Our full departmental research profile can be found on Scholars@UK.
A cautionary tale about properly vetting datasets used in supervised learning predicting metabolic pathway involvement
Huckvale, E. D. & Moseley, H. N. B., May 2024, In: PLoS ONE. 19, 5 MAY, e0299583.Research output: Contribution to journal › Article › peer-review
A dynamic model of inorganic arsenic-induced carcinogenesis reveals an epigenetic mechanism for epithelial–mesenchymal plasticity.
Rea, M., Kimmerer, G., Mittendorf, S., Xiong, X., Green, M., Chandler, D., Saintilnord, W., Blackburn, J., Gao, T. & Fondufe-Mittendorf, Y. N., Apr 15 2024, In: Environmental Pollution. 347, 123586.Research output: Contribution to journal › Article › peer-review
AI is a viable alternative to high throughput screening: a 318-target study
Wallach, I., Bernard, D., Nguyen, K., Ho, G., Morrison, A., Stecula, A., Rosnik, A., O’Sullivan, A. M., Davtyan, A., Samudio, B., Thomas, B., Worley, B., Butler, B., Laggner, C., Thayer, D., Moharreri, E., Friedland, G., Truong, H., van den Bedem, H. & Ng, H. L. & 668 others, , Dec 2024, In: Scientific Reports. 14, 1, 7526.Research output: Contribution to journal › Article › peer-review
Aldh2 deficiency plays a dual role in lung tumorigenesis and tumor progression
Zhang, H., Sun, X., Li, Z., Liu, T., Zhang, F., Meng, X., Li, K., Xu, J., He, W., Jing, B., Wang, T., Ni, N., Sun, B., Yao, F., Wu, Y., Wang, Q., Du, J., Chin, E. Y., Zhou, B. P. & Jiang, P. & 2 others, , May 2024, In: Genes and Diseases. 11, 3, 100999.Research output: Contribution to journal › Article › peer-review
A Novel Protozoa Parasite-Derived Protein Adjuvant Is Effective in Immunization with Cancer Cells to Activate the Cancer-Specific Protective Immunity and Inhibit the Cancer Growth in a Murine Model of Colorectal Cancer
Mani, R., Martin, C. G., Balu, K. E., Wang, Q., Rychahou, P., Izumi, T., Evers, B. M. & Suzuki, Y., Jan 2024, In: Cells. 13, 2, 111.Research output: Contribution to journal › Article › peer-review
A Probabilistic Approach to Estimate the Temporal Order of Pathway Mutations Accounting for Intra-Tumor Heterogeneity
Wang, M., Xie, Y., Liu, J., Li, A., Chen, L., Stromberg, A., Arnold, S. M., Liu, C. & Wang, C., Jul 2024, In: Cancers. 16, 13, 2488.Research output: Contribution to journal › Article › peer-review
A single hydrogen bond that tunes flavin redox reactivity and activates it for modification
Das, D. & Miller, A. F., Apr 24 2024, In: Chemical Science. 15, 20, p. 7610-7622 13 p.Research output: Contribution to journal › Article › peer-review
Astrocyte involvement in metabolic regulation and disease
Naveed, M., Smedlund, K., Zhou, Q. G., Cai, W. & Hill, J. W., 2024, (Accepted/In press) In: Trends in Endocrinology and Metabolism.Research output: Contribution to journal › Review article › peer-review
Atypical Mycobacterium abscessus BlaRI Ortholog Mediates Regulation of Energy Metabolism but Not β-Lactam Resistance
Bonefont, L. E., Davenport, H. C., Chaton, C. T., Korotkov, K. V. & Rohde, K. H., Sep 22 2024, (E-pub ahead of print) In: Molecular Microbiology.Research output: Contribution to journal › Article › peer-review
Cooperative nucleic acid binding by Poly ADP-ribose polymerase 1
Melikishvili, M., Fried, M. G. & Fondufe-Mittendorf, Y. N., Dec 2024, In: Scientific Reports. 14, 1, 7530.Research output: Contribution to journal › Article › peer-review
Correction to: NAC1 promotes stemness and regulates myeloid-derived cell status in triple-negative breast cancer (Molecular Cancer, (2024), 23, 1, (188), 10.1186/s12943-024-02102-y)
