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Intravenous Drug Self-administration in Mice: Practical Considerations

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Abstract

Chronic intravenous drug self-administration in rodents is a useful procedure for predicting the abuse liability of novel drugs in humans, for evaluating candidate treatments for drug abuse and dependence, and for studying the biological basis of addiction. Despite the technical challenge in achieving chronic self-administration behavior in the mouse species, researchers are increasingly using genetically engineered mice to investigate the role of specific genes in abuse-related effects of drugs. This review focuses on recent technical innovations as well as theoretical considerations for comparing intravenous (i.v.) drug self-administration behavior between mouse strains, including mice with targeted mutations. Part I of the present article describes techniques for successfully conducting self-administration studies in mice, including advantages, disadvantages and possible implications of employing various experimental approaches. Part II provides a review of recent data that address how the genetic background on which mutations are expressed may influence results from gene-targeting studies.

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Acknowledgments

Parts of this manuscript may be similar or identical to previous publications by the authors. Content from Unit 9.20, “Chronic intravenous drug self-administration in rodents” Thomsen and Caine, in: Current Protocols in Neuroscience 2005, is reprinted with kind permission of John Wiley & Son, Inc. Figure 5 and the corresponding discussion of these results were modified from “Cocaine self-administration under fixed and progressive ratio schedules of reinforcement: comparison of C57BL/6J, 129X1/SvJ, and 129S6/SvEvTac inbred mice”, Thomsen and Caine (2006), Psychopharmacology (Berl) 184(2):145–154, with kind permission of Springer Science and Business Media. The authors also wish to gratefully acknowledge the support of the National Institute on Drug Abuse, National Institutes of Health (DA07252, DA12142, DA14528, DA14644, DA17323), The Zaffaroni Foundation and the Lundbeck Foundation. All procedures were carried out in accordance with the NIH Guide for the Care and Use of Laboratory Animals.

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  1. Alcohol and Drug Abuse Research Center, McLean Hospital/Harvard Medical School, 115 Mill Street, Belmont, MA, 02478, USA

    Morgane Thomsen & S. Barak Caine

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Thomsen, M., Caine, S.B. Intravenous Drug Self-administration in Mice: Practical Considerations. Behav Genet 37, 101–118 (2007). https://doi.org/10.1007/s10519-006-9097-0

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