BJP 2001 Chong 29 35
BJP 2001 Chong 29 35
BJP 2001 Chong 29 35
HSIN-YI LO BJP 2001, 178:29-35. Access the most recent version at DOI: 10.1192/bjp.178.1.29
Community study of depression in old age in Taiwan : Prevalence, life events and socio-demographic correlates
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B R I T I S H J O U R N A L O F P S YC H I AT RY ( 2 0 0 1 ) , 1 7 8 , 2 9 ^ 3 5
Background Published studies of prevalence of depression in old age in Taiwan have yielded equivocal results. Aims To study the prevalence of depressive disorders among communitydwelling elderly; further, to assess sociodemographic correlates and life events in relation to depression. Method A randomised sample of1500 subjects aged 65 and over was selected from three communities.Research psychiatrists conducted all assessments using the Geriatric Mental State Schedule. The diagnosis of depressionwas made with the GMS ^AGECAT (Automated Geriatric Examination for Computerised Assisted Taxonomy); data on life events were collected with theTaiwanese version of the Life Events and Difficulties Schedule. Results One-month prevalence of psychiatric disorders was 37.7%, with 15.3% depressive neurosis and 5.9% major depression. A high risk riskof of depressive disorders was found among widows with a low educationallevelliving in the urban community, and among those with physical illnesses. Conclusions Contrary to most previous reports, we found thatthe prevalence of depressive disorders among the elderly in the community inTaiwan is high and comparable to rates reported in some studies of UK samples. Declaration of interest The National Health Research Institute of Taiwan funded this project.
Previous work on depression in old age in Taiwan and other Eastern countries emphasised lower rates of depressive illness than in Western and North American regions (Table 1). The low risk of depression in Taiwan, for example, has been explained by the positive effect of good family support systems, with a tradition of giving respect to the elderly. However, recent epidemiological studies of community subjects in Taiwan have shown that elderly people had a higher risk of minor psychiatric morbidity (Cheng, 1987; Chong, 1992). Moreover, available statistics have shown that elderly people presented a consistently increased risk of suicide (Chong & Cheng, 1995), and many of those who died by suicide were found retrospectively to have suffered from depressive disorders (Cheng, 1995). In view of the above discrepancy, this study attempted to examine the `true prevalence' of depression in old age in the community in Taiwan, using a rigorous epidemiological design.
METHOD
The study the Taiwan Old Age Depression Study (TOADS) comprised a pilot study and the main survey. The pilot study was carried out in order to test and modify the case-finding instruments, and to generate a preliminary prevalence rate for an estimation of the sample size needed for the main study.
et al, 1976). A community version of the GMS was derived from the parent schedule by omitting many of the items designed to tap psychotic disorders less likely to be encountered in the community; this version of the GMS has been used in European community studies (Copeland et al, 1999). The GMS was translated into Mandarin (GMSM), and modified with colloquial terms relevant to the Taiwanese communities. Psychiatrists participating in the study had received training at the Institute of Psychiatry, London. Interrater reliability assessments of the GMS were carried out with their London colleagues and also among the eight research psychiatrists in Taiwan before the study began. Depressive disorders and other types of psychiatric morbidity were diagnosed by means of a computer-assisted system, the Automated Geriatric Examination for Computer Assisted Taxonomy (AGECAT). Its development has been described elsewhere (Dewey & Copeland, 1986; Copeland et al, 1986, 1999). In brief, it uses scores on the symptoms components obtained from the GMS interview described above to derive diagnostic clusters. Each subject is awarded a score (04 or 05) for each diagnostic cluster. The levels on each cluster are then compared to each other according to a hierarchy of diagnoses: organic brain syndrome, schizophrenia, mania, depression (major and neurotic), and obsessional, hypochondriacal, phobic and anxiety neuroses. The system arrives at a main diagnosis and subsidiary diagnosis. A subject who has no symptom components is referred to as `well', while subjects