Type I interferon: friend or foe?

J Exp Med. 2010 Sep 27;207(10):2053-63. doi: 10.1084/jem.20101664. Epub 2010 Sep 13.

Abstract

Although the role of type I interferon (IFN) in the protection against viral infections has been known and studied for decades, its role in other immunologically relevant scenarios, including bacterial infections, shock, autoimmunity, and cancer, is less well defined and potentially much more complicated.

Publication types

  • Review

MeSH terms

  • Animals
  • Autoimmunity / immunology
  • Bacterial Infections / immunology
  • Humans
  • Immunity, Innate
  • Interferon Type I / immunology*
  • Interferon-gamma / immunology
  • Neoplasms / immunology
  • Shock / immunology
  • Signal Transduction / immunology
  • Virus Diseases / immunology

Substances

  • Interferon Type I
  • Interferon-gamma
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