Properties Thiram PDF

EUROPEAN COMMISSION
HEALTH & CONSUMER PROTECTION DIRECTORATE-GENERAL

Directorate E Food Safety: plant health, animal health and welfare, international questions
E1 - Plant health
Thiram
6507/VI/99-Final
27 June 2003
Review report for the active substance thiram

Finalised in the Standing Committee on the Food Chain and Animal Health at its meeting on 4 July
2003 in view of the inclusion of thiram in Annex I of Directive 91/414/EEC
1.
Procedure followed for the re-evaluation process
This review report has been established as a result of the re-evaluation of thiram, made in the context
of the work programme for review of existing active substances provided for in Article 8(2) of
Directive 91/414/EEC concerning the placing of plant protection products on the market, with a
view to the possible inclusion of this substance in Annex I to the Directive.
Commission Regulation (EEC) No 3600/92(1) laying down the detailed rules for the implementation
of the first stage of the programme of work referred to in Article 8(2) of Council Directive
91/414/EEC, as last amended by Regulation (EC) No 2266/2000(2), has laid down the detailed rules
on the procedure according to which the re-evaluation has to be carried out. Thiram is one of the 90
existing active substances covered by this Regulation.
In accordance with the provisions of Article 4 of Regulation (EEC) No 3600/92, JCS
International on 28 June 1993, Uniroyal Chemical Company, Inc. on 15 July 1993, Bayer AG on
21 July 1993, ACI International on 30 July 1993, UCB SA. on 20 July 1993, FMC-foret S.A. on
23 July 1993; Calliope S.A. on 21 July 1993, and B.V. Luxan on 21 July 1993 notified to the
Commission of their wish to secure the inclusion of the active substance thiram in Annex I to the
Directive. A thiram task force, comprising UCB SA and Uniroyal Chemical Company Ltd, now
Crompton Europe Ltd was formed.
In accordance with the provisions of Article 5 of Regulation (EEC) No 3600/92, the Commission, by
its Regulation (EEC) No 933/94(3), as last amended by Regulation (EC) No 2230/95(4), designated
Belgium as rapporteur Member State to carry out the assessment of thiram on the basis of the
dossiers submitted by the notifiers. In the same Regulation, the Commission specified furthermore
the deadline for the notifiers with regard to the submission to the rapporteur Member States of the
dossiers required under Article 6(2) of Regulation (EEC) No 3600/92, as well as for other parties
OJ No L 366, 15.12.1992, p.10.
OJ No L 259, 13.10.2000, p.27.

OJ No L 107, 28.04.1994, p.8.
3
4
OJ No L 225, 22.09.1995, p.1.
-2-
with regard to further technical and scientific information; for thiram this deadline was 31 October
1995.
Only UCB-Uniroyal on behalf of the thiram task force, submitted in time a dossier to the rapporteur
Member State which did not contain substantial data gaps, taking into account the supported uses
and therefore was considered to be the main data submitter. The seed treatment uses are supported by
Uniroyal and UCB, the foliar uses are only supported by UCB.
In accordance with the provisions of Article 7(1) of Regulation (EEC) No 3600/92, Belgium
submitted on 15 January 1998 to the Commission the report of its examination, hereafter referred to
as the draft assessment report, including, as required, a recommendation concerning the possible
inclusion of thiram in Annex I to the Directive. Moreover, in accordance with the same provisions,
the Commission and the Member States received also the summary dossier on thiram from UCBUniroyal, on 21 March 1999.
In accordance with the provisions of Article 7(3) of Regulation (EEC) No 3600/92, the Commission
forwarded for consultation the draft assessment report to all the Member States as well as to UCBUniroyal being the designated representative of the thiram task force, on 25 March 1998.
The Commission organised an intensive consultation of technical experts from a certain number of
Member States, to review the draft assessment report and the comments received thereon (peer
review), in particular on each of the following disciplines:
-
identity and physical /chemical properties ;

fate and behaviour in the environment ;
ecotoxicology ;
mammalian toxicology ;
residues and analytical methods ;
regulatory questions.
The meetings for this consultation were organised on behalf of the Commission by the Pesticide
Safety Directorate (PSD) in York, United Kingdom, from March to October 1999.
The report of the peer review (i.e. full report) was circulated, for further consultation, to Member
States on 17 March 2000 and the main data submitter on 21 March 2000 for comments and further
clarification.
In accordance with the provisions of Article 6(4) of Directive 91/414/EEC concerning
consultation in the light of a possible unfavourable decision for the active substance the
Commission organised a tripartite meeting with the main data submitter and the rapporteur
Member State for this active substance on 22 June 2000.
According to Commission Decision of 14 February 2001 concerning the decision on the possible
inclusion of certain active substances into Annex I to Council Directive 91/414/EEC5 a deadline
of 31.12.2001 for submission of further studies was established.
In accordance with the provisions of Article 7(3) of Regulation (EEC) No 3600/92, the dossier, the
draft assessment report, the peer review report (i.e. full report) and the comments and clarifications
5
OJ No L 49, 20.02.2001, p.13.
-3-
on the remaining issues, received after the peer review were referred to the Standing Committee on
the Food Chain and Animal Health, and specialised working groups of this Committee, for final
examination, with participation of experts from the 15 Member States. This final examination took
place from October 2000 to July 2003, and was finalised in the meeting of the Standing Committee
on 4 July 2003.
The review did not reveal any open questions or concerns which would have required a
consultation of the Scientific Committee on Plants.
The present review report contains the conclusions of the final examination; given the importance of
the draft assessment report, the peer review report (i.e. full report) and the comments and
clarifications submitted after the peer review as basic information for the final examination process,
these documents are considered respectively as background documents A, B and C to this review
report and are part of it.
2.
Purposes of this review report
This review report, including the background documents and appendices thereto, has been
developed and finalised in support of the Directive 2003/81/EC6 concerning the inclusion of thiram
in Annex I to Directive 91/414/EEC, and to assist the Member States in decisions on individual plant
protection products containing thiram they have to take in accordance with the provisions of that
Directive, and in particular the provisions of article 4(1) and the uniform principles laid down in
Annex VI.
This review report provides also for the evaluation required under Section A.2.(b) of the above
mentioned uniform principles, as well as under several specific sections of part B of these principles.
In these sections it is provided that Member States, in evaluating applications and granting
authorisations, shall take into account the information concerning the active substance in Annex II of
the directive, submitted for the purpose of inclusion of the active substance in Annex I, as well as the
result of the evaluation of those data.
In accordance with the provisions of Article 7(6) of Regulation (EEC) No 3600/92, Member States
will keep available or make available this review report for consultation by any interested parties or
will make it available to them on their specific request. Moreover the Commission will send a copy
of this review report (not including the background documents) to all operators having notified for
this active substance under Article 4(1) of this Regulation.
The information in this review report is, at least partly, based on information which is confidential
and/or protected under the provisions of Directive 91/414/EEC. It is therefore recommended that
this review report would not be accepted to support any registration outside the context of Directive
91/414/EEC, e.g. in third countries, for which the applicant has not demonstrated to have regulatory
access to the information on which this review report is based.
3.
Overall conclusion in the context of Directive 91/414/EEC
The overall conclusion from the evaluation is that it may be expected that plant protection products
containing thiram will fulfil the safety requirements laid down in Article 5(1)(a) and (b) of Directive
6
OJ No L 224, 06.09.2003, p.29
-4-
91/414/EEC. This conclusion is however subject to compliance with the particular requirements in
sections 4, 5, 6 and 7 of this report, as well as to the implementation of the provisions of Article 4(1)
and the uniform principles laid down in Annex VI of Directive 91/414/EEC, for each thiram
containing plant protection product for which Member States will grant or review the authorisation.
Furthermore, these conclusions were reached within the framework of the uses which were proposed
and supported by the main data submitter and mentioned in the list of uses supported by available
data (attached as Appendix IV to this Review Report).
Extension of the use pattern beyond those described above will require an evaluation at Member
State level in order to establish whether the proposed extensions of use can satisfy the requirements
of Article 4(1) and of the uniform principles laid down in Annex VI of Directive 91/414/EEC.
With particular regard to residues, the review has established that the residues arising from the
proposed uses, consequent on application consistent with good plant protection practice, have no
harmful effects on human or animal health. The Theoretical Maximum Daily Intake (TMDI;
excluding water and products of animal origin) for a 60 kg adult is 89% of the Acceptable Daily
Intake (ADI), based on the FAO/WHO European Diet (August 1994). Additional intake from
water and products of animal origin are not expected to give rise to intake problems.
The review has identified several acceptable exposure scenarios for operators, workers and
bystanders, which require however to be confirmed for each plant protection product in accordance
with the relevant sections of the above mentioned uniform principles.
The review has also concluded that under the proposed and supported conditions of use there are no
unacceptable effects on the environment, as provided for in Article 4 (1) (b) (iv) and (v) of Directive
91/414/EEC, provided that certain conditions are taken into account as detailed in section 6 of this
report.
4.
Identity and Physical/chemical properties
The main identity and the physical/chemical properties of thiram are given in Appendix I.
The active substance shall comply with the FAO specification and there seem not to be reasons for
deviating from that specification; the FAO specification is given in Appendix I of this report.
The review has established that for the active substance notified by the main data submitter, the task
force UCB-Uniroyal, none of the manufacturing impurities considered are, on the basis of
information currently available, of toxicological or environmental concern.
In accordance with the provisions of Article 13(5) of Directive 91/414/EEC, Belgium is also
satisfied, on the basis of the information currently available, that the substances notified by the
other data submitters (FMC-foret) do not, in the meaning of Article 13(2) and (5) of the
Directive, differ significantly in degree of purity and nature of impurities from the composition
registered in the dossier submitted by the main data submitter.
-5-
5.
Endpoints and related information
In order to facilitate Member States, in granting or reviewing authorisations, to apply adequately the
provisions of Article 4(1) of Directive 91/414/EEC and the uniform principles laid down in Annex
VI of that Directive, the most important endpoints were identified during the re-evaluation process.
These endpoints are listed in Appendix II.
6.
Particular conditions to be taken into account on short term basis by Member States in
relation to the granting of authorisations of plant protection products containing
thiram
On the basis of the proposed and supported uses (as listed in Appendix IV), the following particular
issues have been identified as requiring particular and short term attention from all Member States,
in the framework of any authorisations to be granted, varied or withdrawn, as appropriate:
-
Member States should pay particular attention to the protection of aquatic organism. Risk
mitigation measures should be applied, where appropriate.
Member States should pay particular attention to the protection of small mammals and birds
when the substance is used as a seed treatment in spring uses. Risk mitigation measures
should be applied, where appropriate.
7.
List of studies to be generated
No further studies were identified which were at this stage considered necessary in relation to the
inclusion of thiram in Annex I under the current inclusion conditions.
Some endpoints however may require the generation or submission of additional studies to be
submitted to the Member States in order to ensure authorisations for use under certain conditions.
This may particularly be the case for:
-
processing studies on the intended crops (with special attention to metabolite M1).
8.
Information on studies with claimed data protection
For information of any interested parties, Appendix III gives information about the studies for which
the main data submitter has claimed data protection and which during the re-evaluation process were
considered as essential with a view to annex I inclusion. This information is only given to facilitate
the operation of the provisions of Article 13 of Directive 91/414/EEC in the Member States. It is
based on the best information available to the Commission services at the time this review report
was prepared; but it does not prejudice any rights or obligations of Member States or operators with
regard to its uses in the implementation of the provisions of Article 13 of the Directive 91/414/EEC
neither does it commit the Commission.
-6-
9.
Updating of this review report
The technical information in this report may require to be updated from time to time in order to take
account of technical and scientific developments as well as of the results of the examination of any
information referred to the Commission in the framework of Articles 7, 10 or 11 of Directive
91/414/EEC. Such adaptations will be examined and finalised in the Standing Committee on the
Food Chain and Animal Health, in connection with any amendment of the inclusion conditions for
thiram in Annex I of the Directive.
-7Thiram
APPENDIX I
Identity, physical and chemical properties
07 April 2003
APPENDIX I
THIRAM
Chemical name (IUPAC)
Thiram
tetramethylthiuram disulfide or
bis (dimethylthiocarbamoyl)-disulfide
Chemical name (CA)
tetramethylthioperoxydicarbonic diamide
CIPAC No
CAS No
24
137-26-8
EEC No
205-286-2
FAO SPECIFICATION
24/1/S/18 (1979)
Minimum purity
960 g/kg (FAO specification)
Molecular formula
C6H12N2S4
Molecular mass
240.4
Common name (ISO)
Structural formula
S
CH3
N
CH3
S
S
CH3
N
CH3
-8Thiram
APPENDIX I
07 April 2003
Melting point
144 - 146C
Boiling point
Appearance
not applicable (not a low melting substance)

purified a.s.: white fine crystals with no detectable odour
TC: slightly off-white beige powder with no detectable
odour
Relative density
1.36 g/cm3 at 20C (97.8% pure)
Vapour pressure
2.3 x 10-3 Pa at 25C
Henry's law constant
3.3 x 10-2 Pa.m3.mol-1 at 25C

0.0165 g/l at 20C in pure water
no effect of pH
hexane: 0.093 g/l at 20C
xylene: 8.3 g/l at 20C
methanol: 1.91 g/l at 20C
dichloromethane: 199 g/l at 25C
acetone: 69.7 g/l at 25C
ethylacetate: 13 g/l at 22C
log Pow = 1.73 (distilled water)
no effect of pH
Solubility in water
Solubility in organic solvents
Partition co-efficient (log Pow)

Hydrolytic stability (DT50)
pH 5: DT50 = 68.5 d at 25C

pH 7: DT50 = 3.5 d at 25C
pH 9: DT50 = < 1 d at 25C
Dissociation constant
pKa (BH+) = 8.19
Quantum yield of direct phototransformation in water at >290 nm
= 2.97 x 10-3
Flammability
not highly flammable

not auto-flammable
Explosive properties
not explosive
UV/VIS absorption (max.)
214 nm: = 21884 L.mol-1.cm-1

278 nm: = 11342 L.mol-1.cm-1
(neutral conditions)
DT50 = 8.8 h at pH 5 and 25C
Photostability in water (DT50)
-9Thiram
APPENDIX II
END POINTS AND RELATED INFORMATION
1. Toxicology and metabolism
07 April 2003
APPENDIX II
THIRAM
1 Toxicology and metabolism

Absorption, distribution, excretion and metabolism in mammals
Rate and extent of absorption:
83-87% within 96 h
Distribution:
initially widely distributed ; highest residues in blood

(1.3%) and liver (1.6%) after 7 days
no evidence of accumulation
Potential for accumulation:

Rate and extent of excretion:
Toxicologically significant compounds:
Metabolism in animals:
85-90% within 96 h: 40% exhaled ; 33% in urine and

3.2% in feces
Parent compound and metabolites
Quite similar metabolism in livestock and plants.
>80 % metabolized reduction of disulfide bound leading
to dimethyl dithiocarbamic acid further oxidized mainly
to dimethyl-thiosulfenic acid after high dose, or to
thioxothiazolidine carboxylic acid after low dose and
exhaled in air as CSO, CS2 and CO2 probably.
Acute toxicity
Rat LD50 oral:
male = 3700 mg/kg bw

female = 1800 mg/kg bw
Rat LD50 dermal:

Rat LC50 inhalation:
> 2000 mg/kg bw

Male > 5.04 mg/l
female = 3.46 mg/l
Skin irritation:
non irritant
Eye irritation:
irritant
Skin sensitization (test method used and sensitizer (Split Adjuvant Test)
result):
Supporting evidence for humans
Short term toxicity

Target / critical effect:
Liver (dog)
Non glandular stomach (rat)
Lowest relevant oral NOAEL / NOEL:
Dog, 90 day: 75 ppm (2 mg/kg bw/d)
Lowest relevant dermal NOAEL / NOEL: Rabbit, 21 days: 300 mg/kg bw/d (systemic)
- 10 Thiram
APPENDIX II
07 April 2003
Lowest relevant inhalation NOAEL /

NOEL:
no data, not necessary ( at Member state level)
Genotoxicity
positive Ames test.

