A study explores the circuits through which the dorsolateral prefrontal cortex orchestrates social competition in mice.

A new study reveals an algorithm implemented by neurons in the medial frontal cortex that is involved in flexibly mapping appropriate actions during goal-oriented behaviour to novel situations.

In this Journal Club, Michaela Fencková discusses a study published in 2020 that examined the effects of acute systemic inflammation on brain glucose metabolism in the context of delirium.

A population of macrophages has been found in muscle spindles that release glutamate, activate primary sensory afferents that are part of the stretch reflex, and have a role in regulating locomotion.

Studies in human cell lines and transgenic mouse models show that non-receptor tyrosine-protein kinase TYK2 phosphorylates tau at Tyr29 and thereby promotes its stabilization and accumulation. In mice, knockdown of TYK2 reduced tau levels and attenuated tau neuropathology.

Bats use echolocation to navigate long distances without relying on other sensory information.

Interoceptive, feeding-related inputs are integrated by BDNF-expressing neurons in the ventromedial hypothalamus that project to the brainstem and regulate food intake and feeding-associated jaw movements.

In this Journal Club, Anna Gillespie discusses how the discovery of hippocampal replay during the awake state reshaped our understanding of its role in memory function.

Innate lymphoid cells regulate inhibitory synapse formation in the mouse cortex during early postnatal life.

Tan et al. identify a population of leptin-responsive neurons that regulate food intake and body weight.

After injury, regeneration of retinal ganglion cells and reconnection to their original target — the suprachiasmatic nucleus —is achieved by manipulating guidance cues, leading to the formation of a functional circuit that supports functional recovery.

A series of papers provide an overview of the adult Drosophila melanogaster whole-brain connectome and how the resulting resource allows for more sophisticated approaches to investigate computations in the fly brain.

Manipulating the synaptic strength of cortical neurons alters sleep pressure in mice.

Blocking voltage-gated calcium channels reduces capillary narrowing by pericytes and improves cerebral blood flow in a mouse model of Alzheimer disease.