Abstract
Thyroid-hormone and retinoic-acid receptors exert their regulatory functions by acting as both activators and repressors of gene expression. A nuclear receptor co-repressor (N-CoR) of relative molecular mass 270K has been identified which mediates ligand-independent inhibition of gene transcription by these receptors, suggesting that the molecular mechanisms of repression by thyroid-hormone and retinoic-acid receptors are analogous to the co-repressor-dependent transcriptional inhibitory mechanisms of yeast and Drosophila.
Publication types
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, Non-P.H.S.
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Amino Acid Sequence
-
Animals
-
Base Sequence
-
Binding Sites
-
Cell Line
-
DNA / metabolism
-
Gene Expression Regulation*
-
Humans
-
Ligands
-
Mice
-
Molecular Sequence Data
-
Mutagenesis, Site-Directed
-
Nuclear Proteins / genetics
-
Nuclear Proteins / metabolism*
-
Nuclear Receptor Co-Repressor 1
-
Oligodeoxyribonucleotides
-
Protein Binding
-
Receptors, Retinoic Acid / genetics
-
Receptors, Retinoic Acid / metabolism*
-
Receptors, Thyroid Hormone / genetics
-
Receptors, Thyroid Hormone / metabolism*
-
Recombinant Fusion Proteins / genetics
-
Recombinant Fusion Proteins / metabolism
-
Repressor Proteins / genetics
-
Repressor Proteins / metabolism*
-
Transcription, Genetic
-
Transfection
-
Tretinoin / metabolism
-
Triiodothyronine / metabolism
Substances
-
Ligands
-
NCOR1 protein, human
-
Ncor1 protein, mouse
-
Nuclear Proteins
-
Nuclear Receptor Co-Repressor 1
-
Oligodeoxyribonucleotides
-
Receptors, Retinoic Acid
-
Receptors, Thyroid Hormone
-
Recombinant Fusion Proteins
-
Repressor Proteins
-
retinoic acid receptor beta
-
Triiodothyronine
-
Tretinoin
-
DNA
Associated data
-
GENBANK/U20160
-
GENBANK/U35312