My Bibliography

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Rodgers LT, Villano JL, Hartz AMS, Bauer B. Glioblastoma Standard of Care: Effects on Tumor Evolution and Reverse Translation in Preclinical Models. Cancers (Basel). 2024 Jul 24;16(15). doi: 10.3390/cancers16152638. Review. PubMed PMID: 39123366; PubMed Central PMCID: PMC11311277.

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Rodgers LT, Schulz Pauly JA, Maloney BJ, Hartz AMS, Bauer B. Optimization, Characterization, and Comparison of Two Luciferase-Expressing Mouse Glioblastoma Models. Cancers (Basel). 2024 May 24;16(11). doi: 10.3390/cancers16111997. PubMed PMID: 38893116; PubMed Central PMCID: PMC11171217.

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Nehra G, Promsan S, Yubolphan R, Chumboatong W, Vivithanaporn P, Maloney BJ, Lungkaphin A, Bauer B, Hartz AMS. Cognitive decline, Aβ pathology, and blood-brain barrier function in aged 5xFAD mice. Fluids Barriers CNS. 2024 Mar 27;21(1):29. doi: 10.1186/s12987-024-00531-x. PubMed PMID: 38532486; PubMed Central PMCID: PMC10967049.

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Sziraki A, Zhong Y, Neltner AM, Niedowicz DM, Rogers CB, Wilcock DM, Nehra G, Neltner JH, Smith RR, Hartz AM, Cao J, Nelson PT. A high-throughput single-cell RNA expression profiling method identifies human pericyte markers. Neuropathol Appl Neurobiol. 2023 Dec;49(6):e12942. doi: 10.1111/nan.12942. PubMed PMID: 37812061; PubMed Central PMCID: PMC10842535.

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Vulin M, Zhong Y, Maloney BJ, Bauer B, Hartz AMS. Proteasome inhibition protects blood-brain barrier P-glycoprotein and lowers Aβ brain levels in an Alzheimer's disease model. Fluids Barriers CNS. 2023 Oct 6;20(1):70. doi: 10.1186/s12987-023-00470-z. PubMed PMID: 37803468; PubMed Central PMCID: PMC10559617.

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Schulz JA, Hartz AMS, Bauer B. ABCB1 and ABCG2 Regulation at the Blood-Brain Barrier: Potential New Targets to Improve Brain Drug Delivery. Pharmacol Rev. 2023 Sep;75(5):815-853. doi: 10.1124/pharmrev.120.000025. Epub 2023 Mar 27. Review. PubMed PMID: 36973040; PubMed Central PMCID: PMC10441638.

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Schulz JA, Rodgers LT, Kryscio RJ, Hartz AMS, Bauer B. Characterization and comparison of human glioblastoma models. BMC Cancer. 2022 Aug 3;22(1):844. doi: 10.1186/s12885-022-09910-9. PubMed PMID: 35922758; PubMed Central PMCID: PMC9347152.

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Yanckello LM, Hoffman JD, Chang YH, Lin P, Nehra G, Chlipala G, McCulloch SD, Hammond TC, Yackzan AT, Lane AN, Green SJ, Hartz AMS, Lin AL. Apolipoprotein E genotype-dependent nutrigenetic effects to prebiotic inulin for modulating systemic metabolism and neuroprotection in mice via gut-brain axis. Nutr Neurosci. 2022 Aug;25(8):1669-1679. doi: 10.1080/1028415X.2021.1889452. Epub 2021 Mar 5. PubMed PMID: 33666538; PubMed Central PMCID: PMC8799401.

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Nehra G, Bauer B, Hartz AMS. Blood-brain barrier leakage in Alzheimer's disease: From discovery to clinical relevance. Pharmacol Ther. 2022 Jun;234:108119. doi: 10.1016/j.pharmthera.2022.108119. Epub 2022 Jan 30. Review. PubMed PMID: 35108575; PubMed Central PMCID: PMC9107516.

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Holder BM, Tolan SE, Heinrich KK, Miller KC, Hudson N, Nehra G, Pizzo ME, Storck SE, Elmquist WF, Engelhardt B, Loryan I, Toborek M, Bauer B, Hartz AMS, Kim BJ. Brain barriers virtual: an interim solution or future opportunity?. Fluids Barriers CNS. 2022 Mar 1;19(1):19. doi: 10.1186/s12987-022-00314-2. PubMed PMID: 35232464; PubMed Central PMCID: PMC8886561.