Ngule, C., Shi, R., Ren, X., Jia, H., Oyelami, F., Li, D., Park, Y., Kim, J., Hemati, H., Zhang, Y., Xiong, X., Shinkle, A., Vanderford, N. L., Bachert, S., Zhou, B. P., Wang, J., Song, J., Liu, X. & Yang, J., Dec 2024, In: Molecular Cancer. 23, 1, 220.Research output: Contribution to journal › Comment/debate
Correction to: AI is a viable alternative to high throughput screening: a 318-target study (Scientific Reports, (2024), 14, 1, (7526), 10.1038/s41598-024-54655-z)
The Atomwise AIMS Program, Dec 2024, In: Scientific Reports. 14, 1, 21579.Research output: Contribution to journal › Comment/debate
Creating an Integrated Coaching Culture in Higher Education
Bradley, J. A., Tuck, M. E., Reynolds, M. A. & Bradley, L. H., 2024, In: Journal of appreciative education. 11, p. 15-24 10 p.Research output: Contribution to journal › Article › peer-review
Cryo-EM reconstruction of oleate hydratase bound to a phospholipid membrane bilayer
Oldham, M. L., Zuhaib Qayyum, M., Kalathur, R. C., Rock, C. O. & Radka, C. D., Sep 2024, In: Journal of Structural Biology. 216, 3, 108116.Research output: Contribution to journal › Article › peer-review
Deletion of murine astrocytic vesicular nucleotide transporter increases anxiety and depressive-like behavior and attenuates motivation for reward
Huang, Q., Lee, H. H., Volpe, B., Zhang, Q., Xue, C., Liu, B. C., Abuhasan, Y. R., Li, L., Yang, J. S., Egholm, J., Gutierrez-Vazquez, C., Li, A., Lee, A., Tang, S., Wong, C. W., Liu, T., Huang, Y., Ramos, R. L., Stout, R. F. & El Ouaamari, A. & 5 others, , 2024, (Accepted/In press) In: Molecular Psychiatry.Research output: Contribution to journal › Article › peer-review
Differential processing of VesB by two rhomboid proteases in Vibrio cholerae.
Roberts, C. S., Shannon, A. B., Korotkov, K. V. & Sandkvist, M., Sep 11 2024, In: mBio. 15, 9, p. e0127024Research output: Contribution to journal › Article › peer-review
Differentiation of Prior SARS-CoV-2 Infection and Postacute Sequelae by Standard Clinical Laboratory Measurements in the RECOVER Cohort
RECOVER-Adult Cohort, Sep 2024, In: Annals of Internal Medicine. 177, 9, p. 1209-1221 13 p.Research output: Contribution to journal › Article › peer-review
Disorder regulates homeostasis of extracytoplasmic proteins in streptococci
Rahman, M. M., Zamakhaeva, S., Rush, J. S., Chaton, C. T., Kenner, C. W., Hla, Y. M., Tsui, H.-C. T., Winkler, M. E., Korotkov, K. V. & Korotkova, N., May 8 2024, In: bioRxiv.Research output: Contribution to journal › Article
EcoHIV-Infected Mice Show No Signs of Platelet Activation
Alfar, H. R., Nthenge-Ngumbau, D. N., Saatman, K. E. & Whiteheart, S. W., Jan 2024, In: Viruses. 16, 1, 55.Research output: Contribution to journal › Article › peer-review
Elevating PLK1 overcomes BETi resistance in prostate cancer via triggering BRD4 phosphorylation-dependent degradation in mitosis
Zhang, Y., Fong, K. W., Mao, F., Wang, R., Allison, D., Napier, D., He, D., Liu, J., Zhang, Y., Chen, J., Kong, Y., Li, C., Li, G., Liu, J., Li, Z., Zhu, H., Wang, C. & Liu, X., Jul 23 2024, In: Cell Reports. 43, 7, 114431.Research output: Contribution to journal › Article › peer-review
Everolimus alleviates CD4+ T cell inflammation by regulating autophagy and cellular redox homeostasis
Rockhold, J. D., Marszalkowski, H., Sannella, M., Gibney, K., Murphy, L., Zukowski, E., Kalantar, G. H., SantaCruz-Calvo, S., Hart, S. N., Kuhn, M. K., Yu, J., Stefanik, O., Chase, G., Proctor, E. A., Hasturk, H., Nikolajczyk, B. S. & Bharath, L. P., Dec 2024, In: GeroScience. 46, 6, p. 5681-5699 19 p.Research output: Contribution to journal › Article › peer-review