Negative results in in vivo mammalian studies.
Thiram is not considered a genotoxin of relevance for
humans.
Long term toxicity and carcinogenicity

Target / critical effect:
Lowest relevant NOAEL:
Carcinogenicity:
Liver: C-cell hyperplasia and reduced LH surge in rats

Retina in mice and dogs
Rat, 104 week study , 30 ppm = 1.5mg/kg bw/d
Increased incidence of only benign liver and C-cell
adenoma in target organs above MTD.
No need for classification
Reproductive toxicity
Target / critical effect - Reproduction:
Pup body weight reduction at maternal toxic doses
Lowest relevant reproductive NOAEL /

NOEL:
180 ppm (9 mg/kg bw/d)
Target / critical effect - Developmental

toxicity:
developmental delay (rat)
Lowest relevant developmental NOAEL / 7.5 mg/kg bw/d

NOEL:
Delayed neurotoxicity
Acute and subchronic neurotoxic effects (FOB

parameters)
NOAEL acute neurotoxicity = 60 mg/kg bw/d
NOAEL subchronic = 1.5 mg/kg bw/d
Other toxicological studies
liver enzyme induction, at high doses.
Medical data
Skin irritation is seen sporadically.

Sensitizer , inhibits alcohol metabolism.
Summary
Value
Study
Safety factor
ADI:
0.01 mg/kg bm/d
100
AOEL systemic:
0.02 mg/kg bm/d
2 year rat
supported by the
findings in dogs
90 day dog,
supported by the
1 year findings
100
- 11 Thiram
APPENDIX II
07 April 2003
AOEL inhalation:
Not applicable.
Use systemic
value
AOEL dermal:
ARfD (acute reference dose):
Not applicable.
Use systemic
value
0.6 mg/kg bm/d
Acute
neurotoxicity rat
100
Dermal absorption
Default value of 10 %
- 12 Thiram
APPENDIX II
2. Fate and behaviour in the environment
07 April 2003
2 Fate and behaviour in the environment

2.1 Fate and behaviour in soil
Route of degradation
Aerobic:
Mineralization after 100 days:
65.9% (day 84)
Non-extractable residues after 100 days:
36.1% (day 84)
Major metabolites above 10 % of applied

active substance: name and/or code
% of applied rate (range and maximum)
N,N dimethyl carbamosulfonic acid (DMCS)

found at max. rate of 10.23% at day 16
Supplemental studies
Anaerobic:
Not submitted
Soil photolysis:
DT50 (12 h light/12 h dark) = 3.7 d

DT50 (in the dark) = 15.9 d
Remarks:
None
Rate of degradation
Laboratory studies
DT50lab (20 C, aerobic):
DT50lab (a.s., 20C, aerobic): median 4.6 d (4 soils)

DT50lab (DMCS, 20C, aerobic): median 37.6 d (3
soils)
DT90lab (a.s., 20C, aerobic): median 15.3 d (4 soils)

DT90lab (DMCS, 20C, aerobic): median 124.8 d (3
soils)
DT50lab (a.s., 10C, aerobic): 9.83 d

DT50lab (DMCS, 10C, aerobic): 38.7 d
DT50lab (20 C, anaerobic):
DT50lab (20C, anaerobic): Not submitted,

not required
Field studies (country or region)

DT50f from soil dissipation studies:
DT50f: No studies performed
DT90f from soil dissipation studies:
DT90f: No studies performed
Soil accumulation studies:
Not required
Soil residue studies:
Not required
- 13 Thiram
Remarks:
e.g. effect of soil pH on degradation rate
APPENDIX II
07 April 2003
None
- 14 Thiram
APPENDIX II
07 April 2003
Adsorption/desorption
Kf / Koc:
Kd:
Kf a.s. = 54.10-263.14 l/kg; median = 108 l/kg (4

soils)
Koc a.s.= 2245-24526 l/kg; median = 9629 l/kg (4
soils)
pH dependence:
Koc DMCS = 33.45 l/kg (by calculation)

No
Mobility
Laboratory studies:
Column leaching:
No studies performed
Aged residue leaching:
Field studies:
Lysimeter/Field leaching studies:
Remarks:
None
- 15 Thiram
APPENDIX II
07 April 2003
2.2 Fate and behaviour in water

Abiotic degradation
Hydrolytic degradation:
Major metabolites:
pH 5, 25C, a.s.: 68.5 d

pH 7, 25C, a.s.: 3.5 d
pH 9, 25C, a.s.: 6.9 h
at pH 5, 7, 9
CS2 is the major degradation product, volatile
Photolytic degradation:
pH5, 25C, a.s.: 8.8 h
Major metabolites:
CS2 is the major degradation product, volatile
Biological degradation
Readily biodegradable:
No, no study submitted
Water/sediment study:
DT50 water:
DT90 water:
DT50 whole system:
DT90 whole system:
DT water = DT whole system
Distribution in water / sediment systems

(active substance)
a.s. was only detected in the water phase

The a.s. is not found in the sediment.
Distribution in water / sediment systems

(metabolites)
Accumulation in water and/or sediment:
31.78-46.07 h
105.57-153.03 h
All the metabolites (CS2, dimethyldithiocarbamic

acid methyl ester, unknowns) were detected in the
water phase
No accumulation in water and/or sediment
Degradation in the saturated zone

Remarks:
Not relevant
- 16 Thiram
APPENDIX II
07 April 2003
2.3 Fate and behaviour in air

Volatility
Vapour pressure:
2.3 10-3 Pa at 25C
Henry's law constant:
3.3 10-2 Pa.m3.mol-1 at 25C
Photolytic degradation
Direct photolysis in air:
Not required
Photochemical oxidative degradation in air
DT50 21.3 min
DT50:
Volatilisation:
from plant surfaces: Not required

from soil: Thiram is slightly volatile
(vap pressure = 2.3 10E-3 Pa at 25C)
Remarks:
None
- 17 Thiram
APPENDIX II
3. Ecotoxicology
07 April 2003
3 Ecotoxicology
Terrestrial Vertebrates
Acute toxicity to mammals:
LD50 rat = 1800 mg a.s./kg bw
Acute toxicity to birds:
LD50 > 2000 mg a.s./kg bw
Dietary toxicity to birds:
LC50 > 4423 mg a.s./kg food (equivalent to 947

mg a.s./kg bw/d)
Reproductive toxicity to birds:
NOEC = 500 mg a.s./kg food (equivalent to 37.5

mg a.s./kg bw/d)
Short term oral toxicity to mammals
Parental NOEL (2 gener., rat) = 30 mg a.s./kg

food (equivalent to 1.5 mg a.s./kg bw/d)
Reprod + develop NOEL (2 gener., rat) > 180
mg a.s./kg food (equivalent to > 9 mg a.s./kg
bw/d)
reproductive toxicity to mammals:
Foetal toxicity (terato, rat, 10 days exposure) =

15 mg a.s./kg bw/d
Aquatic Organisms
Acute toxicity fish:
Cyprinodon variegatus: 96 h, LC50: 0.54 mg a.s./l

Oncorynchus mykiss: 96 h, LC50: 0.046 mg a.s./l
Pimephales promelas: 96 h, LC50: 0.27 mg a.s./l
Lepomis macrochirus: 96 h, LC50: 0.13 mg a.s./l
Cyprinus carpio: 96 h, LC50: 0.200 mg 80WG/l
Long term toxicity fish:
Oncorynchus mykiss: 42 d, 4 appl., in sediment/

water system, NOEC(growth rate): 0.012 mg
80WG/l
Oncorynchus mykiss: 96 h prolonged up to 11 d.,
in sediment/water syst, LC50: 0.089 mg 80WG/l
Oncorynchus mykiss: 60 d, EC50: 0.00064 mg
a.s./l
Bioaccumulation fish:
Not required, log Pow = 1.73
Acute toxicity invertebrate:
Daphnia magna: 48 h, EC50: 0.011 mg a.s./l
Chronic toxicity invertebrate:
Daphnia magna: 21 d, LC50: 0.008 mg a.s./l
Acute toxicity algae:
Selenastrum capricornutum: 120 h, EC50: 0.065

mg a.s./l
Chronic toxicity sediment dwelling organism:
Covered by the mesocosm study: chironomus

larvae were not affected up to concentrations of
1000 g a.s./l
Acute toxicity aquatic plants:
Not required
Higher tier studies:
Aquatic invertebrates and algae: outdoor
- 18 Thiram
APPENDIX II
3. Ecotoxicology
07 April 2003
mesocosm, series of concentrations, with

several applications mimicking foliar use
(orchard/vineyard/field)
EAC: 0.010 mg a.s./l
NOEC = 0.001 mg a.s./l
Honeybees
Acute oral toxicity:
LD50 > 100 g a.s./bee
Acute contact toxicity:
LD50 > 100 g a.s./bee
Other arthropod species

Test species
Test
Substance
Dose
Endpoint
% Effect
Aleochara bilineata (adults)
Vitavax 200 FF
400 ml
formulation/10
0 kg seeds
Parasistism
efficiency
21.5 %
Poecilus cupreus (adults)
Vitavax 200 FF
400 ml
formulation
/100 kg seeds
Mortality
0%
Aleochara bilineata (adults)
Aatiram
300 g
formulation
/100 kg seeds
Parasistism
efficiency
28.3 %
Poecilus cupreus (adults)
Aatiram
Mortality
0%
Chrysoperla carnea (larvae)
Thiram 80WG
300 g
formulation
/100 kg seeds
3kg
Mortality
87 %
Mortality
95 %
Mortality
0%
7.69 %
Mortality
52 %
55 %
Laboratory tests
formulation
/ha
Aphidius rhopalosiphi
(adults)
Thiram 80WG
6 kg
formulation /ha
3kg
formulation /ha
6 kg
formulation /ha
3kg
formulation /ha
Reproduction
6 kg
formulation /ha
Coccinella septempunctata
(larvae)
Thiram 80WG
3kg
formulation /ha
6 kg
Reproduction
Mortality
89 %
- 19 Thiram
Aphidius rhopalosiphi
(adults)
Coccinella septempunctata
(larvae)
APPENDIX II
3. Ecotoxicology
07 April 2003
Thiram 80WG
Thiram 80WG
Thiram 80WG
(fresh)
Thiram 80WG
(28 d aged
residue)
formulation /ha
2X 0.28 and
2X0.15 kg
a.s./ha
4X 1.92 kg
a.s./ha
Mortality
Mortality
80 %
0%
Mortality
2.56 %
2X 0.28 and
2X0.15 kg
a.s./ha
4X 1.92 kg
a.s./ha
2X 0.28 and
2X0.15 kg
a.s./ha
4X 1.92 kg
a.s./ha
Reproduction
21 %
Reproduction
16 %
Mortality
16.33 %
Mortality
33.36 %
2X 0.28 and
2X0.15 kg
a.s./ha
4X 1.92 kg
a.s./ha
2X 0.28 and
2X0.15 kg
a.s./ha
4X 1.92 kg
a.s./ha
Reproduction
0%
Reproduction
0%
Mortality
25 %
Mortality
91.67 %
2X 0.28 and
2X0.15 kg
a.s./ha
4X 1.92 kg
a.s./ha
Reproduction
42%
Reproduction
not
determined
2X 0.28 and
2X0.15 kg
a.s./ha
4X 1.92 kg
a.s./ha
Mortality
2%
Mortality
23.78%
2X 0.28 and
2X0.15 kg
a.s./ha
4X 1.92 kg
a.s./ha
Reproduction
0%
Reproduction
0%
Field or semi-field tests
Typhlodromus pyri
apple orchard, 4 appl. at 2.4 kg a.s./ha: E = 24.8 29.9%: sligthly

harmful
Typhlodromus pyri
apple orchard, 4 appl. at 2.4 kg a.s./ha: E = -12 24.8%: harmless
Whole arthropod fauna
field test on Carpinus, 3 appl. at 160 g a.s./hl: E = -17 to 4%:

harmless
- 20 Thiram
APPENDIX II
3. Ecotoxicology
07 April 2003
Earthworms
Acute toxicity:
LC50 (14d) = 540 mg a.s/kg soil
Reproductive toxicity:
Not required.
Soil micro-organisms
Nitrogen mineralization:
Negligible effects at 2.4 and 24 kg a.s./ha (less

than 15% after 90 d)
Carbon mineralization:
Negligible effects at 2.4 and 24 kg a.s./ha
- 21 Thiram
APPENDIX III
List of studies
07 April 2003
APPENDIX IIIA
THIRAM
List of studies for which the main submitter has claimed data protection and
which during the re-evaluation process were considered as essential for the
evaluation with a view to Annex I inclusion.
The evaluation of thiram is based on the dossier which has been submitted by the task
force UCB (now: Taminco) and Uniroyal (now: Crompton). Except a few studies submitted
by FMC, all the studies of this list were submitted by the task force or one of its Members.
Thiram task force I and thiram task force II are equivalent to task force UCB-Uniroyal.
B.1 Identity, B.2 Physical and chemical properties, B.3 Data on application and further
information, B.4 Proposals for classification and labelling, B.5 Methods of analysis
Reports7 on
Author(s)
Year Title
Annex
Source (where different from company) previous use in
point/
Company, Report No.
granting
reference
GLP or GEP status (where relevant)
national
number
Published or not
authorizations
IIA 1.10
IIA 4.1.2
Hull L.B., Forbes P. 1998
IIA 1.11
Comb, A.L.
1997
IIA 1.11/01
Demuynck M.
1999
Accuracy validation of test control methods