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Tajima K, Akanuma SI, Ohishi Y, Yoshida Y, Bauer B, Kubo Y, Inouye M, Hosoya KI. Freshly isolated retinal capillaries to determine efflux transporter function at the inner BRB. J Control Release. 2022 Mar;343:434-442. doi: 10.1016/j.jconrel.2022.01.037. Epub 2022 Jan 29. PubMed PMID: 35104569.

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Drug Delivery to Primary and Metastatic Brain Tumors: Challenges and Opportunities. In: Drug Delivery to the Brain [Internet] AAPS Advances in the Pharmaceutical Sciences Series: Springer; 2022. p.723–762. Available from: https://doi.org/10.1007/978-3-030-88773-5_24.

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Ding Y, Zhong Y, Baldeshwiler A, Abner EL, Bauer B, Hartz AMS. Protecting P-glycoprotein at the blood-brain barrier from degradation in an Alzheimer's disease mouse model. Fluids Barriers CNS. 2021 Mar 6;18(1):10. doi: 10.1186/s12987-021-00245-4. PubMed PMID: 33676539; PubMed Central PMCID: PMC7937299.

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Jomura R, Akanuma SI, Bauer B, Yoshida Y, Kubo Y, Hosoya KI. Participation of Monocarboxylate Transporter 8, But Not P-Glycoprotein, in Carrier-Mediated Cerebral Elimination of Phenytoin across the Blood-Brain Barrier. Pharm Res. 2021 Jan;38(1):113-125. doi: 10.1007/s11095-021-03003-1. Epub 2021 Feb 1. PubMed PMID: 33527223; PubMed Central PMCID: PMC8906351.

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Bauer B, Renfro JL, Karnaky KJ Jr, Masereeuw R, Fricker G, Cannon RE, Hartz AMS. David S. Miller: Scientist, Mentor, Friend-a tribute and thank you. Fluids Barriers CNS. 2020 Sep 14;17(1):56. doi: 10.1186/s12987-020-00220-5. PubMed PMID: 32928243; PubMed Central PMCID: PMC7491162.

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Hartz AMS, Rempe RG, Soldner ELB, Pekcec A, Schlichtiger J, Kryscio R, Bauer B. Cytosolic phospholipase A2 is a key regulator of blood-brain barrier function in epilepsy. FASEB J. 2019 Dec;33(12):14281-14295. doi: 10.1096/fj.201901369RR. Epub 2019 Oct 29. PubMed PMID: 31661303; PubMed Central PMCID: PMC6894050.

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Soldner ELB, Hartz AMS, Akanuma SI, Pekcec A, Doods H, Kryscio RJ, Hosoya KI, Bauer B. Inhibition of human microsomal PGE2 synthase-1 reduces seizure-induced increases of P-glycoprotein expression and activity at the blood-brain barrier. FASEB J. 2019 Dec;33(12):13966-13981. doi: 10.1096/fj.201901460RR. Epub 2019 Oct 22. PubMed PMID: 31638830; PubMed Central PMCID: PMC6894061.

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Hartz AMS, Schulz JA, Sokola BS, Edelmann SE, Shen AN, Rempe RG, Zhong Y, Seblani NE, Bauer B. Isolation of Cerebral Capillaries from Fresh Human Brain Tissue. J Vis Exp. 2018 Sep 12;(139). doi: 10.3791/57346. PubMed PMID: 30272660; PubMed Central PMCID: PMC6235165.

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Lee J, Yanckello LM, Ma D, Hoffman JD, Parikh I, Thalman S, Bauer B, Hartz AMS, Hyder F, Lin AL. Neuroimaging Biomarkers of mTOR Inhibition on Vascular and Metabolic Functions in Aging Brain and Alzheimer's Disease. Front Aging Neurosci. 2018;10:225. doi: 10.3389/fnagi.2018.00225. eCollection 2018. Review. PubMed PMID: 30140223; PubMed Central PMCID: PMC6094969.

