Sulfametoksazol
(IUPAC ) ime
4-amino-N-(5-metil-1,2-oksazol-3-il)benzen-1-sulfonamid
Klinički podaci
Robne marke
Apo-Sulfamethoxazole, Azo-Gantanol, Bactrimel, Gamazole
AHFS/Drugs.com
Monografija
Identifikatori
CAS broj
723-46-6
ATC kod
J01 EC01
PubChem [ 1] [ 2] 5329
DrugBank
DB01015
ChemSpider [ 3] 5138
KEGG [ 4] C07315 Y
ChEMBL [ 5] CHEMBL9332 Y
Hemijski podaci
Formula
C 10 H 11 N 3 O 3 S
Mol. masa
253.278
SMILES
eMolekuli PubHem
InChI InChI=1S/C10H11N3O3S/c1-7-6-10(12-16-7)13-17(14,15)9-4-2-8(11)3-5-9/h2-6H,11H2,1H3,(H,12,13) Y
Fizički podaci
Tačka topljenja
167 °C (333 °F)
Farmakokinetički podaci
Poluvreme eliminacije
10 sata
Farmakoinformacioni podaci
Trudnoća
?
Pravni status
Način primene
Oralno
Sulfametoksazol' je bakteriostatički antibakterijski agens koji ometa sintezu folne kiseline kod podložnih bakterija. On ima širok opseg dejstva, koji u sve većoj meri biva ograničen sticanjem otpornosti.[ 6] [ 7] [ 8]
↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.” . Drug Discov Today 15 (23-24): 1052-7. DOI :10.1016/j.drudis.2010.10.003 . PMID 20970519 . edit ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4 : 217-241. DOI :10.1016/S1574-1400(08)00012-1 . ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining” . J Cheminform 2 (1): 3. DOI :10.1186/1758-2946-2-3 . PMID 20331846 . edit ↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG” . Yeast 17 (1): 48–55. DOI :10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H . ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI :10.1093/nar/gkr777 . PMID 21948594 . edit ↑ Martindale, The Extra Pharmacopoeia, 30th ed, p208
↑ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035-41. PMID 21059682 . ↑ Wishart DS, Knox C, Guo AC, Cheng D, Shrivastava S, Tzur D, Gautam B, Hassanali M (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Res 36 (Database issue): D901-6. PMID 18048412 .
Šablon:Antibiotici inhibitori nukleinskih kiselina