AC1214 and AC1216 for impurities in
Thiram
Generated by: Uniroyal Chemical Limited
Submitted by: Uniroyal Chemical Limited
Project Nr.: 97067 - Uniroyal Ref. T.3.1.13
Date: 4 September 1998
GLP
Unpublished
Thiram (technical): Five-batch analysis
Huntingdon Life Sciences Ltd.
Generated by: FMC Foret S.A.
Submitted by: FMC Foret S.A.
Report N: FRT 002/970098
Date: 5 August 1997
GLP
Unpublished
Presence of dimethylcarbamoyldimethylthiocarbamoyl disulfide in Thiram produced by
UCB
UCB Gent
Generated by: UCB S.A.
Submitted by UCB S.A. (on 20/8/1999)
Company file No.: Date: 1 April 1999
not GLP
Unpublished
Entries are based on information received from the Notifier(s) and in certain cases Member States. Neither the Commission nor
the Member States are responsible for the completeness or validity of this information received.
- 22 Thiram
APPENDIX III
List of studies
07 April 2003
Annex
point/
reference
number
Author(s)
Year
Title
Source (where different from company)
Company, Report No.
Published or not
IIA 1.11/02
Forbes P.J.,
Mertz J.L.
1997
Composition and identification of impurities

in Thiram produced by UCB Chemicals
Uniroyal Chemical Company, Ltd.
Generated by: UCB S.A., Uniroyal Chemical
Limited
Company file No.: 97034
GLP
Unpublished
The melting point range of purified Thiram.
Generated by: Uniroyal Chemical, Ltd.
Submitted by: Uniroyal Chemical, Ltd.
Company file No.: GRL-10494
Date: July 27, 1994
GLP
unpublished
IIA 2.1.1/01 Riggs, A.S.
1994
IIA 2.2/01
1993
Tutty, D.G.
IIA 2.3.2/01 Pierce, T.B.
1995
1994
1994
Determination of the density of Thiram

Technical.
Date: October 14, 1993
GLP
unpublished
Henrys law constant - Thiram
J.B. Pierce
(23/09/97)
Date: March 23, 1995
non-GLP
unpublished
The colour of Technical Thiram
Date: February 4, 1994
GLP
unpublished
The physical state of purified Thiram
GLP
unpublished
Reports7 on
previous use in
granting
national
authorizations
- 23 Thiram
APPENDIX III
List of studies
07 April 2003
Year
Title
Company, Report No.
Published or not
1994
IIA 2.5.1/01 Tutty, D.G.
1994
The odour of Technical Thiram

GLP
unpublished
Determination of the ultraviolet visible
absorption spectrum of pure grade Thiram.
Company file No.: GRL-10495 (93164)
Date: January 24, 1994
GLP
unpublished
IIA 2.5.1/02 Penny, Helen B.
1995
IIA 2.6/01
Tutty, D.G.
1993
IIA 2.6
IIA 2.11.2
IIA 2.14
Flack, I.
1997
IIA 2.7/01
Tutty, D.G.
1993
Annex
point/
reference
number
Author(s)
IR-spectra: Determination of the infrared

spectrum of Thiram
(23/09/97)
GLP
unpublished
Determination of the solubility of Thiram in
water.
Date: December 23, 1993
GLP
unpublished
Thiram physical and chemical properties
Report N: FCC 151/962024
GLP
Unpublished
Determination of the solubility of Thiram in
organic solvents.
GLP
unpublished
Reports7 on
previous use in
granting
national
authorizations
- 24 Thiram
APPENDIX III
List of studies
07 April 2003
Annex
point/
reference
number
Author(s)
Year
Title
Company, Report No.
Published or not
IIA 2.7/04
Baele, G.,
Van De Putte, M.,
Demuynck, M.
1997
IIA 2.8/01
Lemal, R.
1983
Solubility of Thiram in ethyl acetate

UCB Gent
Generated by: UCB Chemicals
Submitted by: UCB Chemicals (23/9/97)
Company file No.: W/RL/9709/001
Date: September 08, 1997
non-GLP
unpublished
TMTD: Determination of octanol/water
partition coefficient.
UCB Gent
Generated by: Thiram Task Force I
Submitted by: Thiram Task Force I
Company file No.: LPCD No 78
non-GLP
unpublished
Determination of the hydrolysis rate of 14CThiram.
Analytical Development Corporation
Company file No.: ADC Project No 1156
GLP
unpublished
Identification of the aqueous
photodegradation products of 14C-Thiram.
Company file No.: Uniroyal Proj. 8926
(T.8.1.8)
GLP
unpublished
Determination of the direct phototransformation of 14C-Thiram in a buffered
medium at pH 7.
RCC Umweltchemie
Submitted by: UCB Chemicals
Company file No.: RCC Project No. 449600
GLP
unpublished
Determination of the dissociation constant of
pure grade Thiram
Generated by: Uniroyal Chemical Ltd
(23/09/97)
GLP
unpublished
IIA 2.9.1/01 Norris, K.J.
1991
IIA 2.9.2/01 McManus, J.P.
1991
IIA 2.9.3/01 Knoch, E.
1994
IIA 2.9.4/01 Thomson, Paul A.
1995
Reports7 on
previous use in
granting
national
authorizations
- 25 Thiram
APPENDIX III
List of studies
07 April 2003
Annex
point/
reference
number
Author(s)
Year
Title
Company, Report No.
Published or not
IIA
2.11.1/01
Tremain S P
1999
IIA 2.13
Krips H.J.
2000
IIA 4.2.1/02 Weber, H.
1993
IIA 4.2.1/03 Weber, H.
1994
IIA 4.2.1/04 Gatti, G.
1992
Thiram Technical: Determination of

flammability (solids)
Safepharm Laboratories Limited
Limited
Submitted by: UCB S.A., Uniroyal Chemical
Limited (on 20/8/1999)
Company file No.: 378/027
Date: 6 August 1999
GLP
Unpublished
Determination of the explosive properties of
Thiram Technical
Notox
Limited
Project Nr.: 279484
Date: 26 January 2000
GLP
Unpublished
Validation of the HPLC method for the
determination of the residues of Thiram in
vine (grapes and wine).
Dr. Specht & Partner
Company file No.: BAS-9302V
GLP
unpublished
Validation of the HPLC method for the
determination of the residues of Thiram in
vine (wet and dry pomace, must).
Company file No.: BAS-9301V
GLP
unpublished
Determination of residues of Thiram on
plums, pears, peaches, cherries and apples
in compliance with good laboratory practice
regulations - liquid chromatograph method.
Company file No.: Study LN 14/HP - GLP
GLP
unpublished
Reports7 on
previous use in
granting
national
authorizations
- 26 Thiram
APPENDIX III
List of studies
07 April 2003
Annex
point/
reference
number
Author(s)
Year
Title
Company, Report No.
Published or not
IIA 4.2.2
Blaszczynski E.
2001
IIA 4.2.3
Blaszczynski E.
2000
Analytical
method
for
determining
Thiram in soil
AGVISE Laboratories, Inc.
Generated by: UCB S.A., Uniroyal
Chemical Limited
Limited (on 26/12/2001)
Study Nr.: 2000-187
Date: 23 February 2001
GLP
Unpublished
Analytical method for determination of thiram
in pond water
Chemical Company Inc.
Company Inc. (on 17/11/2000)
Study Nr.: 99188
Date: 27 March 2000
GLP
Unpublished
IIA 4.2.4/02 Class Th.
2001
Development and validation of an analytical

method for the determination of Thiram in air
PTRL Europe
Limited
Study Nr.: 2001-040
Date: 16 May 2001
GLP
Unpublished
Reports7 on
previous use in
granting
national
authorizations
- 27 Thiram
APPENDIX III
List of studies
07 April 2003
B.6 Toxicology and metabolism

Annex
point/
reference
number
Author(s)
IIA 5.1/02
Nomeir, A.A.,
Markham, P.
1990
IIA 5.1/03
Norris, K.J.
1991
IIA 5.3.3/01 Edwards, J.A.,

Mcrae, l.A.,
Gibson, W.A.,
Crook, D.,
Gopinath, C.,
Singh, H.
IIA 5.7
Williams Jackie
Year
1992
2001
IIA 5.7/01
Driscoll, C.D.,
Hurley, J.M.
1993
IIA 5.7/02
Driscoll, C.D.,
Hurley, J.M.
1993
IIA 5.8.1
Anon
2001
Title
Company, Report No.
Published or not
Disposition and metabolism of Thiram in rats
after pretreatment with Thiram for 14 days.
Company file No.: Uniroyal Project No. 9049
(T.8.3.4)
GLP
unpublished
Identification and comparison of urinary
metabolite profiles of 14C-Thiram in
subchronic vs single oral dose in rats.
Company file No.: Uniroyal Project No. 8833
(T.8.3.8)
GLP
unpublished
Thiram Technical - Twenty-one day dermal
toxicity study in rabbits.
Huntingdon Research Centre (HRC)
Company file No.: UCB 421/920767
GLP
unpublished
Thiram: Acute investigative study in rats
Central Toxicology Laboratory
Submitted by: UCB S.A. (on 26/12/2001)
Study Nr.: AR7090
Date: 19 November 2001
GLP
Unpublished
Thiram single exposure peroral (gavage)
neurotoxicity study in rats.
Bushy Run Research Center (BRRC)
Company file No.: T.7.5.1
GLP
Unpublished
Thiram: Ninety day dietary neurotoxicity
study in Sprague-Dawley rats.
Bushy Run Research Center (BRRC)
Company file No.: T.7.5.2
GLP
Unpublished
TOPKAT toxicity assessment report (DMCS)
Accelerys Inc USA
Submitted by Crompton Europe Ltd
Not GLP
Unpublished
Submitted Dec 2001
Reports on
previous use in
granting
national
authorizations
- 28 Thiram
APPENDIX III
List of studies
07 April 2003
B.7 Residue data