Examining Phosphatases Through Immunofluorescent Microscopy
Smith, C. N. & Blackburn, J. S., 2024, Methods in Molecular Biology. p. 111-122 12 p. (Methods in Molecular Biology; vol. 2743).Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
Extended conformations of bifurcating electron transfer flavoprotein constitute up to half the population, possibly mediating conformational change
Khan, S. A., Hicks, A., Leite, W. C., Byrnes, J., Gorai, B., Mroginski, M. A., O'Neill, H. & Miller, A. F., Oct 23 2024, In: Chemical Science. 15, 45, p. 18796-18817 22 p.Research output: Contribution to journal › Article › peer-review
Fasting and Glucose Metabolism Differentially Impact Peripheral Inflammation in Human Type 2 Diabetes
Kalantar, G. H., Saraswat, S., SantaCruz-Calvo, S., Gholamrezaeinejad, F., Javidan, A., Agrawal, M., Liu, R., Kern, P., Zhang, X. & Nikolajczyk, B. S., May 7 2024, In: Nutrients. 16, 10Research output: Contribution to journal › Article › peer-review
Gestational diabetes augments group B Streptococcus infection by disrupting maternal immunity and the vaginal microbiota
Mercado-Evans, V., Mejia, M. E., Zulk, J. J., Ottinger, S., Hameed, Z. A., Serchejian, C., Marunde, M. G., Robertson, C. M., Ballard, M. B., Ruano, S. H., Korotkova, N., Flores, A. R., Pennington, K. A. & Patras, K. A., Dec 2024, In: Nature Communications. 15, 1Research output: Contribution to journal › Article › peer-review
Gut microbial co-metabolite 2-methylbutyrylcarnitine exacerbates thrombosis via binding to and activating integrin α2β1
Huang, K., Li, Z., He, X., Dai, J., Huang, B., Shi, Y., Fan, D., Zhang, Z., Liu, Y., Li, N., Zhang, Z., Peng, J., Liu, C., Zeng, R., Cen, Z., Wang, T., Yang, W., Cen, M., Li, J. & Yuan, S. & 40 others, , Mar 5 2024, In: Cell Metabolism. 36, 3, p. 598-616.e9Research output: Contribution to journal › Article › peer-review
Identification of Quiescent Cells in a Zebrafish T-Cell Acute Lymphoblastic Leukemia Model Using Cell Proliferation Staining
Al-Hamaly, M. A., Chernyavskaya, Y. & Blackburn, J. S., Jul 2024, In: Journal of Visualized Experiments. 2024, 209, e67059.Research output: Contribution to journal › Article › peer-review
Identification of retinal oligomeric, citrullinated, and other tau isoforms in early and advanced AD and relations to disease status
Shi, H., Mirzaei, N., Koronyo, Y., Davis, M. R., Robinson, E., Braun, G. M., Jallow, O., Rentsendorj, A., Ramanujan, V. K., Fert-Bober, J., Kramerov, A. A., Ljubimov, A. V., Schneider, L. S., Tourtellotte, W. G., Hawes, D., Schneider, J. A., Black, K. L., Kayed, R., Selenica, M. L. B. & Lee, D. C. & 2 others, , Dec 2024, In: Acta Neuropathologica. 148, 1, 3.Research output: Contribution to journal › Article › peer-review
InChI isotopologue and isotopomer specifications
Moseley, H. N. B., Rocca-Serra, P., Salek, R. M., Arita, M. & Schymanski, E. L., Dec 2024, In: Journal of Cheminformatics. 16, 1, 54.Research output: Contribution to journal › Article › peer-review
Influence of FTDP-17 mutants on circular tau RNAs
Margvelani, G., Welden, J. R., Maquera, A. A., Van Eyk, J. E., Murray, C., Miranda Sardon, S. C. & Stamm, S., Apr 2024, In: Biochimica et Biophysica Acta - Molecular Basis of Disease. 1870, 4, 167036.Research output: Contribution to journal › Article › peer-review
