Chemistry Qoustions (M.SC)

Total No. of Questions :6] SEAT No.
:
P1922 [5323]-1001
[Total No. of Pages : 3
M.Sc.
PHYSICAL CHEMISTRY
CHP - 110 : Fundamentals of Physical Chemistry - I
(2013 Pattern) (Semester - I) (Credit System) (Old 5 Credits)
Time : 3 Hours] [Max. Marks : 50

Instructions to the candidates:
1) Answers to the two sections should be written in separate answer books.
2) All questions are compulsory.
3) Figures to the right side indicate full marks.
4) Use of logarithmic table/calculator is allowed.
5) Neat diagrams must be drawn wherever necessary.
[5323]-1001 1 P.T.O.
SECTION - I
Q1) Attempt the following: [10]
a) Give the relation between Gibbs free energy and the equilibrium constant.
Explain its significance.
b) Show that, Cv,m = 3R using equipartition theorem where Cv,m is molar

specific heat and R is the gas constant.
c) What is the physical significance of Δ G?
d) Sketch wavefunctions and probability densities for a particle in one

dimensional box upto n=4.
e) Give the expression for rotational partition function and explain the terms
involved.
Q2) Attempt any two of the following: [10]
a) Explain the experimental evidence for Heisenburgs uncertainty principle.
b) What are colligative properties? Derive the expression for elevation in

boiling point.
c) Explain Bose-Einstein statistics.
d) What is meant by zero point energy? Write a note on simple harmonic

oscillator.
Q3) Solve any one of the following [5]
a) The moment of inertia of oxygen molecule is 1.9373×1046 kg.m2.

Calculate its rotational partition function at 30ºc and 1 bar.
b) When Lithium is irradiated with light of wavelength 250 nm, the

photoelectrons ejected have kinetic energy 3.0×1019J. Calculate the
threshold frequency of metallic lithium.
[5323]-1001 2
SECTION - II
a) For a general reaction, 2A+B → 3C, write the rate law expression.
b) For a given enzyme catalyzed reaction, reaction rate constant of formation

of product is 1.32×103 s1 and initial concentration of enzyme is 0.35
M. Evaluate Vmax.
c) State the principle of microscopic reversibility.
d) Explain the term steric factor.
e) What is steady state approximation.

a) Derive the rate expression for the third order reaction with equal initial
concentration of reactants.
b) Write the postulates of collision theory of biomolecular reactions and
show that k = ZAB .e− Ea /RΓ .P.
c) Write short note on Lineweaver - Burk plot.
d) For a given first order opposed reaction, A R B show that,
xe ⎡ x ⎤
kA = .In ⎢ e ⎥ where, a=initial concentration of A; x =equilibrium
a.t ⎣ xe − x ⎦ e
concentration and x=amount of A consumed at time t.
Q6) Solve any one of the following. [5]

a) Calculate the frequency factor for a reaction having a rate constant 4.0×107
units at 227ºc, if the energy of activation is 100 kJmol1.
b) In a reaction, the decrease in reactant concentration is 15% in 15 minutes
and 30% in 30 minutes. Calculate the order of reaction and rate constant.
[5323]-1001 3
Total No. of Questions : 6] SEAT No. :
P1923 [Total No. of Pages : 2
[5323]-1002
M.Sc. - I
INORGANIC CHEMISTRY
CHI - 130 : Molecular Symmetry and Chemistry of P- Block Elements
(2013 Pattern) (Old - 5 Credit) (Semester - I)

2) Answers to the two sections must be written in separate answer books.
4) Use of logarithmic tables and calculators is allowed.
SECTION - I
Q1) Answer the following. [10]
a) Define symmety operation and symmetry elements.
b) List out the symmetry elements of chlorobenzene and its point group.
c) What is an abelian group? Illustrate with example.
d) Find the order of group and number of classcs in PCl5.
e) Give all associative operations in S6 axis.
Q2) Attempt any two of the following. [10]
a) Give the matrices for C2z and σ hxy . Find out its product. Give metrix for
improper axis of rotation.
b) Derive the character table for C2V point group.
c) Explain all symmetry elements of NH3.
d) For H2O moleule, E, C22 ,σ vxz ,σ vyz are the symmetry elements. Divide
them into appropriate classes using similarity transfromation.
1 P.T.O.
[5323]-1002
Q3) Attempt any one of the following. [5]
a) Find out normalized SALC using projection operator E1 operates on σ 1
orbital of CO32− .
D3h E 2C3 3Cz σh 2σ 3 3σ v
E1 2 1 0 2 1 0
b) Fill in the missing entries in the following table. Justify answer.
D2 E C2z C2x C2y
- 1 1 1 1
A2 - 1 1 1
- 1 - 1 1
B2 1 - 1 1
SECTION - II
a) Give the classification of boron hydrides with examples.
b) The alkali metal solutions in ammanic are good reducing agents why?
c) What is inorganic benzene? Give its reactions.
d) Hydrosilylation reaction.
e) What are carbides?
Q5) Attempt any two of the following.

a) Write a note on fullerene and its metal complexes. [10]
b) Oxyacids of sulphur.
c) What are phosphonitrilic compands? How they are prepared? Give their
applications.
d) Write a note on aluminositricates.
Q6) Complete the following reactions. [5]

a) LiAlH 4 +SiCl4 ⎯⎯
→?
b) SiH 4 +4RO 4 ⎯⎯
→ ?+ 4H 2 ↑
c) CH 2 =CH 2 +SiH 4 ⎯⎯
→
d) 4LiH+SiCl 4 ⎯⎯
→ 4LiCl+?
e) 3 NH 4 Cl+BCl3 ⎯⎯ ⎯→ ?
C 6 H 5 Cl
µ µ µ
[5323]-1002 2
Total No. of Questions : 6] SEAT No :
P 1924 [5323]-1003
[Total No. of Pages :4
M.Sc. - I
ORGANIC CHEMISTRY
CHO - 150 : Organic Reaction Mechanism and Stereochemistry
(2013 Pattern) (Semester-I)

2) Figures to the right indicate full marks.
SECTION-I
Q1) Attempt any three of the following: [9]
a) Discuss carbene and its reactivity.
b) Assign E/z configurational labels to the following compounds.
i)
ii)
c) Label the stereocentres and calculate the no. of stereoisomers in the

following
i)
ii)
d) Assign P/S configurational labels to the following.
i)
ii)
[5323]-1003 1 P.T.O.
Q2) Explain the following (any four): [8]
a) Factors affecting basicity.
b) Stereo selective reactions.
c) Pyrolytic elimination.
d) Vilsmeier - Haak reaction.
e) Inclusion compounds.
Q3) Solve any four of the following: [8]

a) Assign ‘Si’ and ‘Re’ faces in the following.
b) Comment on the optical activity of the following compound.
c) Convert Fischer projection to Newman projection as shown.
d) Assign Pro-R and Pro-S labels to HA and HB.
i) ii)
e) Give the stereochemical relationship between the following compounds.
i) ii)
[5323]-1003 2
SECTION-II
a) Describe in brief hydrogenation of aromatic rings.
b) What is SRNI mechanism? Explain with suitable example.
c) Trans-2-chlorocyclohexanol gives epoxy cyclohexane in high yield on

reaction with a base, how ever the cis-isomer does not react this way.
Explain.
d) Explain hyperconjugation with suitable example.
e) Give examples of ambident nucleo phile.
Q5) Suggest the mechanism (Any four): [8]
a)
b)
c)
d)
e)
[5323]-1003 3
Q6) Predict the products any four: [8]
a)
b)
c)
d)
e)

[5323]-1003 4
Total No. of Questions :6] SEAT No. :
P1925 [5323]-1004
M.Sc.-I
CHEMISTRY
CHA-190 : Safety in Chemical Laboratory and Good Laboratory
Practices
(2013 Pattern) (Semester-I) (Old 5 Credit)
1) Answer to the two sections should be written in seperate answer books.
3) Neat diagram must be drawn wherever necessary.
SECTION-I
Q1) Attempt the following : [10]
a) Define allergen and give its two examples.
b) Give the importance of material safety data sheet.
c) What is the first aid for contact of chemicals on skin and eyes.
d) Mention the objective of fire drill.
e) What is the role of eye wash unit and safety shoes.
Q2) Answer any two of the following : [10]

a) Explain in brief Good House Keeping.
b) Write a note on globally harmonized system for safety data sheet.
c) Give an brief account of safety in chemical laboratory.
d) Write a note on personnel protective equipments.
Q3) Answer any one of the following : [5]

a) Enlist the various hazards and explain any one of it in detail.
b) Write a note on different types of fire extinguisher.
[5323]-1004 1 P.T.O.
SECTION-II
a) What are the safety measures for mercury spillage.
b) Define fire and give its types.
c) What is stock register forchemicals?
d) Comment on losses in accidents.
e) Define Hazardous and non hazardous waste.

a) Write a short note on inventory management.
b) Explain ISO and NABL accreditation.
c) Define the laboratory standards and explain the identification of Hazards.
d) Explain Instrument validation and reagent certification.

a) What is mixed waste? Explain the method for its disposal.
b) What is SOP? Explain its implementation in chemical laboratory.
iiii
[5323]-1004 2
P1880 [5323]-101
M.Sc.
PHYSICAL CHEMISTRY
CHP - 110 : Fundamentals of physical Chemistry - I
(2014 Pattern) (Semester - I) (New) (4 - Credits)
4) Use of Logarithmic table / calculator is allowed.
Physico - Chemical Constants

1. Avogadro Number N = 6.022 × 1023 mol1
2. Boltzmann Constant k = 1.38 × 1016 erg K1 molecule1
= 1.38 × 1023 J K1 molecule1
3. Planck Constant h = 6.626 × 1027 erg s
= 6.626 × 10-34 J s
4. Electronic Charge e = 4.803 × 1010 esu
= 1.602 × 1019C
5. l eV = 23.06 k cal mol1
= 1.602 × 1012 erg
= 1.602 × 1019J
= 8065.5 cm1
6. Gas Constant R = 8.314 × 107 erg K1 mol1
= 8.314 J K1 mol1
= 1.987 cal K1 mol1
7. Faraday Constant F = 96487 C equiv1
8. Speed of light c = 2.997 × 1010 cm s1
= 2.997 × 108 m s1
9. 1 cal = 4.184 × 107 erg
= 4.184 J
10. 1 amu = 1.673 × 1027 kg
11. Bohr magneton β e = 9.274 × 1024 J T1
12. Nuclear magneton β n = 5.051 × 1027 J T1
13. Mass of an electron me = 9.11 × 1031 kg
[5323]-101 1 P.T.O.
SECTION - I
a) Enthalpy can not be the criteria for spontanity? Discuss briefly.
b) What are state and path functions?
c) Show that dA = Pdv SdT, where A is Helmholtzs function.
d) Classical mechanics predicts specific heat of monoatomic solids is

constant for all temperature. Explain.
e) Write clausius clapeyron equation and explain the terms there in.
a) Derive the general form of maxwells equations. How change in entropy

(ΔS) can be obtained from Maxwells relation?
b) What is meant by partial molar quantities? Derive Gibbs-Duhem equation.
c) What are the experimental observations made in black body radiation

experiment? Show that concept of quantization of light explain them
correctly.
d) Discuss Gibbs free energy change during mixing of two ideal gases.
Q3) Solve any one of the following: [5]
a) Calculate the velocity of an ejected electron by a photon of wavelength

300 nm from a metal surface with work function 2.56 eV.
b) A sample of methane gas (4.5 g) occupies 17.16 dm3 at 360 K.
i) Calculate work done when it expands isothermally against external

pressure of 200 Ton until the volume is increased to 20.37 dm3.
ii) Calculate the work done if same expansion occurs reversibly.
[5323]-101 2
SECTION - II
Q4) Write the following: [10]
a) Give Eyring equation and meaning of each terms involved in it.
b) What are diffusion controlled reactions?
c) Explain steady state approximation.
d) Define fast reaction. Give two examples of it.
e) Define partition function.
Q5) Solve any two of the following: [10]

a) Explain pre-equilibrium reaction. Derive the expression for enzyme
catalysis reaction.
b) Show that:
Reaction rate = k (CH 3 CHO) 3/2 for thermal decomposition of
acetaldehyde CH 3CHO U CH 4 + CO using following mechanism
CH 3CHO → CH 3 + CHO (chain initiation)

< <
CH 3 + CH 3CHO
<
→ CH 4 + CH 3CO ⎫ <
⎬ (chain propogation)
CH 3CO <
→ CO + CH 3 ⎭ <
CH 3 + CH 3 → C2 H 6 (chain termination)
< <
c) Obtain an expression for translational partition function in case of rigid

diatomic molecule.
d) Explain primary salt effect. Derive an expression for dependence of
reaction rate on ionic strength.
Q6) Solve any one: [5]

a) The moment of inertia of a rigid diatomic molecule is 4.7 × 10 kg.m2.
47
Calculate rotational partition function (Given 6 = 1) at 300 K.

b) In a first order reaction, reactant is reduced to one half in 50 sec. In how
much time will it be reduced to one tenth.
zzz
[5323]-101 3
P 1881 [5323]-102
M.Sc. - I
INORGANIC CHEMISTRY
CHI-130 : Molecular Symmetry and Chemistry of P-Block Elements
(2014 Pattern) (Semester - I) (4 Credit System)