Annex
point/
reference
number
Author(s)
Year
IIA 6.1/05
Liu, D.D.W.,
Robinson, R.A.
1994
IIA 6.1/06
Liu, D.D.W.,
Robinson, R.A.
1994
IIA 6.1/07
Liu, D.D.W.,
Robinson, R.A.
1994
IIA 6.1/08
Wyss-Benz, M.
1994
IIA 6.1/09
Morgenroth, U.,
Wyss-Benz, M.
1995
Title
Company, Report No.
Published or not
Distribution and metabolism of 14C Thiram in
plants from treated sugarbeet seed.
XenoBiotic Laboratories Inc.
Generated by: Thiram Task Force II
Submitted by: Thiram Task Force II
Company file No.: Uniroyal Study No. 92252
Date: November 1, 1994
GLP
unpublished
Uptake and translocation of [14C]-Thiram in
plants from treated wheat seed.
Company file No.: Uniroyal Project No.
91181
GLP
unpublished
Uptake and translocation of [14C]-Thiram in
plants from treated soybean seed.
92161
GLP
unpublished
14
C-Thiram: Plant metabolism study in field
grown apple.
RCC
Company file No.: RCC Project 319588
GLP
unpublished
14
C-Thiram: Plant metabolism study in field
grown grapes
RCC
Company file No.: RCC Project 319590
Date: July 4, 1995
GLP
unpublished
Reports on
previous use in
granting
national
authorizations
- 29 Thiram
APPENDIX III
List of studies
07 April 2003
Annex
point/
reference
number
Author(s)
Year
IIA 6.1/10
Robinson, R.A.
1996
IIA 6.1/13
Womer, J.M.,
Balba, H.M.
1978
IIA 6.2/01
Norris, K.J.
IIA 6.2/02
Norris, K.J.
IIA 6.3/01
Knight, C.
1995
Title
Company, Report No.
Published or not
Investigation of the stability of 14C-3(Dimethyldithiocarbamoyl)-alanine in the
presence of a soybean straw matrix
Company file No.: Report No. RPT00245 Study No. XBL 95321
GLP
Unpublished
Translocation and soil movement of 14C
Thiram from wheat seeds treated with
Vitavax 200
Generated by: Crompton Corporation
Submitted by: Crompton Europe Ltd. (in
12/2001)
Study Nr.: 7846/7850
Date: 1978
Not GLP
Unpublished
Determination of the metabolic fate of [14C]Thiram orally administered to laying hens.
ADC + Colorado State University
Company file No.: ADC Report No. 1058-1
Date: September 17, 1993
GLP
Unpublished
Determination of the metabolic fate of [14C]Thiram orally administered to lactating goats.
Analytical Development Corporation
Company file No.: ADC Report No. 1057
(T.8.3.11)
GLP
Unpublished
Residues of Thiram in combining peas
treated with Vitavax 200FF seed treatment.
Company file No.: V.6.2.11.1
GLP
unpublished
Reports on
previous use in
granting
national
authorizations
- 30 Thiram
APPENDIX III
List of studies
07 April 2003
Annex
point/
reference
number
Author(s)
Year
IIA 6.3/02
Patel, N.P.
1995
IIA 6.3/03
Knight, C.
1995
IIA 6.3/06
Rockwell, J.C.
1992
IIA 6.3/09
Ball, J.O
1988
IIA 6.3/11
Rockwell, J.C.
1992
IIA 6.3/12
Ball, J.O
1988
Title
Company, Report No.
Published or not
Residues of Thiram in linseed treated with
Vitavax 200FF seed treatment.
Company file No.: V.6.2.12.1
GLP
unpublished
Residues of gamma-HCH and Thiram in
oilseed rape treated with Vitavax RS seed
treatment.
AG/13148
GLP
unpublished
Residues of Thiram and its metabolites in
alfalfa
Gustafson + Hazleton Laboratories
Company file No.: 92-012
Date: June 24, 1992
non-GLP
unpublished
Residues of Thiram and its
monothioglucoside and dithioglucoside in
soybeans (2 volumes).
Company file No.: T.6.2.5.2 (89-013)
non-GLP
unpublished
Residues of Thiram and its metabolite in
cabbage.
Company file No.: Uniroyal Report No. 92013
Date: June 23, 1992
non-GLP
unpublished
Residues of Thiram and its dithioglucoside
and monothioglucoside in sweet corn.
Company file No.: T.6.2.4.3
non-GLP
unpublished
Reports on
previous use in
granting
national
authorizations
- 31 Thiram
APPENDIX III
List of studies
07 April 2003
Annex
point/
reference
number
Author(s)
Year
IIA 6.3/13
Rockwell, J.C.
1992
IIA 6.3/14
Rockwell, J.C.
IIA 6.3/15
Rockwell, J.C.
1989
IIA 6.3/16
Rockwell, J.C.
1990
IIA 6.3/17
Rockwell, J.C.
1989
Title
Company, Report No.
Published or not
cucumbers.
Company file No.: Report No. 92-014,
HLA 6111-134D, Gustafson 01774
Date: June 23, 1992
non-GLP
unpublished
lettuce.
HLA 6111-126K, Gustafson 01488
non-GLP
unpublished
peas.
HLA 6111-126G, Gustafson 01489
non-GLP
unpublished
sugar beets.
HLA 6111-126H, Gustafson 01491
non-GLP
unpublished
table beets.
Company file No.: Report No. 90-011
non-GLP
unpublished
Reports on
previous use in
granting
national
authorizations
- 32 Thiram
APPENDIX III
List of studies
07 April 2003
Annex
point/
reference
number
Author(s)
Year
IIA 6.3/18
Rockwell, J.C.
1992
IIA 6.3/19
Ball, J.O
1988
IIA 6.3/20
Rockwell, J.C.
1989
IIA 6.3/21
Christman, P.J.
1992
IIA 6.3/22
Roland, L.
1993
Title
Company, Report No.
Published or not
fresh and processing tomatoes.
HLA 6111-134F, Gustafson 01775
Date: June 23, 1992
non-GLP
unpublished
Residue of Thiram and its dithioglucoside
and monothioglucoside in cotton (2
volumes).
Company file No.: T.6.2.3.2, 89-008,
HLA 6111-126J, Gustafson 01483
non-GLP
unpublished
safflower.
Company file No.: 90-009, HLA 6111-126L,
Gustafson 01490
non-GLP
unpublished
78-Week frozen storage stability of Thiram
and dithioglucoside of Thiram in crops.
Hazleton Laboratories America, Inc.
Company file No.: HLA 6111-126 A-L
Date: June 23, 1992
GLP
unpublished
Study on the stability of Thiram on frozen
whole plums.
B.E.A.Gx Centre de Recherches de
Phytopharmacie, Gembloux
Company file No.: CRP/93/1025
Date: April 23, 1993
non-GLP
unpublished
Reports on
previous use in
granting
national
authorizations
- 33 Thiram
APPENDIX III
List of studies
07 April 2003
Annex
point/
reference
number
Author(s)
Year
IIA 6.3/23
Roland, L.
1994
IIA 6.3/24
Blaschke, U.
1995
IIA 6.3/25
Blaschke, U.
1995
IIA 6.3/26
IIA 6.3/27
IIA 6.3/28
IIA 6.3/29
Weber, H.
1994
IIA 6.3/30
Blaschke, U.
1995
Title
Company, Report No.
Published or not
Rsidus de Thirame sur raisins, mots et
vins.
Held on file by: UCB Chemicals
Company file No.: FR 7/91 (CRP/94/1295)
Date: August 18, 1994
non-GLP
unpublished
Raw agricultural and processed commodity
study with LX1282-01 (Dirac Express)
applied to grapes in France.
Paragon Global Services
Company file No.: UCB-9301A (28203B002)
Date: May 23, 1995
GLP
unpublished
study with LX1282-02 (Silbos DF) applied to
grapes in France.
Company file No.: UCB 9301c (28203B004)
Date: May 23, 1995
GLP
unpublished
Determination of residues of Thiram in vine
(grapes, must and wine) BASF study
DE/FR/03/92, Trial No. DU2/60/92,
DU2/61/92, DU3/29/92, DU3/30/92.
Company file No.: BAS-9302
GLP
unpublished
Company file No.: UCB-9301b (28203B003)
Date: May 23, 1995
GLP
unpublished
Reports on
previous use in
granting
national
authorizations
- 34 Thiram
APPENDIX III
List of studies
07 April 2003
Annex
point/
reference
number
Author(s)
Year
IIA 6.3/31
Blaschke, U.
1995
IIA 6.3/32
IIA 6.3/33
Balluff, M.
1995
IIA 6.3/34
Schmidt,
Ohs
1990
IIA 6.3/35
Schmidt,
Ohs
1990
IIA 6.3/36
Roland, L.
1992
Title
Company, Report No.
Published or not
Company file No.: UCB-9301 (28203B001)
Date: May 23, 1995
GLP
unpublished
Determination of residues of Thiram 80WG
in grapes under field conditions at two
locations in France.
GAB Biotechnologie GmbH
Company file No.: 94020/01-FPWE
Date: April 7, 1995
GLP
unpublished
Field report and analytical data field trial No.
0318/89, residue on apple, (Germany),
80WP formulation
Bayer AG
Date: April 9, 1990
non-GLP
unpublished
0320/89, residue on apple, (Germany),
80WP formulation
Bayer AG
Date: April 9, 1990
non-GLP
unpublished
Residues of Thiram on apples.
Company file No.: CRP/92/974 (BEVJG1)
Date: November, 1992
non-GLP
unpublished
Reports on
previous use in
granting
national
authorizations
- 35 Thiram
APPENDIX III
List of studies
07 April 2003
Annex
point/
reference
number
Author(s)
Year
IIA 6.3/37
Roland, L.
1992
IIA 6.3/38
Pigeon, O.
1993
IIA 6.3/39
IIA 6.3/40
Ohs
1995
IIA 6.3/41
Gatti, G
1992
Title
Company, Report No.
Published or not
Residues of Thiram on apples.
Company file No.: CRP/92/973 BEVJG2)
non-GLP
unpublished
Determination of residues of Thiram (TMTD)
on apples by selective method.
Station de phytopharmacie de lEtat,
Gembloux
Company file No.: UCB/P.J./B.A.7792c
GLP
unpublished
Determination of residues of Pomarsol
80WG in/on apple under actual use
conditions in Belgium.
Bayer AG
Company file No.: RA-2097/93 (study
numbers 304670 [467/93], 304735 [473/93])
GLP
unpublished
Determination of residues of Thiram in
plums, pears, peaches, cherries and
apples in compliance with good laboratory
practice regulations - CS2 headspace
method, liquid chromatography method.
Neotron
Company file No.: UCB
201/202/203/204/205
(Laboratory study LN 14/HP, LN 14/HD)
GLP
unpublished
Reports on
previous use in
granting
national
authorizations
- 36 Thiram
APPENDIX III
List of studies
07 April 2003
Annex
point/
reference
number
Author(s)
Year
IIA 6.3/42
Gatti, G.
199192
IIA 6.3/43
IIA 6.3/44
Ohs
1995
IIA 6.3/45
Schmidt,
Ohs
1990
IIA 6.3/46
Schmidt,
Ohs
1990
IIA 6.3/47
Roland, L.
1992
Title
Company, Report No.
Published or not
Field reports and analytical data for 1991
trials in Italy on apples, pears, peaches,
cherries and plums (50WG formulation).
Neotron
Company file No.: 58-F91/6009/6010/6011/6012
UCB 911/912/913/914
(Laboratory study LN 12)
Date: 1991-92
GLP
unpublished
80WG in/on Apple under under actual use
conditions in France and of Pomarsol 50WG
in/on Apple under actual use conditions in
Italy.
Bayer AG
numbers 304697, 304700)
GLP
unpublished
0319/89, residue on pear, (Germany), 80WP
formulation
Bayer AG
Date: April 9, 1990
non-GLP
unpublished
0321/89, residue on pear, (Germany), 80WP
formulation
Bayer AG
Date: April 9, 1990
non-GLP
unpublished
Residues of Thiram on pears
Company file No.: CRP/92/978 BEVECON
1)
non-GLP
unpublished
Reports on
previous use in
granting
national
authorizations
- 37 Thiram
APPENDIX III
List of studies
07 April 2003
Annex
point/
reference
number
Author(s)
Year
IIA 6.3/48
Roland, L.
1992
IIA 6.3/49
Pigeon, I.O.
1993
IIA 6.3/53
Balluff, M.
1995
IIA 6.3/57
Balluff, M.
1995
IIA 6.3/60
Balluff, M.
1995
Title
Company, Report No.
Published or not
Residues of Thiram on pears
Company file No.: CRP/92/977 BEVECON
2)
non-GLP
unpublished
on pears by selective method.
Gembloux
Company file No.: BA 7792b (BEWCON)
GLP
unpublished
in pears under field conditions at one
locations in Spain.
Company file No.: 94020/01-FBPI
GLP
unpublished
in cherries under field conditions at one
location in Spain.
Company file No.: 94020/01-FPKI
GLO
unpublished
in plums under field conditions at one
location in south France.
Company file No.: 94020/02-FPPL
GLP
unpublished
Reports on
previous use in
granting
national
authorizations
- 38 Thiram
APPENDIX III
List of studies
07 April 2003
Annex
point/
reference
number
Author(s)
Year
IIA 6.3/64
Ohs
1995
IIA 6.3/65
IIA 6.3/66
Balluff, M.
IIA 6.3/67
IIA 6.3/68
Roland, L.
1992
IIA 6.3/69
Roland, L.
1992
IIA 6.3/70
Roland, L.
1992
Title
Company, Report No.
Published or not
80WG in/on peach under actual use
conditions in France.
Bayer AG
number 304654)
GLP
unpublished
in peaches under field conditions at two
locations in Spain.
Company file No.: 94020/01-FPPF
GLP
unpublished
Rsidus de Thiram sur fraises. Residues of
Thiram on strawberries.
Company file No.: CRP/92/864A
(BC/SELVA1, BC/SELVA2) + CRP/92/865A
Date: May, 1992
GLP
unpublished
Rsidus de Thirame sur fraises. Residues of
Company file No.: CRP/92/862A
(BC/VICODA)
Date: May, 1992
non-GLP
unpublished
Rsidus de Thirame sur fraises. Residues of
Company file No.: CRP/92/863 (91/BC
Elsanta)
Date: May, 1992
non-GLP
unpublished
Reports on
previous use in
granting
national
authorizations
- 39 Thiram
APPENDIX III
List of studies
07 April 2003
Annex
point/
reference
number
Author(s)
Year
IIA 6.3/71
Pigeon, I.O.
1993
IIA 6.3/72
Pigeon, I.O.
1993
IIA 6.3/73
Reynens Ph.,
Doclot Th.,
Dumont de
Chassart Y.
1994
IIA 6.3/74
IIA 6.3/75
Direction rgionale
de lagriculture et
de la fort
1992
IIA 6.3/76
Prevotat M.,
Dumont de
Chassart Y.
1995
Title
Company, Report No.
Published or not
on strawberries (variety Selva) by selective
method.
Gembloux
Company file No.: BA 7792a (BCSEL)
GLP
unpublished
on strawberries by selective method.
Gembloux
Company file No.: BA 7792d(BCIRV)
GLP
unpublished
Determination of the magnitude of residue
resulting from thiram foliar applications on
strawberries - Ittre Belgium
Redebel
UCB Study N: RU 0493 (Ittre UCB-B-93-3)
GLP
unpublished
Experimentations residues 1992 - (France)
Thianosan ultra dispersible, 80WG
formulation).
Company file No.: SPV3301, SPV3302
non-GLP
unpublished
Determination of magnitude of residue
resulting from thiram foliar applications on
strawberries
Prestagro
UCB Study n: RU 0493
Company file No.: UCB 93-10
Date: April, 1995
GLP
unpublished
Reports on
previous use in
granting
national
authorizations
- 40 Thiram
APPENDIX III
List of studies
07 April 2003
Annex
point/
reference
number
Author(s)
Year
IIA 6.3/77
IIA 6.3/78
Balluff, M.
1995
IIA 6.3/85
Perny A.
1998
IIA 6.3/86
Perny A.
1998
IIA 6.3/87
Balluff M.
1999
Title
Company, Report No.
Published or not
in strawberries under field conditions at two
locations in France.
Company file No.: 94020/01-FPEBL
Date: April 7, 1995
GLP
unpublished
Determination of Thiram (as CS2) residues in
apricot raw agricultural commodity following
treatment with the preparation Thianosan
Ultra Dispersible under field conditions in
France in 1997
Anadiag
Company file No.: R 7057 DE - trial No.
7057 BD1 + BD2
GLP
Unpublished
Determination of Thiram (as CS2) residues in
apricot raw agricultural commodity following
treatment with the preparation Thianosan
Ultra Dispersible under field conditions in
France in 1997
Anadiag
Company file No.: R 7059 DE - trial No.
7059 SA1 + BD1
GLP
Unpublished
strawberries following the application of
Thiram Granuflo 80WG under Greenhouse
conditions at 1 location in France, 1998
Company file No.: 98053/F2-FGST - trial
codes: F98035R
Date: 2 March 1999
GLP
Unpublished
Reports on
previous use in
granting
national
authorizations
- 41 Thiram
APPENDIX III
List of studies
07 April 2003
Annex
point/
reference
number
Author(s)
Year
IIA 6.3/88
Balluff M.
1999
IIA 6.3/89
Balluff M.
1998
IIA 6.3/90
Balluff M.
1998
IIA 6.3/91
Perny A.
2001
IIA 6.3/92
Perny A.
2001
Title
Company, Report No.
Published or not
Submitted by: UCB S.A. (on28/05/1999)
Company file No.: 98053/F2-FGST - trial
codes: F98034R
Date: 2 March 1999
GLP
Unpublished
conditions in Spain
Company file No.: 97064/E1-FGST - trial
codes: S97020R
Date: 1 July 1998
GLP
Unpublished
conditions at 1 location in Spain, 1998
Company file No.: 98053/S1-FGST - trial
codes: S98018R
GLP
Unpublished
Determination of residues of Thiram 80 WG
(80% Thiram) in apples at one site in
Northern France, 2001
Andadiag
Company file No.: R A1011
GLP
Unpublished
Andadiag
GLP
Unpublished
Reports on
previous use in
granting
national
authorizations
- 42 Thiram
APPENDIX III
List of studies
07 April 2003
Annex
point/
reference
number
Author(s)
Year
IIA 6.3/93
Perny A.
2001
IIA 6.3/94
Perny A.
2001
IIA 6.3/95
Balluff M.
2001
IIA 6.3/96
Balluff M.
2001
IIA 6.3/97
Perny A.
2001
Title
Company, Report No.
Published or not
Southern France, 2001
Andadiag
GLP
Unpublished
Andadiag
GLP
Unpublished
Determination of residues of Thiram after
application of Thiram 80 WG (containing
80% Thiram) in apples at one site in
Northern Germany, 2000
Company file No.: 20003003/G1-FPAP
Date: 22 March 2001
GLP
Unpublished
Southern Germany, 2000
Date: 21 May 2001
GLP
Unpublished
(80% Thiram) in apples at one site in Italy,
2001
Anadiag
Date: 17 December 2001
GLP
Unpublished
Reports on
previous use in
granting
national
authorizations
- 43 Thiram
APPENDIX III
List of studies
07 April 2003
Annex
point/
reference
number
Author(s)
Year
IIA 6.3/98
Balluff M.
2001
IIA 6.3/99
Perny A.
2001
IIA 6.3/100
Perny A.
2001
IIA 6.3/101
Perny A.
2001
IIA 6.3/102
Perny A.
2001
Title
Company, Report No.
Published or not
80% Thiram) in apples at one site in Spain,
2000
Company file No.: 200036003/S1-FPAP
Date: 27 March 2001
GLP
Unpublished
(80% Thiram) in apples at one site in Spain,
2001
Anadiag
Submitted by: UCB S.A. (submitted on
26/12/2001)
GLP
Unpublished
(80% Thiram) in apples at one site in Spain,
2001
Anadiag
GLP
Unpublished
(80% Thiram) in pears at one site in
Anadiag
GLP
Unpublished
Anadiag
GLP
Unpublished
Reports on
previous use in
granting
national
authorizations
- 44 Thiram
APPENDIX III
List of studies
07 April 2003
Annex
point/
reference
number
Author(s)
Year
IIA 6.3/103
Balluff M.
2001
IIA 6.3/104
Perny A.
2001
IIA 6.3/105
Perny A.
2001
IIA 6.3/106
Balluff M.
2001
IIA 6.3/107
Balluff M.
2001
Title
Company, Report No.
Published or not
80% Thiram) in pears at one site in
Company file No.: 20003003/F1-FPPE
Date: 22 March 2001
GLP
Unpublished
Anadiag
GLP
Unpublished
Anadiag
GLP
Unpublished
Company file No.: 20003003/G1-FPPE
Date: 31 March 2001
GLP
Unpublished
Date: 21 March 2001
GLP
Unpublished
Reports on
previous use in
granting
national
authorizations
- 45 Thiram
APPENDIX III
List of studies
07 April 2003
Annex
point/
reference
number
Author(s)
Year
IIA 6.3/108
Perny A.
2001
IIA 6.3/109
Balluff M.
2001
IIA 6.3/110
Perny A.
2001
IIA 6.3/111
Perny A.
2001
IIA 6.3/112
Perny A.
2001
Title
Company, Report No.
Published or not
(80% Thiram) in pears at one site in Italy,
2001
Anadiag
GLP
Unpublished
80% Thiram) in pears at one site in Spain,
2000
Company file No.: 20003003/S1-FPPE
Date: 27 March 2001
GLP
Unpublished
(80% Thiram) in pears at one site in Spain,
2001
Anadiag
GLP
Unpublished
(80% Thiram) in pears at one site in Spain,
2001
Anadiag
GLP
Unpublished
(80% Thiram) in apricots at one site in
France, 2001
Anadiag
GLP
Unpublished
Reports on
previous use in
granting
national
authorizations
- 46 Thiram
APPENDIX III
List of studies
07 April 2003
Annex
point/
reference
number
Author(s)
Year
IIA 6.3/113
Balluff M.
2001
IIA 6.3/114
Perny A.
2001
IIA 6.3/115
Perny A.
2001
IIA 6.3/116
Balluff M.
2001
IIA 6.3/117
Balluff M.
2001
Title
Company, Report No.
Published or not
80% Thiram) in apricots at one site in Spain,
2000
Company file No.: 20003003/S1-FPAC
Date: 27 March 2001
GLP
Unpublished
(80% Thiram) in apricots at one site in
Spain, 2001
Anadiag
GLP
Unpublished
(80% Thiram) in peaches at one site in
France, 2001
Anadiag
GLP
Unpublished
80% Thiram) in peaches at one site in
Greece, 2000
Company file No.: 20003003/GR1-FPPC
Date: 27 March 2001
GLP
Unpublished
Greece, 2001
Company file No.: A1024
GLP
Unpublished
Reports on
previous use in
granting
national
authorizations
- 47 Thiram
APPENDIX III
List of studies
07 April 2003
Annex
point/
reference
number
Author(s)
Year
IIA 6.3/118
Perny A.
2001
IIA 6.3/119
Balluff M.
2001
IIA 6.3/120
Balluff M.
2001
IIA 6.3/121
Perny A.
2001
IIA 6.3/122
Perny A.
2001
Title
Company, Report No.
Published or not
(80% Thiram) in peaches at one site in Italy,
2001
Anadiag
GLP
Unpublished
Spain, 2000
Company file No.: 20003003/S1-FPPC
Date: 27 March 2001
GLP
Unpublished
Spain, 2000
Date: 27 March 2001
GLP
Unpublished
Spain, 2001
Anadiag
GLP
Unpublished
Spain, 2001
Anadiag
GLP
Unpublished
Reports on
previous use in
granting
national
authorizations
- 48 Thiram
APPENDIX III
List of studies
07 April 2003
Annex
point/
reference
number
Author(s)
Year
IIA 6.3/123
Balluff M.
2001
IIA 6.3/124
Balluff M.
2001
IIA 6.3/125
Balluff M.
2001
IIA 6.3/126
Balluff M.
2001
IIA 6.3/127
Perny A.
2001
Title
Company, Report No.
Published or not
80% Thiram) in lettuce at one greenhouse
site in France, 2000
Company file No.: 20003003/F1-FGLE
Date: 31 May 2001
GLP
Unpublished
site in Northern Germany, 2000
Company file No.: 20003003/G1-FGLE
Date: 21 May 2001
GLP
Unpublished
site in Southern Germany, 2000
Date: 21 May 2001
GLP
Unpublished
site in Spain, 2000
Company file No.: 20003003/S1-FGLE
Date: 21 May 2001
GLP
Unpublished
(80% Thiram) in lettuce under greenhouse in
Northern and Southern Europe, 2001
Anadiag
GLP
Unpublished
Reports on
previous use in
granting
national
authorizations
- 49 Thiram
APPENDIX III
List of studies
07 April 2003
Annex
point/
reference
number
Author(s)
Year
IIA 6.3/128
Balluff M.
2001
Title
Company, Report No.
Published or not
Final report of the processing part:
Date: 21 May 2001
GLP
Unpublished
B.8 Environmental fate and behaviour

