Tubo-ovarian abscess is seen as a complication of PID cases who are inadequately treated or delay... more Tubo-ovarian abscess is seen as a complication of PID cases who are inadequately treated or delayed in treatment. Recently minimal invasive techniques such as; ultrasound, CT or MRI guided drainage are suggested in the treatm ent of tubo-ovarian abscesses. The current report presents a patient with a tubo-ovarian abscess treated by drainage via transvaginal ultrasonography.
European Journal of Obstetrics & Gynecology and Reproductive Biology, 2012
To determine the prevalence of metabolic syndrome among pre- and post-menopausal women attending ... more To determine the prevalence of metabolic syndrome among pre- and post-menopausal women attending a tertiary clinic in Turkey. This is a cross-sectional study consisting of one hundred and eighty healthy postmenopausal women and fifty-three healthy premenopausal women evaluated for presence or absence of metabolic syndrome. The t test and Fischer exact test were used for continuous variables and chi-square test was used for categorical variables. The prevalence of metabolic syndrome among pre-menopausal women was 15.09% according to NCEP criteria. The prevalence of metabolic syndrome among postmenopausal women was 19.44% according to NCEP criteria. There was no significant difference in the prevalence of metabolic syndrome between premenopausal and postmenopausal women in our study population. There was no significant difference in the prevalence of metabolic syndrome between premenopausal and postmenopausal women attending a tertiary clinic in Turkey.
Moderate exercise is undoubtedly a positive factor in health. Strenuous exercise in women may lea... more Moderate exercise is undoubtedly a positive factor in health. Strenuous exercise in women may lead to disturbances in reproductive function ranging from subtle effects on fe rtility to hypoestrogenic amenorrhea. Exercise-related menstrual dysfunction is more likely to occur with strenuous exercise, in women who are nulliparous, in women with a history of delayed menarche, in women under age 30, and in women with low body fat. The mechanism by which the menstrual dysfunction develops is, to this point, unknown, but no evidence exists to suggest that it has long-term repercussions on reproductive capacity.
Wheeler and Malinak described a treatment algorithm that considers the severity of endometriosis,... more Wheeler and Malinak described a treatment algorithm that considers the severity of endometriosis, the patients' desires for reproduction versus symptom relief and the several acceptable forms of treatment, (revised AFS System) (1). The algorithm is shown in Table I (2). The management of patients with pelvic pain depends largely on the patients' age and her desire for further childbearing. In the absence of absolute indications for surgery, patients who still desire childbearing can be treated with analgesics or periodic medical therapy to reduce symptoms. Laparoscopic surgery is an alternative, particularly if it can be performed at the initial diagnostic laparoscopy. If pain continues to be severe, conservative laparotomy and presacral neurectomy with or without perioperative medical therapy should be considered. When childbearing is no longer a factor and analgesics are ineffective, definitive surgery is indicated (Table II).
Objective: To compare the changes in body composition and in leptin levels in postmenopausal wome... more Objective: To compare the changes in body composition and in leptin levels in postmenopausal women receiving hormone therapy (HT) or tibolone. Design: Prospective comparative study. Setting: Menopause Unit in a tertiary Hospital. Patient(s): One hundred twenty women were recruited. Intervention(s): Women were assigned into a control group, HT, and tibolone group. Main Outcome Measure(s): Anthropometric indices, leptin levels, tissue fat percentage, total fat, and lean mass measurements were performed at baseline and after 6 months. Result(s): The serum leptin levels were in strong correlation with the total fat percentage and total fat mass at baseline. Untreated women had weight gain and a gradual decrease in leptin levels. Women receiving HT had significantly increased leptin levels. Women in the tibolone group, however, had a significant decrease in leptin levels accompanied by decreased total fat mass, fat percentage, and increased total lean mass. The changes in leptin levels were more pronounced in lean women. Conclusion(s): Postmenopausal women tend to gain weight accompanied with a reduction in leptin concentrations. Hormone therapy administration increases leptin levels while maintaining body weight and body fat distribution, whereas tibolone use decreases leptin levels, total fat percentage, and total fat mass. (Fertil Steril Ò 2009;91:425-31. Ó2009 by American Society for Reproductive Medicine.
