The Glaucoma Variant Curation Expert Panel aims to develop variant classification criteria adapted from the ACMG/AMP guidelines for glaucoma-associated genes. The current scope of the Glaucoma VCEP is to curate variants in the following two genes:

- MYOC (OMIM 601652) is the most common gene associated with adult- and juvenile-onset primary open-angle glaucoma (OMIM 137750) in an autosomal dominant manner with incomplete penetrance. There are over 280 coding MYOC variants reported in the literature.

- CYP1B1 (OMIM 601771) is the most common gene associated with primary congenital glaucoma (OMIM 231300). CYP1B1 variants cause a phenotypic spectrum that also include anterior segment dysgenesis (OMIM 617315) and adult- and juvenile-onset primary open-angle glaucoma. They are transmitted in an autosomal recessive manner with incomplete penetrance. Over 290 coding CYP1B1 variants have been reported.