Author(s)
Year Title
Annex
point/
Company, Report No.
reference
number
Published or not
IIA
7.1.1.1.1/0
1
Morgenroth, U.
1995
IIA
7.1.1.1.1/0
2
Nag J.K, Regis

R.R.
2000
IIA
7.1.1.1.2/0
1
Wyss-Benz, M.
1994
14
C-Thiram: Degradation and metabolism in

one soil incubated under aerobic conditions
RCC
Company file no.: RCC 326182
GLP
unpublished
Rate of degradation of 14C-Thiram under
aerobic conditions in three soils
Uniroyal Chemical Company, Inc. + RCC
Ltd.
Chemical Limited
Submitted by: UCB S.A., Uniroyal
Chemical Limited (on 13/3/2000)
Study Nr.: 98204
Date: March 2000
GLP
Unpublished
14
C-Thiram: Degradation and metabolism in
an anaerobic aquatic system
RCC
GLP
unpublished
Reports on
previous use in
granting
national
authorizations
Reports on
previous use in
granting
national
authorizations
- 50 Thiram
APPENDIX III
List of studies
07 April 2003
Annex
point/
reference
number
Author(s)
Year
Title
Company, Report No.
Published or not
IIA
7.1.1.1.2/0
2
Burri, R.
1995
Photodegradation study if 14C-Thiram on soil

RCC
GLP
unpublished
Adsorption/Desorption of 14C-Thiram on 4
soils
RCC
GLP
unpublished
Aged-Soil Column Leaching of 14C-Thiram in
one soil
JSC International Ltd.
Chemical Limited
Submitted by: UCB S.A., Uniroyal
Chemical Limited (on 15/02/2001)
Study Nr.: 2000-090
GLP
Unpublished
Degradation and metabolism of Thiram in
aquatic systems - First amendment to report
RCC Umweltchemie
Company file No.: RCC 303456
Date: 7 July 1992
GLP
Unpublished
Degradation and metabolism of Thiram in
aquatic systems
RCC Umweltchemie
GLP
Unpublished
IIA 7.1.2/01 Morgenroth, U.
1995
IIA 7.1.3
Nag J.K, Regis

R.R.
2001
IIA
7.2.1.3.2/0
2
Mamouni A.
1992
IIA
7.2.1.3.2/0
3
Wyss-Benz, M.
1995
Reports on
previous use in
granting
national
authorizations
- 51 Thiram
APPENDIX III
List of studies
07 April 2003
Annex
point/
reference
number
Author(s)
Year
IIA
7.2.1.3.2/0
4
Vlkl S.
2000
IIA 7.2.2
Frster B.
1992
B.9 Ecotoxicology
Author(s)
Annex
point/
reference
number
IIA 8.1
Pritchard P.R
IIA 8.1
Pritchard P.R
IIA 8.1
Pritchard P.R
(*)
Year
Title
Company, Report No.
Published or not
Reports on
previous use in
granting
national
authorizations
14
C-Ziram: route and rate of degradation in

aerobic aquatic systems - draft report (*)
RCC Umweltchemie
Generated by: Ziram EU Task Force
Submitted by: UCB S.A. (summary,
submitted on 18/08/2000)
Date: 2000
GLP
Unpublished
Estimation of the Atmospheric Residence
Time of Thiram using the Atkinson Method
SCC
Company file No. 152-009-Atkinson
Date: 7 July 1992
Not GLP
Unpublished
Title
Company, Report No.
Published or not
2001a Study to determine the amount of thiram

treated seed and seedlings when treated
seed remains uncovered at drilling
Crompton Europe Ltd
GLP
Unpublished
Submitted Dec 2001
2001b Study to generate seed and seedling
samples from thiram treated seed, broadcast
onto the soil
Crompton Europe Ltd
GLP
Unpublished
Submitted Dec 2001
2001c Study to generate seed samples and
seedlings for the determination of the loss of
detectable thiram from drilled wheat seed
Crompton Europe Ltd
GLP
Unpublished
Submitted Dec 2001
only some parts of the draft report are submitted (cover page + p. 13-15 + p. 56-57)
Reports on
previous use in
granting
national
authorizations
- 52 Thiram
APPENDIX III
List of studies
07 April 2003
Year
Title
Company, Report No.
Published or not
IIA 8.1.1/01 Johnson A.J.
1999
IIA 8.1.1/02 Grolleau G.
1998
IIA 8.1.1/03 Zajk A.
1995
1995
1995
1995
Vitavax 200FF - Assessment to determine

the effect on palatability and dietary toxicity
in the pigeon
Project Nr.: URO 013 - Uniroyal Ref.
V.7.5.2.32
Date: 23 April 1999
GLP
Unpublished
Repellent effect of thiram on partridges
under laboratory conditions
Report Nr.: Uniroyal Ref. T.7.6.1.7
Not GLP
Unpublished
Acute oral toxicity of Biosild T on Japanese
quail
Ecotoxicological Laboratory - Hungary
Company file No.: 25/A-5/1995
Date: 1995
GLP
Unpublished
Acute oral toxicity of Biosild T on Mallard
(Anas platyrhynchos)
Date: 1995
GLP
Unpublished
The dietary LC50 toxicity study of Biosild T
with the Japanese Quail (Coturnix coturnix
japonica)
Date: 1995
GLP
Unpublished
The dietary LC50 toxicity study of Biosild T
with the mallard (Anas platyrhynchos)
Date: 1995
GLP
Unpublished
Annex
point/
reference
number
Author(s)
Reports on
previous use in
granting
national
authorizations
- 53 Thiram
APPENDIX III
List of studies
07 April 2003
Year
Title
Company, Report No.
Published or not
IIA 8.1.3/01 Beavers J. B.,

Chafey K., Mitchell
L. R., Jaber M.
1995
IIA 8.2/01
Peither A.
2000
IIA 8.2/01
Peither, A.
2000
IIA 8.2/05
Chole P., McAllister 198

W.A.
3
IIA 8.2/06
Forbis, A.D.
Thiram Technical: A one generation

reproduction study with the Northern
Bobwhite
Wildlife International, Inc.
Generated by: Thiram Task Force II.
Date: 31 March 1995
GLP
Unpublished
Acute toxicity of Thiram Technical to rainbow
trout (Oncorhynchus mykiss) in a 96-hour
static test
RCC Ltd.
Submitted by: UCB S.A. (range finding
results submitted on 18/08/2000)
Year: 2000
GLP
Unpublished
Acute toxicity of Thiram Technical to rainbow
trout (Oncorhynchus mykiss) in a 96-hour
static test
RCC Ltd.
Year: 2000
GLP
Unpublished
Acute toxicity of Thiurad to Fathead
Minnows (Pimephales promelas)
ABC Labs
Generated by: UCB S.A..
Year: 27 December 1983
GLP
Unpublished
Acute toxicity of Thiurad to Bluegill Sunfish
(Lepomis macrochirus)
ABC Labs
Year: 25 August 1983
GLP
Unpublished
Annex
point/
reference
number
Author(s)
1983
Reports on
previous use in
granting
national
authorizations
- 54 Thiram
APPENDIX III
List of studies
07 April 2003
Year
Title
Company, Report No.
Published or not
IIA 8.2.1/02 Croudace, C.P.,

Caunter, J.E.,
Johnson, P.A.
1992
Thiram: acute toxicity to sheepshead

minnow (Cyprinodon variegatus)
IIA 8.2.2.2
Memmert, U.
2001
IIA 8.2.2.2
Memmert U.
2001
Annex
point/
reference
number
Author(s)
IIA 8.2.4/01 Bell, G.
1994
IIA 8.2.4/02 Van der Kerken K.
1999
Imperial Chemical Industries PLC (ICI)

Company file No.: BL4532/B
GLP
Unpublished
Sublethal effects of Thiram 80WG to
Rainbow trout (Oncorhynchus mykiss) after
a fourfold application to a water-sediment
system
RCC Ltd.
Year: 30 October 2001
GLP
Unpublished
Sublethal effects of Ziram 76WG to Bluegill
sunfish (Lepomis macrochirus) after a
fourfold application to a water-sediment
system
RCC Ltd.
Generated by: Ziram Task Force
Submitted by: Ziram Task Force
(submitted on 26/12/01)
Study project No.: 811438
GLP
unpublished
Thiram: Acute toxicity to Daphnia magna.
Huntingdon Research Centre
GLP
Unpublished
Acute toxicity of Thiram 80WG for Daphnia
magna
LISEC
Company file No.: WE-01-222
Year: 1999
Not GLP
Unpublished
Reports on
previous use in
granting
national
authorizations
- 55 Thiram
APPENDIX III
List of studies
07 April 2003
Annex
point/
reference
number
Author(s)
Year
Title
Company, Report No.
Published or not
IIA 8.2.5
Memmert U.
2000
IIA 8.2.6
Jennings A.M.,
Jenkins C.
2001
Ecological effects of Thiram 80WG in a

freshwater mesocosm study
RCC Ltd.
Report Nr.: 733454
Date: 16 June 2000
GLP
Unpublished
Algal Growth Inhibition - 2nd Amendment
Submitted by: UCB S.A.
Report Nr.: Amendment to report UCB
442/921255
GLP
Unpublished
Thiram - Algal growth inhibition.
GLP
unpublished
Assessment of Side Effects of Thiram 80WG
to the Honey Bee, Apis mellifera L. in the
laboratory
Report Nr.: 99452/01-BLEU
Date: 17 May 2000
GLP
Unpublished
Thiram 80 WG: Acute Toxicity to the Aphid
Parasitoid, Aphidius rhopalosiphi
(Hymenoptera, Braconidae) DeStefaniPerez in the Laboratory
99452/01-NLAp
Limited
Report Nr.: 99452/01-NLAp
Date: 22 March 2000
GLP
Unpublished
IIA 8.2.6/01 Douglas Mark T.
1995
IIA 8.3.1
2000
Kling A.
IIA 8.3.2/01 Schuld M.
2000
Reports on
previous use in
granting
national
authorizations
- 56 Thiram
APPENDIX III
List of studies
07 April 2003
Author(s)
Year
Title
Company, Report No.
Published or not
IIA 8.3.2/02 Kleiner R.
1991
1992
IIA 8.3.2/04 IBACON
1995
IIA 8.3.2/05 IBACON
1995
IIA 8.3.2/06 Kemmeter, F.
2000
Testing toxicity to beneficial arthropods

