI: Abbiamo condotto uno studio sui melanomi cutanei analizzati presso l'Unità Operativa di Anatomia Patologica del nostro Ospedale dal 1995 al 2014. Si sono presi in considerazione i seguenti parametri: sesso del paziente, sede di localizzazione, spessore istologico del melanoma. Per analizzare i dati statistici abbiamo applicato il calcolo della retta di regressione lineare (legame tra variabile tempo e numero di casi annuali) RISULTATI: Nel periodo analizzato sono stati individuati 673 melanomi cutanei: donne nel 52,8% e uomini nel 47,2%. Nei primi anni dello studio l'incidenza era bassa (4/5 casi x100.00 abitanti) e si notava una prevalenza dei melanomi con spessore istologico >1 mm. Negli ultimi anni invece l'incidenza si attesta su valori di tipo nord-europeo (14/15 casi x 100.00 abitanti) e si nota mag-giore crescita dei melanomi <1 mm (1,3 nuovi casi/anno) contro 0,6 nuovi casi/anno per i melanomi >1 mm. I melanomi sottili sono riscontrati più frequentemente nelle donne. CONCLUSIONI: Il trend riscontrato nella nostra area di intervento mostra un aumento di incidenza del melanoma cutaneo ed un progressivo aumento dei melanomi sottili. L'aumentato numero di visite di screening osservato in questi 20 anni ha portato al riscon-tro di un maggior numero di melanomi sottili (<1 mm) contribuendo al miglioramento della prognosi per questa insidiosa neoplasia. Parole chiave: melanoma-prognosi-epidemiologia. BACKGROUND: The aim of this paper was to value efficacy of Health Education Campaign for early detection of melanoma in Cremona area developed from 1995. The main objective of sensitization campaign is found the major number of thin melanoma and improve the prognosis. The present study was performed to analyze, by epidemiologic survey, if in the period 1995-2014 thin melanomas were significantly increased. METHODS: We conducted a study on cutaneous melanomas (673 cases) analyzed in the Pathology Unit of Cremona Hospital from 1995 to 2014. We considered the following parameters: patient's gender, anatomical site of cutaneous melanoma, histological thickness of melanoma according to Breslow. To analyze statistical data we applied estimation of linear regression straight line (link between time variable and annual case number). RESULTS: In the observed period were identified 673 cutaneous melanoma: 52.8% women and 47.2% men. At the beginning incidence was low (4/5 cases x 100.000 inhabitants) with a high relevance of thick melanomas (thickness >1 mm). In latest years instead incidence was nearly like in North-Europe (14/15 cases x 100.00 inhabitants) and point out increase of thin melanomas (thickness ≤1 mm): 1.3 new annual cases of thin melanomas against 0.6 new annual cases of thick melanomas (thickness >1 mm). Thin melanomas are pointed out more frequently in women. CONCLUSIONS: The trend in the intervention area show an increase of incidence of cutaneous melanoma with prevalence of thin melano-mas. Increased number of screening examination observed in the last 20 years allowed diagnosis of more thin melanomas (thickness ≤1 mm) with a better prognosis for this insidious tumor.
Journal of Investigative Dermatology, 2005
We conducted a case-control study to analyse the association of psoriasis of recent onset with sm... more We conducted a case-control study to analyse the association of psoriasis of recent onset with smoking habits, body mass index (BMI) and stressful life events. Cases (n=560; median age 38) were patients with a first diagnosis of psoriasis and a history of skin manifestations of no longer than two years after the reported disease onset. Patients with a new diagnosis of skin diseases other than psoriasis (n=690; median age 36) were selected as controls. The risk of psoriasis was higher in ex- and current smokers than in never-smokers, the relative risk estimates (OR) being 1.9 for ex-smokers and 1.7 for smokers. Smoking was strongly associated with pustular lesions (32 patients, OR=5.3 for smokers). The frequency of psoriasis varied significantly in relation to a family history of psoriasis in first degree relatives, BMI (OR=1.6 and 1.9 for over weighted, BMI 26-29, and obese, BMI &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;/= 30, respectively) and stressful life event score (compared to the lower index quartile, the OR being 2.2 for index values &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;/=115). Risk estimates, when taking into consideration the combined effect of these factors with smoking habits, were consistent with a multiplicative model of risk combination with no significant statistical interaction.