ABSTRACT Objective: To determine the initiation and continuation rate of hormone therapy (HT) fol... more ABSTRACT Objective: To determine the initiation and continuation rate of hormone therapy (HT) following publication of the Women’s Health Initiative (WHI) study. Methods: A survey was performed on 816 postmenopausal women between July 2002 and July 2005. Questions included sociodemographic characteristics, determinants of HT, use of knowledge and source of information regarding the WHI study. Results: The average age was 49,3±3,6 years. Among the participants 22,1% were using HT whereas 77,9% were not . Of the women; 131, 99, 60, 157 were graduated from university, high school, middle and primary school respectively. HT usage was 25% among primary school and 20% among university graduates, which appeared not to be affected by educational level. The rate of starting HT was 18,6% in the second half of 2002. Initiation of HT was 30,5% in 2003, than decreased to 21,5% in 2004 and 20,9% in 2005. Among women for whom HT was initiated after WHI, the continuation rate was 41%. Conclusion: O...
To determine if a simple morphological classification of embryos was predictive of subsequent pre... more To determine if a simple morphological classification of embryos was predictive of subsequent pregnancy. Prospective case series. University-based in vitro fertilization (IVF) program. Consecutive embryo transfer (ET) cycles (n = 206). Embryos were classified into three grades: (1) equal-size blastomeres with no fragmentation; (2) unequal-size blastomeres; and (3) evidence of fragmentation. Embryo quality, age, indication for IVF, and stimulation protocol were evaluated for their effect on pregnancy rates (PR's). In cycles in which the best embryo transferred was grade 3, 2, or 1, the clinical PRs per ET were 0% (0/11 cycles), 12.8% (6/47 cycles, P less than 0.05), and 21.8% (32/148 cycles, P less than 0.05), respectively. When one, two, or three or more grade 1 embryos were replaced, the clinical PRs per ET were 15.6%, 16.3%, and 40% (P less than 0.05), respectively. Using logistic regression, embryo quality (P = 0.0011) and patient's age (P = 0.0044) were the only variable...
To compare the efficacy of two antiandrogens, spironolactone and flutamide, in the treatment of h... more To compare the efficacy of two antiandrogens, spironolactone and flutamide, in the treatment of hirsutism. Twenty women with idiopathic hirsutism were randomized to receive either flutamide or spironolactone. Twenty hirsute women were recruited from patients presenting to the hirsutism clinic in Marmara University, Istanbul. Each patient underwent a complete medical and gynecological examination as well as endocrine profile, hematologic, hepatic, and renal function analyses. Hirsutism scores were determined according to the Ferriman-Gallwey scoring system. These tests were then repeated at 3, 6, and 9 months of therapy. Ten patients received 250 mg of flutamide two times per day, and 10 patients received 100 mg of spironolactone for 9 months. Ferriman-Gallwey scores were decreased significantly in both groups at the end of 9 months. The percent of change in hirsutism scores in flutamide and spironolactone group were as follows: 26.4% and 20.9% at 3 months; 39.5% and 32.9% at 6 month...
Cardiovascular disease (CVD) is the leading cause of death in women, and after menopause the inci... more Cardiovascular disease (CVD) is the leading cause of death in women, and after menopause the incidence increases rapidly. The premenopausal state and estrogen status, appear to be a prophylactic against the mortality risk from CVD. The protective effect is believed to be mediated by beneficial changes in cholesterol levels. Estrogen decreases low density lipoprotein cholesterol (LDL-C) and increases high density lipoprotein cholesterol (HDL-C). The other possible mechanism is the direct effect of estrogen on arterial intima. The type and route of estrogen used in hormone replacement therapy determines the positive and negative effect of estrogen on the cardiovascular system. Most studies show a 50% or greater reduction in CVD and related mortality with postmenopausal estrogen administration. Progestogen addition to hormone replacement, may attenuate the beneficial effects of estrogen on cholesterol. However if used in low doses progesteron may not exert this negative effect on the c...
To compare the efficacy of two antiandrogens, cyproterone acetate (CPA) and spironolactone, in th... more To compare the efficacy of two antiandrogens, cyproterone acetate (CPA) and spironolactone, in the treatment of hirsutism. Prospective randomized single-blinded study. A tertiary hirsutism clinic. Forty-two premenopausal patients with hirsutism were selected. Subjects were randomized to receive either 100 mg spironolactone and an oral contraceptive (OC) containing 150 microg desogestrel and 30 microg ethinyl E2 or 50 mg CPA daily on days 1 to 10 of the menstrual cycle, which was administered with 35 microg ethinyl E2 daily on days 1 to 21. Hirsutism scores were measured according to Ferriman-Gallwey scoring system and side effects were monitored for 9 months of treatment. Blood samples were taken at each visit for assessment of endocrine, biochemical, and hematologic parameters. Hirsutism scores were decreaded significantly in both groups at the end of 9 months. The percent of change in hirsutism scores in CPA and spironolactone group were as follows: 19.23% +/- 14.77% and 24.48% +/...
