With the introduction of new techniques in molecular biology—such as clinical exome sequencing, whole-genome sequencing, RNA sequencing, and metabolomics—researchers are equipped with more tools than ever to understand the genetic basis of diseases that affect human health.

The National Xenopus Resource was established to maintain, generate and distribute critical animal stocks, disseminate new technology, and optimize animal husbandry techniques all for the purpose of promoting and enhancing the use of Xenopus as a biomedical research model.

With support from ORIP's S10 Shared Instrumentation Programs, researchers at The University of Chicago and the University of Pennsylvania are using supercomputers for radiomics studies on cancers and other disorders.

In recent years, the research community has become increasingly interested in precision disease modeling, and it remains at the forefront of personalized medicine approaches for developing models for human disease. In 2014, ORIP launched the Precision Disease Modeling Initiative (PAR-14-280) and subsequently funded three Pilot Centers for Disease Modeling (U54) in 2015.

ORIP has reissued S10 notices of funding opportunities (NOFOs) as PAR-24-264, PAR-24-265, and PAR 24-326. These NOFOs support the purchase of state-of-the-art, commercially available instruments to be shared by NIH-funded investigators.

ORIP has issued a funding opportunity, PAR-25-061, to invite applications from eligible institutions to modernize existing or construct new biomedical research facilities. Applications from both research-intensive institutions and Institutions of Emerging Excellence in biomedical research from all geographic regions in the nation are strongly encouraged.