Abstract
Activation of the mesolimbic dopamine system is known to trigger relapse in animal models of cocaine-seeking behavior. We found that this "priming" effect was selectively induced by D2-like, and not by D1-like, dopamine receptor agonists in rats. Moreover, D1-like receptor agonists prevented cocaine-seeking behavior induced by cocaine itself, whereas D2-like receptor agonists enhanced this behavior. These results demonstrate an important dissociation between D1- and D2-like receptor processes in cocaine-seeking behavior and support further evaluation of D1-like receptor agonists as a possible pharmacotherapy for cocaine addiction.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Behavior, Addictive / etiology*
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Behavior, Animal / drug effects
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Benzazepines / pharmacology
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Caffeine / pharmacology
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Cocaine* / administration & dosage
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Dopamine Agonists / pharmacology*
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Ergolines / pharmacology
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Male
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Motor Activity / drug effects
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Quinpirole
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Rats
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Rats, Sprague-Dawley
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Receptors, Dopamine D1 / agonists
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Receptors, Dopamine D1 / physiology*
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Receptors, Dopamine D2 / agonists
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Receptors, Dopamine D2 / physiology*
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Recurrence
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Reinforcement, Psychology
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Substance-Related Disorders / etiology*
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Tetrahydronaphthalenes / pharmacology
Substances
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Benzazepines
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Dopamine Agonists
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Ergolines
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Receptors, Dopamine D1
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Receptors, Dopamine D2
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Tetrahydronaphthalenes
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Quinpirole
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Caffeine
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SK&F 81297
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SK&F 82958
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Cocaine
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7-hydroxy-2-N,N-dipropylaminotetralin