To determine if a simple morphological classification of embryos was predictive of subsequent pre... more To determine if a simple morphological classification of embryos was predictive of subsequent pregnancy. Prospective case series. University-based in vitro fertilization (IVF) program. Consecutive embryo transfer (ET) cycles (n = 206). Embryos were classified into three grades: (1) equal-size blastomeres with no fragmentation; (2) unequal-size blastomeres; and (3) evidence of fragmentation. Embryo quality, age, indication for IVF, and stimulation protocol were evaluated for their effect on pregnancy rates (PR's). In cycles in which the best embryo transferred was grade 3, 2, or 1, the clinical PRs per ET were 0% (0/11 cycles), 12.8% (6/47 cycles, P less than 0.05), and 21.8% (32/148 cycles, P less than 0.05), respectively. When one, two, or three or more grade 1 embryos were replaced, the clinical PRs per ET were 15.6%, 16.3%, and 40% (P less than 0.05), respectively. Using logistic regression, embryo quality (P = 0.0011) and patient's age (P = 0.0044) were the only variable...
In an attempt to compare the effects of transdermal and oral conjugated estrogen on serum lipopro... more In an attempt to compare the effects of transdermal and oral conjugated estrogen on serum lipoproteins, 35 premenopausal women who underwent total abdominal hysterectomy and bilateral salpingo-oophorectomy were randomized to receive either 0.625 mg of ...
Journal of the American College of Cardiology, 1999
... Auteur(s) / Author(s). FAK AS ; ERENUS M. ; TEZCAN H. ; CAYMAZ O. ; ATAGUNDUZ P. ; TOKAY S. ;... more ... Auteur(s) / Author(s). FAK AS ; ERENUS M. ; TEZCAN H. ; CAYMAZ O. ; ATAGUNDUZ P. ; TOKAY S. ; TOPRAK A. ; OKTAY S. ; OKTAY A. ; Revue / Journal Title. Journal of the American College of Cardiology ISSN 0735-1097 CODEN JACCDI Source / Source. 1999, vol. ...
In an attempt to compare the effects of transdermal and oral conjugated estrogen on serum lipopro... more In an attempt to compare the effects of transdermal and oral conjugated estrogen on serum lipoproteins, 35 premenopausal women who underwent total abdominal hysterectomy and bilateral salpingo-oophorectomy were randomized to receive either 0.625 mg of conjugated oral estrogen or 0.05 mg transdermal 17 beta-E2 during the first postoperative year. Lipid profiles were assessed before surgery and at 3, 6, 9, and 12 months of therapy in each subject. Neither oral nor transdermal estrogen replacement therapy produced significant changes on serum lipoproteins at the end of first year when compared with baseline preoperative values. We conclude that both transdermal and oral administration of estrogen are promising in the maintenance of premenopausal lipid values after menopause.
To compare the efficacy of two antiandrogens, spironolactone and flutamide, in the treatment of h... more To compare the efficacy of two antiandrogens, spironolactone and flutamide, in the treatment of hirsutism. Twenty women with idiopathic hirsutism were randomized to receive either flutamide or spironolactone. Twenty hirsute women were recruited from patients presenting to the hirsutism clinic in Marmara University, Istanbul. Each patient underwent a complete medical and gynecological examination as well as endocrine profile, hematologic, hepatic, and renal function analyses. Hirsutism scores were determined according to the Ferriman-Gallwey scoring system. These tests were then repeated at 3, 6, and 9 months of therapy. Ten patients received 250 mg of flutamide two times per day, and 10 patients received 100 mg of spironolactone for 9 months. Ferriman-Gallwey scores were decreased significantly in both groups at the end of 9 months. The percent of change in hirsutism scores in flutamide and spironolactone group were as follows: 26.4% and 20.9% at 3 months; 39.5% and 32.9% at 6 month...
