The Structure of DNA: Thymine, T Adenine, A Guanine, G Cytosine, C
The Structure of DNA: Thymine, T Adenine, A Guanine, G Cytosine, C
The Structure of DNA: Thymine, T Adenine, A Guanine, G Cytosine, C
James Watson and Francis Crick worked out the structure of DNA in 1953. By using data from
other scientists they were able to build a model of DNA. The X-ray data they used showed that
DNA consists of two strands coiled into a double helix.
Base pairs
Each strand of DNA is made of chemicals called bases. Note that these are different to bases in
relation to acids and alkalis in chemistry. There are four different bases in DNA:
thymine, T
adenine, A
guanine, G
cytosine, C
There are chemical cross-links between the two strands in DNA, formed by pairs of bases. They
always pair up in a particular way, called complementary base pairing:
thymine pairs with adenine (T–A)
guanine pairs with cytosine (G–C)
Mitosis
In mammals, body cells are diploid. The chromosomes need to be copied exactly so that new
cells can be produced for:
growth
repair to damaged tissue
replacement of worn-out cells
The type of cell division involved is called mitosis. The diagram shows how it works.
Identical cells
Mitosis produces two genetically identical cells in which the number of chromosomes is the same
as in the original cell.
Meiosis
Meiosis is the type of cell division that produces gametes. A human body cell contains
46 chromosomes arranged in 23 pairs. Human gametes are haploid – so their nucleus only
contains a single set of 23 unpaired chromosomes.
The diagram shows the stages of meiosis.
Reduction division
Meiosis produces four genetically different haploid cells. Unlike mitosis, meiosis is a reduction
division – the chromosome number is halved from diploid (46 chromosomes in 23 pairs in
humans) to haploid (23 chromosomes in humans).
Mitosis Meiosis
Number of cells
produced 2 4
Chromosome
number Diploid Haploid
Mitosis Meiosis
Genetically
identical Yes No
Growth, repair,
Used for asexual Production of gametes
reproduction for sexual reproduction