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BMC Musculoskeletal Disorders
Open Access
Research article
Effectiveness of physiotherapy exercise following hip arthroplasty
for osteoarthritis: a systematic review of clinical trials
Catherine J Minns Lowe*
1,2
, Karen L Barker
2
, Michael E Dewey
3
and
Catherine MSackley
1
Address:
1
Department of Primary Care Clinical Sciences, University of Birmingham, Edgbaston, Birmingham, UK,
2
Physiotherapy Research Unit,
Nuffield Orthopaedic Hospital NHS Trust, Windmill Road, Headington, Oxford, UK and
3
School of Community Health Sciences, University of
Nottingham, University Park, Nottingham, UK
Email: Catherine J Minns Lowe* - catherine.minnslowe@noc.anglox.nhs.uk; Karen L Barker - karen.barker@noc.anglox.nhs.uk;
Michael E Dewey - med@aghmed.fsnet.co.uk; Catherine MSackley - c.m.sackley@bham.ac.uk
* Corresponding author
Abstract
Background: Physiotherapy has long been a routine component of patient rehabilitation following hip
joint replacement. The purpose of this systematic review was to evaluate the effectiveness of
physiotherapy exercise after discharge from hospital on function, walking, range of motion, quality of life
and muscle strength, for osteoarthritic patients following elective primary total hip arthroplasty.
Methods: Design: Systematic review, using the Cochrane Collaboration Handbook for Systematic
Reviews of Interventions and the Quorom Statement.
Database searches: AMED, CINAHL, EMBASE, KingsFund, MEDLINE, Cochrane library (Cochrane reviews,
Cochrane Central Register of Controlled Trials, DARE), PEDro, The Department of Health National
Research Register. Handsearches: Physiotherapy, Physical Therapy, Journal of Bone and Joint Surgery (Britain)
Conference Proceedings. No language restrictions were applied.
Selection: Trials comparing physiotherapy exercise versus usual/standard care, or comparing two types of
relevant exercise physiotherapy, following discharge from hospital after elective primary total hip
replacement for osteoarthritis were reviewed.
Outcomes: Functional activities of daily living, walking, quality of life, muscle strength and range of hip joint
motion. Trial quality was extensively evaluated. Narrative synthesis plus meta-analytic summaries were
performed to summarise the data.
Results: 8 trials were identified. Trial quality was mixed. Generally poor trial quality, quantity and diversity
prevented explanatory meta-analyses. The results were synthesised and meta-analytic summaries were
used where possible to provide a formal summary of results. Results indicate that physiotherapy exercise
after discharge following total hip replacement has the potential to benefit patients.
Conclusion: Insufficient evidence exists to establish the effectiveness of physiotherapy exercise following
primary hip replacement for osteoarthritis. Further well designed trials are required to determine the
value of post discharge exercise following this increasingly common surgical procedure.
Published: 4 August 2009
BMC Musculoskeletal Disorders 2009, 10:98 doi:10.1186/1471-2474-10-98
Received: 17 December 2008
Accepted: 4 August 2009
This article is available from: http://www.biomedcentral.com/1471-2474/10/98
2009 Minns Lowe et al; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
BMC Musculoskeletal Disorders 2009, 10:98 http://www.biomedcentral.com/1471-2474/10/98
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Background
Osteoarthritis is the commonest cause of disability in
older people [1]. Prevalence figures for hip osteoarthritis
range from 725% in people aged over fifty five [2] with
over 70% of sufferers experience pain and limitations in
performing activities of daily living, such as mobility out-
side the home [3]. Effective treatment exists for end-stage
disease in the form of joint arthroplasty [4]. The number
of primary total hip replacements procedures for osteoar-
thritis continues to rise steadily with 51,981 procedures
reported for England and Wales in 2006 [5]. Traditionally,
physiotherapy has been a routine component of patient
rehabilitation following hip joint replacement. Due to the
introduction of initiatives such as integrated care path-
ways, the length of hospital stay following joint replace-
ment surgery has markedly and rapidly decreased [6],
with the duration period for post operative in-patient
physiotherapy being reduced. For patients without inca-
pacitating systemic or life threatening disease the average
length of stay in hospital between 20032006 was 7.4
8.9 days in England and Wales [6]. It is known that
impairments and functional limitations remain a year
after surgery [7] so the effectiveness of post discharge
physiotherapy upon functional ability after hip replace-
ment is a valid question. Current uncertainty regarding
effectiveness makes it difficult for primary care commis-
sioning organisations to determine whether to provide a
post discharge physiotherapy service to patients, for pri-
mary health care practitioners advising patients regarding
follow up after discharge and for patients making deci-
sions about their own health care. Several general reviews
of the literature surrounding rehabilitation following hip
joint replacement exist [7-9] and one recent review, lim-
ited to Medline and Cochrane databases, for literature
regarding physical training before and after hip and knee
arthroplasty [10]. This narrative review was date limited
(19962006), did not include physiotherapy/physical
therapy as a search term, did not search other databases
likely to contain allied health professional research
records and did not identify the majority of trials included
in this review. Since Dauty et al (1997) [10] considered
physical training rather than physiotherapy practice there
have not been, as yet, any systematic reviews exploring the
effectiveness of post discharge physiotherapy following
hip joint replacement surgery. We aimed to review, sys-
tematically, randomised controlled trials in order to
answer the following question 'To what extent is post dis-
charge physiotherapy exercise effective, in terms of
improving function, quality of life, mobility, range of hip
joint motion and muscle strength, for osteoarthritic
patients following elective primary unilateral total hip
arthroplasty?'