Tubo-ovarian abscess is seen as a complication of PID cases who are inadequately treated or delay... more Tubo-ovarian abscess is seen as a complication of PID cases who are inadequately treated or delayed in treatment. Recently minimal invasive techniques such as; ultrasound, CT or MRI guided drainage are suggested in the treatm ent of tubo-ovarian abscesses. The current report presents a patient with a tubo-ovarian abscess treated by drainage via transvaginal ultrasonography.
European Journal of Obstetrics & Gynecology and Reproductive Biology, 2012
To determine the prevalence of metabolic syndrome among pre- and post-menopausal women attending ... more To determine the prevalence of metabolic syndrome among pre- and post-menopausal women attending a tertiary clinic in Turkey. This is a cross-sectional study consisting of one hundred and eighty healthy postmenopausal women and fifty-three healthy premenopausal women evaluated for presence or absence of metabolic syndrome. The t test and Fischer exact test were used for continuous variables and chi-square test was used for categorical variables. The prevalence of metabolic syndrome among pre-menopausal women was 15.09% according to NCEP criteria. The prevalence of metabolic syndrome among postmenopausal women was 19.44% according to NCEP criteria. There was no significant difference in the prevalence of metabolic syndrome between premenopausal and postmenopausal women in our study population. There was no significant difference in the prevalence of metabolic syndrome between premenopausal and postmenopausal women attending a tertiary clinic in Turkey.
Moderate exercise is undoubtedly a positive factor in health. Strenuous exercise in women may lea... more Moderate exercise is undoubtedly a positive factor in health. Strenuous exercise in women may lead to disturbances in reproductive function ranging from subtle effects on fe rtility to hypoestrogenic amenorrhea. Exercise-related menstrual dysfunction is more likely to occur with strenuous exercise, in women who are nulliparous, in women with a history of delayed menarche, in women under age 30, and in women with low body fat. The mechanism by which the menstrual dysfunction develops is, to this point, unknown, but no evidence exists to suggest that it has long-term repercussions on reproductive capacity.
Wheeler and Malinak described a treatment algorithm that considers the severity of endometriosis,... more Wheeler and Malinak described a treatment algorithm that considers the severity of endometriosis, the patients' desires for reproduction versus symptom relief and the several acceptable forms of treatment, (revised AFS System) (1). The algorithm is shown in Table I (2). The management of patients with pelvic pain depends largely on the patients' age and her desire for further childbearing. In the absence of absolute indications for surgery, patients who still desire childbearing can be treated with analgesics or periodic medical therapy to reduce symptoms. Laparoscopic surgery is an alternative, particularly if it can be performed at the initial diagnostic laparoscopy. If pain continues to be severe, conservative laparotomy and presacral neurectomy with or without perioperative medical therapy should be considered. When childbearing is no longer a factor and analgesics are ineffective, definitive surgery is indicated (Table II).
Objective: To compare the changes in body composition and in leptin levels in postmenopausal wome... more Objective: To compare the changes in body composition and in leptin levels in postmenopausal women receiving hormone therapy (HT) or tibolone. Design: Prospective comparative study. Setting: Menopause Unit in a tertiary Hospital. Patient(s): One hundred twenty women were recruited. Intervention(s): Women were assigned into a control group, HT, and tibolone group. Main Outcome Measure(s): Anthropometric indices, leptin levels, tissue fat percentage, total fat, and lean mass measurements were performed at baseline and after 6 months. Result(s): The serum leptin levels were in strong correlation with the total fat percentage and total fat mass at baseline. Untreated women had weight gain and a gradual decrease in leptin levels. Women receiving HT had significantly increased leptin levels. Women in the tibolone group, however, had a significant decrease in leptin levels accompanied by decreased total fat mass, fat percentage, and increased total lean mass. The changes in leptin levels were more pronounced in lean women. Conclusion(s): Postmenopausal women tend to gain weight accompanied with a reduction in leptin concentrations. Hormone therapy administration increases leptin levels while maintaining body weight and body fat distribution, whereas tibolone use decreases leptin levels, total fat percentage, and total fat mass. (Fertil Steril Ò 2009;91:425-31. Ó2009 by American Society for Reproductive Medicine.
