Breeding environmental adaptive crop cultivars under the climate changing scenario is anything but easy. Here, the authors review the concepts of plasticity and canalization and their integration with contemporary studies of genotype-environmental interactions with the objective to facilitate crop breeding.

In this review, authors highlight the unique safety challenges of natural hydrogen extraction wells, such as hydrogen embrittlement, microbiological corrosion, and H2-cement reaction. They identify potential solutions within the literature, emphasizing the need for more research under real-world conditions.

A single reference genome is not enough to harness the full genetic variation of a species. Here, the authors review pangenomics principles, construction and applications for orphan crop improvement, and discuss the possible ways to support pangenomics-driven molecular breeding.

Modern biotechnology necessitates robust biosecurity protocols to address the risk of engineered biological threats. In this Perspective, the authors review cutting-edge methods for DNA analysis and recommend avenues to improve biosecurity in an adaptable manner.

In this scoping review, the authors explore the challenges and opportunities of implementing data-driven geospatial models—namely machine learning and deep learning algorithms—in environmental research.

Technical advances have enabled simultaneous study of the molecular and biomechanical inputs involved in regulating development. In this Perspective, the authors give a historical view of these advances and propose that biomechanical cues in the marine environment may have helped foster metazoan evolution.

Success is being increasingly studied as a collective phenomenon. Here the authors review how this perspective has deepened our understanding of success, uncovering regularities and predictive signals across diverse domains, as well as biases that challenge meritocratic views of success.

Immune cells pursue metabolic adaptations to accommodate the dynamic changes of their functions. Here in this review the authors summarize immune metabolic states of various innate lymphoid cells and advocate single-cell level methods for studying the complex networks of immune metabolism.

The human cell atlas (HCA) is intended as an exhaustive guidebook of human cell types and their properties. Here Kirby et al. outline how the HCA Ethics Working Group is working to build a solid foundation to address the complexities of data collection and sharing.

The Human Cell Atlas (HCA) aims to characterize cells from diverse individuals across the globe to better understand human biology. Here, the authors lay out principles and action items that have been adopted to affirm HCA’s commitment to equity so that the atlas is beneficial to all of humanity.

The rise of high-throughput methods and computer-aided techniques has led to a shift in the design and discovery patterns of nanomedicines to a data-driven and rational mode. In this perspective, the authors describe a directed evolution mode of nanomedicines driven by data to accelerate the discovery of nanomaterials with high delivery efficiency.

In this perspective, the authors summarize some 25 years of research on PIN auxin transport proteins and reflect on consequences for the understanding of cellular processes underlying plant development and adaptation.

Individualized genetic therapies present unique challenges for trial design. Here, the authors present a framework which emphasizes scientific rigor, using natural history, tailored clinical outcomes, and statistical considerations to optimize trial efficiency.

Long-term machine perfusion holds great promise in the field of liver transplantation, potentially allowing for extended viability checks as well as treatment of marginal discarded organs. Here, the authors discuss the advances in machine perfusion techniques for liver transplants as well as future potential clinical avenues that it will open up including potential splitting of livers.

Fetal growth restriction remains a global health problem. In this systematic review, the authors identify altered metabolites and metabolomic signatures associated with fetal growth restriction and/or small for gestational age in maternal and newborn tissues and body fluids samples.

Authors present a scoping review synthesizing new and upcoming technologies providing rapid phenotypic antimicrobial susceptibility testing (AST).

Brain imaging analysis lacks accessible ground-truth approaches, leading to varied results across the field. Embracing analytical variability may allow researchers to enhance the generalizability of findings and accelerate progress.

Bacterial extracellular vesicles are rapidly gaining attention in biomarker discovery and therapeutic innovation. Here, the authors map current BEV research practices, highlight knowledge gaps and best practices to ensure advances in BEV research and accelerate BEV applications.

Application of RNAi-based technology for crop pest control is hampered by the lacking of efficient system for the delivery of dsRNA molecules to pests or plants. Here, the authors review polymer systems for dsRNA delivery and provide perspectives on their application in sustainable agriculture production.

In this work, authors aim to address the critical challenges in diagnosing and managing beta-lactamase-producing Enterobacteriaceae, which are pivotal in the context of antimicrobial resistance (AMR).