Christian Kane was born in Dallas, Texas. Christian and his family moved around a lot throughout the South before settling down in Norman, Oklahoma. Christian attended the University of Oklahoma where he had plans to major in Art History. However, Christian wanted to try out acting, so he took his truck and his life savings of a few hundred dollars and headed to Hollywood. Christian had many jobs, including mail-room clerk for a talent agency. His big break came when he played Ryan "Flyboy" Legget, the male lead, in a new show called Fame L.A. (1997) based on the hit movie and 80s TV show. Christian's next role was on the short-lived Aaron Spelling's Rescue 77 (1999), where he played Wick Lobo a.k.a. "Cowboy" because of his radical application of "gutter" medicine. In 1999 he played the duplicitous role of Lindsey McDonald, in the popular Horror/Fantasy series Angel (1999). Christian was soon cast as a production assistant in Edtv (1999) starring Woody Harrelson as well as a made-for-TV Western called Crossfire Trail (2001) with Tom Selleck.

Kane's TV resume also includes a leading role on Leverage (2008)(2008-2012) as Eliot Spencer. He also appeared in the Jerry Bruckheimer-produced, CBS series Close to Home (2005) (2005-2007) and a featured slot in the Stephen Spielberg/TNT miniseries Into the West (2005). In addition, Kane made his mark in big-screen films that include Life or Something Like It (2002); Secondhand Lions (2003) in which he was honored to play a young Robert Duvall;Just Married (2003) where he starred with Ashton Kutcher and Brittany Murphy ; and Friday Night Lights (2006).

Kane starred in 50 to 1 (2014), along side Skeet Ulrich and William Devane. Kane starred in The Librarians (2014) on TNT, which was produced by Dean Devlin who also produced Leverage (2008). His portrayal of Jake Stone earned him a nomination for Best Supporting Actor on Television with the Academy of Science Fiction, Fantasy, and Horror. Christian collaborated with his friend Clayne Crawford on Tinker' (2017) which won him Best Supporting Actor at the Sutter Creek Intl Film Festival. He's also an avid supporter of the Clayne Crawford Foundation.

Christian is well-known for performing his own stunts on most of his shows! Continuing his collaboration with Dean Devlin, he stars as former DEA agent Alex Walker on Almost Paradise (2020) on WGN America and the Leverage: Redemption (2021) reboot for IMDB TV!