ABSTRACT Objective: To determine the initiation and continuation rate of hormone therapy (HT) fol... more ABSTRACT Objective: To determine the initiation and continuation rate of hormone therapy (HT) following publication of the Women’s Health Initiative (WHI) study. Methods: A survey was performed on 816 postmenopausal women between July 2002 and July 2005. Questions included sociodemographic characteristics, determinants of HT, use of knowledge and source of information regarding the WHI study. Results: The average age was 49,3±3,6 years. Among the participants 22,1% were using HT whereas 77,9% were not . Of the women; 131, 99, 60, 157 were graduated from university, high school, middle and primary school respectively. HT usage was 25% among primary school and 20% among university graduates, which appeared not to be affected by educational level. The rate of starting HT was 18,6% in the second half of 2002. Initiation of HT was 30,5% in 2003, than decreased to 21,5% in 2004 and 20,9% in 2005. Among women for whom HT was initiated after WHI, the continuation rate was 41%. Conclusion: O...
To determine if a simple morphological classification of embryos was predictive of subsequent pre... more To determine if a simple morphological classification of embryos was predictive of subsequent pregnancy. Prospective case series. University-based in vitro fertilization (IVF) program. Consecutive embryo transfer (ET) cycles (n = 206). Embryos were classified into three grades: (1) equal-size blastomeres with no fragmentation; (2) unequal-size blastomeres; and (3) evidence of fragmentation. Embryo quality, age, indication for IVF, and stimulation protocol were evaluated for their effect on pregnancy rates (PR's). In cycles in which the best embryo transferred was grade 3, 2, or 1, the clinical PRs per ET were 0% (0/11 cycles), 12.8% (6/47 cycles, P less than 0.05), and 21.8% (32/148 cycles, P less than 0.05), respectively. When one, two, or three or more grade 1 embryos were replaced, the clinical PRs per ET were 15.6%, 16.3%, and 40% (P less than 0.05), respectively. Using logistic regression, embryo quality (P = 0.0011) and patient's age (P = 0.0044) were the only variable...
To compare the efficacy of two antiandrogens, spironolactone and flutamide, in the treatment of h... more To compare the efficacy of two antiandrogens, spironolactone and flutamide, in the treatment of hirsutism. Twenty women with idiopathic hirsutism were randomized to receive either flutamide or spironolactone. Twenty hirsute women were recruited from patients presenting to the hirsutism clinic in Marmara University, Istanbul. Each patient underwent a complete medical and gynecological examination as well as endocrine profile, hematologic, hepatic, and renal function analyses. Hirsutism scores were determined according to the Ferriman-Gallwey scoring system. These tests were then repeated at 3, 6, and 9 months of therapy. Ten patients received 250 mg of flutamide two times per day, and 10 patients received 100 mg of spironolactone for 9 months. Ferriman-Gallwey scores were decreased significantly in both groups at the end of 9 months. The percent of change in hirsutism scores in flutamide and spironolactone group were as follows: 26.4% and 20.9% at 3 months; 39.5% and 32.9% at 6 month...
Cardiovascular disease (CVD) is the leading cause of death in women, and after menopause the inci... more Cardiovascular disease (CVD) is the leading cause of death in women, and after menopause the incidence increases rapidly. The premenopausal state and estrogen status, appear to be a prophylactic against the mortality risk from CVD. The protective effect is believed to be mediated by beneficial changes in cholesterol levels. Estrogen decreases low density lipoprotein cholesterol (LDL-C) and increases high density lipoprotein cholesterol (HDL-C). The other possible mechanism is the direct effect of estrogen on arterial intima. The type and route of estrogen used in hormone replacement therapy determines the positive and negative effect of estrogen on the cardiovascular system. Most studies show a 50% or greater reduction in CVD and related mortality with postmenopausal estrogen administration. Progestogen addition to hormone replacement, may attenuate the beneficial effects of estrogen on cholesterol. However if used in low doses progesteron may not exert this negative effect on the c...
To compare the efficacy of two antiandrogens, cyproterone acetate (CPA) and spironolactone, in th... more To compare the efficacy of two antiandrogens, cyproterone acetate (CPA) and spironolactone, in the treatment of hirsutism. Prospective randomized single-blinded study. A tertiary hirsutism clinic. Forty-two premenopausal patients with hirsutism were selected. Subjects were randomized to receive either 100 mg spironolactone and an oral contraceptive (OC) containing 150 microg desogestrel and 30 microg ethinyl E2 or 50 mg CPA daily on days 1 to 10 of the menstrual cycle, which was administered with 35 microg ethinyl E2 daily on days 1 to 21. Hirsutism scores were measured according to Ferriman-Gallwey scoring system and side effects were monitored for 9 months of treatment. Blood samples were taken at each visit for assessment of endocrine, biochemical, and hematologic parameters. Hirsutism scores were decreaded significantly in both groups at the end of 9 months. The percent of change in hirsutism scores in CPA and spironolactone group were as follows: 19.23% +/- 14.77% and 24.48% +/...