SECTION - I
Q1) Answer the following: [10]
a) Define centre of inversion. Illustrate using example.
b) List out symmetry elements of SO2Cl2 and find its point group.
c) What are commutative symmetry operations? Illustrate using suitable
example.
d) Give all associative operations of S3.
e) Draw the planes of symmetry of C6H6 molecule.

a) Explain all the symmetry elements of CH4 and classify it into appropriate
point group.
b) Give symmetry elements of NH3 molecule and divide them into classes
using similarity transformation.
c) Derive the character table for trans - 1, 2 - dichloroethylene.
d) Define improper axis of rotation. Prove that 6Q K = ( using suitable example.
[5323]-102 1 P.T.O.
Q3) Attempt any one of the following: [5]
a) Find out normalized SALC using projection operator B1 operates on φ2

orbital No2 ion:
C2V E &] σ 9;= σ 9<=
B 1 1 1 1
b) Find out reducible representation in [Fe(CO)s] considering sigma bond

as basis of representation and find out the orbitals offered for sigma
banding by iron. [Given character table]
SECTION-II
a) Write short notes on metal complexes of fullerene.
b) What are silicones? Give their two reactions.
c) Give classification of hydrides with examples.
d) Alkali metals in ammonia acts as reducing agents. Explain.
e) Discuss graphite intercalation compounds.
a) Write a note on zeolites and molecular sieves. Give advantages of zeolites.
b) What is borazole? How it is obtained? Why it is called as inorganic

benzene?
c) Give an account of oxoanions of sulphur.
d) Give an account of nitrogen activation.
[5323]-102 2
Q6) Draw the structures of following: [5]
a) [B6H6]2
b) Si2O76
c) N2O 4
d) S2N 2
e) B3N3H3Cl3
f) P 4O 10
Given : Character table for D3h point graph:

D3h E 2C3 3C2 σh 2S3 3σV
$′ 1 1 1 1 1 1 x2 + y2, z2
$ ′ 1 1 1 1 1 1 Rz
(′ 2 1 0 2 1 0 (X,Y) (x2 y2, xy)
$′′ 1 1 1 1 1 1
$ ′′ 1 1 1 1 1 1 z
(′′ 2 1 0 2 1 0 (Rx,Ry) (xz,yz)
O O O
[5323]-102 3
P1882 [5323]-103
M.Sc. - I
ORGANIC CHEMISTRY
CHO - 150 : Basic Organic Chemistry
(2014 Pattern) (Semester - I) (4 - Credits)
SECTION - I
a) Discuss in brief stereoselective reactions.
b) Why indene and fluorene are acidic?
c) What is the concept of antiaromaticity?
d) Cyclohexane does not exist in planner form. Give reason.
e) What is the conecpt of NGP?
Q2) Attempt any five of the following: [10]
a) Discuss the structure and stability of carbene.
b) Chlorobenzene resist hydrolysis where as, benzyl choloride undergoes

hydrolysis. Explain.
c) Comment on the stability of the following.
[5323]-103 1 P.T.O.
d) Discuss the acidity of the following
e) Comment on the optical activity of biphenyls.

f) 3-hydroxy-2-butanone on reduction with sodium borohydride gives meso
compound. Explain.
Q3) Attempt any five of the following: [10]

a) Comment on the basicity of the following.
b) Assign E/Z configuration of the following.
c) Describe the stereochemistry of the product formed by the reaction of

maleic acid with osmium tetraoxide.
d) Assign R/S labels to the chiral carbons.
e) Write the equivalent structures.
[5323]-103 2
f) Make the conversion from Newmann projection into Fischer projection
and assign the configuration at each Chiral Centres.
SECTION - II
a) Describe regioselectivity in ambident nucleophile.
b) Write any one reaction involving SET mechanism.
c) Explain hydrolysis of 2-bromopropionic acid.
d) What is SN2 reaction?
e) Benzyne intermediate. Explain.
Q5) Suggest the mechanism (any five) : [10]
a)
b)
c)
d)
[5323]-103 3
e)
f)
g)
Q6) Predict the products (any five) : [10]
a)
b)
c)
d)
e)
[5323]-103 4
f)
g)
zzz
[5323]-103 5
P1883 [5323]-104
M.Sc.-I
ANALYTICAL CHEMISTRY
CHA-190 : Safety in Chemical Laboratory and Good Laboratory
Practices
(2013 Pattern) (Semester-I) (Credit System) (4-Credits)
1) Answer to the two sections should be written in separate answer books.
4) Use of logarithmic table/non-programmable calculator is allowed.
SECTION-I
Q1) Answer the following : [10]
a) What is explosive hazard?
b) Describe eye wash unit.
c) Define -
i) Reactive chemicals
ii) Flammable chemicals
d) What are neurotoxins? Give any two examples.
e) What is microscale work?
Q2) Attempt any two of the following : [10]

a) Give the guidelines for chemical storage.
b) Explain in brief use of personnel protective equipment.
c) Describe the assessing route of exposure for toxic chemicals with respect
to inhalation.
d) Explain the flammability characteristics.
Q3) Attempt any one of the following : [5]

a) Explain the importance of chemical safety and security.
b) What are the chemical of concern? Explain the responsibility of CSSOs.
[5323]-104 1 P.T.O.
SECTION-II
a) State any four rules of good house keeping.
b) What are the different types o ∀ spillage?
c) Enlist the special safety measures for compressed gas.
d) What is waste?
e) Define :
i) GLP
ii) Chemical hygiene

a) Explain the general procedure for working with biohazard.
b) Explain the fundamental point of GLP.
c) Write a short note on mercury spillage of its safety measures.
d) What are the general guidelines for working with compressed gases.

a) Give a brief account of SOP and its approval procedure.
b) Explain-Dos and donts in chemical laboratory.
iiii
[5323]-104 2
P1926 [5323]-2001
M.Sc. - I
PHYSICAL CHEMISTRY
CHP - 210 : Fundamentals of Physical Chemistry - II
(2013 Pattern) (Semester - II) (5 - Credits)

= 1.38 × 1023 J K1 molecule1
= 6.626 × 10-34 J s
= 1.602 × 1019 C
5. l eV = 23.06 k cal mol1
= 1.602 × 1012 erg
= 1.602 × 1019 J
= 8065.5 cm1
= 8.314 J K1 mol1
= 1.987 cal K1 mol1
= 2.997 × 108 m s1
9. 1 cal = 4.184 × 107 erg
= 4.184 J
10. 1 amu = 1.673 × 1027 kg
[5323]-2001 1 P.T.O.
SECTION - I
a) Explain signal to noise ratio.
b) Distinguish between prolate and oblate symmetric top with examples.
c) Define:
i) Zero point energy
ii) Hot bands
d) Why linear triatomic molecules shows only three vibrational modes instead
of three.
e) Distinguish between Rayleigh scattering and Raman Scattering.
a) What is centrifugal distortion? Explain the effect of centrifugal distortion

on the rotational energy levels of a diatomic molecule.
b) Discuss the break down of Born-Oppenhiemer approximation.
c) Explain the rule of mutual exclusion and its converse. Describe the various
modes of vibration of CO2 molecule.
d) State franck condon principle and write a brief note on dissociation

energy and dissociation products.
a) What is the value of B for H 37Cl if the rotational constant of H 35Cl is
10.5909 cm1?
b) The spectrum of HCl shows a fundamental absorption at 2886 cm1,

and first overtone at 5668 cm1. Evaluate equilibrium vibrational frequency
and force constant.
[5323]-2001 2
SECTION - II
a) Sketch the plane (100) in simple cubic cell.
b) What is self and tracer diffusion?
c) Write any secular determinant for ethylene molecule.
d) Define the term Curie and Becquerel (Bq).
e) Give preparation of 14C and 137I radioisotopes.

a) Discuss the principle of isotope dilution analysis. How it is used to
determine the volume of blood in patient?
b) Discuss main assumptions of Huckel theory.
c) Describe how the x-rays are used to determine the Crystal Structure.
d) Explain different applications of Neutron activation analysis.

a) Miller indices of the plane of a Crystal are 436. Calculate the intercept on
Crystallographic axes.
b) An isotope loses 9/10th of its activity in 23 hours. What is its half life and
mean life.
zzz
[5323]-2001 3
P 1927 [5323]-2002
M.Sc. - I
INORGANIC CHEMISTRY
CHI - 230 : Co-Ordination and Bioinorganic Chemistry
(2013 Pattern) (Semester-II) (Old) (5-Credit)

2) Answers to the two sections should be written in separate answer book.
4) Given: Atomic number: V = 23, Ce = 58, Co = 27, Mn = 25.
SECTION-I
a) Give the ground state term symbol for the following ions:
i) V3+
ii) Ce3+
b) Classify the following transitions as vibronically allowed, orbitally allowed
and forbidden in octahedral complex. Justify your answer. A1g → T1u,
A2g → A1g.
c) Which one of the following complex is more intense in colour? Why?
CiS Cu ( NH3 )4 Cl2  and Trans Cu ( NH3 )4 Cl2  .
d) What is meant by quenching of orbital magnetic moment? Explain why
Co ( H 2O )6  Cl2 complex exibit orbital contribution in their magnetic
moment. Justify your answer.
e) State Curie-Weiss law.
Q2) Answer any two of the following: [10]

2
a) Prepare the micro state table for np configuration and hence derive the
allowed R.S. term for the same.
5
b) D R.S. term is allowed for d4 configuration or M3+
n
ion. Find out how it
looses its degeneracy when  Mn ( H 2O )6  complex ion is formed.
3+
[5323]-2002 1 P.T.O.
c) Assign the spin multiplicities to the state arrising for e′t′2 configuration
infinitely strong tetrahedral field is relaxed to strong field using Bethe’s
method of desending symmetry, correlation table and direct product.
d) Write note on Nephelauxetic effect and Nephelanxetic series.
Q3) Answer any one of the following: [5]

a) An octahedral complex of Co(II) show three absorption bonds at 8450,
17900 and 19900 cm-1 respectively within∈ = 2.75, 8.2 and 5.8 lit mol-1 cm-1.
Calculate the spectrochemical parameter 10 Dq and Nephelauxetic
parameter B and β with the help of following data B° = 970 cm-1 for
Co(II) ion.
b) Calculate μeff for  Ni ( H 2 O )6  SO 4 complex. Given: λ = –320 cm-1,
Dq = 850 cm-1
SECTION-II
a) Explain the role of metal ions in Biological system.
b) Explain the term nucleoside and nucleotides.
c) What is Bleomycin? Explain its role in biology.
d) Explain the functioning of molybdenum-Binding co-factors.
e) Explain the term biomineralization with suitable example.

a) Explain the mechanism of cisplatin as anticancer drug.
b) Explain the concept of Irwing-Williams series.
c) Explain the structure and function of Calmodulin.
d) Write note on Model Complexes.
a) Match the following-
i) Haemoglobin 1) Co
ii) Cardiolyte 2) Fe
iii) Chlorophill 3) Tc
iv) Hydrolase 4) Mg
v) Vitamin B12 5) Zn
b) Draw the structures of following:
i) Enterobactin.
ii) Flavin.
iii) 3Fe - 4S.
iv) Cytosine.
v) Guanine.
[5323]-2002 2
[5323]-2002 3

[5323]-2002 4
[5323] - 2003
M.Sc. - I
ORGANIC CHEMISTRY
CHO - 250 : Synthetic Organic Chemistry and Spectroscopy
(2013 Pattern) (5 Credit) (Semester - II)
Time : 3 Hours] [Max. Marks :50

SECTION - I
Q1) Explain any five of the following. [10]
a) Baeyer - villiger rearrangement in preparation of acetutes.
b) Significance of witting - Horner - E mmons reaction.
c) The reduction of chiral carbonyl compounds with NaBH4 proceeds
without racemization.
d) Two methods for preparation of Nitrene.
e) Mechanism of swern oxidation.
f) Synthetic applications of organocopper and organomagnesium
compounds.
Q2) Attempt any five of the following. [10]

a) Curtius rearrangemnet.
b) Use of SeO2 in organic synthesis.
c) Epoxidation reactions.
d) Grignard reagent.
e) Nitrogen ylides.
f) Claisen rearrangement.
[5323] -2003 1 P.T.O.
Q3) Predict the product is and suggest the mechanism any two of the following:[5]
a)
b)
c)
d)
SECTION - II

a) Calculate λ max for the following compounds.
b) Distinguish the following compounds by IR spectroscopy.
[5323] -2003 2
c) Write a note on chemical shift.
d) Explain the genesis of the following ions in the given compound.
e) Explain CDCl3 is used as solvent in CMR spectroscopy.
Q5) Deduce the structure of any five of the Following and Justify your answer.[10]
a) MF : C4M5O2N
UV : Featureless above 210 nm
IR : 2250, 1750 cm–1
PMR : δ : 3.5 (s, 10 mm)
3.8 (S, 15 mm)
b) MF : C7 H14 O
UV : Featurless above 220 nm
IR : 1720 cm–1
PMR : δ: 0.9 (t; 30mm)
1.6 (hex, 20 mm)
2.4 (t, 20 mm)
c) MF: C10 H15 N

IR : 1510, 1610 cm–1
PMR :δ: 2.48 (S, 6 mm)
2. 89 (S, 6 mm)
6.38 (bs, 2 mm)
7.27 (t, 1 mm)
d) MF : C8H8O2
UV : 250 - 265nm
IR : 2700 - 3000 (b), 1700, 1600, 1500, 920cm–1
PMR : δ: 3.5 (S, 12 mm)
7.2 (S, 30 mm)
12.3 (S, 6 mm)
[5323] -2003 3
e) MF : C9 H12 S
UV : 265 nm
IR : 1585, 1470 cm–1
PMR : δ: 1.2(d, J = 6H2, 36 mm)
3. 25 (Sep. J = 6H2, 6 mm)
7.25 (m, 30 mm)
f) MF : C5H10O
UV : 285 nm
IR : 1720 cm–1
PMR : δ: 1.05 (t, J = 6Hz, 30 mm)
2.40 (q, J = 6Hz, 20 mm)

a) How will you distinguish primary, secondary and tertiory alchols by PMR
Spectroscopy?
b) Deduce the structure of the following compound
MF : C6H10O
CMR : δ : 204(S)
36 (t, strong)
28 (t, strong)
24 (t)
c) Give the genesis of the following compound
m/z = 73, 57.