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Hartz AMS, Zhong Y, Shen AN, Abner EL, Bauer B. Preventing P-gp Ubiquitination Lowers Aβ Brain Levels in an Alzheimer's Disease Mouse Model. Front Aging Neurosci. 2018;10:186. doi: 10.3389/fnagi.2018.00186. eCollection 2018. PubMed PMID: 29997495; PubMed Central PMCID: PMC6028735.

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Akanuma SI, Yamakoshi A, Sugouchi T, Kubo Y, Hartz AMS, Bauer B, Hosoya KI. Role of l-Type Amino Acid Transporter 1 at the Inner Blood-Retinal Barrier in the Blood-to-Retina Transport of Gabapentin. Mol Pharm. 2018 Jun 4;15(6):2327-2337. doi: 10.1021/acs.molpharmaceut.8b00179. Epub 2018 May 2. PubMed PMID: 29688723.

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Rempe RG, Hartz AMS, Soldner ELB, Sokola BS, Alluri SR, Abner EL, Kryscio RJ, Pekcec A, Schlichtiger J, Bauer B. Matrix Metalloproteinase-Mediated Blood-Brain Barrier Dysfunction in Epilepsy. J Neurosci. 2018 May 2;38(18):4301-4315. doi: 10.1523/JNEUROSCI.2751-17.2018. Epub 2018 Apr 9. PubMed PMID: 29632167; PubMed Central PMCID: PMC5932641.

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Ma D, Wang AC, Parikh I, Green SJ, Hoffman JD, Chlipala G, Murphy MP, Sokola BS, Bauer B, Hartz AMS, Lin AL. Ketogenic diet enhances neurovascular function with altered gut microbiome in young healthy mice. Sci Rep. 2018 Apr 27;8(1):6670. doi: 10.1038/s41598-018-25190-5. PubMed PMID: 29703936; PubMed Central PMCID: PMC5923270.

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Hoffman JD, Parikh I, Green SJ, Chlipala G, Mohney RP, Keaton M, Bauer B, Hartz AMS, Lin AL. Age Drives Distortion of Brain Metabolic, Vascular and Cognitive Functions, and the Gut Microbiome. Front Aging Neurosci. 2017;9:298. doi: 10.3389/fnagi.2017.00298. eCollection 2017. PubMed PMID: 28993728; PubMed Central PMCID: PMC5622159.

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Tang F, Hartz AMS, Bauer B. Drug-Resistant Epilepsy: Multiple Hypotheses, Few Answers. Front Neurol. 2017;8:301. doi: 10.3389/fneur.2017.00301. eCollection 2017. Review. PubMed PMID: 28729850; PubMed Central PMCID: PMC5498483.

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Hartz AM, Pekcec A, Soldner EL, Zhong Y, Schlichtiger J, Bauer B. P-gp Protein Expression and Transport Activity in Rodent Seizure Models and Human Epilepsy. Mol Pharm. 2017 Apr 3;14(4):999-1011. doi: 10.1021/acs.molpharmaceut.6b00770. Epub 2017 Mar 2. PubMed PMID: 28195743; PubMed Central PMCID: PMC5498434.

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Louie SW, Bauer B, Ronaldson PT. Hitting the BBB: Technological advancements in CNS research and drug targeting. The AAPS journal. 2017 April; :14-18.

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Parikh I, Guo J, Chuang KH, Zhong Y, Rempe RG, Hoffman JD, Armstrong R, Bauer B, Hartz AM, Lin AL. Caloric restriction preserves memory and reduces anxiety of aging mice with early enhancement of neurovascular functions. Aging (Albany NY). 2016 Nov 8;8(11):2814-2826. doi: 10.18632/aging.101094. PubMed PMID: 27829242; PubMed Central PMCID: PMC5191872.

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Ronaldson PT, Bauer B, El-Kattan AF, Shen H, Salphati L, Louie SW. Highlights From the American Association of Pharmaceutical Scientists/ International Transporter Consortium Joint Workshop on Drug Transporters in Absorption, Distribution, Metabolism, and Excretion: From the Bench to the Bedside - Clinical Pharmacology Considerations. Clin Pharmacol Ther. 2016 Nov;100(5):419-422. doi: 10.1002/cpt.439. Epub 2016 Sep 13. PubMed PMID: 27500791; PubMed Central PMCID: PMC5466066.