with diagnostic confidence levels 1 and 2 are referred to as `sub-cases', and those with diagnostic confidence levels 3, 4 or 5 are `cases'. The diagnostic agreement between the research psychiatrists and AGECAT was good, with generalised k scores of 0.87 for depressive disorders and 0.73 for organic brain syndrome. The LEDS was used to collect detailed information about the occurrence and context of adverse life events during the year prior to the interview. This is a semistructured interview developed by Brown & Harris (1978), of Bedford College, London University, for describing discrete events and ongoing long-term difficulties experienced by an individual. The Taiwanese version (LEDST) was modified from the original version, and each category of event or difficulty was extensively defined. The exact date of an event
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T Table able 1 Comparison between different community studies of depression in the elderly
RESULTS
Prevalence (%)
Authors GMS studies Copeland et al (1976) Kay et al (1985) Copeland et al (1987) Lobo et al (1995) Kua et al (1996) Kirby et al (1997) Bhatnagar & Frank (1997) Newman et al (1998) Taiwan studies Yeh et al (1994) Liu et al (1997)
Site
Criteria
Liverpool Hobart New York Zaragoza Singapore Dublin Bradford, UK Edmonton Taiwan Kinmon, Taiwan
GMS GMS GMS^AGECAT GMS^AGECAT GMS^AGECAT GMS^AGECAT GMS^AGECAT GMS^AGECAT DIS: major depression, dysthymia DSM^III^R GDS
11.3 16.1 16.2 4.8 6.0 10.3 20.0 11.2 0.5 0.8 12.9 26.0
GMS,Geriatric Mental State Schedule; AGECAT, Automated Geriatric Examination for Computer Assisted Taxonomy; DIS, Diagnostic Interview Schedule; GDS, Geriatric Depression Scale.
The study was carried out between mid1996 and the end of 1998. It took a longer time than a typical community survey because of the need for careful preparation, the training of research psychiatrists, and the wide area of distribution of the subjects studied. Altogether, 1350 (90.0%) subjects successfully completed the interview (the respondents); 123 (8.2%) subjects refused (non-respondents); and 27 (1.8%) died before the interview. Most of those who died suffered from chronic physical illness related to ageing. The respondent rates were especially high in the rural (95.6%) and semi-urban (95.4%) communities, and somewhat lower (at 81.1%) in the urban community.
or difficulty was sought out and recorded during the interview. The degree of threat contained in each life event was rated on a four-point scale: 1 indicating `a marked threat'; 2, `a moderate threat'; and 4, `little or no threat'. If an event rated moderate affected the subject, it was classified as `an important moderately threatening event'. The interrater reliability of threat rating was satisfactory (k0.75). The average annual rate of life events reported per subject was 0.8. The mean range of uncertainty about the date of events was 2.1 weeks (s.d.3.8); 25.5% felt certain about the exact date on which an event had occurred; 29.3% felt certain within 1 week; 17.5% felt certain within 12 weeks; and 25.3% felt certain within 34 weeks.
Subjects
Estimation of sample size
In the pilot study, 120 randomised subjects aged 65 and above were selected from a community. A senior psychiatrist trained in using the GMS assessed all subjects. Thirteen subjects (10.9%; 95% CI 5.3 16.5) were diagnosed as having depressive disorders using the GMSAGECAT system. With this estimate as a reference, an adequate sample size required for the main study was then calculated as 1485 (to achieve a power of 0.95, with P50.05).
Kaohsiung) in south Taiwan were selected for the study. In order to avoid a selection bias towards underestimation of the `true' residency of old people in these communities, the census was first consulted at the respective registration offices. It was then scrutinised for different age groups and re-checked for their residence by local officials before the study was carried out. A random selection procedure was used to select subjects with a probability proportional to the size of the aged population studied. A multi-stage random selection was adopted in the urban community, first in selecting districts, then the Li and Ling (district subdivisions in Taiwan). In the semi-urban and rural communities, randomised selection proportional to size was adopted because of the relatively smaller number of elderly in the population. For logistical reasons, a total number of 1500 subjects (500 from each community) were recruited for the main study.