Carabid beetle - Poecilus cupreus L.
according to BBA Guideline VI, 23-2.1.8
BioChem GmbH Karlsruhe
Company file No.: 94 10 48 052
Date: 1991
GLP
Unpublished
Testing toxicity to beneficial arthropods Rove
beetle - Aleochara bilineata Gyll. according
to IOBC Guideline (Moreth & Naton)
Date: 1992
GLP
Unpublished
Effects of Vitavax 200FF on the reproduction
of Aleochara bilineata in the lab.
Project Nr. 452070 - Uniroyal Ref.
V.7.5.2.22
Date: 6 June 1995
GLP
Unpublished
Effects of Vitavax 200FF on Poecilus
cupreus
In the lab.
Project Nr.: 451006 - Uniroyal Ref.
V.7.5.2.23
Date: 31 May 1995
GLP
Unpublished
Thiram 80 WG: Toxicity to the Green
Lacewing, Chrysoperla carnea Steph.
(Neuroptera, Chrysopidae) in the
Laboratory
Project Nr.: 99452/01-NLCc
Date: 23 June 2000
GLP
Unpublished
Annex
point/
reference
number
Reports on
previous use in
granting
national
authorizations
- 57 Thiram
APPENDIX III
List of studies
07 April 2003
Year
Title
Company, Report No.
Published or not
IIA 8.3.2/07 Rhlig R., Kstner

A.
2001
Toxicity of Thiram 80WG to larvae of the

ladybird Coccinella septempunctata L.
under laboratory conditions
BioChem agrar
Study Nr.: 00 10 48 076
GLP
Unpublished
2001
Thiram 80 WG: An extended study to

evaluate the effects on the Aphid
Parasitoid, Aphidius rhopalosiphi
(Hymenoptera, Braconidae) DeStefaniPerez in the Laboratory
Study Nr.: 99452/01-NEAp
GLP
Unpublished
IIA 8.3.2/09 Stbler P.
2001
Thiram 80WG: An extended Laboratory

study to evaluate the effect on the
ladybird Coccinella septempunctata L.
(Coleoptera, Coccinellidae)
Study Nr.: 99452/01-NECs
GLP
Unpublished
2001
Thiram 80WG: An extended laboratory

study to evaluate the effects on the green
lacewing, Chrysoperla carnea Steph.
(Neuroptera, Chrysopidae)
Study Nr.: 99452/01-NECc
GLP
Unpublished
Annex
point/
reference
number
Author(s)
Reports on
previous use in
granting
national
authorizations
- 58 Thiram
APPENDIX III
List of studies
07 April 2003
Annex
point/
reference
number
Author(s)
Year
Title
Company, Report No.
Published or not
IIA 8.5
Wachter S.
2000
IIA 8.7
Van der Kerken K.
1999
Assessment of the side effects of Thiram

80WG on the activity of the soil microflora
Limited
Report Nr.: 99452/01-ABMF
GLP
Unpublished
Activated sludge respiration inhibition test of
Thiram
LISEC
Project Nr.: WE-09-041
Year: 1999
GLP
Unpublished
Reports on
previous use in
granting
national
authorizations
- 59 Thiram
APPENDIX III
List of studies
07 April 2003
APPENDIX IIIB
THIRAM
List of studies which were submitted during the evaluation process and were
not cited in the draft assessment report:
B.1 Identity, B.2 Physical and chemical properties, B.3 Data on application and further
information, B.4 Proposals for classification and labelling, B.5 Methods of analysis
Annex
Author(s)
Year Title
point/
reference
Company, Report No.
number
Published or not
IIA 1.10
IIA 4.1.2
Hull L.B., Forbes P. 1998
IIA 1.11
Comb A.L.
1997
IIA 1.11/01
Demuynck M.
1999
IIA 2.6
IIA 2.11.2
IIA 2.14
Flack I.
1997
Accuracy validation of test control methods AC1214 and

AC1216 for impurities in Thiram
Project Nr.: 97067 - Uniroyal Ref. T.3.1.13
GLP
Unpublished
Thiram (technical): Five-batch analysis
Report N: FRT 002/970098
Date: 5 August 1997
GLP
Unpublished
Presence of dimethylcarbamoyldimethylthio-carbamoyl
disulfide in Thiram produced by UCB
UCB Gent
Company file No.: Date: 1 April 1999
not GLP
Unpublished
Thiram physical and chemical properties
Report N: FCC 151/962024
GLP
Unpublished
- 60 Thiram
APPENDIX III
List of studies
07 April 2003
Annex
Author(s)
point/
reference
number
Year
Title
Company, Report No.
Published or not
IIA 2.6/02
Van de Putte M.
1997
IIA
2.11.1/01
Tremain S. P.
1999
IIA 2.13
Krips H.J.
2000
IIA 2.15
Penny H.B.
1995
Solubility of Thiram in water: effect of pH

UCB Gent
Company file No.: Report W/RL/9710/006
Date: 30 October 1997
not GLP
Unpublished
Thiram Technical: Determination of flammability (solids)
Safepharm Laboratories Limited
Generated by: UCB S.A., Uniroyal Chemical Limited
Submitted by: UCB S.A., Uniroyal Chemical Limited (on
20/8/1999)
Date: 6 August 1999
GLP
Unpublished
Determination of the explosive properties of Thiram Technical
Notox
8/6/2000)
Project Nr.: 279484
GLP
Unpublished
Determination of the oxidizing and reducing characteristics of
Thiram
Uniroyal Chemical Company, Ltd.
Submitted by: Uniroyal Chemical Limited (on 23/9/1997)
Project Nr.: GRL-10501
Date: 1995
GLP
Unpublished
HPLC method for the determination of Thiram in fruits
validation of some critical points
Facult des Sciences Agronomiques - GEMBLOUX
Company file No.: Date: March 1996
not GLP
Unpublished
Residue analysis of thiram in fruits and lettuce: method
validation
Project Nr.: 20011109/01-RVP
GLP
Unpublished
IIA 4.2.1/10 Roland L.
1996
IIA 4.2.1/11 Klumpp M.
2001
- 61 Thiram
APPENDIX III
List of studies
07 April 2003
Annex
Author(s)
point/
reference
number
Year
Title
Company, Report No.
Published or not
IIA 4.2.2
Blaszczynski E.
2001
IIA 4.2.3
Blaszczynski
Elizabeth
2000
Analytical method for determining Thiram in soil

26/12/2001)
Study Nr.: 2000-187
GLP
Unpublished
Analytical method for determination of thiram in pond water
Generated by: UCB S.A., Uniroyal Chemical Company Inc.
Submitted by: UCB S.A., Uniroyal Chemical Company Inc. (on
17/11/2000)
Study Nr.: 99188
Date: 27 March 2000
GLP
Unpublished
Thiram - NIOSH Method 5005 - Determination in air
NIOSH Manual of Analytical Methods (NMAM), 4th Edition,
Issue 2, dated 15 August 1994, pp. 1-3 (submitted on
19/2/1999)
not GLP
Published
IIA 4.2.4/01 NIOSH
1994
IIA 4.2.4/02 Class Th.
2001
B.6 Toxicology and metabolism

Annex
Author(s)
Year
point/
reference
number
IIA 5.7
Williams Jackie
2001
Development and validation of an analytical method for the

determination of Thiram in air
PTRL Europe
7/9/2001)
Study Nr.: 2001-040
Date: 16 May 2001
GLP
Unpublished
Title
Company, Report No.
Published or not
Thiram: Acute investigative study in rats
Central Toxicology Laboratory
Study Nr.: AR7090
GLP
Unpublished
- 62 Thiram
APPENDIX III
List of studies
07 April 2003
Annex
Author(s)
point/
reference
number
Year
Title
Company, Report No.
Published or not
IIA 5.8.1
2001
TOPKAT toxicity assessment report (DMCS)

Accelerys Inc USA
Not GLP
Unpublished
Submitted Dec 2001
Year
Title
Company, Report No.
Published or not
Investigation of the stability of 14C-3-(Dimethyldithiocarbamoyl)alanine in the presence of a soybean straw matrix
3/11/1997)
Company file No.: Report No. RPT00245 - Study No. XBL
95321
GLP
Unpublished
The systemic action of dimethyldithiocarbamates on cucumber
scab caused by Cladosporium cucumerinum and the
conversion of these compounds by plants
Neth. J. Plant. Path., 1964, Vol. 70 - Suppl. 1, pp. 1-75
Submitted by: UCB (on 8/9/1999)
Not GLP
Published
Contribution l'tude de l'action systemique du Thiram
(TMTD) chez les plantes l'aide de thiram marqu au 35S
Mededelingen vd Lanbouwhogeschool & de
Opzoekingsstations vd Staat te Gent, 28, (1963), pp. 590-596
not GLP
Published
Translocation and soil movement of 14C Thiram from wheat
seeds treated with Vitavax 200
Generated by: Crompton Corporation
Submitted by: Crompton Europe Ltd. (in 12/2001)
Study Nr.: 7846/7850
Date: 1978
Not GLP
Unpublished
Anon
B.7 Residue data

Annex
Author(s)
point/
reference
number
IIA 6.1/10
Robinson, R.A.
1996
IIA 6.1/11
Dekhuijzen
1964
IIA 6.1/12
Massaux F.
1963
IIA 6.1/13
Womer, J.M.,
Balba, H.M.
1978
- 63 Thiram
APPENDIX III
List of studies
07 April 2003
Annex
Author(s)
point/
reference
number
Year
Title
Company, Report No.
Published or not
IIA 6.3/85
Perny A.
1998
IIA 6.3/86
Perny A.
1998
IIA 6.3/87
Balluff M.
1999
IIA 6.3/88
Balluff M.
1999
IIA 6.3/89
Balluff M.
1998
Determination of Thiram (as CS2) residues in apricot raw

agricultural commodity following treatment with the preparation
Thianosan Ultra Dispersible under field conditions in France in
1997
Anadiag
Company file No.: R 7057 DE - trial No. 7057 BD1 + BD2
GLP
Unpublished
Determination of Thiram (as CS2) residues in apricot raw
agricultural commodity following treatment with the preparation
Thianosan Ultra Dispersible under field conditions in France in
1997
Anadiag
Company file No.: R 7059 DE - trial No. 7059 SA1 + BD1
GLP
Unpublished
Determination of residues of Thiram in strawberries following
the application of Thiram Granuflo 80WG under Greenhouse
Company file No.: 98053/F2-FGST - trial codes: F98035R
Date: 2 March 1999
GLP
Unpublished
Company file No.: 98053/F2-FGST - trial codes: F98034R
Date: 2 March 1999
GLP
Unpublished
conditions in Spain
Company file No.: 97064/E1-FGST - trial codes: S97020R
Date: 1 July 1998
GLP
Unpublished
- 64 Thiram
APPENDIX III
List of studies
07 April 2003
Annex
Author(s)
point/
reference
number
Year
Title
Company, Report No.
Published or not
IIA 6.3/90
Balluff M.
1998
IIA 6.3/91
Perny A.
2001
IIA 6.3/92
Perny A.
2001
IIA 6.3/93
Perny A.
2001
IIA 6.3/94
Perny A.
2001

conditions at 1 location in Spain, 1998
Company file No.: 98053/S1-FGST - trial codes: S98018R
GLP
Unpublished
Determination of residues of Thiram 80 WG (80% Thiram) in
apples at one site in Northern France, 2001
Andadiag
GLP
Unpublished
apples at one site in Northern France, 2001
Andadiag
GLP
Unpublished
apples at one site in Southern France, 2001
Andadiag
GLP
Unpublished
apples at one site in Southern France, 2001
Andadiag
GLP
Unpublished
- 65 Thiram
APPENDIX III
List of studies
07 April 2003
Annex
Author(s)
point/
reference
number
Year
Title
Company, Report No.
Published or not
IIA 6.3/95
Balluff M.
2001
IIA 6.3/96
Balluff M.
2001
IIA 6.3/97
Perny A.
2001
IIA 6.3/98
Balluff M.
2001
IIA 6.3/99
Perny A.
2001
Determination of residues of Thiram after application of Thiram

80 WG (containing 80% Thiram) in apples at one site in
Date: 22 March 2001
GLP
Unpublished
80 WG (containing 80% Thiram) in apples at one site in
Date: 21 May 2001
GLP
Unpublished
apples at one site in Italy, 2001
Anadiag
GLP
Unpublished
80 WG (containing 80% Thiram) in apples at one site in Spain,
2000
Company file No.: 200036003/S1-FPAP
Date: 27 March 2001
GLP
Unpublished
apples at one site in Spain, 2001
Anadiag
Submitted by: UCB S.A. (submitted on 26/12/2001)
GLP
Unpublished
- 66 Thiram
APPENDIX III
List of studies
07 April 2003
Annex
Author(s)
point/
reference
number
Year
Title
Company, Report No.
Published or not
IIA 6.3/100
Perny A.
2001
IIA 6.3/101
Perny A.
2001
IIA 6.3/102
Perny A.
2001
IIA 6.3/103
Balluff M.
2001
IIA 6.3/104
Perny A.
2001
IIA 6.3/105
Perny A.
2001

apples at one site in Spain, 2001
Anadiag
GLP
Unpublished
pears at one site in Northern France, 2001
Anadiag
GLP
Unpublished
pears at one site in Northern France, 2001
Anadiag
GLP
Unpublished
80 WG (containing 80% Thiram) in pears at one site in
Company file No.: 20003003/F1-FPPE
Date: 22 March 2001
GLP
Unpublished
pears at one site in Southern France, 2001
Anadiag
GLP
Unpublished
pears at one site in Southern France, 2001
Anadiag
GLP
Unpublished
- 67 Thiram
APPENDIX III
List of studies
07 April 2003
Annex
Author(s)
point/
reference
number
Year
Title
Company, Report No.
Published or not
IIA 6.3/106
Balluff M.
2001
IIA 6.3/107
Balluff M.
2001
IIA 6.3/108
Perny A.
2001
IIA 6.3/109
Balluff M.
2001
IIA 6.3/110
Perny A.
2001

Date: 31 March 2001
GLP
Unpublished
Date: 21 March 2001
GLP
Unpublished
pears at one site in Italy, 2001
Anadiag
GLP
Unpublished
80 WG (containing 80% Thiram) in pears at one site in Spain,
2000
Company file No.: 20003003/S1-FPPE
Date: 27 March 2001
GLP
Unpublished
pears at one site in Spain, 2001
Anadiag
GLP
Unpublished
- 68 Thiram
APPENDIX III
List of studies
07 April 2003
Annex
Author(s)
point/
reference
number
Year
Title
Company, Report No.
Published or not
IIA 6.3/111
Perny A.
2001
IIA 6.3/112
Perny A.
2001
IIA 6.3/113
Balluff M.
2001
IIA 6.3/114
Perny A.
2001
IIA 6.3/115
Perny A.
2001

pears at one site in Spain, 2001
Anadiag
GLP
Unpublished
apricots at one site in France, 2001
Anadiag
GLP
Unpublished
80 WG (containing 80% Thiram) in apricots at one site in
Spain, 2000
Company file No.: 20003003/S1-FPAC
Date: 27 March 2001
GLP
Unpublished
apricots at one site in Spain, 2001
Anadiag
GLP
Unpublished
peaches at one site in France, 2001
Anadiag
GLP
Unpublished
- 69 Thiram
APPENDIX III
List of studies
07 April 2003
Annex
Author(s)
point/
reference
number
Year
Title
Company, Report No.
Published or not
IIA 6.3/116
Balluff M.
2001
IIA 6.3/117
Balluff M.
2001
IIA 6.3/118
Perny A.
2001
IIA 6.3/119
Balluff M.
2001
IIA 6.3/120
Balluff M.
2001