[5323] -2003 4
P1929 [Total No. of Pages :14
[5323] - 2004
M.Sc.
CHA - 290 : General Chemistry - II
(2013 Pattern) (Semester - II) (New 5 Credits)
Part - A - Modern Separation Methods and Hyphenated Techniques

(2.0 credits / 25 marks)
Part - B - Basic Biochemistry (4.0 Credits / 50 marks)
Part - C - Concept of Analytical Chemistry (2.0 credits / 25 marks)
Part - D - Industrial Methods of Analysis (2.0 credits / 25 marks)
Part - E - Organometallic and Inorganic Reaction Mechanism (2.0
credits / 25 Marks)
Part - F - Mathematics for Chemists (2.0 credits / 25 marks)
Part - G - Pericyclic, Photochemistry and Free radical reactions

1) All questions of respective section/part are compulsory.
2) Figures to right hand side indicate full marks.
3) Neat labelled diagrams must be drawn wherever necessary.
4) Use of log tables or /non-programmable calculator is allowed.
5) Students should attempt any two parts from Part A,C,D,E,F and G or full paper of
Basic Biochemistry (Part B).
6) Write the answers of two parts on separate answer books.
[5323] -2004 1 P.T.O.

PART - A
Modern Separation Methods and Hyphenated Techniques

a) Explain what is a metastable ion in mass spectrometry.
b) Explain the principle of size exclusion chromatography.
c) Differentiate between gradient elution and isocratic elution.
d) Give any two applications of mass spectrometry.
e) Give the expression for resolution of a chromatographic column and
explain the terms involved in it.

a) Write a short note on Inductively coupled plasma Mass spectrometry.
b) Explain the various carrier gases and columns used in Gas
chromatography.
c) Explain the stationary phases and mobile phases used in Normal phase
and Reverse Phase Chromatography.
d) Explain the principle and working of GCMS.
Q3) Answer any one of the following. [5]

a) Following data was abtained for a liquid chromatographic column:
Length of packing = 24.7 cm
Flow Rate = 0.313 mL/min
Vm = 1.37 mL
Vs = 0.164 mL
Compound tR(min) W(min)
Nonretained 3.1
A 13.3 1.07
B 14.1 1.16
[5323] -2004 2
Calculate for components A and B
i) Resolution
ii) Selectivity factor
iii) Plate height for the column
b) Explain the principle, construction and working of Thermal conductivity

Detector used in Gas chromatography.
[5323] -2004 3
Total No. of Questions :6]
P1929
[5323] - 2004
M.Sc. - I
CHEMISTRY
CHA - 290 (B) : Basic Biochemistry
(2013 Pattern) (Semester - II) (5 Credit)
PART - B
Basic Biochemistry

2) Answer to both the sections should be solved in separate answer sheets.
SECTION - I
a) Explain the importance of biochemistry in pharmaceutical science.
b) Enlist the different sub cellular components of eukaryotes and explain

any one.
c) Classify proteins with suitable example.
d) Explain biological role of different types of fatty acids.
[5323] -2004 4
Q2) Answer any two of the following. [8]
a) How carbohydrates are classified? Give the structure and metabolim of

complex carbohydrate with example.
b) What are the difference between globular and fibrous protein explain
with example.
c) Explain the mechanism of glucose transport through membrane.
Q3) Write short notes on any four of the following: [8]
a) Drug transport.
b) Amino acid theraphy.
c) Structure of starch and chitin.
d) Lysosomes and peroxisomes.
e) Active and passive transport.
f) Essential and non essential amino acids.
SECTION - II
Q4) Answer any three of the following. [9]
a) What is DNA damage? Explain any one mechanism of DNA repair.
b) Enlist the different types of enzyme inhibition, explain any one of it.
c) What is Rho dependent and Rho independent of termination of

transcription?
d) Explain the flow of genetic information.
[5323] -2004 5
a) What are the factors affecting enzyme activity? Describe the effect of
substrate concentration on enzyme activity.
b) Classify vitamins, enlist water soluble vitamins with their deficiency

diseases.
c) Describe translation process in prokaryotes.
Q6) Write short notes on any four of the following: [8]
a) Types of vitamins B
b) Therapeutic uses of enzymes.
c) Effect of temperature on the rate of enzyme reaction.

d) DNA recombination.
e) Structure of A, B and Z form of DNA.
f) Role of penicillin acylase for the production of 6-APA.
[5323] -2004 6
PART - C
Concept of Analytical Chemistry
a) Define the terms.
i) Stationary Phase
ii) Mobile Phase
b) What are the steps involoved in obtaining a laboratory sample.
c) If the results of an analysis are 40.98g compared with the accepted true
value of 41.32g. What is the elative error in parts per thousand?
d) Give any two applications of nano - materials.
e) Give the principle of separation by distillation.
a) Explain the Q test of significance with an example.
b) Explain the principle of separation of ions by ion exchange chromatography

technique. Give their classification with examples of each type.
c) What is propogation of errors? Explain the terms absolute variance and

relative variance.
d) Explain the following terms:
i) Significant figures.
ii) Micro-analysis
iii) Trace constituents
iv) Random sample
v) Gross sample
[5323] -2004 7
a) The tin and zinc contents of a brass sample are analyzed with the following
results.
Zn : 33.27, 33.37 and 33.34% and Sn = 0.022, 0.025 and 0.026%
Calculate the standard deviation and coefficient of variation for each

analysis.
b) Explain solid phase extraction with the help of neat labelled diagram.
[5323] -2004 8
PART - D
Industrial Methods of Analysis

a) Enlist different types of process analyzers.
b) Explain the term benefit of quality system.
c) How will you prepare 15 ppm, K+ solution from KCl.
[Given : mol. wt of KCl = 744gm]
d) Give any two types of quality standards for laboratory.
e) Define the following.
i) PPB
ii) PPM

a) Write a note on : Oxygen analyser.
b) Explain the terms mmole and gmole with suitable examples.
c) Explain the terms
i) Theortical yield
ii) Limiting reactant
d) What is acidic buffer? Explain the buffer action of acidic buffer with
suitable example.

a) What is chromatography? Explain the technique of gas chromatography.
b) From 0.290 gm of sample containing Ca, was dissolved in acid and Ca
was precipitate as ca-oxalate. The ppt was dissolved in dil. H2 SO4 and
solution was diluted to 100ml. An aliquot of 10ml was titrated with 0.025
N KMnO4 & gave burette reading . 7.1 ml calculate percentage of calcium.
[Given, At. wt:- Ca = 40, 0 = 16, C = 12]
Y
[5323] -2004 9
PART - E
Organometallic and Inorganic Reaction Mechanism

a) Determine the valence electron counts for the transition metals in the
following complexes.
i) Ni (CO)4
ii) [(η − C H ) CO]⊕
5
5 5 2
b) Define and give one example of oxidative addition reaction.

c) Give the rate law for dissociation reaction mechanism.
d) State, Ir(CO) Cl(PPh3)2 complex obeys 18e rule or not.
!
e) Predict the type of reaction.
o
||
H C − Mn(CO)5 + CO ⎯⎯
3
→ CH3 − C− Mn(CO)5

a) Explain formation of aldenyde by Hydroformylation process.
b) Write a note on - Trans effect.
c) Explain the bonding in metal - alkene compounds.
d) Write a note on - olefin metathesis.

a) Explain the role of IR spectroscopy in spectral analysis and
characterisation of organometallic compounds.
b) Draw the following structures.
i) Co2 (CO)8
ii) [(η 5 C5H5)2V(CO)]
iii) [Co(H)(N2)(PPh3)3]
iv) Fe(CO)5
v) Trans - Ir (CO)Cl (PEt3)2
Y
[5323] -2004 10
PART - F
Mathematics for Chemists

a) Define:
i) Square matrix
ii) Diagonal matrix
b) Enlist two rules about scalar multiplication
c) Give transpose of :-
⎡6 6 2⎤
i) ⎢ ⎥
⎣⎢3 2 1 ⎦⎥
⎡ −1 3 4⎤
⎢ ⎥
ii) ⎢7 0 5⎥
⎢
⎣2 3 −1⎥⎦
du
d) If μ. is a homogeneous function of x and y of degrees n, then and
∂x
∂y
dy are also homogeneous functions of degree n.
e) Define:
i) Node.
ii) Cusp.

a) Discuss any two differential equations in physical chemistry.
b) Differentiate the following functions w.r.t. x:
i) sin (2x + 7).
ii) tan2x.
[5323] -2004 11
c) Evaluate the following integrals.
i) ∫ x dx
8
−7
ii) x dx
2
d) Find the adjoint of the matrix A is
⎡1 1 3⎤
⎢ ⎥
A = ⎢0 1 −1⎥
⎢
⎣2 0 4 ⎥⎦

a) Discuss any two applications of Taylors theorem.
⎡1 2 ⎤ ⎡ −1 5 ⎤
b) If A = ⎢ ⎥, B = ⎢ ⎥ then prove that 5( A + B) = 5A + 5B.
⎣⎢3 4 ⎦⎥ ⎢⎣ 5 7 ⎦⎥
[5323] -2004 12
PART - G
Pericyclic, Photochemistry and Free radical reactions
Q1) Answer Any Three of the following. [9]

a) Write a note on photoisomerisation of Benzene.
b) Draw the co-relation diagram for photochemical cyclization of 1,3 -
butadiene to cyclobutene.
c) Explain with the help of FMO approach whether supra - supra
cycloadditon reaction between allylic anion and butadiene is thermally or
photochemically allowed.
d) Stability of free radicals.
Q2) a) Predict the product/s and explain the mechanism Any Two. [4]
i)
ii)
iii)
b) Answer any two of the following. [4]

i) Discuss the synthetic application of Barton reaction.
ii) What would be the configuration of the product of (2E, 4E) - Hexa
Thermal ring closure→ .
- 2, 4-diene ⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯
iii) Write a note on auto-oxidation.
[5323] -2004 13
Q3) a) Explain the mechanism for the following reaction Any Two. [4]
i)
ii)
iii)
b) Attempt any Two of the following. [4]

i) Explain with the help of FMO approach, whether suprafacial [1, 5]
- Sigmatropic H - Shift is thermally or photochmically allowed.
ii) Write the major product of reaction between 1-methyl cyclohexene
and HBr in presence of H2O2. Justify your answer.
iii) Write a short note on dimerization of butadiene.
[5323] -2004 14
P1884 [5323]-201
M.Sc. - I
PHYSICAL CHEMISTRY
CHP - 210 : Fundamentals of Physical Chemistry - II
(2014 Pattern) (Semester - II) (New 4 Credit)
4) Use of logarithmic table / calculator is allowed.
P.T.O.
SECTION - I
a) Explain the different factors affecting the intensities of spectral lines.
b) What are the criteria for a molecule to be microwave active? Give an
example.
c) State the rule of mutual exclusion.
d) What are the conditions for fluorescence?
e) Explain the term pre-dissociation.

a) Sketch the polarizability ellipsoid for fundamental vibrational modes of
CO2 molecule and explain its Raman activity.
b) Explain the Fortrat diagram for B′ < B′′ .
c) How does isotopic substitution help in determining the CO and CS bond
lengths in linear OCS molecule?
d) Explain the principle of NMR spectroscopy and give its applications.
Q3) Solve any one of the following : [5]

a) If the bond length of H2 is 0.07417 nm. What would be the position of
first three rotational Raman lines in the spectrum.
b) The equilibrium vibrational frequency and unharmonicity constant for
HI molecule are 2309.5 cm–1 and 0.0172 cm–1 respectively. Calculate the
fundamental and first overtone transition.
SECTION - II
a) What is design parameter? Give its significance.
b) Give the preparation of 22Na and 35S.
c) What is hydrated electron? Draw its structure.
d) Draw a graph showing effect of applied voltage on current pulse height
for detection and measurement of radioactivity.
e) Obtain energy released during the fission of 1 Kg 235U.
(1 eV = 1.6 × 10–19 J and 1 fission = 200 meV.)
[5323]-201 2
a) What are the various units for measurements of radiation energy? How
are they related with each other?
b) How Uranium and plutonium are recovered from spent fuel?
c) What is Fricke dosimetry? With appropriate reactions obtain the
G Fe3+ = 15.6 .
d) Discuss the principle of isotope dilution analysis. How it is used to

determine the volume of blood in patient?

a) A ruby weighing 0.5 gram was irradiated in a neutron flux of 1012 n cm–2 s–1.
for exactly 24 hour and 51Cr activity (t½ = 27.7d) counted immediately
thereafter. It was found to give 35000 c/s. Give that the σ for 50Cr to be
15.9 barn, the counting efficiency 10% and the 50Cr content of natural
chromium to be 4.35%. Find the chromium content of the ruby.
b) An isotope losses 9/10th of its activity in 23 hours. What is its half life
and mean life.

