Scribd
Upload
958 views

ACTIVITY-14 Tablet Hardness

This document describes an experiment to test the hardness of tablets using a tablet hardness tester. Tablet hardness, or breaking force, is an important quality control measure that ensures tablets can withstand manufacturing and distribution stresses without breaking. The experiment involves using a hardness tester to apply increasing force to tablets placed between its platens until they fracture. Readings in kiloponds or newtons are recorded for 6 tablets and averaged. The results are used to monitor tablet strength specifications and make adjustments to the tableting machine if needed.

Uploaded by

daven
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as DOCX, PDF, TXT or read online on Scribd
958 views

ACTIVITY-14 Tablet Hardness

This document describes an experiment to test the hardness of tablets using a tablet hardness tester. Tablet hardness, or breaking force, is an important quality control measure that ensures tablets can withstand manufacturing and distribution stresses without breaking. The experiment involves using a hardness tester to apply increasing force to tablets placed between its platens until they fracture. Readings in kiloponds or newtons are recorded for 6 tablets and averaged. The results are used to monitor tablet strength specifications and make adjustments to the tableting machine if needed.

Uploaded by

daven
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as DOCX, PDF, TXT or read online on Scribd
You are on page 1/ 6

EXPERIMENT 14

TABLET HARDNESS

Tablets must be able to withstand the severities of handling and transportation


from the production, distribution, and in the consumer’s handling. Therefore, physical
strength of the tablets is of considerable importance and frequently monitored. This
tablet strength is checked and monitored in product development and quality control
specification. To check the integrity of tablets is to measure their breaking force or
commonly known as TABLET HARDNESS. To do this, the tablets are placed between
two platens, in which one platen moves to apply force to the tablet to cause fracture.

Tablet hardness testers are used to determine the hardness of tablets. These
measuring devices were typically hand-operated, such as the Stokes (Mosanto)
hardness tester thru a spring gauge and screw, Pfizer hardness tester resembled a pair
of pliers and Strong Cobb hardness tester thru the action of a small hydraulic pump.

Nowadays, hardness testers or breaking force testers are calibrated in kiloponds


or newtons. The conversion between these units is 1 kilopond (kp) = 1 kilogram-force
(kgf)= 9.80 N.

Like, any other equipment, hardness testers or breaking force testers are
calibrated periodically, annually or more frequently depending on the frequency of use,
using traceable counterweights.

In determining the average breaking force, a minimum of 6 tablet samples should


be tested. These values are also needed to determine the need for pressure
adjustments on the tableting machine. Hardness can affect the tablet disintegration. If
the tablet is too hard, it may not disintegrate.
FIGURE 9. Hardness Tester (Stokes Type)

FIGURE 10. Hardness Tester

OBJECTIVE : To be able to perform the in process quality control, tablet hardness


or tablet breaking force.

APPARATUS/ GLASSWARE : Hardness tester

MATERIALS/ SAMPLES : 10 Tablets


PROCEDURE

Note The following procedure is for the Figure 9b, Tablet hardness tester.

1. Turn the power switch to ON position, the indicator light, initialize


the tester for 20 minutes.
2. Place the tablet between the probe and the test plate.
3. Press the START button and probe move left automatically.
4. When the tested tablet is shattered, the displayed value come to
maximum and locked by the system, and beep sounds which
means the test is completed.
5. Record, and repeat step 2-5, until all tablets are tested.
6. If the tester has a printer, press the PRINT button, then the result
will print out.
7. Turn power switch to OFF position, the indicator is off, tester stop
working.
WORKSHEET

Name : _______________________________________ Date : _______________

Group No : _______________________________________ Score : _______________

EXPERIMENT 14

TABLET HARDNESS

DATA AND RESULT

Sample Tablet Hardness (N) Hardness (kgf)


1
2
3
4
5
6
7
8
9
10
Average

COMPUTATIONS:

CONCLUSION:
QUESTIONS:

1. Draw and describe each of the following Tablet Hardness Testers, the Stokes
Hardness Tester, Pfizer Hardness Tester and Strong Cobb Hardness Tester.
2. What are the importance of the tablet hardness test?

You might also like

pFad - Phonifier reborn

Pfad - The Proxy pFad of © 2024 Garber Painting. All rights reserved.

Note: This service is not intended for secure transactions such as banking, social media, email, or purchasing. Use at your own risk. We assume no liability whatsoever for broken pages.


Alternative Proxies:

Alternative Proxy

pFad Proxy

pFad v3 Proxy

pFad v4 Proxy