Data analysis
The prevalence of all psychiatric and depressive morbidity was calculated using the GMSAGECAT, with a 95% CI. Univariate analyses of various sociodemographic variables and life events were performed in relation to the depressive disorders, first with descriptive statistics, including odds ratio (with 95% CI). Identified significant variables were then further analysed with multivariate analyses using logistic regression (applying the likelihood ratio estimation).
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TA I W A N OL D A G E D E P R E S S I ON S T U DY
low (average 3.3 years). Half of them had not received any formal education, with the greater proportion in the rural and semi-urban communities. Most of those with religious beliefs practised a mixture of Buddhist and Taoist rituals.
Table 2
Urban n (%) Gender Male Female Age 65^74 75^84 585 Ethnicity Taiwanese Chinese Marital status Never married Married Widowed Divorced Religion Yes No Education (years) 0 1^6 57 Living conditions Alone With family Offspring (number) 0 1^2 3^5 56 Physical illness Yes No 350 (88.6) 45 (11.4) 17 (4.3) 58 (14.7) 222 (56.3) 97 (24.6) 48 (12.2) 347 (87.8) 147 (37.6) 142 (36.3) 102 (26.1) 323 (82.4) 69 (17.6) 9 (2.3) 235 (59.5) 132 (33.4) 19 (4.8) 275 (69.8) 119 (30.2) 253 (64.1) 121 (30.6) 21 (5.3) 212 (53.7) 183 (46.3)
Rural n (%)
Semi-urban n (%)
Total n (%)
267 (56.0) 210 (44.0) 336 (70.4) 109 (22.9) 32 (6.7) 461 (97.5) 12 (2.5) 3 (0.6) 332 (70.2) 136 (28.8) 2 (0.4) 450 (95.3) 22 (4.7) 234 (49.5) 186 (39.3) 53 (11.2) 49 (10.3) 425 (89.7) 7 (1.5) 34 (7.2) 232 (49.0) 200 (42.3) 382 (81.1) 89 (18.9)
194 (40.6) 284 (59.4) 303 (63.4) 139 (29.1) 36 (7.5) 459 (96.2) 18 (3.8) 13 (2.7) 281 (58.9) 175 (36.7) 8 (1.7) 428 (89.7) 49 (10.3) 307 (64.4) 142 (29.8) 28 (5.9) 58 (12.2) 419 (87.8) 17 (3.6) 35 (7.3) 227 (47.6) 198 (41.5) 408 (85.5) 69 (14.5)
673 (49.9) 677 (50.1) 892 (66.1) 369 (27.3) 89 (6.6) 1195 (88.9) 149 (11.1) 25 (1.9) 848 (63.0) 443 (32.9) 29 (2.2) 1201 (89.6) 140 (10.4) 688 (51.3) 470 (35.0) 183 (13.6) 155 (11.5) 1191 (88.5) 41 (3.1) 127 (9.4) 681 (50.7) 495 (36.8) 1140 (84.9) 203 (15.1)
life event in the year prior to the interview; the odds ratio (OR) was 3.30 (95% CI 1.387.86). Life events of an important moderate or mildly threatening nature were also significantly associated with depression; their ORs were 2.94 (95% CI 1.88 4.60) and 1.93 (95% CI 1.402.66), respectively. Experience of general moderate threatening life events (OR1.47; 95% CI 0.593.69) and events holding little threat (OR1.23; 95% CI 0.911.67) were not significantly associated with depression. When the mild events were further examined, a high proportion of health events were found to be in this category. This association was insignificant after the exclusion
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disorders was also found in females, among widows, among those with low education, and among the older ages (the `oldestold') and in those with physical illness. The rates of depressive disorders were 2.1 times higher in women than in men (OR2.7; 95% CI 2.13.6; P50.001). The risk for females as against males of neurotic depression (138 v. 69; OR2.95; 95% CI 2.144.07; P50.001) was slightly higher than of major depression (48 v. 32; OR2.2; 95% CI 1.43.5; P50.001). When the above significant factors were analysed for the risk of depressive disorders using multiple regression, it was found that female gender, low education and urban region exerted significant independent effects, while female gender and urban region demonstrated a significant interactive effect (Table 4). Age was confounded by physical illness, for older ages had a higher risk of physical illness. In summary, a high risk of depressive disorders was typically found in an urban widow with a low level of education, while those with physical illness were highly vulnerable to depression.