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Rempe RG, Hartz AMS, Bauer B. Matrix metalloproteinases in the brain and blood-brain barrier: Versatile breakers and makers. J Cereb Blood Flow Metab. 2016 Sep;36(9):1481-507. doi: 10.1177/0271678X16655551. Epub 2016 Jun 20. Review. PubMed PMID: 27323783; PubMed Central PMCID: PMC5012524.

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Hartz AM, Zhong Y, Wolf A, LeVine H 3rd, Miller DS, Bauer B. Aβ40 Reduces P-Glycoprotein at the Blood-Brain Barrier through the Ubiquitin-Proteasome Pathway. J Neurosci. 2016 Feb 10;36(6):1930-41. doi: 10.1523/JNEUROSCI.0350-15.2016. PubMed PMID: 26865616; PubMed Central PMCID: PMC4748076.

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Wolf A, Bauer B, Abner EL, Ashkenazy-Frolinger T, Hartz AM. A Comprehensive Behavioral Test Battery to Assess Learning and Memory in 129S6/Tg2576 Mice. PLoS One. 2016;11(1):e0147733. doi: 10.1371/journal.pone.0147733. eCollection 2016. PubMed PMID: 26808326; PubMed Central PMCID: PMC4726499.

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Akkaya BG, Zolnerciks JK, Ritchie TK, Bauer B, Hartz AM, Sullivan JA, Linton KJ. The multidrug resistance pump ABCB1 is a substrate for the ubiquitin ligase NEDD4-1. Mol Membr Biol. 2015;32(2):39-45. doi: 10.3109/09687688.2015.1023378. Epub 2015 May 26. PubMed PMID: 26006083; PubMed Central PMCID: PMC4844833.

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Wolf A, Bauer B, Hartz AM. ABC Transporters and the Alzheimer's Disease Enigma. Front Psychiatry. 2012;3:54. doi: 10.3389/fpsyt.2012.00054. eCollection 2012. PubMed PMID: 22675311; PubMed Central PMCID: PMC3366330.

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Hartz AM, Bauer B, Soldner EL, Wolf A, Boy S, Backhaus R, Mihaljevic I, Bogdahn U, Klünemann HH, Schuierer G, Schlachetzki F. Amyloid-β contributes to blood-brain barrier leakage in transgenic human amyloid precursor protein mice and in humans with cerebral amyloid angiopathy. Stroke. 2012 Feb;43(2):514-23. doi: 10.1161/STROKEAHA.111.627562. Epub 2011 Nov 23. PubMed PMID: 22116809; PubMed Central PMCID: PMC5761312.

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Jacob A, Hartz AM, Potin S, Coumoul X, Yousif S, Scherrmann JM, Bauer B, Declèves X. Aryl hydrocarbon receptor-dependent upregulation of Cyp1b1 by TCDD and diesel exhaust particles in rat brain microvessels. Fluids Barriers CNS. 2011 Aug 25;8:23. doi: 10.1186/2045-8118-8-23. PubMed PMID: 21867498; PubMed Central PMCID: PMC3180256.

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Shukla S, Skoumbourdis AP, Walsh MJ, Hartz AM, Fung KL, Wu CP, Gottesman MM, Bauer B, Thomas CJ, Ambudkar SV. Synthesis and characterization of a BODIPY conjugate of the BCR-ABL kinase inhibitor Tasigna (nilotinib): evidence for transport of Tasigna and its fluorescent derivative by ABC drug transporters. Mol Pharm. 2011 Aug 1;8(4):1292-302. doi: 10.1021/mp2001022. Epub 2011 Jun 16. PubMed PMID: 21630681; PubMed Central PMCID: PMC3148428.

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Hartz AM, Bauer B. ABC transporters in the CNS - an inventory. Curr Pharm Biotechnol. 2011 Apr;12(4):656-73. doi: 10.2174/138920111795164020. Review. PubMed PMID: 21118088.

