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    JWSN Ari Reprt

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    Junrhey Ocampo
    The document presents results from a study that tested the ability of extracts and fractions from Geranium sibiricum to inhibit aldose reductase (AR) in rat lenses. It shows that the ethanol extract and chloroform, ethyl acetate, and trimethoprim fractions all demonstrated high AR inhibition at low concentrations, with IC50 values ranging from 0.27 to 0.43 μg/mL. The n-hexane and n-butanol fractions had slightly higher IC50 values of 0.43 and 0.38 μg/mL, respectively, indicating less potency in inhibiting AR.

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    JWSN Ari Reprt

    Uploaded by

    Junrhey Ocampo
    10 views3 pages
    The document presents results from a study that tested the ability of extracts and fractions from Geranium sibiricum to inhibit aldose reductase (AR) in rat lenses. It shows that the ethanol extract and chloroform, ethyl acetate, and trimethoprim fractions all demonstrated high AR inhibition at low concentrations, with IC50 values ranging from 0.27 to 0.43 μg/mL. The n-hexane and n-butanol fractions had slightly higher IC50 values of 0.43 and 0.38 μg/mL, respectively, indicating less potency in inhibiting AR.

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    Aldose Reductase

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    Jwsn Ari Reprt

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    The document presents results from a study that tested the ability of extracts and fractions from Geranium sibiricum to inhibit aldose reductase (AR) in rat lenses. It shows that the ethanol extract and chloroform, ethyl acetate, and trimethoprim fractions all demonstrated high AR inhibition at low concentrations, with IC50 values ranging from 0.27 to 0.43 μg/mL. The n-hexane and n-butanol fractions had slightly higher IC50 values of 0.43 and 0.38 μg/mL, respectively, indicating less potency in inhibiting AR.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    10 views3 pages

    JWSN Ari Reprt

    Uploaded by

    Junrhey Ocampo
    The document presents results from a study that tested the ability of extracts and fractions from Geranium sibiricum to inhibit aldose reductase (AR) in rat lenses. It shows that the ethanol extract and chloroform, ethyl acetate, and trimethoprim fractions all demonstrated high AR inhibition at low concentrations, with IC50 values ranging from 0.27 to 0.43 μg/mL. The n-hexane and n-butanol fractions had slightly higher IC50 values of 0.43 and 0.38 μg/mL, respectively, indicating less potency in inhibiting AR.

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    © All Rights Reserved
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    Download as docx, pdf, or txt
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    Table 1.

    IC50 of the EtOH extract and fractions from Geranium sibiricum on rat lens AR

    Concentration AR inhibitiona IC50b


    Samples
    (μg/mL) (%) (μg/mL)

    5 88.08

    EtOH ext. 1 83.46 0.28

    0.1 46.92

    5 73.08

    n-hexane fr. 1 56.54 0.43

    0.1 41.54

    10 90.38

    CHCl3 fr. 5 81.92 0.27

    1 49.62

    5 93.46

    EtOAc fr. 1 75.38 0.27

    0.1 54.23

    5 75.38

    n-BuOH fr. 1 55.77 0.38

    0.1 47.31

    10 99.62

    TMG c 1 67.31 0.31

    0.1 55.38

    a
    Inhibition rate was calculated as a percentage of the control value.

    b
    IC50 calculated from the least-squares regression line of the logarithmic concentrations plotted

    against the residual activity.


    c
    TMG was used as a positive control.

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