Table T able 3
Relationship between socio-demographic factors, physical illness, life events and depression:
univariate analysis
Depression n (%) Area Urban Semi-urban Rural Gender Male Female Age 65^74 75^84 585 Ethnicity Taiwanese Chinese Marital status Married Widowed/other Religion Yes No Education (years) 0 1^6 57 Living conditions Alone With family Physical illness Yes No Life events (threat) Marked Important moderate General moderate Mild Little/no 11 (5.2) 41 (19.2) 7 (3.3) 76 (35.7) 78 (36.6) 268 (25.4) 18 (9.9) 37 (30.3) 249 (24.9) 174 (33.3) 84 (19.8) 28 (15.9) 255 (25.2) 31 (27.4) 160 (21.6) 126 (33.0) 249 (25.3) 37 (26.8) 181 (22.9) 87 (30.1) 19 (40.4) 101 (16.8) 186 (35.4) 102 (29.9) 97 (25.4) 88 (21.7)
Non-case n (%)
w2 (d.f.)
6.537 (2) 239 (70.1) 285 (74.6) 317 (78.3) 51.107 (1) 501 (83.2) 340 (64.6) 11.671 (2) 611 (77.1) 202 (69.9) 28 (59.6) 0.155 (1) 737 (74.7) 101 (73.2) 17.339 (1) 582 (78.4) 256 (67.0) 0.262 (1) 756 (74.8) 82 (72.6) 32.768 (2) 348 (66.7) 341 (80.2) 148 (84.1) 1.720 (1) 85 (69.7) 753 (75.1) 27.323 (1) 675 (71.6) 163 (90.1) 14.07 (4) 10 (2.5) 45 (11.4) 14 (3.5) 132 (33.3) 195 (49.3)
50.05
50.001
50.01
NS
50.001
NS
50.001
NS
50.001
50.005
Table T able 4
Variable Constant Physical illness Education (illiterate) Gender (female) Urban female
d.f. 1 1 1 1 1
OR (95% CI)
Physical illness dichotomised as present/absent; education dichotomised as illiterate/high; region dichotomised as urban/rural.
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TA I W A N OL D A G E D E P R E S S I ON S T U DY
difficulty in distinguishing patients with depression from normal subjects who have depressive symptoms. The measurement of life events was carried out by means of a comprehensive, interview-based schedule, the LEDST. Because of the considerable length of the full and probing interview, the quality of life-event information collected is of great importance, particularly when used in a community epidemiological survey of elderly people. The results show a satisfactory interrater reliability of threat rating, a short mean range of uncertainty and limited fall-off. High response rates were found in this study, especially in the semi-urban and rural communities. The importance of a sound response rate in any epidemiological study has long been stressed. Similarly high response rates were also noticed in epidemiological surveys of other types of psychiatric morbidity in the community in Taiwan (Cheng, 1987; Chong, 1992). They were accounted for by the close collaboration of various professions, particularly public nurses and local community officers. With their assistance and thanks to their frequent communication with the subjects and their families, high response rates were able to be achieved. Besides, because interviews were conducted at temples that also served as community centres in some villages, subjects were more likely to cooperate and provide reliable information.