80 WG (containing 80% Thiram) in peaches at one site in
Greece, 2000
Company file No.: 20003003/GR1-FPPC
Date: 27 March 2001
GLP
Unpublished
peaches at one site in Greece, 2001
GLP
Unpublished
peaches at one site in Italy, 2001
Anadiag
GLP
Unpublished
Spain, 2000
Date: 27 March 2001
GLP
Unpublished
Spain, 2000
Date: 27 March 2001
GLP
Unpublished
- 70 Thiram
APPENDIX III
List of studies
07 April 2003
Annex
Author(s)
point/
reference
number
Year
Title
Company, Report No.
Published or not
IIA 6.3/121
Perny A.
2001
IIA 6.3/122
Perny A.
2001
IIA 6.3/123
Balluff M.
2001
IIA 6.3/124
Balluff M.
2001
IIA 6.3/125
Balluff M.
2001

peaches at one site in Spain, 2001
Anadiag
GLP
Unpublished
peaches at one site in Spain, 2001
Anadiag
GLP
Unpublished
80 WG (containing 80% Thiram) in lettuce at one greenhouse
site in France, 2000
Company file No.: 20003003/F1-FGLE
Date: 31 May 2001
GLP
Unpublished
site in Northern Germany, 2000
Date: 21 May 2001
GLP
Unpublished
site in Southern Germany, 2000
Date: 21 May 2001
GLP
Unpublished
- 71 Thiram
APPENDIX III
List of studies
07 April 2003
Annex
Author(s)
point/
reference
number
Year
Title
Company, Report No.
Published or not
IIA 6.3/126
Balluff M.
2001
IIA 6.3/127
Perny A.
2001
IIA 6.3/128
Balluff M.
2001

site in Spain, 2000
Company file No.: 20003003/S1-FGLE
Date: 21 May 2001
GLP
Unpublished
lettuce under greenhouse in Northern and Southern Europe,
2001
Anadiag
GLP
Unpublished
Final report of the processing part: Determination of residues of
Thiram after application of Thiram 80 WG (containing 80%
Thiram) in apples at one site in Southern Germany, 2000
Date: 21 May 2001
GLP
Unpublished
B.8 Environmental fate and behaviour

Annex
Author(s)
Year Title
point/
reference
Company, Report No.
number
Published or not
IIA
7.1.1.1.1/0
2
Nag J.K, Regis

R.R.
2000
Rate of degradation of 14C-Thiram under aerobic conditions in

three soils
Uniroyal Chemical Company, Inc. + RCC Ltd.
13/3/2000)
Study Nr.: 98204
Date: March 2000
GLP
Unpublished
- 72 Thiram
APPENDIX III
List of studies
07 April 2003
Annex
Author(s)
point/
reference
number
Year
Title
Company, Report No.
Published or not
IIA 7.1.3/01 Nag J.K, Regis

R.R.
2000
IIA 7.1.3/01 Nag J.K, Regis

R.R.
2001
IIA
7.2.1.3.2/0
2
Mamouni A.
1992
IIA
7.2.1.3.2/0
3
Wyss-Benz, M.
1995
IIA
7.2.1.3.2/0
4
Vlkl S.
2000
Aged-Soil Column Leaching of 14C-Thiram in one soil Protocol

Submitted by: UCB S.A., Uniroyal Chemical Limited
(Protocol submitted on 18/08/2000)
Study Nr.: 2000-090
Date: 2000
GLP
Unpublished
Aged-Soil Column Leaching of 14C-Thiram in one soil
15/02/2001)
Study Nr.: 2000-090
GLP
Unpublished
Degradation and metabolism of Thiram in aquatic systems First amendment to report
RCC Umweltchemie
Date: 7 July 1992
GLP
Unpublished
Degradation and metabolism of Thiram in aquatic systems
RCC Umweltchemie
GLP
Unpublished
14
C-Ziram: route and rate of degradation in aerobic aquatic
systems - draft report (*)
RCC Umweltchemie
Generated by: Ziram EU Task Force
Submitted by: UCB S.A. (summary, submitted on 18/08/2000)
Date: 2000
GLP
Unpublished
(*)
only some parts of the draft report are submitted (cover page + p. 13-15 + p. 56-57)
- 73 Thiram
APPENDIX III
List of studies
07 April 2003
Annex
Author(s)
point/
reference
number
Year
Title
Company, Report No.
Published or not
IIA 7.2.2
Frster B.
1992
IIIA 9.1.3
Gro R.
1999
IIIA 9.2.1
Schlter W.
1999
IIIA 9.2.1
Moyle J
2001
IIIA
9.2.1/02
Wanner U
2002
Estimation of the Atmospheric Residence Time of Thiram using

the Atkinson Method
SCC
Company file No. 152-009-Atkinson
Date: 7 July 1992
Not GLP
Unpublished
Calculation of the predicted environmental concentration of
Thiram in soil
SCC
Company file No.: 152-009/PECsoil
Date: 18 August 1999
Not GLP
Unpublished
Estimation of the leaching potential of Thiram by model
calculations with PELMO (Pesticide leaching Model)
Company file No.: 152-009-PELMO
Date: 30 March 1999
Not GLP
Unpublished
PELMO estimates of the concentration of DCMS in percolate
at 1 meter soil depth using the FOCUS groundwater scenarios
Crompton Europe Ltd
Not GLP
Unpublished
Submitted Dec 2001
FOCUS modelling of thiram and its soil metabolite DMCS in
European groundwater
Crompton Corporation USA
Not GLP
Unpublished
Submitted Sept 2002
B.9 Ecotoxicology
Annex
Author(s)
point/
reference
number
IIA 8.1
Pritchard P.R
Year
Title
Company, Report No.
Published or not
2001a Study to determine the amount of thiram treated seed and

seedlings when treated seed remains uncovered at drilling
Crompton Europe Ltd
GLP
Unpublished
Submitted Dec 2001
- 74 Thiram
APPENDIX III
List of studies
07 April 2003
Annex
Author(s)
point/
reference
number
Year
IIA 8.1
Pritchard P.R
IIA 8.1
Pritchard P.R
2001b Study to generate seed and seedling samples from thiram

treated seed, broadcast onto the soil
Crompton Europe Ltd
GLP
Unpublished
Submitted Dec 2001
2001c Study to generate seed samples and seedlings for the
determination of the loss of detectable thiram from drilled
wheat seed
Crompton Europe Ltd
GLP
Unpublished
Submitted Dec 2001
1999 Vitavax 200FF - Assessment to determine the effect on
palatability and dietary toxicity in the pigeon
Project Nr.: URO 013 - Uniroyal Ref. V.7.5.2.32
Date: 23 April 1999
GLP
Unpublished
1998 Repellent effect of thiram on partridges under laboratory
conditions
Report Nr.: Uniroyal Ref. T.7.6.1.7
Not GLP
Unpublished
1995 Acute oral toxicity of Biosild T on Japanese quail
Date: 1995
GLP
Unpublished
1995 Acute oral toxicity of Biosild T on Mallard (Anas platyrhynchos)
Date: 1995
GLP
Unpublished
1995 The dietary LC50 toxicity study of Biosild T with the Japanese
Quail (Coturnix coturnix japonica)
Date: 1995
GLP
Unpublished
IIA 8.1.1/01 Johnson A.J.
IIA 8.1.1/02 Grolleau G.
Title
Company, Report No.
Published or not
- 75 Thiram
APPENDIX III
List of studies
07 April 2003
Annex
Author(s)
point/
reference
number
Year
Title
Company, Report No.
Published or not
1995
IIA 8.1.3/01 Beavers J. B.,

Chafey K., Mitchell
L.R., Jaber M.
1995
IIA 8.2/01
Peither A.
2000
IIA 8.2/01
Peither A.
2000
IIA 8.2/04
1978
IIA 8.2/05
Chole P., McAllister 198

W.A.
3
The dietary LC50 toxicity study of Biosild T with the mallard

(Anas platyrhynchos)
Date: 1995
GLP
Unpublished
Thiram Technical: A one generation reproduction study with
the Northern Bobwhite
Wildlife International, Inc.
Generated by: Thiram Task Force II.
Date: 31 March 1995
GLP
Unpublished
Acute toxicity of Thiram Technical to rainbow trout
(Oncorhynchus mykiss) in a 96-hour static test
RCC Ltd.
Submitted by: UCB S.A. (range finding results submitted on
18/08/2000)
Year: 2000
GLP
Unpublished
Acute toxicity of Thiram Technical to rainbow trout
(Oncorhynchus mykiss) in a 96-hour static test
RCC Ltd.
Year: 2000
GLP
Unpublished
Fish toxicity
Bayer AG
Company file No.: FO - 154
Year: 5 April 1978
GLP
Unpublished
Acute toxicity of Thiurad to Fathead Minnows (Pimephales
promelas)
ABC Labs
Year: 27 December 1983
GLP
Unpublished
- 76 Thiram
APPENDIX III
List of studies
07 April 2003
Annex
Author(s)
point/
reference
number
Year
Title
Company, Report No.
Published or not
IIA 8.2/06
Forbis A.D.
1983
IIA 8.2.2.2
Memmert U.
2001
IIA 8.2.2.2
Memmert U.
2001
Acute toxicity of Thiurad to Bluegill Sunfish (Lepomis

macrochirus)
ABC Labs
Year: 25 August 1983
GLP
Unpublished
Sublethal effects of Thiram 80WG to Rainbow trout
(Oncorhynchus mykiss) after a fourfold application to a watersediment system
RCC Ltd.
Year: 30 October 2001
GLP
Unpublished
Sublethal effects of Ziram 76WG to Bluegill sunfish (Lepomis
macrochirus) after a fourfold application to a water-sediment
system
RCC Ltd.
Generated by: Ziram Task Force
Submitted by: Ziram Task Force (submitted on 26/12/01)
Study project No.: 811438
GLP
unpublished
Acute toxicity of Thiram 80WG for Daphnia magna
LISEC
Company file No.: WE-01-222
Year: 1999
Not GLP
Unpublished
Aquatic toxicological aspects of dithiocarbamates and related
compounds. I. Short-term toxicity test
Aquatic toxicology, Vol. 7, (1985), 145-164
Not GLP
Published
Ecological effects of Thiram 80WG in a freshwater mesocosm
study
RCC Ltd.
Report Nr.: 733454
Date: 16 June 2000
GLP
Unpublished
IIA 8.2.4/02 Van der Kerken K.
1999
IIA 8.2.4/03 Van Leeuwen C.J.,

Maas-Diepeveen
J.L., Niebeek G.,
Vergouw W.H.A.,
Griffioen P.S.,
Luijken M.W.
IIA 8.2.5
Memmert U.
1985
2000
- 77 Thiram
APPENDIX III
List of studies
07 April 2003
Annex
Author(s)
point/
reference
number
Year
Title
Company, Report No.
Published or not
IIA 8.2.6
Jennings A.M.,
Jenkins C.
2001
IIA 8.3.1
Kling A.
2000
Algal Growth Inhibition - 2nd Amendment

Report Nr.: Amendment to report UCB 442/921255
GLP
Unpublished
Assessment of Side Effects of Thiram 80WG to the Honey
Bee, Apis mellifera L. in the laboratory
Report Nr.: 99452/01-BLEU
Date: 17 May 2000
GLP
Unpublished
Thiram 80 WG: Acute Toxicity to the Aphid Parasitoid, Aphidius
rhopalosiphi (Hymenoptera, Braconidae) DeStefani-Perez in
the Laboratory
99452/01-NLAp
8/6/2000)
Report Nr.: 99452/01-NLAp
Date: 22 March 2000
GLP
Unpublished
Testing toxicity to beneficial arthropods Carabid beetle Poecilus cupreus L. according to BBA Guideline VI, 23-2.1.8
Date: 1991
GLP
Unpublished
Testing toxicity to beneficial arthropods Rove beetle Aleochara bilineata Gyll. according to IOBC Guideline (Moreth
& Naton)
Date: 1992
GLP
Unpublished
Effects of Vitavax 200FF on the reproduction of Aleochara
bilineata in the lab.
Project Nr. 452070 - Uniroyal Ref. V.7.5.2.22
Date: 6 June 1995
GLP
Unpublished
2000
1991
1992
IIA 8.3.2/04 IBACON
1995
- 78 Thiram
APPENDIX III
List of studies
07 April 2003
Annex
Author(s)
point/
reference
number
Year
Title
Company, Report No.
Published or not
IIA 8.3.2/05 IBACON
1995
IIA 8.3.2/06 Friedhelm

Kemmeter
2000
IIA 8.3.2/07 Rhlig R., Kstner

A.
2001
Effects of Vitavax 200FF on Poecilus cupreus

In the lab.
Project Nr.: 451006 - Uniroyal Ref. V.7.5.2.23
Date: 31 May 1995
GLP
Unpublished
Thiram 80 WG: Toxicity to the Green Lacewing, Chrysoperla
carnea Steph. (Neuroptera, Chrysopidae) in the Laboratory
Project Nr.: 99452/01-NLCc
Date: 23 June 2000
GLP
Unpublished
Toxicity of Thiram 80WG to larvae of the ladybird Coccinella
septempunctata L. under laboratory conditions
BioChem agrar
Study Nr.: 00 10 48 076
GLP
Unpublished
2001
Thiram 80 WG: An extended study to evaluate the effects

on the Aphid Parasitoid, Aphidius rhopalosiphi
(Hymenoptera, Braconidae) DeStefani-Perez in the
Laboratory
Study Nr.: 99452/01-NEAp
GLP
Unpublished
2001
Thiram 80WG: An extended Laboratory study to evaluate

the effect on the ladybird Coccinella septempunctata L.
(Coleoptera, Coccinellidae)
Study Nr.: 99452/01-NECs
GLP
Unpublished
- 79 Thiram
APPENDIX III
List of studies
07 April 2003
Annex
Author(s)
point/
reference
number
Year
Title
Company, Report No.
Published or not
2001
IIA 8.5
Wachter S.
2000
IIA 8.7
Van der Kerken K.
1999
IIIA 10.1
IIIA 10.3
Grolleau G.
2000
IIIA
10.1.3/01
Beavers J. B.,
1995
Haberlein D.,
Grimes J., Jaber M.
IIIA
10.1.3/02
Beavers Joann B.,