Methods
Ethical Approval
The Oxford Local Research Ethics Committee awarded
approval for this study (AQREC No: A03.018).
Searching
In March 2005 and April 2007 we identified clinical trials
by simultaneously searching AMED (from 1985),
CINAHL (from1982), EMBASE (from1974), KingsFund
Database (from1979) and MEDLINE (from 1966). The
Cochrane library, PEDro physiotherapy evidence database
and The Department of Health National Research Register
were also searched. In July 2005 and April 2007 we hand
searched Physiotherapy (1985March 2007 inclusive),
Physical Therapy (1985April 2007 inclusive) to double
check for trials. The conference proceedings in the Journal
of Bone and Joint Surgery (Britain) (19852006 inclusive)
were also handsearched, as were the reference lists of
included trials. The location of Physiotherapy trials is dif-
ficult therefore, although time consuming, multiple gen-
eral searches were considered the optimum location
method. This review is part of a series with both knee and
hip search terms being included. Searches are summarised
in Table 1. No language restrictions were applied. Profes-
sional translation of non English language articles was
obtained using a translation service familiar with medical
terminology.
Selection
We sought prospective comparative clinical trials of
patients undergoing total hip replacement for osteoarthri-
tis who received a physiotherapy exercise rehabilitation
intervention following discharge from hospital post-oper-
atively. We used broad definitions of "physiotherapy" and
"exercise" to include any exercises or exercise programme
advised or provided by physiotherapists/physical thera-
pists during the rehabilitative period after discharge from
hospital after surgery occurring in the out patient, com-
munity or home setting. This is not to say other forms of
exercise are considered lesser in any way, only that our
area of interest was physiotherapy practice. Trials were
included if they compared a physiotherapy intervention
versus usual or standard care or compared two different
types of relevant physiotherapy intervention. We excluded
trials in which the intervention consisted of an electrical
adjunct to physiotherapy. Effectiveness outcomes
included in trials were measures of functional activities of
daily living, walking, self report measures of quality of
life, muscle strength and range of hip joint motion. As
most trials use functional measures, which include pain,
rather than specific pain outcomes, it was not considered
possible to include pain as a separate effectiveness out-
come. Study eligibility was assessed and agreed by two
reviewers (CML and CS).
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Table 1: Search Strategy for Systematic Review.
Source Searches and Search Terms MarJul 2005 Hits*
(number of new relevant records)
2005April 2007 Hits*
(number of new relevant records)
KA24:
AMED 1985 -
CINAHL 1982-
EMBASE 1974-
Kingsfund 1979-
MEDLINE 1966-
1. "hip" OR "knee"
(whole document)
AND "replacement" OR
"arthroplast$" (whole document)
AND "rehabilitation" AND "trial$"
(whole document)
587 (25) 180 (0)
2. "hip" OR "knee"
(whole document)
AND "rehabilitation" AND "trial$"
(title)
118 (11) 1 (0)
3. "hip" OR "knee"
(whole document)
AND "physiotherapy" AND
"trial$" (title)
2 (0) 4 (0)
4. "hip" OR "knee"
(whole document)
AND "physiotherapy" (title)
39 (0) 14 (0)
5. "hip" OR "knee"
(whole document)
AND "physical therapy" (title)
43 (8) 15 (0)
6. "hip" OR "knee"
(whole document)
AND "home programme" (title)
2 (0) 1 (0)
7. "hip" OR "knee"
(whole document)
AND "home programme"
(whole document)
22 (2) 27 (0)
8. "hip" OR "knee"
(whole document)
AND "occupational therapy "
(whole document)
35 (0) 3 (0)
9. "hip" OR "knee"
(whole document)
AND "occupational therapist$"
(title)
0 (0) 3 (0)
Cochrane library:
Cochrane reviews
CCRCT DARE
1. Browsed by topic
musculoskeletal
Search narrowed osteoarthritis
Search narrowed rehabilitation
9 11
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Validity assessment, data abstraction and quality
assessment
We developed and piloted a data extraction form, using
quality indicators from the CONSORT statement [11] and
the CASP guidelines [12] (Table 2). Similar analysis of
individual quality components is a previously used
approach within physiotherapy reviews [13,14] and is
advocated to avoid known problems associated with exist-
ing composite scores [15]. Items could be marked as yes,
no, unclear or partial. Items were only marked as yes if
they fully and explicitly met the detailed criteria laid out
in the CONSORT standards [11]. Two non English lan-
guage trials were identified and translated, one of which
was written up in summary form rather than as a journal
paper and could not be included in this assessment of
quality for the review [16]. Two reviewers independently
extracted the data (CML and KB). KB was masked to the
key details of each English language paper and the extent
to which masking was successful was assessed. The two
non English trials were excluded from this masked moni-
toring process since the translations arrived in non journal
format after this process was completed. The masking
rates were 83.33% for authors, 33.33% for journals, and
100% for author affiliations, funding sources, and study
location; all rates were considered successful bar journal
of publication. The level of agreement between reviewers,
using the component checklist, was 70.45%, (kappa
0.570, intraclass correlation coefficient (2,1) 0.699 (95%
CI 0.606 to 0.770).