[5323]-201 3
P1885 [5323]-202
M.Sc.-I (Inorganic Chemistry)

CHI - 230 : COORDINATION AND BIOINORGANIC CHEMISTRY
(2014 Pattern) (Semester-II)
3) Neat and labelled diagrams must be drawn wherever necessary.
SECTION-I
a) Why is [Ti (H2O)6]37 purple in colour?
b) Give the statement of curie Law and Curie-Weiss Law.
c) Show that all octahedral complexes of Ni27 must be outer orbital
complexes.
d) Determine the ground state term for the following :
i) Gd 3+
ii) Co 3+
e) What is Zeeman effect?

a) Calculate number of microstates present in 3F term.
b) How would you account for the magnetic moments listed against each
of the following complexes :
i) Na 4 ⎡⎣ Co ( No 2 )6 ⎤⎦ μ = 1.88B.M.
ii) Cs ⎡⎣ Ti (So 4 )2 ⎤⎦ μ = 1.84B.M.
[5323]-202 1 P.T.O.
c) Classify the following transitions in the octahedral complex as orbitally
allowed, vibrionically allowed and forbidden transitions. Justify your answer:
i) E9 → E9
ii) A24 → T29
iii) A29 → T29
d) Calculate the degeneracy for :
i) 4
F
ii) t 429 e129

a) Write a short note on Tanabe-sugano diagrams.
b) i) Ni27 (oh) complex shows 15% increase in its observed magnetic
moment value. Calculate spin orbit coupling constant λ for Ni2T ion
using following data Dq = 850 cm1.
ii) What is spin-pairing energy?
SECTION-II
a) Give biological functions of the following elements : Co, Ca, K, Mo.
b) Why is iron suitable for redox processes in biological systems?
c) Give names of enzymes involved in mercury detoxification.
d) Give the Irwing-Williams series for divalent first row transition metal ions.
e) List two types of ion-channels.

a) Discuss the concept of tuning of redox potentials with respect to
bioinorgamic chemistry.
b) Write a short note on transferrin.
c) Give a detailed account of zinc finger proteins.
d) Discuss the structure and functions of copper type II proteins.
[5323]-202 2
Q6) Draw structures of (any 5): [5]
a) Aurinofin
b) Oxyhaemoglobin
c) Vitamin B12
d) Pterin
e) Uracil
f) 2Fe-2S cluster
[5323]-202 3
[5323]-202 4
[5323]-202 5
iiii
[5323]-202 6
[5323] - 203
M.Sc. - I
ORGANIC CHEMISTRY
CHO - 250 : Synthetic Organic Chemistry and Spectroscopy
(2014 Pattern) (4 Credit) (Semester - II)

3) Answers to the two sections to be written in separate answer book.
SECTION - I
Q1) Explain any Five of the following. [10]
a) Oxime of ethyl -methyl ketone gives two products on treatment with
H2SO4.
b) Uses of DIBAL in organic synthesis.
c) Organolithium reagent react with CO2 to produce Ketones, whereas
grignard reagent gives carboxylic acids.
d) Swern oxidation is preferred for oxidation of 2º alcohol over KMnO4.
e) Spiro Ketones are prepared by using rearrangement reactions.
f) Significance of the Wittig reaction.
Q2) Attempt any five of the following. [10]

a) Wilkinson’s catalyst.
b) Applications of MCPBA in organic synthesis.
c) Synthetic applications of nitrogen ylides.
d) Cope and Oxy - Cope rearrangement.
e) Organocopper reagent in organic synthesis.
f) Ozonolysis reactions.
[5323] -203 1 P.T.O.
Q3) Predict the product/s and suggest the mechanism for any two of the following:
[5]
a)
b)
c)
d)
SECTION - II

a) Calculate λ max for the following compounds.
i)
b) Write a note on CMR spectroscopy.

c) How will you monitor the following reaction sequence by IR and suggest
the reagent
[5323] -203 2
d) Explain the genesis of the following ions in the given compound.
e) Why ethyl acetoacetate shows IR bands at 3300, 1750, 1720, 1660 and
1620 cm–1?
Q5) Deduce the structure of any five of the Following using spectral data and
Justify your answer. [10]
a) C5H6O 2
UV : Featureless above 210 nm
IR : 1820 & 1770 cm–1
PMR : 1.95 δ (quin, J = 6Hz, 12 mm)
2.70 δ (t, J = 6Hz, 24 mm)
b) C 8H7 N
UV : 235 nm
IR : 2220, 1620 & 1510 cm–1
PMR : 2.4 δ (S, 15mm)
7.2 δ (d, J = 8Hz, 10 mm)
7.5 δ (d, J = 8Hz, 10 mm)
c) C4H7BrO2
UV : Transparent above 210 nm
IR : 3300 – 2700 & 1720 cm–1
PMR : 1.08 δ (t, J = 7Hz, 15 mm)
2. 07 δ (m, 10 mm)
4.23 δ (t, J = 7Hz, 5mm)
10.97 δ (S, exchangable with D2O, 5 mm)
d) C6H5NO
IR : 2720 & 1690 cm–1
PMR : 8.7 δ (d, J = 5.5 Hz, 10 mm)
7.3 δ (d, J = 5.5 Hz, 10 mm)
10.0 δ (S, 5 mm)
[5323] -203 3
e) C7H7Br
UV : 260 - 275 nm
IR : 1600, 1480, 880 & 780 cm–1
PMR : 2.35 δ (S, 21 mm)
7.02 δ (m, 14 mm)
7.30 δ (m, 14 mm)
f) C10H12
UV : < 210 nm
IR : 3300 & 2120 cm–1
PMR : 2.0 δ (s, 8 mm)
2.4 δ (t, 8 mm)
2.6 δ (S, 32 mm)

a) Give the genesis of the following compound.
m/z = 107, 79 & 77
b) Deduce the structure from the following CMR spectral data.

M.F. C3H7NO
CMR : 168 (s), 35 (t) & 22 (q).
c) Write a short note on ‘Coupling constant’.

[5323] -203 4
[5323] - 204
M.Sc. - I
CHA - 290 : General Chemistry
(2014 Pattern) (Semester - II) (New 4 Credits)
Part - A - Modern Separation Methods and Hyphenated Techniques

Part - B - Basic Biochemistry (4.0 Credits / 50 marks)
Part - C - Concept of Analytical Chemistry (2.0 credits / 25 marks)
Part - D - Industrial Methods of Analysis (2.0 credits / 25 marks)
Part - E - Organometallic and Inorganic Reaction Mechanism (2.0
credits / 25 Marks)
Part - F - Mathematics for Chemists (2.0 credits / 25 marks)
Part - G - Pericyclic, Photochemistry and Free radical reactions

1) All questions of the respective section/part are compulsory.
2) Figures to right hand side indicate full maks.
3) Neat diagramsmust be drawn wherever necessary.
5) Students should attempt any two parts from Part A,C,D,E,F and G or full paper of
Basic Biochemistry (Part B).
6) Write the answers of two parts in separate answer books.
[5323] -204 1 P.T.O.

PART - A
Modern Separation Methods and Hyphenated Techniques
Q1) Attempt the following. [10]

a) Define
i) Molecular ion peak
ii) Metastable ion
b) Give the applications of GLC.
c) How cis and trans isomers are identified using mass spectrometry?
d) State and explain size exclusion chromatography.
e) Distinguish between isocratic elution and gradient elution in HPLC.

a) Draw a schematic diagram of mass spectrometer and explain the working
of its essential components.
b) Describe the construction and working of FID.
c) Explain the mechanism involved in ion-pair chromatography.
d) Explain the Time of flight mass analyzer.

a) Enlist the different types of ionisation methods in MS. Explain any one
in detail.
b) A xylen chromatogram was obtained and recorded. The recorder speed
was 3.68cm/min. The gas flowrate was 50.0 ml/min. The retention time
for xylenc was 54.0cm and for the air it was 6.2 cm.
Calculate:
i) Uncorrected retention time in min.
ii) Uncorrected retention volume in ml.
iii) The adjusted retention time in min
iv) The adjusted retention volume in ml.
S S S
[5323] -204 2
PART - B
Basic Biochemistry

2) Answer to the two sections to be written in separeate answer books.
3) Draw diagrams wherever necessary.
SECTION - I
Q1) Answer any four of the following. [12]
a) Classify proteins based on their biological roles.
b) How aminoacid sequence in a protein is determined by Edman

dagradation?
c) Explain in brief fibrous proteins.
d) What is meant by active transport? How do Na+K+ pump operate in

membranes?
e) Compare and Contrast structural and functional properties of starch and

Glycogen.
Q2) Disuss any two of the following. [8]
a) Reactons of TCA cycle.
b) Quaternary structure of protein.
c) Essential and Non essential amino acids with structures.
[5323] -204 3
Q3) Explain the following terms. (any five) [5]
a) β- Oxidation.
b) Conjugated lipids.
c) Nonstandard aminoacids.
d) Nucleocytoplasmic Communication.
e) Drug transport.
f) Optical isomerism (in carbohydrates)
g) Glycolysis.
SECTION - II
Q4) Answer any four of the following. [12]
a) Give experimental evidences for semiconservative replication of DNA.
b) Explain the basic features of Genetic Code.
c) Discuss major components of balanced diet.
d) What are fat soluble vitamins? Add a note on visual cycle.
e) What is non competitive inhibition of enzyme? Discuss with suitable

example.
a) Give an account on protein synthesis. (Translation Process) in

prokaryotes.
b) Explain factors affecting rate of enzyme activity.
c) Write a note on different types of RNA With their structures & functions.
[5323] -204 4
Q6) Explain the following terms (any five) [5]
a) Active site of enzyme.
b) Okazaki fragments.
c) Cofactors.
d) Scurvy.
e) Transcription bubble.
f) Template DNA.
g) Exons.
S S S
[5323] -204 5
PART - C
Concept of Analytical Chemistry
a) Define term sampling and sample handling.
b) Give the procedure for sampling of metals and alloys.
c) What is F test?
d) What is determinate error?
e) What are the methods of improving column performance?
a) Explain addition and substration with suitable example.
b) What is least - squares method of calibration? Give its assumptions.
c) Describe the principles of separation by extraction.
d) Explain the term propagation of error with suitable example.
a) What is confidence limit? Explain tests of significance.
b) Calculate the uncertainty in the number of millimoles of chloride contained

in 250 ml of a sample. When three equal aliquots of 25ml are titrated with
silver nitrate gave the following results 36.78, 36.82 and 36.75 ml. The
molarity of AgNO3 solution is 0.1167 ± 0.0002M.
S S S
[5323] -204 6
PART - D
Industrial Methods of Analysis

a) Explain the term stability constant. List the factors affecting stability of
the complex.
b) Calculate the molar concentration of ethanol in an aqueous solution that
contains 2.30 grams of C2H5OH in 3.50 liter of solution.
(Molecular weight : C2H5OH = 46.07 g/mole)
c) What is buffer capacity of a buffer solution? Give examples of acidic
and basic buffer solutions.
d) Why H2S is employed in presence of dilute HCl in qualitative analysis of
II-group metal ions?
e) Explain theoretical yield and pratical yield.

a) What is solubility product? Explain any two applications of solubility
product in qualitaive analysis.
b) To a solution of 0.1 M ammonium hydroxide, a solution of 0.1M
ammonium chloride is added. Calculate hydroxyl ion concentration before
and after addition of ammonium chloride. (Kb = 1.8 ×105)
c) Explain the types of quality standards for chemical laboratories.
d) Explain cost and benefits of quality system.

a) Explain automatic chemical analyzer and automatic elemental analyzer.
b) A precipitate of lead sulphate is washed with 200 ml of distilled water.
Calculate how many milligrams of the precipitate will be lost in washing
operation.
(Molecular weight = 303.2, solubility Product = 2.2 × 106).
S S S
[5323] -204 7
PART - E
Organometallic and Inorganic Reaction Mechanism

a) Determine the number of metal-metal bonds in the following complex
which obey the 18 electron rule and draw the structure.
(CO) (η 5 C5H5) Fe(μCO)2Fe(η 5 C5H5) (CO)
b) Predict the type of reaction.
(η 5 C5H5)2 TaH3 ⎯⎯
→ (η 5C5H5)2TaH
c) What is Zeiglar-Natta polymerisation?
d) What is meant by inert and labile complex? Give suitable example.
e) DescribeTolman angle and its effect on dissociation of ligands.