Inhibition of Carbohydrate Metabolism Potentiated by the Therapeutic Effects of Oxidative Phosphorylation Inhibitors in Colon Cancer Cells
Guo, L., Zhang, B., Zhang, W., Xie, Y., Chen, X., Sun, X., Watt, D. S., Liu, C., Spielmann, H. P. & Liu, X., Apr 2024, In: Cancers. 16, 7, 1399.Research output: Contribution to journal › Article › peer-review
Inhibition of ribonucleotide reductase subunit M2 enhances the radiosensitivity of metastatic pancreatic neuroendocrine tumor
Chow, Z., Johnson, J., Chauhan, A., Jeong, J. C., Castle, J. T., Izumi, T., Weiss, H., Townsend, C. M., Schrader, J., Anthony, L., Yang, E. S., Evers, B. M. & Rychahou, P., Aug 1 2024, In: Cancer Letters. 596, 216993.Research output: Contribution to journal › Article › peer-review
Knockout of the intellectual disability-linked gene Hs6st2 in mice decreases heparan sulfate 6-O-sulfation, impairs dendritic spines of hippocampal neurons, and affects memory
Moon, S., Lee, H. H., Archer-Hartmann, S., Nagai, N., Mubasher, Z., Parappurath, M., Ahmed, L., Ramos, R. L., Kimata, K., Azadi, P., Cai, W. & Zhao, J. Y., Feb 1 2024, In: Glycobiology. 34, 2, cwad095.Research output: Contribution to journal › Article › peer-review
L858R/L718Q and L858R/L792H Mutations of EGFR Inducing Resistance Against Osimertinib by Forming Additional Hydrogen Bonds
Imam, I., Al Adawi, S., Liu, X., Ellingson, S., Brainson, C., Moseley, H. ., Zinner, R., Zhang, S. & Shao, Q., 2024, (Accepted/In press) In: Proteins: Structure, Function and Bioinformatics.Research output: Contribution to journal › Article › peer-review
Measurement of circulating viral antigens post-SARS-CoV-2 infection in a multicohort study
Swank, Z., Borberg, E., Chen, Y., Senussi, Y., Chalise, S., Manickas-Hill, Z., Yu, X. G., Li, J. Z., Alter, G., Henrich, T. J., Kelly, J. D., Hoh, R., Goldberg, S. A., Deeks, S. G., Martin, J. N., Peluso, M. J., Talla, A., Li, X., Skene, P. & Bumol, T. F. & 1,255 others, , Dec 2024, In: Clinical Microbiology and Infection. 30, 12, p. 1599-1605 7 p.Research output: Contribution to journal › Article › peer-review
NAC1 promotes stemness and regulates myeloid-derived cell status in triple-negative breast cancer
Ngule, C., Shi, R., Ren, X., Jia, H., Oyelami, F., Li, D., Park, Y., Kim, J., Hemati, H., Zhang, Y., Xiong, X., Shinkle, A., Vanderford, N. L., Bachert, S., Zhou, B. P., Wang, J., Song, J., Liu, X. & Yang, J. M., Dec 2024, In: Molecular Cancer. 23, 1, 188.Research output: Contribution to journal › Article › peer-review
Neurotensin accelerates atherosclerosis and increases circulating levels of short-chain and saturated triglycerides
Li, J., Yang, L., Song, J., Yan, B., Morris, A. J., Moseley, H., Flight, R., Wang, C., Liu, J., Weiss, H. L., Morris, E. F., Abdelhamid, I., Gerl, M. J., Melander, O., Smyth, S. & Evers, B. M., May 2024, In: Atherosclerosis. 392, 117479.Research output: Contribution to journal › Article › peer-review
NF-κB represses retinoic acid receptor-mediated GPRC5A transactivation in lung epithelial cells to promote neoplasia
Song, H., Ye, X., Liao, Y., Zhang, S., Xu, D., Zhong, S., Jing, B., Wang, T., Sun, B., Xu, J., Guo, W., Li, K., Hu, M., Kuang, Y., Ling, J., Zhang, T., Wu, Y., Du, J., Yao, F. & Chin, Y. E. & 3 others, , Oct 8 2024, In: JCI insight. 9, 19Research output: Contribution to journal › Article › peer-review
Overexpression of Fatty Acid Synthase Upregulates Glutamine–Fructose-6-Phosphate Transaminase 1 and O-Linked N-Acetylglucosamine Transferase to Increase O-GlcNAc Protein Glycosylation and Promote Colorectal Cancer Growth
