Inzulizin
| Inzulizin | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.24.56 | ||||||||
| CAS broj | 9013-83-6 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Inzulizin (EC 3.4.24.56, insulinaza, insulin-degradirajući enzim, insulinska proteaza, insulinska proteinaza, insulin-degradirajuća neutralna proteinaza, insulin-specifična proteaza, insulin-glukagonska proteaza, metaloinsulinaza, IDE) je enzim.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Degradacija insulina, glukagona i drugih polipeptida. Nije aktivan na drugim proteinima
Ovaj citosolni enzim je prisutan kod sisara i voćne mušice, Drosophila melanogaster.
- ↑ Duckworth, W.C. (1988). „Insulin degradation: mechanisms, products, and significance”. Endocrine Rev. 9: 319-345. PMID 3061785.
- ↑ Affholter, J.A., Hsieh, C.-L., Francke, U. and Roth, R.A. (1990). „Insulin-degrading enzyme: stable expression of the human complementary DNA, characterization of its protein product, and chromosomal mapping of the human and mouse genes”. Mol. Endocrinol. 4: 1125-1135. PMID 2293021.
- ↑ Duckworth, W.C., Hamel, F.G., Bennett, R., Ryan, M.P. and Roth, R.A. (1990). „Human red blood cell insulin-degrading enzyme and rat skeletal muscle insulin protease share antigenic sites and generate identical products from insulin”. J. Biol. Chem. 265: 2984-2987. PMID 1689296.
- ↑ Kuo, W.-L., Gehm, B.D. and Rosner, M.R. (1990). „Cloning and expression of the cDNA for a Drosophila insulin-degrading enzyme”. Mol. Endocrinol. 4: 1580-1591. PMID 2126597.
- ↑ Ding, L., Becker, A.B., Suzuki, A. and Roth, R.A. (1992). „Comparison of the enzymatic and biochemical properties of human insulin-degrading enzyme and Escherichia coli protease III”. J. Biol. Chem. 267: 2414-2420. PMID 1733942.
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.