A Bacteroides vulgatus metabolite, pantothenate, induces secretion of the hormones GLP1 in the gut and FGF21 in the liver, which act on the hypothalamus to reduce sugar intake.
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References
Ahmad, E., Lim, S., Lamptey, R., Webb, D. R. & Davies, M. J. Lancet 400, 1803–1820 (2022).
de Wouters d’Oplinter, A. et al. Gut Microbes 13, 1959242 (2021).
de Wouters d’Oplinter, A. et al. Microbiome 11, 94 (2023).
Zhang, T. et al. Nat. Microbiol. https://doi.org/10.1038/s41564-024-01902-8 (2025).
Jensen-Cody, S. O. et al. Cell Metab. 32, 273–286.e6 (2020).
Hirasawa, A. et al. Nat. Med. 11, 90–94 (2005).
Liu, D. et al. Hepatology 74, 2154–2169 (2021).
Chen, Q. et al. Free Radic. Biol. Med. 224, 600–617 (2024).
Fan, S. et al. Cell Metab. 35, 2011–2027 (2023).
Agustí, A. et al. Mol. Neurobiol. 58, 4959–4979 (2021).
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A.E. is an inventor on patent applications dealing with the use of Akkermansia muciniphila and its components in the treatment of metabolic disorders. A.E. is an inventor on patent applications dealing with gut microorganisms in food reward dysregulations. The other authors declare no competing interests.
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Fayt, C., Morales-Puerto, N. & Everard, A. A gut microorganism turns the dial on sugar intake. Nat Microbiol (2025). https://doi.org/10.1038/s41564-024-01917-1
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DOI: https://doi.org/10.1038/s41564-024-01917-1