Haberlein Doug,
Grimes Jennie,
Jaber Mark
Thiram 80WG: An extended laboratory study to evaluate

the effects on the green lacewing, Chrysoperla carnea
Steph. (Neuroptera, Chrysopidae)
Study Nr.: 99452/01-NECc
GLP
Unpublished
Assessment of the side effects of Thiram 80WG on the
activity of the soil microflora
8/6/2000)
Report Nr.: 99452/01-ABMF
GLP
Unpublished
Activated sludge respiration inhibition test of Thiram
LISEC
Project Nr.: WE-09-041
Year: 1999
GLP
Unpublished
Repulsive efficiency of Thiram used as seed treatment for the
red-legged partridge
Submitted by: UCB S.A. (submitted on 11/07/2000)
Company file No.: Date: 9 June 2000
Not GLP
unpublished
Thiram Technical: A palatability/repellency study with the
Mallard under multiple choice conditions
Date: 14 March 1995
GLP
unpublished
Thiram Technical: A palatability/repellency study with the
Northern Bobwhite (Colinus virginianus) under multiple choice
conditions
Date: 14 March 1995
GLP
unpublished
1995
- 80 Thiram
APPENDIX III
List of studies
07 April 2003
Annex
Author(s)
point/
reference
number
Year
IIIA 10.3.1
Thompson H.M
IIIA
10.3.1/01
Thompson H.M.
IIIA
10.3.1/02
Thompson H.M.
2001a Thiram: palatability of treated seed to wood mice

Central Science Lab, UK
GLP
Unpublished
Submitted Dec 2001
2001 Thiram: Palatability of treated seeds to wood mice
(Apodemus sylvaticus)
Study Nr.: HT1200
Date: 21 June 2001
GLP
Unpublished
2001 Additional analysis of data from report: Thiram: Palatability of
treated seeds to wood mice (Apodemus sylvaticus)
Study Nr.: HT1200
GLP
Unpublished
Title
Company, Report No.
Published or not
- 81 Thiram
APPENDIX IV
List of uses supported by available data
07 April 2003
APPENDIX IV
THIRAM
Crop and/
or situation
Member
State
or
Country
Product
name
(a)
F
G
or
I
(b)
Pests or
Group of pests
controlled
(c)
Formulation
Application rate per treatment
Application
PHI
(days)
(l)
Type
Conc.
of as
method
kind
(d-f)
(i)
(f-h)
growth
stage &
season
(j)
Apple
All Europe
Thiram 80 WG
Venturia
inaequalis
(Scab)
WG
800
foliar
First
application
on young
leaves
Apple
All Europe
Thiram 80 WG
Monilia
WG
800
foliar
First
application
before
flowering
Apple
All Europe
Thiram 80 WG
Gloeosporium
Gloeodes
pomigena
Schizothirium
pomi
WG
800
foliar
First
application
half June
number
min
max
(k)
4
(treatments
agains
t
Monili
a and
Gloeosporiu
m
included)
2
4
(treatments
agains
t
Monili
a and
Gloeosporiu
m
inclu-
interval
between
applications
(min)
kg as/hl
water l/ha
kg as/ha
min max
min max
min max
7-14 days
0.1 to
0.24
2,4
42
7-14 days
0.16 to
0.24
2,4
42
7-14 days
0.16 to
0.2
2,0
42
Remarks:
(m)
- 82 Thiram
APPENDIX IV
07 April 2003
Crop and/
or situation
Member
State
or
Country
Product
name
(a)
F
G
or
I
(b)
Pests or
Group of pests
controlled
(c)
Formulation
Application
PHI
(days)
(l)
Type
Conc.
of as
method
kind
(d-f)
(i)
(f-h)
growth
stage &
season
(j)
number
min
max
interval
between
applications
(min)
kg as/hl
water l/ha
kg as/ha
min max
min max
min max
(k)
ded)
4
7-14 days
0.1 to
0.24
2,4
42
Pear
All Europe
Thiram 80 WG
Venturia pirina
(Scab)
Stemphylium
vesicarium
WG
800
foliar
First
application
on young
leaves
Pear
All Europe
Thiram 80 WG
Monilia
WG
800
foliar
First
application
before
flowering
7-14 days
0.16 to
0.24
2,4
42
Pear
All Europe
Thiram 80 WG
Gloeosporium
Gloeodes
pomigena
Schizothirium
pomi
WG
800
foliar
First
application
half June
7-14 days
0.16 to
0.2
2,00
42
Almond
South-Europe
Thiram 80 WG
Monilia spp.
Coryneum
Taphrina
WG
800
foliar
Winter
application
and during
flowering
7-14 days
0.16 to
0.24
2,4
150
Apricot
South- Europe
Thiram 80 WG
Coryneum
beijerinckii
Monilia spp.
Fusicladium
WG
800
foliar
First
application
during leaf
fall then
before
flowering
7-14 days
0.16 to
0.24
2,4
42
Peach
All Europe
Thiram 80 WG
Monilia spp
Fusicladium.
WG
800
foliar
First
application
before
flowering
7-14 days
0.16 to
0.24
2,4
42
Peach
All Europe
Thiram 80 WG
Taphrina
deformans
WG
800
foliar
Autumn/
Winter
treatment
0.16 to
0.24
(0.3 to
0.4 kg
a.s./hl
2,4
42
Remarks:
(m)
- 83 Thiram
APPENDIX IV
07 April 2003
Crop and/
or situation
Member
State
or
Country
Product
name
(a)
F
G
or
I
(b)
Pests or
Group of pests
controlled
(c)
Formulation
Application
PHI
(days)
(l)
Type
Conc.
of as
method
kind
(d-f)
(i)
(f-h)
growth
stage &
season
(j)
number
min
max
interval
between
applications
(min)
kg as/hl
water l/ha
kg as/ha
min max
min max
min max
(k)
for low
volume
spray at
500 l/ha)
Peach
All Europe
Thiram 80 WG
Coryneum
beijerinckii
(Stigmina
carpophila)
Fusicoccum
amygdali
WG
800
foliar
Autumn/
Winter
treatment
0.16 to
0.24
(0.3 to
0.4 kg
a.s./hl
for low
volume
spray at
500 l/ha)
2,4
42
Wine grapes
All Europe
Thiram 80 WG
Botrytis
Colletotrichum
WG
800
foliar
0.16 to
0.32
3,2
35
Strawberry
(indoor &
outdoor)
All Europe
Thiram 80 WG
F
G
Botrytis
Colletorichum
Mycosphaerella
WG
800
foliar
First
application
during
flowering
During
flowering
Repeat
every 7 14 days if
necessary
0.16 to
0.32
1.6-2.4
Ornamentals
(indoor &
outdoor)
Ornamentals
bulbs
All Europe
Thiram 80 WG
F
G
Botrytis
WG
800
foliar
7 days
0.2 to
0.32
3,2
All Europe
Thiram 80 WG
Sclerotinia
WG
800
foliar
after
flowering
7-10 days
0.32
3,2
Peony
All Europe
Thiram 80 WG
Botrytis
WG
800
1.5
Seed
All Europe
Bird repellent
FS
533
rot
soaking
seed
treatment
Seed
dressing
as
neede
d
as
neede
d
1
1
0,2
Remarks:
(m)
- 84 Thiram
APPENDIX IV
07 April 2003
Crop and/
or situation
Member
State
or
Country
(a)
Product
name
F
G
or
I
(b)
Pests or
Group of pests
controlled
(c)
Formulation
Application
(l)
Type
Conc.
of as
method
kind
(d-f)
(i)
(f-h)
growth
stage &
season
(j)
number
min
max
interval
between
applications
(min)
kg as/hl
water l/ha
min max
min max
g as/100
kg seed
min max
seed
treatment
seed
treatment
(k)
-
160
533
seed
treatment
160
FS
533
seed
treatment
480
soil / seed borne

fungi
FS
533
seed
treatment
400
soil / seed borne

fungi
FS
533
seed
treatment
400
All Europe
soil / seed borne

fungi
FS
533
seed
treatment
400
Grass
All Europe
soil / seed borne

fungi
FS
533
seed
treatment
160
Leek
All Europe
soil / seed borne

fungi
FS
533
seed
treatment
5600
Lettuce
All Europe
soil / seed borne

fungi
FS
533
seed
treatment
400
Linseed
All Europe
soil / seed borne

fungi
FS
533
seed
treatment
300
Lupin
All Europe
soil / seed borne

fungi
FS
533
seed
treatment
160
Maize
All Europe
soil / seed borne

fungi, animal
repellency
FS
533
seed
treatment
160
Afalfa
All Europe
Barley
All Europe
Beans
All Europe
Beet (leaf,
sugar)
All Europe
Cabbage
PHI
(days)
soil / seed borne

fungi
soil / seed borne
fungi, animal
repellency
soil / seed borne
fungi
FS
533
FS
533
FS
soil / seed borne

fungi
All Europe
Celery
All Europe
Cucumber
160
Remarks:
(m)
- 85 Thiram
APPENDIX IV
07 April 2003
Crop and/
or situation
Member
State
or
Country
(a)
Product
name
F
G
or
I
(b)
Pests or
Group of pests
controlled
(c)
Formulation
Application
PHI
(days)
(l)
Type
Conc.
of as
method
kind
(d-f)
(i)
(f-h)
growth
stage &
season
(j)
number
min
max
interval
between
applications
(min)
kg as/hl
water l/ha
min max
min max
g as/100
kg seed
min max
Oats
All Europe
soil / seed borne

fungi
FS
533
seed
treatment
(k)
-
Oilseed rape
All Europe
FS
533
440
All Europe
FS
533
seed
treatment
seed
treatment
Onion
soil / seed borne

fungi
soil / seed borne
fungi
400
Parsley
All Europe
soil / seed borne

fungi
FS
533
seed
treatment
400
Peas
All Europe
FS
533
seed
treatment
160
Poppy
All Europe
soil / seed borne

fungi, animal
repellency
soil / seed borne
fungi
FS
533
seed
treatment
400
Potato
All Europe
FS
533
80
All Europe
FS
533
seed
treatment
seed
treatment
Radish
soil / seed borne

fungi
soil / seed borne
fungi
400
Rye
All Europe
soil / seed borne

fungi
FS
533
seed
treatment
160
Spinach
All Europe
soil / seed borne

fungi
FS
533
seed
treatment
400
Turnip
All Europe
soil / seed borne

fungi
FS
533
seed
treatment
400
Vetch
All Europe
soil / seed borne

fungi
FS
533
seed
treatment
160
Wheat
All Europe
soil / seed borne

fungi, animal
repellency
FS
533
seed
treatment
160
160
Remarks:
(m)
- 86 Thiram
APPENDIX IV
07 April 2003
Crop and/
or situation
Member
State
or
Country
Product
name
(a)
F
G
or
I
(b)
Pests or
Group of pests
controlled
(c)
Formulation
Application
PHI
(days)
(l)
Type
Conc.
of as
method
kind
(d-f)
(i)
(f-h)
growth
stage &
season
(j)
number
min
max
interval
between
applications
(min)
kg as/hl
water l/ha
min max
min max
Remarks:
(m)
g as/100
kg seed
min max
(k)
Wheat
All Europe
Vitavax 200FF
Soil/seed borne
fungi
FS
200
60
Barley
All Europe
Vitavax 200FF
Soil/seed borne
fungi
FS
200
60
Oats
All Europe
Vitavax 200FF
Soil/seed borne
fungi
FS
200
60
Rye
All Europe
Vitavax 200FF
Soil/seed borne
fungi
FS
200
60
Triticale
All Europe
Vitavax 200FF
Soil/seed borne
fungi
FS
200
60
Remarks:
(a)
(b)
(c)
(d)
(e)
(f)
(g)
(h)
For crops, the EU and Codex classifications (both) should be used; where relevant, the
use situation should be described (e.g. fumigation of a structure)
Outdoor or field use (F), glasshouse application (G) or indoor application (I)
e.g. biting and suckling insects, soil born insects, foliar fungi, weeds
e.g. wettable powder (WP), emulsifiable concentrate (EC), granule (GR)
GCPF Codes - GIFAP Technical Monograph No 2, 1989
All abbreviations used must be explained
Method, e.g. high volume spraying, low volume spraying, spreading, dusting, drench
Kind, e.g. overall, broadcast, aerial spraying, row, individual plant, between
the plants - type of equipment used must be indicated
(i)
(j)
(k)
(l)
(m)
g/kg or g/l
Growth stage at last treatment (BBCH Monograph, Growth Stages of Plants, 1997,
Blackwell, ISBN 3-8263-3152-4), including where relevant, information on season
at time of application
The minimum and maximum number of application possible under practical
conditions of use must be provided
PHI - minimum pre-harvest interval
Remarks may include: Extent of use/economic importance/restrictions

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EUROPEAN COMMISSION

HEALTH & CONSUMER PROTECTION DIRECTORATE-GENERAL

Review report for the active substance thiram

Procedure followed for the re-evaluation process

OJ No L 366, 15.12.1992, p.10.

OJ No L 259, 13.10.2000, p.27.

OJ No L 225, 22.09.1995, p.1.

identity and physical /chemical properties ;

OJ No L 49, 20.02.2001, p.13.

Purposes of this review report

Overall conclusion in the context of Directive 91/414/EEC

OJ No L 224, 06.09.2003, p.29

Identity and Physical/chemical properties

Endpoints and related information

List of studies to be generated

Information on studies with claimed data protection

Updating of this review report

Chemical name (IUPAC)

Chemical name (CA)

960 g/kg (FAO specification)

Common name (ISO)

not applicable (not a low melting substance)

1.36 g/cm3 at 20C (97.8% pure)

2.3 x 10-3 Pa at 25C

Henry's law constant

3.3 x 10-2 Pa.m3.mol-1 at 25C

Partition co-efficient (log Pow)

pH 5: DT50 = 68.5 d at 25C

pKa (BH+) = 8.19

Quantum yield of direct phototransformation in water at >290 nm

not highly flammable

UV/VIS absorption (max.)

214 nm: = 21884 L.mol-1.cm-1

Photostability in water (DT50)

1 Toxicology and metabolism

initially widely distributed ; highest residues in blood

Potential for accumulation:

85-90% within 96 h: 40% exhaled ; 33% in urine and

male = 3700 mg/kg bw

Rat LD50 dermal:

> 2000 mg/kg bw

Short term toxicity

Lowest relevant oral NOAEL / NOEL:

Dog, 90 day: 75 ppm (2 mg/kg bw/d)

Lowest relevant inhalation NOAEL /

no data, not necessary ( at Member state level)

positive Ames test.

Long term toxicity and carcinogenicity

Liver: C-cell hyperplasia and reduced LH surge in rats

Pup body weight reduction at maternal toxic doses

Lowest relevant reproductive NOAEL /

180 ppm (9 mg/kg bw/d)

Target / critical effect - Developmental

developmental delay (rat)

Lowest relevant developmental NOAEL / 7.5 mg/kg bw/d

Acute and subchronic neurotoxic effects (FOB

Other toxicological studies

liver enzyme induction, at high doses.

Skin irritation is seen sporadically.