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Neuwelt EA, Bauer B, Fahlke C, Fricker G, Iadecola C, Janigro D, Leybaert L, Molnár Z, O'Donnell ME, Povlishock JT, Saunders NR, Sharp F, Stanimirovic D, Watts RJ, Drewes LR. Engaging neuroscience to advance translational research in brain barrier biology. Nat Rev Neurosci. 2011 Mar;12(3):169-82. doi: 10.1038/nrn2995. Review. PubMed PMID: 21331083; PubMed Central PMCID: PMC3335275.

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Bauer B, Schlichtiger J, Pekcec A, Hartz AM. The blood-brain barrier in epilepsy. In: Afawi Z, editor. Clinical and Genetic Aspects of Epilepsy United States: InTech; 2011. Chapter 2; p.23-54. 23-54p.

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Agarwal S, Hartz AM, Elmquist WF, Bauer B. Breast cancer resistance protein and P-glycoprotein in brain cancer: two gatekeepers team up. Curr Pharm Des. 2011;17(26):2793-802. doi: 10.2174/138161211797440186. Review. PubMed PMID: 21827403; PubMed Central PMCID: PMC3269897.

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Hartz AM, Mahringer A, Miller DS, Bauer B. 17-β-Estradiol: a powerful modulator of blood-brain barrier BCRP activity. J Cereb Blood Flow Metab. 2010 Oct;30(10):1742-55. doi: 10.1038/jcbfm.2010.36. Epub 2010 Mar 10. PubMed PMID: 20216549; PubMed Central PMCID: PMC3023406.

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Hartz AM, Bauer B. Regulation of ABC transporters at the blood-brain barrier: new targets for CNS therapy. Mol Interv. 2010 Oct;10(5):293-304. doi: 10.1124/mi.10.5.6. Review. PubMed PMID: 21045243.

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Hartz AM, Madole EK, Miller DS, Bauer B. Estrogen receptor beta signaling through phosphatase and tensin homolog/phosphoinositide 3-kinase/Akt/glycogen synthase kinase 3 down-regulates blood-brain barrier breast cancer resistance protein. J Pharmacol Exp Ther. 2010 Aug;334(2):467-76. doi: 10.1124/jpet.110.168930. Epub 2010 May 11. PubMed PMID: 20460386; PubMed Central PMCID: PMC2913769.

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Hartz AM, Miller DS, Bauer B. Restoring blood-brain barrier P-glycoprotein reduces brain amyloid-beta in a mouse model of Alzheimer's disease. Mol Pharmacol. 2010 May;77(5):715-23. doi: 10.1124/mol.109.061754. Epub 2010 Jan 25. PubMed PMID: 20101004; PubMed Central PMCID: PMC2872973.

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Bauer B. Targeting regulation of ABC transporters at the blood-brain barrier to improve pharmacotherapy of CNS disorders. International drug discovery. 2010; (August/September):76-79.

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Stenehjem DD, Hartz AM, Bauer B, Anderson GW. Novel and emerging strategies in drug delivery for overcoming the blood-brain barrier. Future Med Chem. 2009 Dec;1(9):1623-41. doi: 10.4155/fmc.09.137. Review. PubMed PMID: 21425983.

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Hartz AM, Notenboom S, Bauer B. Signaling to P-glycoprotein-A new therapeutic target to treat drug-resistant epilepsy?. Drug News Perspect. 2009 Sep;22(7):393-7. doi: 10.1358/dnp.2009.22.7.1401354. Review. PubMed PMID: 19890496.

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Pekcec A, Unkrüer B, Schlichtiger J, Soerensen J, Hartz AM, Bauer B, van Vliet EA, Gorter JA, Potschka H. Targeting prostaglandin E2 EP1 receptors prevents seizure-associated P-glycoprotein up-regulation. J Pharmacol Exp Ther. 2009 Sep;330(3):939-47. doi: 10.1124/jpet.109.152520. Epub 2009 Jun 3. PubMed PMID: 19494186.

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Ott M, Fricker G, Bauer B. Pregnane X receptor (PXR) regulates P-glycoprotein at the blood-brain barrier: functional similarities between pig and human PXR. J Pharmacol Exp Ther. 2009 Apr;329(1):141-9. doi: 10.1124/jpet.108.149690. Epub 2009 Jan 15. PubMed PMID: 19147857.

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