Abstract
In healthy blood donors, serological positivity for human cytomegalovirus (HCMV) is associated with an increased proportion of NK cells bearing the CD94/NKG2C NK cell receptor (NKR). The expression of the activating CD94/NKG2C NKR and of the inhibitory CD94/NKG2A NKR was studied in a cohort of 45 aviremic human immunodeficiency virus type 1 (HIV-1)-positive patients receiving highly active antiretroviral therapy. The proportions of NKG2C+ NK cells were significantly increased in HIV-1-positive patients (mean +/- SD, 25.9% +/- 23.0%), compared with those in 31 healthy individuals (mean +/- SD, 16.1% +/- 20.7%). Yet, the association vanished when HCMV serological status was considered in a multivariate regression model. These results support the conclusion that changes in the NKR repertoire in HIV1-positive patients are related to a concomitant HCMV infection.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Antiretroviral Therapy, Highly Active
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Cytomegalovirus Infections / complications*
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Cytomegalovirus Infections / virology
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Gene Expression Profiling / methods
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Gene Expression Regulation, Viral / physiology
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HIV Infections / complications*
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HIV Infections / virology
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HIV-1* / physiology
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Humans
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Killer Cells, Natural / physiology*
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Killer Cells, Natural / virology
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Middle Aged
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NK Cell Lectin-Like Receptor Subfamily C
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NK Cell Lectin-Like Receptor Subfamily D / biosynthesis*
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Receptors, Immunologic / biosynthesis*
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Receptors, Immunologic / blood
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Receptors, Immunologic / physiology
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Receptors, Natural Killer Cell
Substances
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KLRC1 protein, human
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KLRC2 protein, human
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NK Cell Lectin-Like Receptor Subfamily C
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NK Cell Lectin-Like Receptor Subfamily D
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Receptors, Immunologic
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Receptors, Natural Killer Cell