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    2623 2014 1 S154

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    deepika
    This document contains exam questions for a pharmacy practice course focusing on pharmacokinetics and therapeutic drug monitoring. The exam consists of long essays, short essays, and short answer questions on topics related to pharmacokinetics modeling, protein binding, methods for measuring drug concentrations, factors affecting drug distribution, criteria for therapeutic drug monitoring, and kinetics of orally and intravenously administered drugs. Students are asked to define key terms, describe models and kinetics, discuss clinical significance, and provide examples of concepts like therapeutic monitoring of carbamazepine.

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    2623 2014 1 S154

    Uploaded by

    deepika
    50 views1 page
    This document contains exam questions for a pharmacy practice course focusing on pharmacokinetics and therapeutic drug monitoring. The exam consists of long essays, short essays, and short answer questions on topics related to pharmacokinetics modeling, protein binding, methods for measuring drug concentrations, factors affecting drug distribution, criteria for therapeutic drug monitoring, and kinetics of orally and intravenously administered drugs. Students are asked to define key terms, describe models and kinetics, discuss clinical significance, and provide examples of concepts like therapeutic monitoring of carbamazepine.

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    Rguhs previous year question paper

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    2623_2014_1_S154

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    This document contains exam questions for a pharmacy practice course focusing on pharmacokinetics and therapeutic drug monitoring. The exam consists of long essays, short essays, and short answer questions on topics related to pharmacokinetics modeling, protein binding, methods for measuring drug concentrations, factors affecting drug distribution, criteria for therapeutic drug monitoring, and kinetics of orally and intravenously administered drugs. Students are asked to define key terms, describe models and kinetics, discuss clinical significance, and provide examples of concepts like therapeutic monitoring of carbamazepine.

    Copyright:

    © All Rights Reserved
    Download as DOC, PDF, TXT or read online from Scribd
    Download as doc, pdf, or txt
    50 views1 page

    2623 2014 1 S154

    Uploaded by

    deepika
    This document contains exam questions for a pharmacy practice course focusing on pharmacokinetics and therapeutic drug monitoring. The exam consists of long essays, short essays, and short answer questions on topics related to pharmacokinetics modeling, protein binding, methods for measuring drug concentrations, factors affecting drug distribution, criteria for therapeutic drug monitoring, and kinetics of orally and intravenously administered drugs. Students are asked to define key terms, describe models and kinetics, discuss clinical significance, and provide examples of concepts like therapeutic monitoring of carbamazepine.

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    Rajiv Gandhi University of Health Sciences, Karnataka


    IV Year B.Pharm Degree Examination - Jan 2014
    Time: Three Hours Max. Marks: 70 Marks

    PHARMACY PRACTICE – II (RS-3)


    a. Pharmacokinetics and therapeutic Drug Monitoring

    Q.P. CODE: 2623


    Your answers should be specific to the questions asked
    Draw neat labeled diagrams wherever necessary

    LONG ESSAYS (Answer any Two) 2 x 10 = 20 Marks


    1. Discuss the mono-exponential decline with the help of graphs and equations for a drug
    administered as i.v. bolus following one compartment model.
    2. Explain in detail protein binding, its kinetics and clinical significance.
    3. Discuss the various methods that can be used for plasma/serum concentration measurement in
    TDM.

    SHORT ESSAYS (Answer any Six) 6 x 5 = 30 Marks


    4. What do you understand by a model? Give the differences between compartment and non-
    compartment model.
    5. Explain the factors affecting distribution.
    6. Give the schematic diagram, graph and bi-exponential equation for a drug following two
    compartment model.
    7. Explain the need for adjusting the dose in patients with hepatic impairment.
    8. Give the criteria for a valid TDM.
    9. Explain briefly the TDM of carbamazepine.
    10. Write a short note on physiological model.
    11. Discuss the kinetics of drugs (metabolized) given as i.v. bolus following one compartment
    model when urine samples are collected.

    SHORT ANSWERS 10 x 2 = 20 Marks


    12. Define TDM.
    13. Explain the organization of a TDM service.
    14. Define AUC and give the formula to calculate the same.
    15. Give the schematic representation differentiating two compartment model from three
    compartment model.
    16. Write brief note on patient compliance.
    17. What are the consequences of multiple dosing? Give the formula for accumulating index and
    Css.
    18. Give the relationship between clearance and volume of distribution.
    19. How do you calculate absorption rate constant. Enumerate the methods.
    20. What are the advantages of pharmacokinetic models? Explain.
    21. Explain briefly the kinetics of a drug administered orally following one compartment model.
    *****

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