a) Explain hydroformylation reaction in detail.
b) Explain the bonding in Π - ethylene complexes.
c) Write a note on trans effect.
d) Explain the difference in IR spectra of Mo(PF 3 ) 3 (CO) 3 versus
Mo(pme3)3(CO)3.

a) Write a short note on kinetic chelate effect.
b) Explain the formation of acetaldehyde by Wacker process.
S S S
[5323] -204 8
PART - F
Mathematics for Chemists

⎡1 2 ⎤ ⎡ ⎤ 2 1 ⎡5 1 ⎤
a) If A = ⎢ ⎥ B=⎢ ⎥ C = ⎢7 4 ⎥ then verify that A(B + C) = AB +
⎣3 4 ⎦ ⎣ 4 2⎦ ⎣ ⎦
AC.
b) Define:-
i) Point of inflexion
ii) Cusps.
c) Define and illustrate:
i) Unit matrix
ii) Vector matrix
d) Give derivatives of the following:-
i) Sec x
ii) ax
iii) cos x
iv) xn
v) tan x.
e) Give differential coefficients of the following w.r.t. x.
i) 10x
ii) 3x4

a) Differentiate the following functions w.r.t. x.
x2 + 2 x + 2
i) Y=
x−4
Sinx
ii) Y=
Cosx
b) What is the maxima and minima of a function of single independent
variable? Give the rules.
[5323] -204 9
c) With a suitable example explain the Taylor and McLaurin theorem.
d) Evaluate the following:-
tan x
i) ∫ sec x + tan x dx
ii) ∫ (x + x + 5 ) dx.
3

a) What are exact and inexact differentials? Give their applications in
thermodynamics.
b) Solve the linear equations by Cramers rule.
i) 2x 2y = 1, x + 2y = 2
ii) 3x + 4y = 27, 5x 3y = 16
S S S
[5323] -204 10
PART - G
Pericyclic, Photochemistry and Free radical reactions
Q1) Attempt any three of the following. [9]

a) Construct a correlation diagram for the conrotatary opening of the
cyclohexadiene to hexatriene. Predict whether these transformation are
allowed thermally or photochemically.
b) Give mechanism of Norrish Type II reaction with the help of gas phase
irradiation of 2 - pentanone.
c) Explain free radical arylation of aromatic rings.
d) Discuss the mechanism of claisen rearrangment.
Q2) a) Predict the product/s and explain (any two) [4]
i)
ii)
iii)
b) Explain any two of the following. [4]

i) Reaction of 6-bromo-1-hexene on heating with Bu3SnH and AIBN
gives mixture of 1 - hexene, methylcyclopentane and cyclohexane.
ii) Why [1.5] sigmatropic shift of hydrogen is thermally allowed process.
iii) Irradiation of O-xylene yields a mixture at m-xylene and p-xylene.
[5323] -204 11
Q3) a) Explain the mechanism for the following reaction (any two) [4]
i)
ii)
iii)
b) Write a short note on any two of the following. [4]

i) Telomerisation
ii) Paterno-Buchii reaction
iii) 1, 4, Photoaddition of benzene.
S S S
[5323] -204 12
P1888 [5323]-301
M.Sc.
PHYSICAL CHEMISTRY
CHP - 310 : Quantum Chemistry and Solid State Chemistry
(2013 Pattern) (Semester - III) (New)

1 P.T.O.
[5323]-301
SECTION - I
d2
a) Show that f ( x ) = 32 e 3x
is an eigenfunction of . What is the
dx 2
corresponding eigenvalue?
b) Write the condition for operator to be hermitian. Define the terms in it.
c) State the need of approximate methods in quantum chemistry.
d) Explain the following figures:-
i)
ii)
e) State the following operators linear or non linear, justify.
i) ∫ dx and
ii) exp
2
[5323]-301
a) Derive the expression for the first order correction to the wave function
for non-degenerate perturbation method.
b) Discuss the application of variation method to helium atom.
c) Construct the energy opearator for
i) H −2 ion and
ii) H2 molecule. Explain the terms involved in these.
d) Apply HMO theory to butadiene and hence calculate the magnitude of

the delocalisation energy.
a) State Whether each of the following entities is an operator or a function.

Justify.
i) ˆˆ
AB
ii) Âf ( x )
iii) f ( x )Â
iv) ˆ ˆ g (x )
f ( x )AB
v) ˆ f (x)
B̂A
b) Show that
∂2 ∂
2 (
3cos 2 θ − 1) + cot θ (3cos 2 θ − 1) = 6= 2 (3cos 2 θ − 1) .
∂θ ∂θ
3
[5323]-301
SECTION - II
a) Define Burgers circuit.
b) Give the classification of defects.
c) State the Bravais law in relation to the crystal growth.
d) What is nucleation? Write its equation in case of decomposition of a

single solid.
e) How does the McLeod and Pirani gauges measure the pressure of the
evolved gas?
a) Discuss the various rate laws for gas-solid reactions.
b) Explain the mechanism of crystal growth from vapour phase.

c) Explain the mechanism of the following solid-solid reactions
i) Agcl(s)+NaI(s) → AgI(s) + Nacl(s) .
ii) Cu(s)+Agcl(s) → Cucl(s) + Ag(s) .
d) Derive the expression for Frenkel defects in a crystal at a given

temperature.
a) Calculate the mean free time for an electron in a semiconductor crystal

having drift mobility 625 cm2/volt sec.
b) If 1 ev energy is required to move an atom from the crystals interior to

the surface, What is the proportion of vacancies present in the crystal at
1000K? At 500K?
Y
4
[5323]-301
[5323] - 302
M.Sc.
PHYSICAL CHEMISTRY
CHP-311: Nuclear, Radiation and Photo-Chemistry
(2013 Pattern) (Semester - III)
P.T.O.
SECTION-I
a) What are the properties of scintillator?
b) What is RBE and REM?
c) What is the role of H2SO4 in ceric sulphate dosimeter? Write the

expression for G(Ce3+).
d) Explain the role of moderator and coolant in reactor.
e) What is the role of Tl in NaI (Tl) scintillator?
a) Discuss the working of Li-drifted detector with schematic diagram.
b) Explain projectile acceleration & target preparation in PIXE.
c) Explain the general aspects of reactor design with suitable schematic

diagram.
d) Write the sequence of filling of nuclear orbitals. What is necessity of

proposing spin-orbital coupling?
a) Calculate the energies of the two peaks in the RBS spectrum corraspond
to 28Si and 65Cu assuming an incident 4He+ ions of 2 meV energy and a
scattering angle of 170o.
b) Calculate the thickness of Zn (Z=30 & A = 64) plate required to reduced

the level radiation from 1.4 Gy/min to 1.4 mGy/hr. Given: e = 0.211b/e

Density of Zn = 7.1 g/m3.
[5323]-302 2
SECTION-II
a) State Grotthuss-Draper’s law.
b) Define quantum efficiency.
c) Explain briefly the Uranyl Oxalate Actinometer.
d) What are primary and secondary photochemical processes?
e) Calculate the frequency of ultraviolet light having a wavelength of

1500 Å.
a) Discuss the types of electronic transitions in organic molecules. Explain

Kasha’s test for the identification of different transition in organic
molecules.
b) Discuss lifetimes of excited electronic states of atoms and molecules.

Give relation between the natural radiative lifetime and the oscillator
strength.
c) Explain the characteristics of fluorescence.
d) Explain with the help of derivation the photophysical kinetics of

unimolecular processes.
a) Explain the working of Ruby and Nd: YAG Laser.
b) A certain system absorbs 2.8 × 1016 quanta of light per second. At the
end of the 12 minutes, it is observed that 0.12 mole of the irradiated
substance was reacted. What is the quantum yield of the process?
EEE
[5323]-302 3
P 1890 [Total No. of Pages :3
[5323]-303
M.Sc. : PHYSICAL CHEMISTRY
CHP-312 :Physico-Chemical Methods of Analysis

4) Use of logarithmic tables and calculators is allowed.
[5323]-303 1 P.T.O.
SECTION-I
Q1) Answer precisely the following : [10]
a) What are X-rays ? Which is the useful region of X-ray for chemical
analysis?
b) Define the terms -

i) Binding energy
ii) Work function of spectrometer
iii) K.E. of ejected electron
iv) Fermi energy level.
c) What is the basic difference between DTA and DSC.

d) Write Duane - Hunt equation and explain the terms involved in it.
e) Draw a neat labeled diagram of an ESCA spectrometer.

a) Describe heat flux DSC instrument.
b) Discuss typical X-ray absorption spectra.
c) Write a note on spectral splitting.
d) Draw the energy level diagram for the sample and spectrometer used in
ESCA technique and explain the same.
a) The mass absorption coefficient of metal foil measured with CuKα is 50

Cm2/g. Calculate the thickness of metal foil that was found to transmit
45.8% of incident power beam of CuKα radiations. The density of metal
is 8.90 g/Cm2.
b) TGA of plaster of paris showed mass loss of about 6.5% of original
sample mass for complete dehydration of POP at about 100ºC. Determine
the number of water molecules present in POP
[Given : At. Wt. of Ca = 40, S=32, O = 16, H = 1]
[5323]-303 2
SECTION - II

a) State the principle of hydrodynamic voltammetry.
b) What is plasma ? State its types.
c) Give the mechanism of Chemiluminescence.
d) What is heavy - atom effect observed in photoluminescence?
e) What is controlled potential coulometry?
a) Discuss ‘S’ route and ‘T’ route mechanisms observed in

electrochemiluminescence.
b) With a neat labelled diagram, describe the construction and working of a

Plasma torch.
c) Explain the application of coulometry to perform neutralization titrations.

d) Write a note on cyclic voltammetry.
a) A current of 1.7A is passed through 300.0 ml of 0.16 M solution of

ZnSO4 for 230S with current efficiency of 90%. Find out the molarity of
Z n2 + after the deposition of Zn.
Assume the volume of solution remains constant during electrolysis.

[At.Wts : Zn = 65.4, S = 32, O = 16]
b) Potassium ferrocyanide (n=1) has a diffusion coefficient of 6.5 x 10-6

cm2s-1 during its oxidation in 0.1M KCl. It was used to measure the area
of a stationary disk electrode. At a scan rate of 100 mV/s the amedic
peak current for the oxidation of 1.0mM solution of potassium
ferrocyanide was 32 μA. Estimate the electrode area.

[5323]-303 3
P1891 [5323]-304
M.Sc.
PHYSICAL CHEMISTRY
CHP - 313: Polymer Chemistry

2) ALL questions are compulsory.
[5323]-304 1 P.T.O.
SECTION - I
Q1) Answer precisely the following. [10]
a) Define theta temperature.
b) Explain Deborah number.
c) Define glass transition temperature.
d) Explain creep phenomenon.
e) Define flory temperature.
a) Discuss the WLF equation and give its application.
b) Explain stress-strain curves at higher elongation in elastomers.
c) Discuss the Voigt mode of viscoelastic behaviour.
d) Give limitations of Hilderbrand theory.
Q3) Attempt any one of the following [5]
a) Write a note on membrane osmometry.
b) Explain the process of dissolution of a polymer.
[5323]-304 2
SECTION - II
a) Define viscosity and state the S1 unit of it.
b) What is meant by thermosetting polymer?

c) Define the term random degradation.
d) Define the term copolymerization.
e) Distinguish between homochain polymers and heterochain polymers.

a) Describe in detail the molecular forces and chemical bonding in polymers.
b) Describe sedimentation transport method to determine the molecular
weight of polymer.
c) Explain the conduction mechanism in conducting polymers.
d) Derive copolymer equation.
Q6) Answer any one of the following [5]

a) 210g of vinyl acetate and 50g of methyl acrylate copolymerize. Find the
polymer composition.
[monomer reactivity ratios: 0.23 and 1.68 respectively.
At. wts: c = 12, H = 1, cl = 35.5, 0 = 16]
b) Describe the process of vulcanization with suitable example.
S S S
[5323]-304 3
P1892 [5323]-305
M.Sc.
PHYSICAL CHEMISTRY
CHP - 314 : Modern Trends in Physical Chemistry
(2013 Pattern) (Optional) (Semester - III)

4) Use of logarithmic tables and calculator is allowed.
[5323]-305 1 P.T.O.
SECTION - I
Q1) Answer precisely the following. [10]
a) Explain the term the degree of freedom with examples.
b) Draw a neat labeled temperature - composition diagram for an ideal

mixture with component A more volatile than B.
c) Write charge balance for a solution of KCl.
d) Write mass balance on phosphate in 0.1 M NaH2PO4.
e) Write the proton condition for NaHS.
a) Describe experimental procedure for one component system.
b) What is meant by eutectic. Explain the temperature-composition phase

diagram for two immiscible solids.
c) Interprete the vapour pressure phase diagram for two component system.
d) Draw a logarithmic concentration diagram for 0.01M H2CO3.
⎡ Given : K = 4.47 × 10−7 , K = 5.62 × 10−11 ⎤

⎣⎢ a1 a2 ⎦⎥
a) The pH of 0.01 M solution of a salt succinic acid is 9.2. Find the fractions
of C6H6O4, C6 H 5O 4− and C6 H 4 O 24− .
⎡⎣ Given : K a1 = 6.45 × 10−5 , K a2 = 3.31× 10−6 ⎤⎦
b) Calculate pH and concentration of all the species in 0.1M CH3COONa

[Given : Ka = 1.8×105]
[5323]-305 2
SECTION - II
a) Define the term smart materials.
b) Write the abbey equation. Explain the terms involved in it.

c) What is edge effect?
d) Which are the principle images produced in SEM.
e) Define the term resolution and resolving power.

a) How are rubber like ceramics prepared.
b) Explain in brief the schottky emission electron gun.
c) Discuss the properties of nanoparticles.
d) Write a note on smart polymers.

a) Describe briefly electron beam lithography.
b) Give an account of scanning tunneling microscope.
S S S
[5323]-305 3
[5323] - 306
M.Sc. - II (Inorganic Chemistry)
CHI - 326 : ORGANOMETALLIC CHEMISTRY AND
HOMOGENEOUS CATALYSIS


a) Give the general features of homogeneous catalysis.
b) What are the prerequisite conditions for asymmetric catalysis?
c) List the various biphasic systems.
d) Which of the following complexes obey 18 e rule?
i) Fe2(Co)g
ii)
e) What is hapticity? Explain with example.

f) Define one angle and bite angle.
g) What are similarities between Suzuki and Heck couplling reaction.
h) List the different methods for the preparation of metal-carbonyl
compounds.
i) Why do transition metals acts as catalyst? Give two examples.
j) Comment on the therapeutic properties of.
i) Mercurochrome.
ii) Cisplatin.
[5323] - 306 1 P.T.O.