using the DIS in community surveys generally demonstrated consistently lower rates than most studies with other standardised instruments. When comparing different studies using the GMS, it was found that the prevalence rate of depression in old age in this study is comparable to that recorded in a recent report on migrants from the Indian subcontinent living in Bradford, UK (Bhatnagar & Frank, 1997), but higher than those reported from Liverpool (Copeland et al, 1976), Dublin (Kirby et al, 1997) and other European (Beekman et al, 1999) and most Asian studies. Moreover, the prevalence rate of depression in old age is three times higher than that reported from Singapore (Kua et al, 1996), a community composed predominantly of ethnic Chinese. There were, however, great differences in rates of suicide between Singapore and Taiwan, with a higher rate as well as a trend of higher suicidal risk with age in Taiwan (Kok & Tseng, 1992; Chong & Cheng, 1995). The high rate of depression in this study is also comparable to that shown in a recent study using the Geriatric Depression Scale (Brink et al, 1982) in Kimen, an island just off the coast of mainland China, which is populated by Chinese (Liu et al, 1997).
however, twice as high in women than in men. A similar gender ratio distribution was also seen in other surveys of minor psychiatric morbidity in Taiwan (Cheng, 1987; Chong, 1992).
Marital status
The relation of marital status to depression among elderly people is less controversial. It is generally believed that depression associated with widowhood is probably due to the bereavement. In addition, loneliness, one of the depressive manifestations, is commonly seen in elderly people regardless of their marital status.
Prevalence studies
A high prevalence rate of depression in old age was found in this study, which contradicted the findings of most previous studies in Taiwan (Table 1) and other Oriental countries (Komahashi et al, 1994; Kua et al, 1996), where lower rates have long been emphasised. Comparison with these studies is difficult, because of differences in research methodology, diagnostic criteria and instruments used. In general, significantly lower rates of depression were found in a study employing lay interviewers to collect information using the Diagnostic Interview Schedule (DIS) (Yeh et al, 1994). The DIS is based on the criteria of DSMIII (American Psychiatric Association, 1980), which require high specificity. This is appropriate for biological research but not suitable in a community survey where high sensitivity is needed to identify cases for treatment. This being so, it is not surprising that studies
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C HON G E T A L
CLINICAL IMPLICATIONS
& The prevalence rate of depressive disorders among the elderly inTaiwan is as high as rates reported in the West. &
Health problems were the main stressful life events experienced by the elderly.
& Being female, a widow, with low education and physical morbidity gave high risks for depression in the elderly.
LIMITATIONS
& & &
Prevalence of sub-threshold depression was not addressed. Organic brain disorders with depression were excluded in the analysis. No further cross-comparison among different studies was attempted.
MIAN-YOON CHONG, MRCPsych, HIN-YEUNG TSANG, MD,CHENG-SHEN CHEN, MD,TZE-CHUN TANG, MD, Department of Psychiatry, Kaohsiung Medical University, Kaohsiung, Taiwan; CHWEN-CHENG CHEN, MRCPsych, TZUNG-LIEH YEH, MD,YI-HUI LEE, MD, HSIN-YI LO, MD, Department of Psychiatry, National Cheng Kung University, Tainan, Taiwan Correspondence: Dr Mian-Yoon Chong, Associate Professor and Director, Department of Psychiatry, Kaohsiung Medical University,100 University, 100 Shih-Chuan First Road,Kaohsiung 807,Taiwan.Tel: 8 07,Taiwan.Tel: 886 7 3208219; fax: 886 7 3112492; e-mail: mchong @cc.kmu.edu.tw (First received 4 November 1999, final revision 25 April 2000, accepted 19 June 2000)
REFERENCES
American Psychiatric Association (1980) Diagnostic
and Statistical Manual of Mental Disorders (3rd edn) (DSM ^ III).Washington, DC: APA.
_ & Cheng, T. A. (1995) Suicidal behaviour observed inTaiwan: Trends over four decades. In Chinese Society and Mental Health (edsT. (edsT.Y. Y. Lin,W . S. Teng & E. K.Yeh), K. Y eh), pp. 209^218. Hong Kong: Oxford University Press.