Drury, J., Geisen, M. E., Tessmann, J. W., Rychahou, P. G., Kelson, C. O., He, D., Wang, C., Evers, B. M. & Zaytseva, Y. Y., May 2024, In: International Journal of Molecular Sciences. 25, 9, 4883.Research output: Contribution to journal › Article › peer-review
Paving the way to factor X deficiency therapies
Wood, J. P., Jul 11 2024, In: Blood. 144, 2, p. 134-135 2 p.Research output: Contribution to journal › Editorial
Perfluorooctanesulfonic acid exposure leads to downregulation of 3-hydroxy-3-methylglutaryl-CoA synthase 2 expression and upregulation of markers associated with intestinal carcinogenesis in mouse intestinal tissues
Tessmann, J. W., Deng, P., Durham, J., Li, C., Banerjee, M., Wang, Q., Goettl, R. A., He, D., Wang, C., Lee, E. Y., Evers, B. M., Hennig, B. & Zaytseva, Y. Y., Jul 2024, In: Chemosphere. 359, 142332.Research output: Contribution to journal › Article › peer-review
Periodontitis and Diabetes Differentially Affect Inflammation in Obesity
SantaCruz-Calvo, S., Saraswat, S., Hasturk, H., Dawson, D., Zhang, X. & Nikolajczyk, B. S., Nov 2024, In: Journal of Dental Research. 103, 12, p. 1313-1322 10 p.Research output: Contribution to journal › Article › peer-review
Predicting the Association of Metabolites with Both Pathway Categories and Individual Pathways
Huckvale, E. D. & Moseley, H. N. B., Sep 2024, In: Metabolites. 14, 9, 510.Research output: Contribution to journal › Article › peer-review
Predicting the Pathway Involvement of All Pathway and Associated Compound Entries Defined in the Kyoto Encyclopedia of Genes and Genomes
Huckvale, E. D. & Moseley, H. N. B., Nov 2024, In: Metabolites. 14, 11, 582.Research output: Contribution to journal › Article › peer-review
Predicting the Pathway Involvement of Metabolites Based on Combined Metabolite and Pathway Features
Huckvale, E. D. & Moseley, H. N. B., May 2024, In: Metabolites. 14, 5, 266.Research output: Contribution to journal › Article › peer-review
Sedimentation of large, soluble proteins up to 140 kDa for 1H-detected MAS NMR and 13C DNP NMR – practical aspects
Bell, D., Lindemann, F., Gerland, L., Aucharova, H., Klein, A., Friedrich, D., Hiller, M., Grohe, K., Meier, T., van Rossum, B., Diehl, A., Hughes, J., Mueller, L. J., Linser, R., Miller, A. F. & Oschkinat, H., Sep 2024, In: Journal of Biomolecular NMR. 78, 3, p. 179-192 14 p.Research output: Contribution to journal › Article › peer-review
Sex and sleep disruption as contributing factors in Alzheimer's disease
Johnson, C. E., Duncan, M. J. & Murphy, M. P., Feb 20 2024, Handbook of Prevention and Alzheimer's Disease. p. 321-364 44 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
Sex and Sleep Disruption as Contributing Factors in Alzheimer's Disease
Johnson, C. E., Duncan, M. J. & Paul Murphy, M., Jan 2 2024, In: Journal of Alzheimer's Disease. 97, 1, p. 31-74 44 p.Research output: Contribution to journal › Review article › peer-review
Sex and Sleep Disruption as Contributing Factors in Alzheimer's Disease
Johnson, C. E., Duncan, M. J. & Murphy, M. P., 2024, In: Advances in Alzheimer's Disease. 10, p. 321-364 44 p.Research output: Contribution to journal › Review article › peer-review
Staphylococcus aureus oleate hydratase produces ligands that activate host PPARα
Radka, C. D., Frank, M. W., Simmons, T. S., Johnson, C. N., Rosch, J. W. & Rock, C. O., 2024, In: Frontiers in Cellular and Infection Microbiology. 14, 1352810.Research output: Contribution to journal › Article › peer-review