Q2) Attempt any TWO of the following: [10]
a) Give the systematic classification of σ -bonded transition metal

hydrocarbonyls.
b) Discuss Tollman catalytic cycle.
−2
c) Explain the γ (co ) band in the IR spectrum of ⎡⎣ Fe (co )4 ⎤⎦ is at about
1>90 cm1; whereas for Ni(co)4 it is about 2060 cm1.
d) Explain with the help of suitable example of the role of organometallic

compound as a protecting agent.
Q3) Attempt any TWO of the following: [10]
a) Give synthesis, bonding and properties of cyclobutadienes compounds.
b) What do you mean by Heck reaction? Explain the steps involved in

cyclopropanation reaction.
c) Give the typical reactions of (η 6 - arene ) - metal derivatives.
d) Give an account of the chemistry, structure and bonding of the π -alhyl

complexes of transition metals.
Q4) A) Write note on any one. [5]
a) Importance of chiral ligand in Asymmetric catalyst.
b) Fluxional behaviour of organometallics.
[5323] - 306 2
B) Complete the following reactions [5]
a)
b)
c)
d)
e)
[5323] - 306 3
[5323] - 307
M.Sc. - II
INORGANIC CHEMISTRY
CHI-330: Inorganic Reaction Mechanism, Photochemistry and
Magnetic Properties of Coordination Compounds
(2013 Pattern) (Semester - III) (4 Credit)
3) Use of calculator is allowed.
a) Four coordinated tetrahedral or square planer complexes reacts faster

than six coordinated octahedral complexes. Explain.
b) Thermodynamically stable complexes could be kinetically inert or labile.

Illustrate with suitable example.
c) How does following modifications affects the rate of substitution reactions

in square planer complexes.
i) Adding bulky subtituent to the cis ligand.
ii) Inoresing positive charge on metal complex.
d) Suggest the mechanism for following reaction.
[Co (NH3)5 SCN]2+  [Co(NH3)5 NCS]2+
e) List out the characterestics of outer sphere electron transfer reactions.
P.T.O.
f) Which of the following octahedral substitution reaction is faster? Why?
[NiCl (NH3)5]+ +H2O  [Ni (H2O) (NH3)5]2+ + Cl–
[NiCl (NH3)5]++NH3  [Ni (NH3)6]2+ + Cl–
g) List out the reactions coordinated ligands.
h) Describe the phenomenon of phosphorescence.
i) Find out the R.S. term symbol for Cr2+ & Cu2+
j) What do you mean by magnetically dilute and concentrated systems.
Q2) Answer the following: (Any Two) [10]
a) Differentiate between intimate and stoicheometric mechanism.
b) How isotope labelling technique is used in studying the kinetics and

mechanism of the reactions.
c) What is base hydrolysis? Explain with suitable example.
d) What do you mean by quenching of orbital angular momentum. Provide

explaination by VBT and CFT for the same.
Q3) Attempt the following: (Any Two) [10]
a) Discuss the mechanism of cis-trans isomerism in octahedral complexes

with suitable example.
b) Explain the nudeophilic behaviour of coordinated ligand.
c) Discuss the mechanism of inner sphere electron transfor reaction with

suitable example.
d) Predict the magnetic exchange which occurs via the 90o exchange pathway
in the system d1 - d1, d2 - d2, d3 - d3, d8 - d8, and d9 - d9.
[5323]-307 2
Q4) Write a note on (Any Two): [10]
a) Methyl migration and CO insertion reactions.
b) Applications of photochemic reactions of coordination compounds.
c) Complementary and Non complementary reactions.
d) Magnetic properties of mixed valence compounds.
EEE
[5323]-307 3
[5323]-308
M.Sc. - II
INORGANIC CHEMISTRY
CH1-331 : Physical Methods in Inorganic Chemistry
(2013 Pattern) (Semester - III) (Credit System)
2) Draw neat diagrams wherever necessary
4) Use of log tables and calculators is allowed.
a) Define quadrupole splitting.
b) Why XPS required Ultrahigh Vacuum (UHV) condition.

c) Predict the number of lines expected in ESR of •CD3 radical.
d) Which changes can be detected by DSC.
e) What is cyclic voltammetry.
f) Write the equation for calculating chemical shift in mössbauer

spectroscopy.
g) Draw the following planes in cubic cess [100] [110]
h) What is mean by non-isothermal thermogravimetry?
i) Calculate the number of atom present in BCC lattice.
j) Draw the Mössbauer spectrum for Fe2O3.
[5323]-308 1 P.T.O.
a) Calculate the interplanar spacing of a set of planes, if the angle for the
first order diffraction is 450. When X-rays of wavelength 1.54 A0 are
used.
b) Explain the cyclic voltammogram of benzene hexachloride.
c) Draw the ESR - spectrum for iso-propyl-alcohol.
d) Sodium chloride (Mol.wt.=58.5) and density (2.16 gmL-1) exists in FCC

lattices with unit cell edge 5.64 A0. The unit cell containt Four molecules.
Calculate Arogadros is number.

a) Explain the application of thermogravi-metry in evaluation of suitable
standard for the gravimetric estimation.
b) Explain the instrumental factors affecting on D>A curve.
c) Explain the principle; instrumentations of XPS.
d) Draw the structure of Fe 3 (CO) 12 with the help of Mossbauer

spectroscopy.
a) Spin-lattice relaxation in ESR spectroscopy.
b) Role of supporting electrolyte in CV.

c) Draw the DTA - curve for Mn(PH2O2)H2O.
d) Discuss the application of XPS.

[5323]-308 2
[5323] - 309
M.Sc. - II
INORGANIC CHEMISTRY
CHI - 332 : Bioinorganic and Inorganic Medicinal Chemistry
(2013 Pattern) (Credit System) (Semester - III)

3) Draw neat labelled diagrams wherever necessary.
a) What is the rate determining step in hydrolysis of CO2 catalyzed by

carboanhydrase?
b) Which element is present at the active centre of carboxy peptidase and

give an account of its role in biological system?
c) Why type-1 cu proteins are blue in color.
d) Name the naturally occuring organometallic enzyme. Which element is

present at the active site?
e) Define P-Cluster. Give its role.
f) What are Rieske profeins? Mention oxidation states of Fe centres.
g) What are structurally important components of Mo containing enzymes?
h) Draw the structure of Cu-PSTM and Cu-ASTM.
i) Name any four biological processes in which Fe-s proteins are involved.
j) Which element is present in SOD? Mention their roles in biological

processes.
[5323] -309 1 P.T.O.
a) Explain the following actions of alkyl cobalamin.
i) One electron redox reaction.
ii) Co-c band cleavage.
b) Write an account of zn- cataining enzymes.
c) Discuss the mechanistic aspects of the reactions of hydrolysis of CO2
catalyzed by carboanhydrase.
d) Explain in detail the model complexes of blue- copper proteins.
Q3) Answer any two of the follwoing: [10]

a) Give an account of therapeutic and diagnostic applications of
radiopharmaceuticals.
b) Mention the deficiency of vit - B12 and give an account of model
compounds of vit - B12.
c) Explain the model of pathway for reduction and accumulation of varadium.
d) Give the schematic diagram for the following types of reaction.
i) Biological oxidation of phenyl alanine in presence of Dopamine - β
- mono oxygenase.
ii) O2 production at a four Mn cluster.

a) Write note on
i) Galactose oxidase
ii) Ribonucleotide reductase.
b) Give the mechanism of how cu-PSTM is trapped inside the cell.
c) Write a note on
i) Antitumor agents
ii) MRI
d) Write a note on hypoxia imaging agants.
S S S
[5323] -309 2
[5323] - 310
M.Sc. - II
ORGANIC CHEMISTRY
CHO - 350 : Organic Reaction Mechanism

SECTION - I
a) Give synthetic applications of EAA.
b) Pyrrole on reaction with CHCl3 in aq. NaOH gives 2-Formyl pyrrole and
3-Chloropyridine. Explain.
c) Explain in brief the stork-enamine synthesis.
d) Give synthetic utility of nitrenes.
e) Explain anchimeric assistance involving π -bonds.
Q2) A) Suggest suitable mechanism in any three [6]

a)
b)
[5323] - 310 1 P.T.O.

c)
O
||
d) NaOH
PhCHO+CH3COCH3 ⎯⎯⎯→ Ph-CH=CH-C-CH=CH-Ph .
B) Write short notes on any two. [4]
a) Role of pyridoxal phosphate in nature.
b) Perkin condensation.
c) Benzoin condensation.
a) Michael reaction fails with o-phenylcinnamic ester. Explain.
b) Explain the use of thymine phosphate as an acyl anion equivalent.
SECTION - II
a) The peroxyester PhCH=CHCH2COOOCMe3 decomposes about 5000

times as rapid as t-butyl peroxyacetate. Explain.
b) Give synthetic applications of malonate ester.
c) Explain generation of free radicals using heat with suitable example.
d) List any two reactions involving enamine approach.
e) Give role of AIBN in organic radical chemistry.
[5323] - 310 2
Q5) A) Suggest the mechanism in any three. [6]
a)
b)
c)
d)
B) Answer any two of the following. [4]
a) Write short note on acyloin condensation.
b) Write a note on Sandmeyer Reaction.
c) Write a note on arylation of aromatic ring.
[5323] - 310 3
a) Irradiation of 2,2,5,5 - tetraphenylcyclohexanone gives two products.
Explain.
b) Compound A exists primarily in the dimeric form. Compound B exists
as a free radical even in the solid state. Explain.
[5323] - 310 4
P1898 [5323]-311
M.Sc. - II
ORGANIC CHEMISTRY
CHO-351: Spectroscopic Methods in Structure Determinations
(2013 Pattern) (Semester-III) (4-Credits)
2) Answer to the two sections to be written on two separate answer books.
SECTION-I
Q1) Answer any four of the following : [8]
a) Why CDCl3 gives triplet (1:1:1) in 13CNMR?
b) How will you differentiate the following pair of isomers by advanced
1
HNMR spectrosocpy?
c) The compound C6H6 shows two peaks in 13CNMR However, DEPT-

135 gives only one-ve peak at 90 ppm. suggest the structure.
d) How will you differentiate following underlined protons using 1HNMR
spectroscopy?
e) Assign the structure to isomers A and B [MF:C4H8O]