Dermatology, 2008
To evaluate the association of psoriasis with selected medical conditions and a number of drugs u... more To evaluate the association of psoriasis with selected medical conditions and a number of drugs used before diagnosis. Multicenter case-control study involving outpatient services of 20 general and teaching hospitals. Entry criteria for cases were a first diagnosis of psoriasis made by a dermatologist and a history of skin manifestations of no more than 2 years after the reported onset of the disease. Controls were the first eligible dermatological patients observed on randomly selected days in the same centers as cases. A total of 560 cases and 690 controls were recruited. The odds ratio (OR) of psoriasis was 0.8 (95% confidence interval, CI, 0.5-1.3) in hypertensive subjects, 1.1 (95% CI 0.6-2.0) in diabetics and 1.1 (95% CI 0.7-1.7) in hyperlipidemic subjects. Histamine 2 receptor antagonist exposure was negatively associated with psoriasis: OR 0.3 (95% CI 0.1-0.8). Our study rules out a strong association of psoriasis at its first ever diagnosis with common chronic conditions. The reported associations of psoriasis with relatively common conditions such as diabetes mellitus, hypertension and hyperlipidemia may represent a late effect of well-known risk factors for psoriasis such as smoking and overweight or reflect factors related to the long course of psoriasis itself.
Giornale italiano di dermatologia e venereologia : organo ufficiale, Società italiana di dermatologia e sifilografia, 1989
Follicular mucinosis is a not uncommon but frequently misidentified disease. Actually this peculi... more Follicular mucinosis is a not uncommon but frequently misidentified disease. Actually this peculiar condition is divided in three groups: in one group the lesion cleared spontaneously within a few months (acute follicular mucinosis); in a second group there is a chronic relapsing but benign course over several years (chronic follicular mucinosis) and in a third group appeared in association with a lymphoma (15%). Some Authors believe that follicular mucinosis is a histological term for a reactive pattern in follicular epithelium. We report the case of a patient affected by this dermatosis. The eruption consisted of follicular papules and inflammatory plaques widespread. No instance of transition from follicular mucinosis to lymphoma was observed. Very important to the diagnosis was the histological findings. We believe that the case in exam was a form of chronic follicular mucinosis.
Giornale italiano di dermatologia e venereologia : organo ufficiale, Società italiana di dermatologia e sifilografia, 1990
The therapeutic effectiveness and the tolerability of a collagenase-chloramphenicol ointment were... more The therapeutic effectiveness and the tolerability of a collagenase-chloramphenicol ointment were studied on a group of 20 patients (mean age 73.4 +/- 13.6 years, range 25-88 years) with lower limb ulcerations of various origin. The ointment proved capable of favourably influencing the debridment and the healing process of these lesions. Statistically significant improvements were observed after days of treatment for debridment, inflammation and granulation, after eight days for the lesion size and after ten days for epithelization. Tolerability was very good.
The frequency of atopic dermatitis in Italian children and its relationship with selected variabl... more The frequency of atopic dermatitis in Italian children and its relationship with selected variables were analysed in a large survey of skin health conducted in Italy. In 1997 we conducted a survey on schoolchildren aged 12-17 years from 13 areas of northern, central and southern Italy. For the present analyses, 3179 Caucasian children (1618 males, 1561 females) were considered. A diagnosis of atopic dermatitis was reported in 224 cases (7.0%). The frequency of reported atopic dermatitis was significantly higher in children with asthma (rate ratio (RR) 4.5; 95% confidence interval (CI) 3.1-6.5). The lifetime prevalence of a diagnosis of atopic dermatitis was higher among schoolchildren reporting a diagnosis of psoriasis (RR 5.5, 95% CI 3.0-10.1) and vitiligo (RR 16.1, 95% CI 6.5-39.5). This study gives estimates of the lifetime prevalence of atopic dermatitis in adolescents in Italy and emphasizes the direct association between the condition and other immune-related skin diseases.
Dermatology, 2014
It is believed that vitiligo has an impact on the overall patient quality of life (QoL). To estim... more It is believed that vitiligo has an impact on the overall patient quality of life (QoL). To estimate QoL in a fairly large sample of Italian vitiligo patients by using the Dermatology Life Quality Index (DLQI) questionnaire. One hundred and sixty-one vitiligo patients referred to 9 dermatological centers were offered to participate by filling in the Italian version of the DLQI questionnaire. The mean total DLQI score was 4.3 (SD ±4.9; range: 0-22). In multivariate analysis, DLQI &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;5 was associated with female gender, stability of the disease over time and involvement of the face at disease onset. The impairment of QoL is overall limited in Italian vitiligo patients, especially if it is compared with results from other available studies. This could be due to cultural and ethnic characteristics of the sample.
