Figure 8.
Abcg2 KO mice injected with Cy5.5-labeled Aβ1–40 peptides show increased fluorescence concentration in the heads and brains. Equal amounts of Cy5.5-labeled Aβ1–40 were injected intravenously into 8 pairs of adult wt and Abcg2 KO mice. A, Mice were scanned alive at 15 min, 2, 4, 6, 8, and/or 24 h after injection. Higher fluorescence was found in the heads of the Abcg2 KO mice compared with wt mice at different time points. B, The mice were killed at 8 or 24 h after injection and the ex vivo brains were scanned. Higher Cy5.5 fluorescence was found in the ex vivo brains of Abcg2 KO mice compared with wt mice. C, The average of Cy5.5 fluorescence was significantly higher in the heads of Abcg2 KO mice compared with wt mice at different time points (one-way ANOVA, ***p < 0.0001).