Any initial disagreements regarding study quality were
discussed until consensus was reached. Major disagree-
ment was rare, usually disagreement was the more minor
"yes" to "partial/unclear" or "no" to "partial/unclear" and
100% agreement was obtained. A third reviewer (CS) was
available in the event of consensus not being reached but
in the event this was not required. Where key study details
were absent or unclear the authors were contacted for fur-
ther information.
The quality of the studies evaluated in this review was
mixed and generally poor (Table 2) with much relevant
2. General search term "joint
replacement"
80 18
PEDro physiotherapy evidence
database
1. "joint replacement AND
rehabilitation"
1 (0) 17 (0)
2. "joint replacement" 5 (0) 45 (0)
Dept of Health National Research
Register
rehabilitation"
0 19 (1)
physiotherapy"
7 9 (0)
exercise"
2 (0) 6 (0)
physical therapy"
3 (0) 5 (0)
5. "joint arthroplasty AND
physiotherapy"
0 0
6. "joint arthroplasty AND
rehabilitation"
2 (1) 2 (0)
occupational therapy"
5 (0) 5 (0)
Physiotherapy Key journal Hand search of
contents pages
Nil new Nil new
Physical Therapy Key journal Hand search of
contents pages
Nil new Nil new
JBJS [Br] Hand search of all conference
proceedings
2 new 1
Reference lists Hand searching of papers included
in the review
1 new.
Totals 965 (50) 386 (2)
* Numbers following use of removal of duplicates commands when available.
Table 1: Search Strategy for Systematic Review. (Continued)
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Table 2: Quality component checklist and quality evaluation of seven trials included in the review (Kaae et al.,1989 excluded*).
Does the study/author
information adequately
contain the following:
Jan et al.,
2004
Johnsson et al.,
1988
Nyberg &
Kreuter, 2002
Patterson et
al., 1995
Sashika et al.,
1996
Suetta et al.,
2004
Trudelle-
Jackson &
Smith 2004
Rationale for study Y Y Y Y Y Y Y
Eligibility criteria Y P Y Y Y Y Y
Recruitment method N N P P Y P Y
Settings and location of
study
P P Y Y P P P
Intervention Y P Y P Y P Y
Objectives/hypotheses P P N P P Y Y
Defined outcome
measures
Y P N N P Y Y
Quality enhancers (e.g.
multiple observations)
Y N P N P Y
Sample size
determination
Y N N N P Y N
Randomisation Alternately
assigned
Y Alternately
assigned
Assigned by
location
Not
randomised
Y Y
Randomisation
sequence generation
Y N Y Y I Y Y
Allocation concealment N N Y N N N N
Randomisation
implementation
methods
N N N N N N N
Blinding participant N N N N N N Y
Blinding of those
administering the
intervention
N N N N N P N
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Blinding outcome/
assessments
Y N Y Y N Not all blinded Not blinded
Statistical methods Y P Y Y N Y Y
Flow of participants
through each stage
Y U Y N P P Y
Recruitment and follow
up dates
N N Y N N P N
Baseline demographics Y N P Y Y Y Y
Numbers analysed
(and ITT)
Y U P U Y P Y
Summary of Results P P P Y P Y Y
Estimated effect sizes N P N N N N N
Precision N N N Y N Y N
Results for each
outcome
Y Y Y Y P Y Y
Ancillary analyses P N I N N N N
Adverse events P P Y N P N N
Interpretation P P P P N N P
Generalisability P P Y P N N N
Results placed into
context
P P P P P P P
Judged to be of sufficient
quality for inclusion in
explanatory meta-
analyses?
N N N N N Y Y for Oxford
hip score only
Key: Y = Yes, included in paper/information to meet CONSORT level standards. N = not provided in paper/information. I = considered
inappropriate/impossible.
P = Partially evident in paper/information. U = not fully provided/explained in paper/information and therefore unclear/ambiguous. *This trial was
written up in summary form rather than as a journal paper.
Table 2: Quality component checklist and quality evaluation of seven trials included in the review (Kaae et al.,1989 excluded*).
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information initially missing from papers. Consideration
was paid to the likelihood of serious potential bias being
created throughout the assessment of quality decision
making processes and this was taken into account when
assessing individual trials. Only two papers were judged
to be of sufficient quality to have been fully able to
include in explanatory meta-analyses (with appropriate
sensitivity analyses for blinding) if differing outcomes had
not prevented these from occurring (Table 2). Problems
existed within essential areas of trial quality in some trials.