Journal of The European Academy of Dermatology and Venereology, 1997
Giornale Italiano di Dermatologia e Venereologia
Giornale Italiano di Dermatologia e Venereologia
Journal of Investigative Dermatology, 2005
We conducted a case-control study to analyse the association of psoriasis of recent onset with sm... more We conducted a case-control study to analyse the association of psoriasis of recent onset with smoking habits, body mass index (BMI) and stressful life events. Cases (n=560; median age 38) were patients with a first diagnosis of psoriasis and a history of skin manifestations of no longer than two years after the reported disease onset. Patients with a new diagnosis of skin diseases other than psoriasis (n=690; median age 36) were selected as controls. The risk of psoriasis was higher in ex- and current smokers than in never-smokers, the relative risk estimates (OR) being 1.9 for ex-smokers and 1.7 for smokers. Smoking was strongly associated with pustular lesions (32 patients, OR=5.3 for smokers). The frequency of psoriasis varied significantly in relation to a family history of psoriasis in first degree relatives, BMI (OR=1.6 and 1.9 for over weighted, BMI 26-29, and obese, BMI &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;/= 30, respectively) and stressful life event score (compared to the lower index quartile, the OR being 2.2 for index values &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;/=115). Risk estimates, when taking into consideration the combined effect of these factors with smoking habits, were consistent with a multiplicative model of risk combination with no significant statistical interaction.
Journal of the American Academy of Dermatology, 2012
BACKGROUND: Genetic and environmental components may contribute to acne causation. OBJECTIVE: We ... more BACKGROUND: Genetic and environmental components may contribute to acne causation. OBJECTIVE: We sought to assess the impact of family history, personal habits, dietary factors, and menstrual history on a new diagnosis of moderate to severe acne. METHODS: We conducted a case-control study in dermatologic outpatient clinics in Italy. Cases (205) were consecutive those receiving a new diagnosis of moderate to severe acne. Control subjects (358) were people with no or mild acne, coming for a dermatologic consultation other than for acne. RESULTS: Moderate to severe acne was strongly associated with a family history of acne in first-degree relatives (odds ratio 3.41, 95% confidence interval 2.31-5.05). The risk was reduced in people with lower body mass index with a more pronounced effect in male compared with female individuals. No association with smoking emerged. The risk increased with increased milk consumption (odds ratio 1.78, 95% confidence interval 1.22-2.59) in those consuming...
European Journal of Pediatrics, 1997
Dermatology, 2008
To evaluate the association of psoriasis with selected medical conditions and a number of drugs u... more To evaluate the association of psoriasis with selected medical conditions and a number of drugs used before diagnosis. Multicenter case-control study involving outpatient services of 20 general and teaching hospitals. Entry criteria for cases were a first diagnosis of psoriasis made by a dermatologist and a history of skin manifestations of no more than 2 years after the reported onset of the disease. Controls were the first eligible dermatological patients observed on randomly selected days in the same centers as cases. A total of 560 cases and 690 controls were recruited. The odds ratio (OR) of psoriasis was 0.8 (95% confidence interval, CI, 0.5-1.3) in hypertensive subjects, 1.1 (95% CI 0.6-2.0) in diabetics and 1.1 (95% CI 0.7-1.7) in hyperlipidemic subjects. Histamine 2 receptor antagonist exposure was negatively associated with psoriasis: OR 0.3 (95% CI 0.1-0.8). Our study rules out a strong association of psoriasis at its first ever diagnosis with common chronic conditions. The reported associations of psoriasis with relatively common conditions such as diabetes mellitus, hypertension and hyperlipidemia may represent a late effect of well-known risk factors for psoriasis such as smoking and overweight or reflect factors related to the long course of psoriasis itself.
Dermatology, 2014
in 61 (41.8%) of 146 subjects who underwent laboratory tests. Anti-thyroperoxidase (25.6%), anti-... more in 61 (41.8%) of 146 subjects who underwent laboratory tests. Anti-thyroperoxidase (25.6%), anti-thyroglobulin (23.4%), antinuclear antibodies (16.8%) and anti-gastric parietal cell antibodies (7.8%) were the most noticed autoantibodies. 74 (41.5%) autoimmune comorbidities, mainly autoimmune thyroiditis (37%), were reported. Conclusion: The prevalence of autoimmune comorbidities and circulating autoantibodies in this study was in agreement with other surveys conducted on Caucasian patients.
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Papers by Enrico Pezzarossa