Isomer A : +ve iodoform test and characteristic 13CNMR chemical
shift, δ= 207ppm.
Isomer B: ve iodoform test and characteristic 13CNMR chemical
shift, δ=101ppm
(No peak above 160 ppm).
[5323]-311 1 P.T.O.
Q2) A) Answer any three of the following : [12]
a) Assign the structure to the following using the given spectroscopic
data:
i) m+=152
ii) IR cm1=3190, 2954, 1674cm1
iii) 1
HNMR (δppm): 4.2 (S, 12mm); 6.8 (dt, J=8,2 Hz, 4mm);
6.91 (dd J=8,2 Hz 4mm); 7.45 (dt,J=8, 2Hz, 4mm); 7.92
(dd,J= 8,2 Hz, 4mm); 10.9 (S, exch. 4mm).
iv) Normal 13CNMR(δ,PPM): 52, 112, 118, 119, 128, 137, 160,
174
DEPT-135 : 118,160 and 174 absent remaining are +ve peaks
DEPT-90 : except disappearence of peak at 52 everything is
same as DEPT-135.
b) The compound A has two stereoisomers X and Y. Using following spectral
data of aliphatic region, assign the correct structure. Justify your
assignment and stereochemistry
1
HNMR Data-1:
3.69ppm (d, J=2Hz 1H, exch. D2O)
4.05ppm (d, J=7 Hz 1H)
4.20 ppm (dd, J = 7, 2 Hz 1H)
1
HNMR Data-2:
3.65ppm (d, J=2Hz, 1H, exch. D2O)
4.10ppm (d, J=16 Hz, 1H)
4.27 ppm (dd, J = 16, 2 Hz 1H)
c) In the following compound Z , the proton d shows δ at 5.2 ppm on 600
MHz NMR instrument. Predict the multiplicity pattern and find out the
chemical shift for each line of multiplet in Hz. Justify your assignment
with the help of tree diagram.
Jad = 1Hz
Jbd = 16Hz
Jcd = 8 Hz
Jbc = 2.5Hz
[5323]-311 2
d) Deduce the structure of the product formed in the following reaction.
Justify your assignment.
1
HNMR, (δin ppm): 7.12 (ddd, J = 7.6, 5.5, 1.5 Hz, 5mm) 7.15 (dd, J=7.6,
1.5 Hz, 5mm); 7.60 (dt, 7.6, 1.0 Hz 5mm 8.48 (dd, J=5.5, 1.0 Hz 5mm)
B) Assign the signals to the various protons of natural product rutin. The
1
HNMR was recorded using D2O. [5]
Natural product Rutin
a) 7.58 (dd, J = 8, 2 Hz, 1H)

b) 7.47 (d, J = 2 Hz, 1H)
c) 6.85 (d, J = 8 Hz 1H)
d) 6.73 (d, J = 2 Hz, 1H)
e) 6.65 (d, J = 2 Hz, 1H)
f) 5.82 (d, J = 12Hz, 1H)
g) 5.58 (d, J = 5 Hz, 1H)
h) 4.15 (ddd, J = 13,6, 6.5Hz, 1H)
i) 3.99 (dd, J = 5, 12Hz, 1H)
j) 3.85 (t; J = 5 Hz, 1H)
k) 3.82 (dd, J = 5Hz, 13 Hz, 1H)
l) 3.81 (dd, J = 18,6 Hz, 1H)
m) 3.80 (dd, J = 18,6.5 Hz, 1H)
n) 3.78 (dd, J = 5, 3Hz, 1H)
o) 3.75 (dd, J = 5, 3Hz, 1H)
p) 3.62 (dd, J = 11, 7Hz, 1H)
q) 1.42 (ddq, J = 11, 7,5 Hz, 1H)
r) 1.21 (d, J = 7 Hz, 3H)
s) 1.15 (d, J = 7 Hz, 3H)
[5323]-311 3
SECTION-II
Q3) Write short notes on any three of the following : [9]
a) Chemical ionisation.
b) INEPT in 13C-NMR signal enhancement.
c) Chiral shift reagents.
d) Time of flight.
Q4) Answer any four of the following : [8]

a) Explain the genesis of ions in the following compound.
b) How will you differentiate the following pair of isomers by mass

spectrometry?
c) How will you follow the following reaction sequence by mass

spectrometry?
mass M/z = 115(7%); 100 (10%), 64 (5%), 60 (21%), 59 (17%), 58(100),

56(7)
Deduce the structure of M using the M/z tragments.
d) How isotopic peaks in MS will help to determine the number and type of
halogens in unknown compound?
e) Which spectroscopic method will you use to differentiate the following
pair of isomers?
and
[5323]-311 4
Q5) The spectra of an unknown compound are shown on adjacent page. Analyse
the spectral data and by using this data arrive at a correct structure of the
unknown compound. Justify your assignments. [8]
[5323]-311 5
[5323]-311 6
iiii
[5323]-311 7
[5323]-312
M.Sc. - II
ORGANIC CHEMISTRY
CHO-352 : ORGANIC STEREOCHEMISTRY
(2014 Pattern) (Semester - III) (New) (4 Credits)

3) Answers to the two sections should be written in separate answer book.
SECTION - I

a) Cyclopropanone and cyclobutanone prefers to undergo addition reaction
than substitution reaction. Explain
b) Which of the following isomer gets solvolysed Faster and why.
c) Give two methods of preparation of compounds with bridged ring

systems.
d) What is the difference between uv spectra at paracyclophanes when
n = m= 2 and when n = m = 6 and why ?
e) Why β - benzene hexachloride reacts more slowly by several powers of
10 than any of its isomers?
a) Draw all possible conformations of cis and Trans1-Phenyl-2-

Aminocyclohexanol and comment on their stability giving reasons.
[5323]-312 1 P.T.O.
b) Explain giving reason the orientation of hydroxyl group during reduction
of cyclohexanone by
i) Catalytic hydrogenation
ii) MPV reduction
iii) Reduction with metal hydride.
c) Write the stable conformation at trans-anti-trans and trans - syn - trans

perhydroanthracene. Calculate their energies and comment on their optical
activity.
d) Explain the product formation giving mechanism in following reactions.

Justify your answer.
i)
ii)
Q3) Answer the following (Any one) [5]
a) Write short note on

i) 3 - alkyl ketone effect
ii) Enolization in cyclohexanone
b) i) Why HA in Compound A can undergo tautomerism and HB in

compound B can not.
ii) Explain the concept of bond opposition strain with suitable example.
[5323]-312 2
SECTION - II
Q4) Answer Any Three of the following : [09]
a) Describe the method of resolution via molecular complexes.
b) Cis, 1,2 dichloro, Cis 1,2 dibromo Ethylene have dipole moments of
1.89, and 1.35 D respectively whereas the trans isomers are zero. Explain
c) Describe the method of resolution via biochemical transformation with
suitable examples.
d) Explain, how Cis and trans isomers of trisubtituted ethylenes of the
CH3aC = CHb differentiate by using N.M.R spectroscopy study.
Q5) Answer Any Four of the following [08]
a) Explain the stereochemistry of addition reaction of Olefins.
b) Describe enantiomeric excess with suitable examples.

c) Explain use of chiral solvating agents.
d) Describe the methods of determination of relative configuration of

diastereomers.
e) Malic acid on treatment with PCl5 gives (+) chlorosuccinic acid while on
treatment with SOCl2 gives (-) chlorosuccinic acid. Explain.
Q6) a) Predict the product/s in Any Two of the following and explain
stereochemical principles involved. Justify. [04]
i)
[5323]-312 3
ii)
iii)
b) Draw the correct stereostructure of a compound C with the help of

1
H-NMR data given below and justify your assignment. [04]
1
H-NMR (δ, ppm)
1.16 (d, J = 6.5Hz, 3H): 1.86 (ddd),
J = 12.5, 9.5, 5.5 1H); 2.02 (ddd,

J = 12.5, 2.0, 6Hz 1H); 3.36 (S, 9H)
3.54 (dd, J = 13, 9 1H); 3.74 (dd,
J = 13,10 Hz, 1H); 3.92 (dq J = 2.5,
6.5, 1H); 4.03 (m, 1H); 4.30 (1 H

d J = 3.5exch. D2O); 4.68 (m, 1H)

[5323]-312 4
[5323] - 313
M.Sc. - II
ORGANIC CHEMISTRY
CHO - 353 : Photochemistry, Pericyclic Reactions and
Heterocyclic Chemistry
(2014 Pattern) (4 Credit) (Semester - III)

3) Answer to the two sections should be written in separate answer book.
SECTION - I
Q1) Explain the following (all sub questions are compulsory). [10]
a) Norrish type II reaction.
b) Irradiation of benzophenone in the presence of (ph)2 CHOH gives

benzpinacol as the only product.
c) Compound A gives cyclobuta -1, 3-diene and carbondioxide on

irradiation. Show the reaction and explain.
d) Draw the π molecular orbitals of H2C = CH-CH. Indentify the Homo and
LUMO and find out their symmetry elements.
e) Ene reaction.
[5323] -313 1 P.T.O.

Q2) Predict the products and suggest the mechanism. [10]
a)
b)
c)
d)
e)
f)
Q3) Answer Any Two. [5]
a) Photochemical reactions in cedrene synthesis.
[5323] -313 2
b) Construct the correlation diagram for the following transformation.
c) Explain with the help of FMO approach whether suprafacial [1, 5]

sigmatropic Hydrogen shift is thermally or photochemically allowed.
SECTION - II
Q4) Answer all the questions in brief. [10]

a) N - Methyl imidazole has lower boiling point than imidazole.
b) Diazines are more resistant to electrophilic attack than pyridine.
c) Reactivity of pyrrole is much higher than pyridine & Pyrimidine in
electrophilic substitution reactions.
d) Pyridine N-Oxide readily undergoes electrophilic substitution at
4 - position.
e) Furan is less aromatic than pyrrole and thiophene.
Q5) Predict the products suggesting suitable mechanism for any two of the
following. [10]
a)
b)
[5323] -313 3
c)
d)
Q6) Write short note on any two of the following. [5]

a) Hantzsch synthesis
b) Reissert synthesis
c) Hinsberg synthesis
S S S
[5323] -313 4
[5323] - 314
M.Sc. II (Analytical Chemistry)
CHA - 390 : ELECTROANALYTICAL AND
RADIOANALYTICAL METHODS OF ANALYSIS
(2013 Pattern) (Semester - III) (Credit System)

4) Use of the logarithmic table, non programmable calculator is allowed.
SECTION - I
a) Explain following terms
i) Half wave potential.
ii) Capacitive current.
b) State and explain faraday first law of electrolysis.
c) Give advantages and limitations of amperostatic coulometry.
d) State Koutecky equation and give meaning of each term involved in it.
e) What are the applications of coulometric titrations?

a) What are different pulse methods in voltammetry? Explain why pulse
methods are better than direct methods.
b) Define limiting current. Discuss the factors affecting the limiting current
in polarography.
c) State principle of amperometry. Describe the nature of ampero metric
titration curve of lead nitrate with potassium dichromate.
[5323] - 314 1 P.T.O.

d) Calculate the diffusion current flowing through the cell containing solution
of cd having concentration 5.5 millimoles per litre. if the drop time was
measured at the rate of 3.51 second per drop.
The mercury flow rate was 1.68 mg per second.
(Given: D=7.58×106 cm2/s).
a) What is coulometry? Describe a method of separation of nickel and

cobalt by controlled potential coulometer.
b) A constant current of 10.3 A is passed through a copper chloride solution

for 14.80 min. Calculate the weight of Cu metal deposited on cathode
and oxygen evolved at anode,
Given: At. wt. Cu = 63.54, O = 15.9.
SECTION - II

a) Give the different applications of DSC techniques.
b) State and explain the principle of isotope dilution analysis.

c) State and explain the principle of thermogravimetry.
d) Explain the terms
i) isotopic abundance
ii) flux
e) Discuss the principle of radiometric titrations.

a) State and explain the principle of neutron activation analysis. Discuss the
steps involved in neutron activation analysis.
b) State the principle of DTA. Discuss with neat labelled diagram the working
of differential thermal analysis.
[5323] - 314 2
c) Explain the characteristic of thermometric titrations. How it differs from
conventional titrations?
d) 5 mg of Mno2 powder was irradiated in a neutron flux of 107n.cm2.s1
for a period of 15 min. calculate the activity induced in the sample due to
manganese at the end of irradiation.
Given: t1/2 56Mn = 2.58 hours, 6(55Mn) = 13.3 barns.
% abundance of Mn = 100%
At. wt. Mn = 54.93, O = 16.0.

a) Distinguish between direct isotope dilution analysis and inverse isotope
dilution analysis.
b) A TG curve was obtained for 5.80 mg of sample containing Cuso4.
5H2o, when the monohydrate formation was complete at 200ºc. The
loss in mass was 0.89 mg. Find the percentage of the Cuso4. 5H2o in the
sample.
Given: At. wt. Cu = 63.54, S = 32.0, O = 16.0, H = 1.0.
[5323] - 314 3
P 1902 [5323]-315
M.Sc. - II
CHA - 391 : Pharmaceutical Analysis
(2013 Pattern) (Semester-III) (Credit System)

4) Use of logarithmic table, non-programmable calculator is allowed.
SECTION-I
a) What are the types of waters used in pharmaceuticals?
b) What is biological assay?
c) Name the stages of new drug development.
d) What are substandard drugs?
e) Define undue toxicity.

a) What is sterilization? Explain in detail steam sterilization and sterilization
by ionizing radiation.
b) Give biological assay of insulin in solution.
c) Explain in detail “Stability study of tablets”.
d) Give procedure for preparation of Karl Fisher’s reagent. Explain it’s
standardization.

a) How is ash and sulphated ash estimate from pharmaceutical preparations?
b) Write a note on ‘cup plate method’.
[5323]-315 1 P.T.O.
SECTION-II

a) What are parentals?
b) Give advantages of suspensions.
c) Define shelf life of drug.
d) What is packaging error?

e) Define cross contamination.
a) What are Nonaqeous type of solutions in Pharamaceuticals. Explain in

details.
b) Write a note on ‘Manufacturing Hazards.

c) Give an analytical method for determination of sodium benzoate.
d) 0.5 gm of isoniazid (C6H7N3O)sample was dissolved in 40 ml water and

diluted to 100 ml. 10 ml of diluted solution was transferred to stoppered
bottle to which 10 ml 0.1 N bromine solution, 5 ml conc. HCL and 10 ml
(10%) KI solution was added. The liberated iodine was titrated with 0.1
N Na2S2O3 solution using starch indicator. The titration reading was 7.0ml.
The blank titration reading was 10.0 ml. Calculate the percentage of
isoniazid present in the given sample. (Given C = 12, H = 1, N = 14, O = 16).

a) What are waters in pharmaceuticals? How aromatic water is prepared?
b) 0.5 gm adrenaline (CgHl3O3N) sample was dissolved in 50 ml glacial

acetic acid. It was titrated with 0.1 N perchloric acid using 2 drops of
crystal violet indicator. The burette reading was 14.5ml. Determine the
percentage of adrenaline in given sample. [Given C = 12, H = 1, O = 16,
N = 14].

