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    Comparison Histamine-2 Receptor Antagonist & Antacid

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    Rajesh Gupta
    Histamine-2 receptor antagonists like ranitidine work by blocking H2 receptors on parietal cells, inhibiting acid secretion. Their onset of action is slower than antacids but their effects last 10-12 hours, allowing once daily dosing. Common side effects include headache. Antacids neutralize gastric acid for rapid relief but effects don't last long as acid production resumes. They require frequent redosing as symptoms return. Studies show ranitidine provides better and faster relief of acid-related symptoms than antacids.

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    Comparison Histamine-2 Receptor Antagonist & Antacid

    Uploaded by

    Rajesh Gupta
    30 views5 pages
    Histamine-2 receptor antagonists like ranitidine work by blocking H2 receptors on parietal cells, inhibiting acid secretion. Their onset of action is slower than antacids but their effects last 10-12 hours, allowing once daily dosing. Common side effects include headache. Antacids neutralize gastric acid for rapid relief but effects don't last long as acid production resumes. They require frequent redosing as symptoms return. Studies show ranitidine provides better and faster relief of acid-related symptoms than antacids.

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    Comparison Histamine

    Original Title

    Comparison Histamine

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    Histamine-2 receptor antagonists like ranitidine work by blocking H2 receptors on parietal cells, inhibiting acid secretion. Their onset of action is slower than antacids but their effects last 10-12 hours, allowing once daily dosing. Common side effects include headache. Antacids neutralize gastric acid for rapid relief but effects don't last long as acid production resumes. They require frequent redosing as symptoms return. Studies show ranitidine provides better and faster relief of acid-related symptoms than antacids.

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    © All Rights Reserved
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    Download as docx, pdf, or txt
    30 views5 pages

    Comparison Histamine-2 Receptor Antagonist & Antacid

    Uploaded by

    Rajesh Gupta
    Histamine-2 receptor antagonists like ranitidine work by blocking H2 receptors on parietal cells, inhibiting acid secretion. Their onset of action is slower than antacids but their effects last 10-12 hours, allowing once daily dosing. Common side effects include headache. Antacids neutralize gastric acid for rapid relief but effects don't last long as acid production resumes. They require frequent redosing as symptoms return. Studies show ranitidine provides better and faster relief of acid-related symptoms than antacids.

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    Comparison Histamine-2 Receptor Antagonist &

    Antacid
    Histamine-2 Receptor Antagonist
     Their onset is slower than that of antacids, but their duration is
    longer.
     In large heartburn studies the earliest onset of symptom relief
    occurs around 30 minutes and peak effects are 1-1.5 hours after
    treatment.
     The anti-secretory effect, even with low doses, is prolonged and
    lasts for around 10-12 hours. This means dosing frequency compared
    to antacids can be reduced and many subjects require only one dose
    per day.

    Antacid
     Acid in the oesophagus and stomach may be partly or completely
    neutralised for rapid relief of symptoms but further gastric acid
    production will occur and may be stimulated via a gastrin-mediated
    response to a rise in gastric pH.
     The consumption of further food will contribute to the termination
    of activity as gastric acid production is stimulated.
     By virtue of their mode of action, antacids cannot be used to
    prevent symptoms associated with ‘trigger’ foods.
     For these reasons antacids require regular re-dosing as
    symptoms return.
    HISTAMINE-2 RECEPTOR
    ANTACIDS
    ANTAGONISTS
    (Magnesium Trisilicate)
    (Ranitidine)
    Mechanism of Inhibit acid secretion by Antacids can neutralize
    Action blocking H2 receptors on the gastric acid and reduce acid
    parietal cell delivery to the
    duodenum. They may also
    stimulate the defensive
    systems in the stomach by
    increasing bicarbonate and
    mucus secretion.
    Side Effects Side effects of H2RAs are Antacid side effects depend
    rare upon the quantity consumed
    and the duration of therapy.
    A common side effect
    associated with ranitidine is Magnesium-containing
    headache, occurring in about antacids cause diarrhea and
    3% of people who take it. hypermagnesemia; the latter
    only becomes important in
    Confusion: Rare cases of patients with renal
    reversible confusion have insufficiency.
    been associated with
    ranitidine; usually elderly or Long-term, excessive use has
    severely ill patients, or in been associated with the
    patients with renal or hepatic development of silica-based
    impairment. renal calculi.

    Hepatic effects: Elevation in


    ALT levels has occurred with
    higher doses (≥100 mg) or
    prolonged IV therapy (≥5
    days); monitor ALT levels
    daily for the remainder of
    treatment.

    Vitamin B12 deficiency:


    Prolonged treatment (≥2
    years) may lead to vitamin
    B12 malabsorption and
    subsequent vitamin
    B12 deficiency

    Rebound acid hypersecretion


    has been reported after
    discontinuation of therapy.
    Special Relief of symptoms does not May alter absorption of other
    Precautions preclude the presence of a drugs, therefore
    gastric malignancy. antacids, tetracyclines or iron
    salts should be given 1-2
    hours apart.
    Use with caution in patients
    with hepatic impairment At high dosage, magnesium
    (ranitidine undergoes hepatic salts not only
    metabolism). cause diarrhoea but also
    Ranitidine is primarily possible CNS depression.
    excreted renally; dosage
    adjustment is recommended Magnesium trisilicate mixture
    in patients with renal has a sodium content of 6.4
    impairment. mmol equivalent to 73.4
    mg/5 ml or 147mg/10 ml
    dose. This must be taken into
    consideration for patients on
    a controlled sodium diet.
    Used with caution in patients
    with fluid retention

    There is a risk of metabolic


    alkalosis when oral
    magnesium salts are given
    with polystyrene
    sulphonate resins.
    Effectiveness Hotz et al, 1994
     With ranitidine, acid-related as well as general
    dyspeptic symptoms disappeared in a significantly higher
    percentage after two and four weeks compared with antacid.
     Complete disappearance of symptoms was
    documented with ranitidine after two weeks in 37% and
    after four weeks in 66% compared with antacid in 13% and
    30% respectively (p < 0.005).
     Patients with severe symptoms, history of ulcer and
    long-term dyspepsia and slight endoscopic changes in the
    upper gastrointestinal tract showed a significant faster and
    more distinct response. Both kinds of treatment were well
    tolerated

    References
    1. https://www.uptodate.com.
    2. http://www.kck.usm.my/husm/pharmacy/formulary/5.htm
    #5a
    3. https://www.uspharmacist.com/article/updates-in-
    nonprescription-therapy-for-heartburn-and-gerd
    4. https://www.ncbi.nlm.nih.gov/pubmed/8164599
    5. http://selfcarejournal.com/article/self-care-of-heartburn/
    6. https://www.drugs.com/ppa/ranitidine.htm
    7. https://www.medicines.org.uk/emc/medicine/25289
    8. http://www.nytimes.com/health/guides/disease/gastroesop
    hageal-reflux-disease/medications.html
    Posted by AskUsAtDis at 4:01 PM
    Email ThisBlogThis!Share to TwitterShare to FacebookShare to Pinterest
    Labels: Indication, others
    1 comment:
    1.

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