While one trial accurately identified itself as a non ran-
domised trial [17] three others erroneously stated they
were randomised trials. Two of these studies alternately
assigned participants [18,19] which, since alternation is a
non random "deterministic" approach [11], cannot be
considered true randomisation. One further study
assigned participants upon the basis of where they lived
[20], another non random approach. Information pro-
vided regarding allocation concealment was inadequate
for the majority of trials. Many studies either provided
inadequate information regarding whether outcomes
were measured by an assessor blinded to treatment alloca-
tion [17,21] or stated that such blind outcome measure-
ment could not take place [22,23]. Whilst more recent
trials were more likely to provide a justification of sample
size, sample sizes were generally small (see Additional file
1) with most trials including fewer than forty subjects
(range n = 2058).
Quantitative Data Synthesis
Despite the mixed and generally poor quality of the trials
and their diverse outcomes we decided that it would be
helpful to present a formal summary of the results where
it was possible to perform such summaries. Sufficient data
made this possible for both walking speed and hip abduc-
tor muscle strength but not function, range of joint
motion or quality of life. For walking speed we first syn-
thesised the results within in each study using the meth-
ods described by Gleser and Olkin (1994) [24] and we
then combined these weighted mean differences to form
a conventional fixed effects meta-analytic summary.
Because we have no information about the correlation
between measures within studies we carried out the anal-
ysis assuming a correlation of 0.8 and as a sensitivity anal-
ysis also used values of 0.2 and 0.5. For hip abductor
muscle strength we carried out a conventional fixed effects
analysis using standardised effect sizes. Since it is our
object to present a summary rather than to encourage gen-
eralisability beyond these studies we neither used random
effects nor present a formal assessment of heterogeneity.
The assessment of publication bias was felt to be inappro-
priate due to the small number of trials available for inclu-
sion in the review.
Results
27 potentially relevant studies were identified and
screened for retrieval. Of these, a total of 8 studies [16-23]
were included in the systematic review. A summary is pro-
vided in the flow diagram in Figure 1. Table 3 contains a
list of excluded studies [25-43].
Study Characteristics
The characteristics of the studies included in the trial are
summarized in a table in Additional file 1. This table pro-
vides information regarding the participants, the interven-
tions, the main outcomes and the conclusions reached by
the authors.
Summary of the Interventions and Comparisons
Details of the intervention and comparison groups were
available from the papers and authors and these are sum-
marised in a table in Additional file 2. The interventions
provided to participants in the trials included in this
review showed variation. One trial intervention consisted
of a home exercise programme [17], one intervention was
a home exercise programme with follow up visits to check
and progress exercises [23], another also included a home
exercise programme but with additional visits and tele-
phone calls where necessary [18]. The exercises incorpo-
rated into trials also varied from addressing range of
Table 3: Studies Excluded from the Review.
Reason for Exclusion Study
Not a clinical trial Cullen et al., 1973 [25]
Drabsch et al., 1998 [26]
Freburger 2000 [27]
Lapshin et al., 2002 [28]
Richardson 1975 [29]
Shih et al., 1994 [30]
In patient intervention Chen et al., 2004 [31]
Grange et al., 2004 [32]
Hesse et al., 2003 [33]
Hughes et al., 1993 [34]
Lang 1998 [35]
Maire et al., 2004 [36]
Munin et al., 1998 [37]
Osteopathic manipulation intervention Licciardone et al., 2004 [38]
Pre operative intervention Gursen & Ahrens 2003 [39]
Pre op and post op intervention Gilbey et al., 2003 [40]
Apparent multiple trial reports Gilbey et al., 2003b [41]
Werner et al., 2004 [42]
Inclusion criteria of injurious falls Hauer et al., 2002 [43]
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motion and strengthening [17,18] to targeting strength,
postural stability and functional exercises [23].
The majority of trial interventions included some form of
outpatient physiotherapy. This ranged from aerobic dance
routines [20] to individualised physiotherapy treatment
[16] to group training [19] to supervised strengthening
sessions [22] and supervised exercising sessions plus
home exercises [21]. The majority of trials allocated par-
ticipants to intervention or control groups [16-18,20,21].
Three trials, occurring soon after surgery, compared the
intervention group against an intervention based on usual
care. These were described as traditional isometric and
active range of movement exercises [23], a home exercise
programme [19] and standard rehabilitation [22].
The timing of the intervention also varied. Some interven-
tions started soon after surgery [22], and five weeks [16]
and eight weeks [19] after discharge from hospital, while
others took place up to several years post operatively
[17,18].
The duration of interventions provided to trial partici-
pants ranged from 58 weeks [16,17,21,23] to pro-
grammes lasting around three to four months [18-20,22].
The frequency of physiotherapy ranged from daily
[16,17,22] to 14 times per week [16,19-21,23]. Partici-
pants were usually followed up immediately post inter-
vention with no long term follow up, except for Kaae et al,
1989 [16] who additionally included a 6 month follow up
(additional file 1).
Trial Flow diagram to summarise the stages of the systematic review Figure 1
Trial Flow diagram to summarise the stages of the systematic review.