To determine if a simple morphological classification of embryos was predictive of subsequent pre... more To determine if a simple morphological classification of embryos was predictive of subsequent pregnancy. Prospective case series. University-based in vitro fertilization (IVF) program. Consecutive embryo transfer (ET) cycles (n = 206). Embryos were classified into three grades: (1) equal-size blastomeres with no fragmentation; (2) unequal-size blastomeres; and (3) evidence of fragmentation. Embryo quality, age, indication for IVF, and stimulation protocol were evaluated for their effect on pregnancy rates (PR's). In cycles in which the best embryo transferred was grade 3, 2, or 1, the clinical PRs per ET were 0% (0/11 cycles), 12.8% (6/47 cycles, P less than 0.05), and 21.8% (32/148 cycles, P less than 0.05), respectively. When one, two, or three or more grade 1 embryos were replaced, the clinical PRs per ET were 15.6%, 16.3%, and 40% (P less than 0.05), respectively. Using logistic regression, embryo quality (P = 0.0011) and patient's age (P = 0.0044) were the only variable...
In an attempt to compare the effects of transdermal and oral conjugated estrogen on serum lipopro... more In an attempt to compare the effects of transdermal and oral conjugated estrogen on serum lipoproteins, 35 premenopausal women who underwent total abdominal hysterectomy and bilateral salpingo-oophorectomy were randomized to receive either 0.625 mg of ...
Journal of the American College of Cardiology, 1999
... Auteur(s) / Author(s). FAK AS ; ERENUS M. ; TEZCAN H. ; CAYMAZ O. ; ATAGUNDUZ P. ; TOKAY S. ;... more ... Auteur(s) / Author(s). FAK AS ; ERENUS M. ; TEZCAN H. ; CAYMAZ O. ; ATAGUNDUZ P. ; TOKAY S. ; TOPRAK A. ; OKTAY S. ; OKTAY A. ; Revue / Journal Title. Journal of the American College of Cardiology ISSN 0735-1097 CODEN JACCDI Source / Source. 1999, vol. ...
In an attempt to compare the effects of transdermal and oral conjugated estrogen on serum lipopro... more In an attempt to compare the effects of transdermal and oral conjugated estrogen on serum lipoproteins, 35 premenopausal women who underwent total abdominal hysterectomy and bilateral salpingo-oophorectomy were randomized to receive either 0.625 mg of conjugated oral estrogen or 0.05 mg transdermal 17 beta-E2 during the first postoperative year. Lipid profiles were assessed before surgery and at 3, 6, 9, and 12 months of therapy in each subject. Neither oral nor transdermal estrogen replacement therapy produced significant changes on serum lipoproteins at the end of first year when compared with baseline preoperative values. We conclude that both transdermal and oral administration of estrogen are promising in the maintenance of premenopausal lipid values after menopause.
To compare the efficacy of two antiandrogens, spironolactone and flutamide, in the treatment of h... more To compare the efficacy of two antiandrogens, spironolactone and flutamide, in the treatment of hirsutism. Twenty women with idiopathic hirsutism were randomized to receive either flutamide or spironolactone. Twenty hirsute women were recruited from patients presenting to the hirsutism clinic in Marmara University, Istanbul. Each patient underwent a complete medical and gynecological examination as well as endocrine profile, hematologic, hepatic, and renal function analyses. Hirsutism scores were determined according to the Ferriman-Gallwey scoring system. These tests were then repeated at 3, 6, and 9 months of therapy. Ten patients received 250 mg of flutamide two times per day, and 10 patients received 100 mg of spironolactone for 9 months. Ferriman-Gallwey scores were decreased significantly in both groups at the end of 9 months. The percent of change in hirsutism scores in flutamide and spironolactone group were as follows: 26.4% and 20.9% at 3 months; 39.5% and 32.9% at 6 month...
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