Abstract
A human IgGI antibody has been reshaped for serotherapy in humans by introducing the six hypervariable regions from the heavy- and light-chain variable domains of a rat antibody directed against human lymphocytes. The reshaped human antibody is as effective as the rat antibody in complement and is more effective in cell-mediated lysis of human lymphocytes.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Animals
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Antibodies, Monoclonal / genetics*
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Antibodies, Monoclonal / therapeutic use
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Base Sequence
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Binding Sites, Antibody
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Genes, Synthetic
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Humans
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Immunoglobulin G / genetics*
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Immunoglobulin G / therapeutic use
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Immunoglobulin Heavy Chains / genetics
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Immunoglobulin Light Chains / genetics
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Immunoglobulin Variable Region / genetics
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Lymphocytes / immunology
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Molecular Sequence Data
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Rats
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Recombinant Fusion Proteins / genetics*
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Recombinant Fusion Proteins / therapeutic use
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Recombinant Proteins / genetics*
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Species Specificity
Substances
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Antibodies, Monoclonal
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Immunoglobulin G
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Immunoglobulin Heavy Chains
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Immunoglobulin Light Chains
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Immunoglobulin Variable Region
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Recombinant Fusion Proteins
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Recombinant Proteins