Citations identified by all searches (n=1351)

Rejected on title, abstract and keywords (n=1299)

Citations only relevant to knee review removed (n=25)

Potentially relevant RCT abstracts identified and screened for retrieval (n=27)
13 abstracts excluded (see Table 3)
n= 5 not a rct
n= 4 inpatient intervention
n=2 duplicate trial reports
n=1 osteopathic manipulation intervention
n= 1 pre op and post op intervention

Full papers obtained and screened for retrieval (n=14)
6 papers excluded
n= 1 preoperative intervention
n= 3 inpatient intervention
n=1 not a trial
n = 1 patients with injurious falls
RCTs evaluated in detail (n=8)

RCTs suitable for inclusion/part RCTs excluded from meta-analysis (n=6)
inclusion in meta-analysis (n=2)
Page 9 of 14
Self Report measures of Function (5 trials, 190
participants)
Six studies reported results for functional activity meas-
ures [16-19,21,23]. The measures used included the fol-
lowing: The Oxford Hip Score [23], The McMaster
Toronto Arthritis Patient Preference Disability Question-
naire (MACTAR) [19], the functional component of the
Harris Hip Score [18], Unspecified activities of daily liv-
ing/patterns of activity self report measures [16,21] and
the Japanese Orthopaedic Score [17]. It can be seen that
every study measured function differently and we felt that
there was too much variety to usefully combine the results
in a meta-analytic summary.
Within the individual trials, three demonstrated no
observed significant differences between groups
[16,19,21] while one trial used the score to describe the
group characteristics at baseline [17]. Two recent trials
[18,23] showed significant within group differences for
the treatment arm only, indicating a treatment benefit
within the treatment groups. Trudelle-Jackson and Smith,
2004[23] report a pre-intervention median Oxford Hip
Score of 21 (range 1533) and post-intervention median
of 16 (range 1238) for the treatment arm; Wilcoxon
signed-rank test results revealed a significant difference z =
-2.55, p = 0.01. Jan et al, 2004 [18] report functional com-
ponent Harris Hip Score pre and post intervention means
for their high compliance group of 11.7 (SD 0.8) and
13.1 (SD 0.6) respectively; Wilcoxon signed-rank test
results reported a significant difference at p < 0.05 level. A
personal communication from the authors reports the sig-
nificant results (p < 0.05) for the exercise group as a
whole; namely a pre intervention mean of 11.8 ( 0.8)
and post mean of 12.9 ( 0.6).
Walking (6 trials, 212 participants)
Some form of walking outcome measurement was used in
six trials [16-21] although the means by which walking
was measured varied. Mean "comfortable" walking speed
over an unspecified time/distance measured in m/sec was
measured in one trial [20]. Walking speeds in m/min were
provided in two trials [17,18]. Jan et al, 2004 [18] meas-
ured fast and free walking speeds on hard and grass sur-
faces plus free walking speed measured on a spongy
surface, whilst Sashika et al, 1996 [17] provided no fur-
ther details of the test. Maximum walking speeds were
provided in two trials [19,21]. Few procedural details were
provided by Johnsson et al, 1998 [21] while Nyberg and
Kreuter, 2002 [19] measured self selected maximum walk-
ing speed in seconds over a 30 m walkway. A twelve
minute stamina walking test, without walking aids, on a
treadmill was used by Kaae et al, 1989 [16]. In addition,
cadence [17] and subjective gait analyses were included in
one trial each [16].
The results from these trials are mixed. No significant dif-
ferences were observed between groups in 2 trials [19,21].
Observed differences between groups were noted in walk-
ing stamina by Kaae et al, 1989 [16] and found to be sig-
nificant in another trial (p < 0.05) [20]. In this trial, by
Patterson et al, 1995, walking speed (m/sec) changed
from a baseline mean of 1.28 (95% CI 1.18 to 1.38) to
1.41 (95% CI 1.31 to 1.51) post intervention for the inter-
vention group and from 1.25 (95% CI 1.14 to 1.36) to
1.20 (95% CI 1.04 to 1.36) for the control group.
In addition, significant differences within interventions
groups within a trial were observed within 2 trials [17,18].
Sashika et al, 1996 [17] report significant (p < 0.05) mean
changes from 60.1 m/min to 63.6 m/min for group 1
(Table 1), and from 64.4 m/min to 69 m/min for group 2.
Control group changes (non significant) were slower
throughout from 57.4 m/min to 58.7 m/min. Jan et al,
2004 [18] report significant results for all forms of walk-
ing measured within the high compliance subgroup.
However, within the exercise group as a whole, significant
pre and post intervention differences (p < 0.05) were
present for fast walking on level ground (pre intervention
mean 86.8 m/min, SD 8.4 and post intervention mean
94.6 m/min, SD 16.8) and fast walking on grass (pre
intervention mean 77.7 m/min, SD 8.1 and post inter-
vention mean 84.4 m/min, SD 10.2). Free walking and
walking on spongy surfaces results were not significant
(personal communication).
