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    Wilms Tumor

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    Chichi Basar
    Wilms tumor is the most common childhood renal tumor, accounting for approximately 6% of pediatric malignancies. It typically occurs in children between ages 1 and 3. The incidence is 1 in 10,000 children. Wilms tumor is an embryonal renal neoplasm composed of blastemal, stromal, and epithelial cells. Nephrogenic rests are precursor lesions that persist after normal kidney development is complete and can progress to Wilms tumor. The Wilms tumor suppressor gene is located on chromosome 11p15. Clinical presentation includes abdominal masses, hematuria, hypertension, and metastases. Staging and treatment involve surgery with or without chemotherapy and radiation therapy depending on tumor extent and histology.

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    Wilms Tumor

    Uploaded by

    Chichi Basar
    3K views11 pages
    Wilms tumor is the most common childhood renal tumor, accounting for approximately 6% of pediatric malignancies. It typically occurs in children between ages 1 and 3. The incidence is 1 in 10,000 children. Wilms tumor is an embryonal renal neoplasm composed of blastemal, stromal, and epithelial cells. Nephrogenic rests are precursor lesions that persist after normal kidney development is complete and can progress to Wilms tumor. The Wilms tumor suppressor gene is located on chromosome 11p15. Clinical presentation includes abdominal masses, hematuria, hypertension, and metastases. Staging and treatment involve surgery with or without chemotherapy and radiation therapy depending on tumor extent and histology.

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    Wilms tumor is the most common childhood renal tumor, accounting for approximately 6% of pediatric malignancies. It typically occurs in children between ages 1 and 3. The incidence is 1 in 10,000 children. Wilms tumor is an embryonal renal neoplasm composed of blastemal, stromal, and epithelial cells. Nephrogenic rests are precursor lesions that persist after normal kidney development is complete and can progress to Wilms tumor. The Wilms tumor suppressor gene is located on chromosome 11p15. Clinical presentation includes abdominal masses, hematuria, hypertension, and metastases. Staging and treatment involve surgery with or without chemotherapy and radiation therapy depending on tumor extent and histology.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as PPT, PDF, TXT or read online from Scribd
    Download as ppt, pdf, or txt
    3K views11 pages

    Wilms Tumor

    Uploaded by

    Chichi Basar
    Wilms tumor is the most common childhood renal tumor, accounting for approximately 6% of pediatric malignancies. It typically occurs in children between ages 1 and 3. The incidence is 1 in 10,000 children. Wilms tumor is an embryonal renal neoplasm composed of blastemal, stromal, and epithelial cells. Nephrogenic rests are precursor lesions that persist after normal kidney development is complete and can progress to Wilms tumor. The Wilms tumor suppressor gene is located on chromosome 11p15. Clinical presentation includes abdominal masses, hematuria, hypertension, and metastases. Staging and treatment involve surgery with or without chemotherapy and radiation therapy depending on tumor extent and histology.

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    At a glance
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    Wilms tumor is the most common childhood renal tumor. It typically occurs in children between ages 1-3 years.

    Wilms tumor is a type of childhood kidney cancer. It arises from embryonic renal cells and is the most common renal tumor in children.

    Clinical presentations can include an abdominal mass, hypertension, fever, malaise, anemia, and hematuria.

    WILMS TUMOR

    Introduction
    Wilms tumor is the most common childhood renal tumor,accounting for approximately 6 % off all pediatric malignancies

    This tumor tends to occur between ages 1 and 3 years

    The incidence of wilms tumor is 1 in 10000 children

    HISTOLOGY
    EMBRIONAL RENAL NEOPLASMA
    BLASTEMAL

    STROMAL

    EPITHELIAL CELLS

    NEPHROGENIC REST

    Nephrogenic rest is defined as the persisitance of metanephric tissue in the kidney after 36th of gestation This lession precursor of wilms tumor

    CYTOGENETIC

    Wilms tumor suppressor gene chromosome 11p15

    CLINICAL PRESENTATION
    Asymptoma tic adominal mass

    Gross or microscopic hematuria

    Hypertensio n

    Cardiac murmur,hepatosplenome galy,asites,varicoco;e,goa n metastasi

    Fever ,malaise,an emia

    Diagnosis

    Chest radiography detect pulmonary metastatis Abdominal radiography linear calcification Ultrasound consistency of the mass,intravascular involment Ct scan of abdomen renal mass, anatomic extent of tumor,the precense of a normalcontralateral kidney and possibility of bialteral tumor involment

    staging

    Stage 1

    Tumor confined to the kidney and completely resected; no penetration of the renal capsule or involvement of renal sinus vessels

    Stage 2 Stage 3

    Tumor extend beyond the kidney but is completely resected 9 negative margins and lymph nodes; at least of the following has occured : Penetration of the renal capsule,invasion of the renal sinus vessels,biopsy of tumor perfomed before removal,spillage of tumor lacally during removal

    Gross of microscopic residual tumor remains postoperativvely,inducing inoperable tumor,positive surgical margins, tumor sillage invo;ving peritoneal surfaces,regional lymph node metastases or transected tumor trombus

    Hematogenous or lymph node metastases outside the abdomen ( lung,liver,bone,brain)

    Bilateral renal wilms tumor

    Treatment
    Full exploration
    Surgical

    intravascular extension

    Dactinomycin Vincristine doxorubbicin chemotherapy Combination of cyclophospamid,ifosfamide,carboplatin,etoposide

    Radiotion therapy

    Local abdominal irradition for stage III favorable histology tumor and for stage II,III with diffuse anaplatic wilms tumor

    Considered for wilms tumor that are not completely resectable at initial operation. Benefit in children whoolment,extensive have Preope bilateral inv intravascular involment,inoperable therapyerativ massiv tumor

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