A Bacteroides vulgatus metabolite, pantothenate, induces secretion of the hormones GLP1 in the gut and FGF21 in the liver, which act on the hypothalamus to reduce sugar intake.

Vaccine-induced neutralizing antibodies are widely considered sufficient and required for protection from yellow fever and related viral infections. Emerging evidence shows how cellular immunity may compensate for a lack in appropriate humoral responses.

Immune cells can destroy cancer, but tumours often evade such responses. The bidirectional transfer of mitochondria between cancer and immune cells is a newly discovered mechanism that thwarts anticancer defences.

Myoglobin (Mb) is the critical pathogenic factor for Rhabdomyolysis or Crush syndrome-related AKI (RM/CS-AKI). Here, the authors show that anti-Mb RabMAb injection blocking the passage of free Mb through the glomerular filtration barrier significantly rescues both homologous and heterologous RM/CS-AKI animal models.

Artificial intelligence (AI) is increasingly permeating the fabric of medicine, but getting full benefits will likely require fundamental changes in practice. Accepting this will be challenging for many clinicians. However, it may be necessary to ensure that AI’s ambitious promises translate into real-life improvement.

Low-dose colchicine is the only anti-inflammatory drug approved for secondary prevention of coronary disease. The CLEAR-SYNGERY trial of colchicine in acute myocardial infarction challenges the results of previous colchicine trials; however, clinicians should be aware of how its design and the COVID-19 pandemic affected the trial outcome.

A Bacteroides vulgatus metabolite, pantothenate, induces secretion of the hormones GLP1 in the gut and FGF21 in the liver, which act on the hypothalamus to reduce sugar intake.

Brian J. Druker describes how his research on imatinib validated protein kinases as therapeutic targets for cancer and led to a life-saving treatment for leukemia.

Vaccine-induced neutralizing antibodies are widely considered sufficient and required for protection from yellow fever and related viral infections. Emerging evidence shows how cellular immunity may compensate for a lack in appropriate humoral responses.

Nature asked the world’s largest health-research funders what they are doing to study a life stage experienced by half of humanity. Here is what some of them told us.