Figure 2 presents the results of the quantitative analysis of
walking speeds. The top part presents the results for each
study for each measure considered, and for Sashika et al,
1996 [17] it shows the results of splitting the treatment
group (as reported in the publication) as well as that of
pooling it. The next part of the figure shows the summa-
rised effect within each study (where appropriate). It is
these four effects which are the subject of the meta-analy-
sis. We have assumed that the correlation between each
measure within each study was 0.8. The final part of the
figure presents our summary values from the meta-analy-
sis. The top one is for a correlation of 0.8 and the other
two represent our sensitivity analysis assuming correla-
tions of 0.2 or 0.5. As can be seen the substantive conclu-
sion is similar but the smaller the within study correlation
the more striking the overall summary appears and we
have therefore chosen the more conservative value for our
presentation.
Range of joint motion (4 trials, 134 participants)
Range of motion was used as an outcome measure in four
trials [16,17,19,21]. Johnsson et al, 1998 [21] measured
passive hip flexion, extension defect, abduction and
adduction. Nyberg and Kreuter, 2002 [19] measured pas-
sive hip flexion, extension, abduction and internal rota-
Page 10 of 14
tion using a goniometer for all measurements. Kaae et al,
1989 [16] provide few details regarding measurement.
Sashika et al, 1996 [17] evaluated hip range of motion
finding that hip flexion did not improve significantly
within any groups. No significant differences between
groups for hip joint range of motion were reported in the
remaining three trials [16,19,21] and the lack of reported
data prevented a useful meta-analytic summary.
Muscle strength (6 trials, 207 participants)
Muscle strength was used as an outcome measure in six
trials [16-18,21-23] and, once again, methodologies var-
ied. Isometric quadriceps muscle force measurements,
measured using dynamometry, were obtained by Suetta et
al, 2004 [22], who used a maximal voluntary contraction
approach, and Sashika et al, 1996 [17], who measured hip
abductor maximal isometric torque. Johnsson et al, 1998
[21] also measured isometric muscle strength, of hip flex-
ors, extensors, abductors and adductors and knee exten-
sors and flexors, but used a different approach
incorporating a strain gauge. Jan et al, 2004 [18] again
used dynamometry, this time to measure isokinetic hip
abductor, flexor and extensor muscle strength. Trudelle-
Jackson and Smith, 2004 [23], used a BEP-IIIa force trans-
ducer and measured hip flexor, hip extensor, hip abductor
and knee extensor muscle strength via a "make test".
Finally both Kaae et al, 1989 [16] and Sashika et al, 1996
[17] used manual muscle testing.
In summary, no differences between groups were
observed in 2 studies [16,21]. Statistically significant dif-
ferences (p < 0.05) between and within groups were
observed in one study [22]. Baseline quadriceps isometric
strength mean values (operated leg) were 122.9 Nm (SE
17.2) for the intervention group and 119.2 (SE 15.9) for
the standard rehabilitation group. At 12 weeks these val-
ues had changed to 119.2 Nm (SE 17.8) for the interven-
tion group and 117.4 (SE 13.8) for the standard group.
Between group significant differences (p < 0.05) were also
present for vastus lateralis mean average voltages, using
EMG, again in favour of the intervention group. Within
group significant differences were also observed within
Meta-analytic summary for walking speed Figure 2
Meta-analytic summary for walking speed. Figure provides standardised effect sizes plus 95% confidence intervals.
CI SES 95%
Study (original data)
Jan - level free
Jan - level fast
Jan - grass free
Jan - grass fast
Jan - sponge free
Nyberg self speed
Nyberg max speed
Patterson
Sashika group 1
Sashika group 2
Sashika groups 1 and 2
Study (summarised)
Patterson
Nyberg
Jan
Summary, r=0.8
Summary, r=0.2
Summary, r=0.5
0.47
1.03
0.72
1.19
0.55
-0.35
-0.36
1.03
0.44
0.89
0.71
1.03
0.71
-0.35
0.64
0.42
0.51
0.47
-0.09
0.44
0.15
0.59
-0.01
-1.05
-1.06
0.04
-0.60
-0.19
-0.22
0.04
-0.22
-1.02
0.12
0.07
0.25
0.15
1.02
1.61
1.29
1.78
1.11
0.36
0.34
2.02
1.49
1.98
1.64
2.02
1.64
0.31
1.16
0.77
0.78
0.79
1 -1 -0.5 0 0.5 1.5 2
Page 11 of 14
the intervention group for contractile rapid force develop-
ment (2645% increase p < 0.05) and contractile impulse
(2732% p < 0.05).
In addition, statistically significant differences, within
intervention groups, were observed in 2 studies [18,23].
