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    Pathophysiology Cholelithiasis

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    Christine Joy Ilao Pasno
    This document summarizes the pathophysiology of gallstone disease. It outlines predisposing factors like age, gender, ethnicity, and medical conditions. Gallstones form when bile stagnates and crystals precipitate in the gallbladder. This can lead to obstruction of the cystic duct, causing bile stasis, inflammation, and increased pressure. This results in biliary colic. Without treatment, it can progress to acute cholecystitis, gallbladder necrosis, rupture, and potentially sepsis. With proper treatment of surgery, diet, and medications, the prognosis is typically good.

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    Pathophysiology Cholelithiasis

    Uploaded by

    Christine Joy Ilao Pasno
    5K views2 pages
    This document summarizes the pathophysiology of gallstone disease. It outlines predisposing factors like age, gender, ethnicity, and medical conditions. Gallstones form when bile stagnates and crystals precipitate in the gallbladder. This can lead to obstruction of the cystic duct, causing bile stasis, inflammation, and increased pressure. This results in biliary colic. Without treatment, it can progress to acute cholecystitis, gallbladder necrosis, rupture, and potentially sepsis. With proper treatment of surgery, diet, and medications, the prognosis is typically good.

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    105375378-Pathophysiology-Cholelithiasis

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    This document summarizes the pathophysiology of gallstone disease. It outlines predisposing factors like age, gender, ethnicity, and medical conditions. Gallstones form when bile stagnates and crystals precipitate in the gallbladder. This can lead to obstruction of the cystic duct, causing bile stasis, inflammation, and increased pressure. This results in biliary colic. Without treatment, it can progress to acute cholecystitis, gallbladder necrosis, rupture, and potentially sepsis. With proper treatment of surgery, diet, and medications, the prognosis is typically good.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    5K views2 pages

    Pathophysiology Cholelithiasis

    Uploaded by

    Christine Joy Ilao Pasno
    This document summarizes the pathophysiology of gallstone disease. It outlines predisposing factors like age, gender, ethnicity, and medical conditions. Gallstones form when bile stagnates and crystals precipitate in the gallbladder. This can lead to obstruction of the cystic duct, causing bile stasis, inflammation, and increased pressure. This results in biliary colic. Without treatment, it can progress to acute cholecystitis, gallbladder necrosis, rupture, and potentially sepsis. With proper treatment of surgery, diet, and medications, the prognosis is typically good.

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    PATHOPHYSIOLOGY

    Precipitating Factors:
    Predisposing Factors: Female Age 38 Ethnicity Diabetes Mellitus


    Bile stagnates in the gallbladder

    Birth control pills Low Fat Diet Pregnancy Rapid weight loss Obesity fasting

    Pigment solute precipitate as solid crystals

    Crystals clump together and form stones Gallstones

    Gallbladder contracts after intake of fat to release bile

    Upon contraction, a stone is moved and becomes impacted on the cystic duct

    CHOLELITHIASIS

    Lumen is obstructed by stones

    Bile stasis

    Chemical reaction inside gallbladder triggers the release of inflammatory enzymes (Prostaglandins)

    Fluids leak into gallbladder Edema

    Inflammation of the gallbladder

    Increased intraluminal pressure and distention of the gallbladder

    Biliary Colic (RUQ pain)

    Constriction of blood vessels

    Murphys Sign

    ACUTE CHOLECYSTITIS
    If not treated If treated with: Continued lack of blood supply to gallbladder Continued increase in intraluminal pressure of gallbladder

    Surgery, proper diet (low fat, high fiber), compliance to medications

    Necrosis Rupture of gallbladder

    Good prognosis

    Gangrene and empyema Spread of bile indigenous microorganisms peritoneal cavity and into

    Perforation of gallbladder

    Sepsis

    Death

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