Santiago Cabrera was born in Caracas, Venezuela, to Chilean parents, and grew up in London, Romania, Toronto, and Madrid. Although he considers Santiago, Chile, his hometown, he splits his time between London and Los Angeles.

Cabrera is a classically trained actor, having studied at London's prestigious Drama Centre. He made his television debut with small roles on British television, and on the London stage, playing Montano in Shakespeare's "Othello", at the London Greenwich Theatre, directed by Rupert Goold. His most recent stage role was Romeo in London's Middle Temple Hall production of "Romeo and Juliet".

Cabrera's roles have varied from playing Isaac Mendez, in the highly successful first season of NBC's ensemble drama series "Heroes" (2006-2007), the mythical character Lancelot, in the hit BBC series "Merlin" (2008-2010). He portrayed Cuban Guerrilla Commander Camilo Cienfuegos in Steven Soderbergh's film, "CHE. Part 1" (2008), opposite Benicio del Toro, for which he won critical acclaim. Santiago also portrayed the famed War Photographer Robert Capa in the HBO Film, "Hemingway and Gelhorn", opposite Nicole Kidman and Clive Owen.

In 2014, Cabrera starred as Aramis in the BBC One hit show "The Musketeers" (2014-2016), a fresh and exciting look at the much-loved novel by Alexandre Dumas. He went on to the hit HBO show "Big Little Lies" (2017) directed by Jean Marc Vallee, starring opposite Reese Witherspoon and Nicole Kidman. He played Commander Santos in Michael Bay's "Transformers" (2017) and the lead role of Darius Tanz in two seasons of the CBS show "Salvation" (2017-2018).

Santiago worked under the Direction of Pablo Larrain in the Venice and Toronto Film Festival film "Ema" (2019), where he starred alongside Gael Garcia Bernal.

He also played the first Latin captain in the Star Trek Universe, starring as Captain Rios in the beloved Star Trek Series "Picard". (2020-2022).

Cabrera graced our screens in the hit MAX show, "The Flight Attendant" (2022), working opposite Kaley Cuoco, and in 2024 he can be seen in the Apple TV+ Show, "The Land of Women", opposite Eva Longoria and Carmen Maura and season 3 of the Warner Bros and FOX show, "The Cleaning Lady".

In addition to his native Spanish language, he is fluent in English, French, and Italian.