Trudelle-Jackson and Smith, 2004 [23] report muscle
strength (Nm) percentage change from baseline to post
intervention. Within the intervention group, hip flexors =
24.4%, hip extensors = 47.8, hip abductors = 41.2% and
knee extensors = 23.4%; all statistically significant
changes (p < 0.05) which demonstrated improved muscle
strength. Whereas no significant differences occurred
within the control group; hip flexors = 7.2% change, hip
extensors = 3.6%, hip abductors = 3.3% and knee exten-
sors = 1%. Jan et al (2004) [18] demonstrated hip abduc-
tor, flexor and extensor muscle strength (operated side) to
be significantly different (p <0.05) between pre and post
intervention time points within the exercise group but not
within the control group (personal communication). Hip
abductor mean values were 53.5 Nm (SD 18.4) pre
intervention and 59.9 (SD 18.2) post intervention for
the intervention group and 55.7 (SD 17.7) and 52 (SD
21) for the control group. Hip flexor strength was 49.2
Nm (SD 19.2) pre intervention and 54.5 (SD 17) post
intervention within the intervention group and 54.2 (SD
22.5) and 50.8 (SD 21.2) within the control group.
Hip extensor mean values were 71.4 Nm (SD 23.4) pre
intervention and 76.1 (SD 24.9) post intervention for
the intervention group and 74.8 (SD 31.1) and 72.5 (SD
24.2) for the control group. When the results were fur-
ther broken down to reflect high and low compliance sub-
groups [18], both operated and non operated sides
demonstrated significantly different pre and post inter-
vention values within the intervention group.
Figure 3 presents the results of the quantitative analysis of
hip abductor muscle strength for studies including suffi-
cient data. The summary suggests that physiotherapy exer-
cise shows promise in increasing hip abductor strength for
this patient group. There were insufficient studies includ-
ing hip extensor and hip flexor strength to make meta-
analytic summaries useful for these muscle groups.
Quality of Life (1 trial, 55 participants)
A 0100 mm visual analogue scale to measure quality of
life was used in one trial [19]. No significant differences
between the groups were demonstrated.
Discussion
Summary of principal findings
This systematic review finds that it is not yet possible to
establish the extent to which post discharge physiotherapy
exercise is effective, in terms of improving function, qual-
ity of life, mobility, range of hip joint motion and muscle
strength, for osteoarthritic patients following elective pri-
mary unilateral total hip arthroplasty. The diversity and
lack of available trials plus the unsatisfactory quality of
existing trials prevent a definitive answer at this time. Tri-
als provided mixed results and it would also be wrong to
conclude at this time that post discharge physiotherapy is
ineffective, especially since the meta-analytic summaries
of the data indicate promising potential benefit.
Strengths and weaknesses of review procedures
The reviewers believe the search strategy to be comprehen-
sive and to have been successful in locating relevant trials
for inclusion in the review. Physiotherapy literature
remains a difficult area to search, with numerous biblio-
graphic data bases and un-indexed journals [44] and
while every attempt was made to identify studies it is pos-
sible other studies exist. However, this review remains the
most comprehensive to date. The two non English lan-
Meta-analytic summary for hip abductor muscle strength Figure 3
Meta-analytic summary for hip abductor muscle strength. Figure provides standardised effect sizes plus 95% confi-
dence intervals.
-0.5 0 0.5 1
CI SES 95%
Study
Jan
Johnsson 6 months
0.40
0.66
0.35
-0.16
-0.09
-0.56
0.95
1.42
1.26
Summary 0.46 0.061 0.86
Page 12 of 14
guage trials identified in the literature search were profes-
sionally translated to allow full inclusion and to prevent
the introduction of language bias [45,46].
The quality of trials was mixed and generally poor. The tri-
als included in the review spanned nearly thirty years and
it was noticeable that the more recent trials reported nec-
essary information more clearly and comprehensively
than trials published many years previously. This may not
be a reflection on the quality of earlier trials as such, rather
it may be that reporting habits and editorial requirements
have altered and improved over recent years, particularly
since the introduction of the CONSORT statement. Simi-
larly, more recent trials were more likely to justify their
sample sizes and comment upon the power of their stud-
ies than earlier ones. The literature search for this review
included trials up to April 2007 and is considered up to
date.
There were no apparent problems with the data extraction
processes used in this review. Although many quality
checklists and scales exist, there is no accepted "gold
standard" score; component approaches are often pre-
ferred since the wide variety of scores and weighting sys-
tems available mean that the same trial may score as both
high quality and low quality depending on which score is
used [15]. Additionally, many scoring systems downgrade
the quality rating of a trial if it is not double blinded. For
many physiotherapy trials, such as those in this review, it
is inevitable that patients and therapists know whether
they are receiving the physiotherapy intervention or the
control and this is not an indication of low/high trial
quality. For these reasons, as previously [14], we used a
component approach although we accept this is a contro-
versial area of debate.
The independent reviewers showed good percentage
agreement with each other and moderate agreements
when using Cohen's kappa [47] and the Intraclass Corre-
lation Coefficient [48]. This level of initial agreement was
considered acceptable since interpretation of some check-
list items, such as generalisability and overall evidence,
can be subjective. Following discussion both reviewers
were in full agreement for all items for all papers.
Where possible, a comprehensive description of trials
interventions has been presented for the majority of trials
(additional file 2). It was not possible to obtain such
details for all trials, particularly early trials where it was
not possible to track down author contact details. As is
often the case with physiotherapy trials [49], the studies
are small with 282 participants in eight studies. The
number of available studies, and their size and quality,
does limit this review. It is perhaps surprising that so few
published trials exist for such a common and longstand-
ing area of physiotherapy practice. This would seem to be
partially attributable to the general lack of rehabilitation
research undertaken on orthopaedic surgery patients post
discharge, rather than hip replacement patients per se,
since a recent search for knee replacement trials by the
authors revealed a similar lack of trials [14].