Beekman, A. T. F., Copeland, J. R. M. & Prince, M. J. (1999) Review of community prevalence of depression in
Copeland, J. R. M., Kelleher, M. J., Kellett, J. M., et al (1976) A semi-structured clinical interview for the
Bhatnagar, K. & Frank, J. (1997) Psychiatric disorders in elderly from the Indian sub-continent living in Bradford. International Journal of Geriatric Psychiatry, 12, 907^912. Boey, K. W. & Chi, I. (1998) A study of life events and psychological well-being of the older adults in Hong Kong. Journal of Clinical Geropsychology, 4, 55^64. Brink, T. L.,Yesavage, J. A., Lum, O., et al (1982)
assessment of diagnosis and mental state in the elderly: The Geriatric Mental State Schedule. I. Development and reliability reliability. . Psychological Medicine, 6, 439^449.
_
Computerized psychiatric diagnostic system and case nomenclature for elderly subjects: GMS and AGECAT. Psychological Medicine, 16, 89^99.
_ , _ ,Wood, N., et al (1987) Range of mental illness among the elderly in the community community. . Prevalence in Liverpool using the GMS ^AGECAT package. British Journal of Psychiatry, 150, 815^823. _
ACKNOWLEDGEMENTS
The authors thank Professor Anthony Mann of the Institute of Psychiatry, London, Professor Tsung-Yi Lin of the University of British Columbia, Canada, and Professor Andrew Cheng of the Institute of Biomedical Sciences, Academia Sinica, Taiwan, for their invaluable advice and supervision. We are obliged to the public health nurses and local officers who helped to locate subjects in this study, and most of all, we are grateful to all the respondents and their families for their cooperation and for making this study a success. The study was conducted under a grant from the National Health Research Institute, Taiwan (85-CNT-MD-501P; DDO1-861X-MD501P).
Depression in Europe. Geographical distribution among older people. British Journal of Psychiatry, 174, 312^321. Computerized psychiatric diagnosis in the elderly: AGECAT. Journal of Microcomputer Applications, 9, 135^140.
Henderson, A. S., Korten, A. E., Jacomb, P. A., et al (1997) The course of depression in the elderly: a Dewey, M. E. & Copeland, J. R. M. (1986)
Minor Psychiatric Morbidity in the Community inTaiwan. PhD thesis, University of London.
Dementia and depression among the elderly living in the Hobart community: the effect of diagnostic criteria on
34
TA I W A N OL D A G E D E P R E S S I ON S T U DY
among the aged living in the community in Japan. Japanese Journal of Psychiatry and Neurology, 48, 517^526. Comorbidity of depression in the elderly ^ an epidemiological study in a Chinese community. International Journal of Geriatric Psychiatry, 11, 699^704. Depressive disorders among older residents in a Chinese rural community community. . Psychological Medicine, 27, 943^949. The prevalence of dementia and depression in the elderly community in a southern European population: the Zaragoza study. Archives of General Psychiatry, 52, 497^506.
Lobo, A., Saz, P., Marcos, G., Dia, J-L., et al (1995) Liu, C.Y.,Wang, S. J., Teng, E. L., et al (1997) Kua, E. H., Ko, S. M., Fones, S. L. C., et al (1996)
Prevalence of depression in an elderly community sample: a comparison of GMS ^AGECATand DSM ^ IV diagnostic criteria. Psychological Medicine, 28,1339^1345.
Prince, M. J., Harwood, R. H., Thomas, A., et al (1998) A prospective population-based cohort study of
disorders among the community-dwelling elderly in Dublin. British Journal of Psychiatry, 171, 369^372.
the effects of disablement and social milieu on the onset and maintenance of late-life depression.The Gospel Oak Project VII. Psychological Medicine, 28, 337^350.
Yeh, E. K., Hwu, H. K., Chang, L.Y., et al (1994)
Kok, L. P. & Tseng,W. S. (1992) Suicidal Behaviour in the Asia-Pacific Region. Singapore: Singapore University Press. Komahashi, M., Ohmori, K. & Nakano, T. (1994)
Mental disorders and cognitive impairment among the elderly community population inTaiwan. In Principles and Practice of Geriatric Psychiatry (eds J. R. M. Copeland, M. T. Abou-Saleh & D. G. Blazer), pp. 865^871. London: John Wiley & Sons.
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