It was not possible to include pain as a main outcome in
this review since the studies identified in this review did
not tend to measure pain as a specific outcome. This does
not mean that pain is considered unimportant. Some
available functional measures include a pain subscale
while others, such as the Oxford hip score, include pain as
a component within the score. The influence of pain on
the performance of objective measures also needs to be
considered. However, the means by which pain is meas-
ured may, as in this review, make pain difficult to explore
systematically across studies.
We have tried to summarise the data fully, using meta-
analytic summaries where the data enabled us to do so
appropriately [24] (Figures 2, 3). These figures are
intended to helpfully summarise the data only; we
emphasise that the mixed quality and diversity of trials in
this review prevented explanatory meta-analyses from
being undertaken, since the results would risk being mis-
leading or erroneous, and we do not intend these figures
to be interpreted in this way.
Clinical implications
This review cannot remove the current uncertainty regard-
ing post discharge physiotherapy for this patient group,
although it is useful in summarising the current available
research, in highlighting the lack of existing evidence and
demonstrating the need for such evidence to be obtained.
Commissioning organisations, health care practitioners
and patients still lack conclusive evidence regarding effec-
tiveness when deciding whether to provide/attend post
discharge physiotherapy following elective primary hip
replacement for osteoarthritis. A systematic review includ-
ing meta-analyses for a similar question following knee
replacement [14] provided support for the use of physio-
therapy functional exercise interventions following dis-
charge to obtain short term benefit to patients following
elective primary knee arthroplasty. Whilst differences
between suitable activities and rehabilitation following
joint replacement are recognised for knee and hip
patients, many similarities remain [9] and these results
contribute to the argument for further trials for hip
replacement patients being necessary.
Future directions
The three trials incorporating home exercise programmes
[17,23,23] demonstrated pre-post intervention differ-
ences within the intervention groups but not in the con-
Page 13 of 14
trols. These trials were for participants who had had their
hip replacements some time previously rather than for
people recently discharged from hospital. Trials compar-
ing differences between groups would be valuable. As
would research to explore the optimum time-point at
which to offer any additional post discharge physiother-
apy exercise intervention to patients. The trials which
included out-patient individual or group training follow-
ing discharge tended to report between group differences
with generally negative results [16,19,21] however the
temptation to count up the number of these negative tri-
als, rather than await future high quality trials, should be
avoided. Across the entire body of hip replacement
knowledge, research indicates that hip replacement
patients experience persistent functional and physical lim-
itations at least one year post-operatively [8] when many
follow up studies cease obtaining outcome data. Whether
physiotherapy exercise post discharge can reduce such
limitations therefore remains an important question to
adequately address. Recent research indicates that tradi-
tional physiotherapy following lower limb joint replace-
ment, consisting of range of joint motion and isometric
muscle strengthening exercises plus transfer and gait/
walking aid practice, may also be less effective than pro-
grammes incorporating a more functional, weight bearing
approach to rehabilitation [7,23,50]. We believe it is both
timely and necessary for well conducted clinical trials
investigating the effectiveness of physiotherapy exercise
interventions following discharge after elective primary
total hip replacement surgery to take place for this com-
mon area of clinical practice.
Conclusion
In conclusion, insufficient evidence currently exists to
establish the effectiveness of physiotherapy exercise fol-
lowing primary hip replacement for osteoarthritis. Further
well designed trials are required to determine the value of
post discharge exercise following this common surgical
procedure.
Competing interests
The authors declare that they have no competing interests.
Authors' contributions
CJML lead and designed the review, carried out searches
and eligibility checks, reviewed and extracted data, per-
formed qualitative analysis and drafted the manuscript.
KB assisted in designing the review, served as a blind
reviewer, extracted data, performed qualitative analysis
and commented upon the draft manuscript. MED
designed and carried out the quantitative data analysis
and commented upon the draft manuscript. CMS assisted
in designing the review, eligibility checking, and com-
mented upon the draft manuscript.
All authors read and approved the final manuscript.
Additional material
Acknowledgements
We thank Margareta Kreuter, Birgitta Nyberg, Charlotte Suetta, Elaine
Trudelle-Jackson and Pei-Fang Tang, for providing additional data for the
review. We also thank Vibeke Pilmark for her assistance in locating the
paper by Kaae et al, 1989.
C J Minns Lowe is funded by a Nursing and Allied Health Professional
Researcher Development Award, from the NIHR. C M Sackley is funded by
a Primary Care Career Scientist Award from the NIHR. All authors state
this research has been carried out independently and has not been influ-
enced in any way by the research funders.
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Additional file 1
Study Characteristics of the Trials Evaluated in the Systematic Review
(n = 8). Table summarising the study characteristics of the trials included
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Click here for file
[http://www.biomedcentral.com/content/supplementary/1471-
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