[5323]-315 2
[5323]-316
M.Sc.-II
CHA-392 : Advanced Analytical Techniques
(2013 Pattern) (Credit System) (Semester-III)

1) Answers to the two sections should be written in separate books.
4) Use of logarithmic table / non programmable calculator is allowed.
SECTION - I

a) Give the classification of liquid-liquid extraction.
b) Enlist the factors affecting on solid phase micro extraction.
c) Give the applications of SPME.
d) Give the stages of solid phase extraction.
e) What is SFE?

a) Describe factors affecting on solid phase extraction.
b) What are the problems arises with liquid-liquid extraction process? How
these are removed?
c) Draw schematic diagram of pressurized microwave assisted extraction
device. Explain its working.
d) Give the applications of SFE.
[5323]-316 1 P.T.O.
a) Outline the analysis procedure of fungicides in water sample by SPME
coupled with HPLC.
b) Describe automation and online SPE with diagram.
SECTION - II

a) Describe the phenomenon of stimulated emission.
b) Explain the interference observed in AFS.
c) Distinguish between FES and AAS.
d) Define the term
i) Releasing agent
ii) Protective agent.
e) Draw the block diagram of mass spectrometry.

a) Enlist the different type of mass analyzer. Explain the construction and
working of time of flight mass analyzer.
b) What is micronutrients and macronutrients? Explain the procedure to
estimation of molybdenum.
c) Write short note on
i) LASERS and
ii) Hollow cathod lamp.
d) What is ICP? Explain the construction and working of ICP-MS with
diagram.
Q6) Solve any one of following : [5]

a) A serum sample is analyzed for potassium by FES using standard addition
method. Two 0.5 ml aliquots are added to 5.0 ml portions of water. To
one portion 10.0 μl of 0.05 M KCl solution is added. The net emission
signals in arbitrary units are 32.1 and 58.6. What is the concentration of
Potassium in the serum.
[5323]-316 2
b) The AAS method was used to determine the concentration of strontium
in sample.
Determine the amount of strontium from the following data
Flask A B C D E
Solution 20 20 20 20 20
Std. ‘Sr’
(5 × 10–3 mg/ml) 0 1 2 3 4
Water (ml) 5 4 3 2 1
Absorbance 0.311 0.470 0.630 0.788 0.949

[5323]-316 3
P1904 [5323]-317
M.Sc. - II
CHA - 380 : Analytical Method Developments and Validation,
Geochemical and Alloy Analysis and Laboratory
Automation and Sensor Based Techniques
1) Attempt any two sections.
3) All questions from respective sections are compulsory.
5) Use of logarithmic table, non-programmable calculator is allowed.
SECTION - I
a) Mention the essential elements of method validation report.
b) Define :
i) Accuracy.
ii) Method transfer.
c) Give the role of communication in method transfer process.
d) Enlist the topics selected for initial harmonization.
e) What is dissolution test?

a) Give an account of limit of detection and limit of quantitation.
b) With the help of schematic diagram, explain USP type I apparatus for
dissolution study.
c) Give essential principle of method transfer process and explain method
modification and revalidation.
P.T.O.
d) Determine the relationship between response and concentration by linear
regression analysis from the below data.
Concentration ºK 0.00 0.10 0.20 0.30 0.40
Standard (mg/l)
Response value 0.00 5.20 9.90 15.30 19.10
Q3) Attempt any one of the folowing : [5]

a) What is an error? Explain its type.
b) Analysis of blood sample for its lead content, gives 0.412, 0.424, 0.436,
0.445 and 0.460 ppm of lead. Calculate mean, mean deviation, standard
deviation, relative stand deviation and relative mean deviation.
SECTION - II
a) Give the principle for determination of tin in gun metal.
b) Outline the method for determination of organic matter in soil.
c) How silica is determined from Ilmenite ore?
d) Give the percentage composition of constituent present in solder and
nichrome alloy.
e) Give the method and reagent used for the determination of copper in
brass.

a) Outline the analytical procedure used for estimation of total nitrogen in
soil.
b) Give an analytical method to estimate aluminium in Bauxite ore.
c) Discuss the method for determination of chromium in Nichrome alloy.
d) 0.5302 g steel sample was dissolved in 15 ml concentrated HCl and
neutralized by ammonia. The nickel was precipitated as Ni - (DMG)2
with DMG reagent. The weight of Ni-(DMG)2 precipitate was 0.3879
gm. Calculate the % of the nickel in steel sample.
[Given : At. wt. Ni = 58.69, O = 15.99, N = 14, C = 12, H = 1]
[5323]-317 2
a) Discuss the method of extraction and estimation of titanium in Ilmenite
ore.
b) A 2.185 g brass sample was dissolved in 30 ml concentrated HCl and
excess of KI was added to liberate iodine. The liberated iodine was
titrated against 0.0879 N Na2S2O3. The burette reading was 12.4 ml.
Determine percentage of copper in the sample.
[Given At. wt. Cu = 63.54, I = 127, Na = 23, S = 32, O = 15.99,
Zn = 65.38].
SECTION - III
a) Define Optical sensor.
b) What is continuous flow analysis?
c) What is control loop? Give its type.
d) State any four criteria for sensor.
e) What is serial and parallel integration?

a) What is Biosensor? Explain its role in analysis.
b) Explain with diagram the construction and working of discrete sample
analyser.
c) Give a brief account of Biotransduction.
d) Define microfabrication. Explain silicone and glass micromatching.

a) Explain in brief surface acoustic wave sensor.
b) Explain discrete sample analyser.

[5323]-317 3
P1905 [5323]-401
M.Sc. - II
PHYSICAL CHEMISTRY
CHP - 410 : Molecular Structure and Spectroscopy
(2013 Pattern) (Semester - IV) (New)

= 1.38 × 1023 J K1 molecule1
= 6.626 × 10-34 J s
= 1.602 × 1019 C
5. l eV = 23.06 k cal mol1
= 1.602 × 1012 erg
= 1.602 × 1019 J
= 8065.5 cm1
= 8.314 J K1 mol1
= 1.987 cal K1 mol1
= 2.997 × 108 m s1
9. 1 cal = 4.184 × 107 erg
= 4.184 J
10. 1 amu = 1.673 × 1027 kg
[5323]-401 1 P.T.O.
SECTION - I
a) Distinguish between δ and τ Chemical Shift Scales.
b) Explain the terms with respect to nmr spectroscopy.
i) Deshielding and
ii) Coupling constant.
c) What is kramers degeneracy?
d) Write the applications of nqr.
e) Why esr spectra are always recorded in the derivative form? Explain.
a) Explain the instrumentation involved in high resolution nmr spectroscopy.
b) What is g-value? Explain the factors affecting it.
c) What is the need of reference for recording high resolution nmr? Explain
the advantages of TMS.
d) Explain the concept of electric field gradient and quadrupole coupling

constant.
a) Differentiate among the following compounds from 19F spectra at high

field.
CH 3 − CH 2 F, CH 2 F− CH 2 F, CH 3 − CF3
b) Calculate the precessional frequency of a proton in a field of 1.8T. The g

factor for proton is 5.585.
[5323]-401 2
SECTION - II
a) What is the principle of X-ray diffraction?
b) Explain how the Wierl equation is used to deduce molecular geometry.
c) Write Van-Vlecks formula and explain the terms therein.
d) Enlist the applications of neutron diffraction technique.
e) State the phase, problems in XRD.

a) Give a brief account of main XRD methods used in the elucidation of
the crystal structure of NaCl and KCl. What are limitations of Braggs
method?
b) Distinguish between ferrimagnetism and antiferromagnetism with suitable
examples.
c) Describe the instrumentation of neutron diffraction technique with a
suitable diagram.
d) Explain the cause of electron diffraction. How is it experimentally studied?

a) The mass and density of copper atom are 63.5 and 8.94 gcm3
respectively. It has FCC structure. Calculate the atomic radius of copper
atom.
b) Calculate molar susceptibility of phenanthroline (C12 H8 N2) and pyridine
(C5 H5 N) from following data.
* pascal constant (χA) in cgs unit
C = 6.0 × 106, H = 2.93 × 106, ring N = 4.61 × 106
* Constitutive corrections (λ)
C in one ring = 0.24 × 106
C shared by two rings = 3.07 × 106
zzz
[5323]-401 3
P1906 [5323]-402
M.Sc. - II
PHYSICAL CHEMISTRY
CHI - 411 : Surface Chemistry and Electrochemistry
(2013 Pattern) (Semester-IV) (New)

1) Avogadro Number N = 6.022 ×1023 mol1
2) Boltzmann Constant k = 1.38 × 1016 erg K1 molecule1
= 1.38 × 1023 JK1 molecule1
3) Planck Constant h = 6.626 × 1027 erg s
= 6.626 ×1034 J s
4) Electronic Charge e = 4.803 × 1010 esu
= 1.602 × 1019 C
5) l eV = 23.06 k cal mol1
= 1.602 × 1012 erg
= 1.602 × 1019 J
= 8065.5 cm1
6) Gas Constant R = 8.314 × 107 ergK1 mol1
= 8.314 J K1 mol1
= 1.987 cal K1 mol1
7) Faraday Constant F = 96487 C equiv1
8) Speed of light c = 2.997 ×1010 cm s1
= 2.997 × 108 m s-1
9) 1 cal = 4.184 × 107 erg
= 4.184 J
10) 1 amu = 1.673 × 1027 kg
11) Bohr magneton β e = 9.274 ×1024 J T1
12) Nuclear magneton β n = 5.051 × 1027 J T1
13) Mass of an electron me = 9.11 ×1031 kg
[5323]-402 1 P.T.O.
SECTION-I
a) What is wetting phenomenon? Give its two applications?
b) Define the terms :
i) interfacial tension and
ii) gibbs monolayer
c) What is isosteric heat of adsorption? Write its equation.
d) Give the assumptions of polarization theory for multilayer adsorption.
e) What is hysteresis of adsorption? Draw different types of hysteresis
loops.

a) Describe the tracer method for verification of Gibbs adsorption equation.
b) Starting with chemical potential, derive the equation for isosteric heat of
adsorption.
c) How is Harkins-Jura equation used to determine the surface area of a
solid?
d) Discuss the Zsigmondy's theory used to explain the hysteresis of
adsorption.

a) Calculate the enthalpy of adsorption, ΔHads at1atm, given that 155cm3 of
the gas (measured at STP) is adsorbed by 1g of charcoal at 88 k and
15 cm3 at 273 k.
b) The adsorption of N2 on charcoal at liquid nitrogen temperature fits the
BET equation. The volume of nitrogen necessary to form a monolayer
on powdered sample is found to be 11.05 cm3 at STP. Calculate the area
per gram of powder if the sample weighs 17.52g and one molecule of N2
occupies 16.2Å2.
[5323]-402 2
SECTION-II
a) Write Butler-Volmer equation, explain the terms involved in it.
b) Enlist the steps in Eley and Evans thought experiment for determining
work of ion solvent interaction.
c) Write Debye-Huckel limiting law and explain the terms involved in it.
d) Enlist the methods of preventing corrosion.
e) Define :
i) faradic efficiency
ii) voltage efficiency
iii) maximum efficiency
iv) overall efficiency

a) Derive Tafels equation from Butler-Volmer equation.
b) Discuss the Stern theory of electrical double layer.
c) Describe with neat diagram H2O2 fuel cell.
d) Show that in Debye-Huckel theory the maximum volue of charge on
spherical shell is at r = x1.

a) Consider the oxidation reaction Fe → Fe+2 + 2e. It overpotential of
0.1V is applied to the anode assuming β = ½ and t = 25°C, By what
factor does this increases i over io.
b) If the mobility of the silver ion in aqueous solution at 298 k is
6.5 × 104 cm2 s1v1. Calculate
i) diffusion coefficient of silver ion
ii) its equivalent conductivity
iiii
[5323]-402 3
P1907 [5323]-403
M.Sc. - II
PHYSICAL CHEMISTRY
CHP - 412 : Materials Chemistry and Catalysis
(2013 Pattern) (Semester - IV)

1) Answers to the two sections should be written in SEPARATE answer books.
2) ALL questions are compulsory.
[5323]-403 1 P.T.O.
SECTION - I
a) What are quantum dots?
b) Draw the schematic cross sectional diagram of the Rf-sputtering system.
c) Define rectifiers & draw the diagram of full wave rectifier.

d) Discuss optical properties of solid devices.
e) What is Langmuir-Blodgett film?

a) What is capacitor? Explain the three types of capacitor on the basis of
dielectric material.
b) Explain the term MOCVD.
c) Explain the normal state properties of 1-2-3 & 2-1-4 materials.
d) What are the applications of hitech material?
Q3) Attempt any one of the following [5]
a) Explain the term photolithography using suitable diagram.
b) Write note on optical photon modes in hitech materials.
SECTION - II
a) Define ‘catalyst deactivation’.
b) Define ‘inhibition’ and ‘support’.

c) Define ‘Functionality’ with example.
d) State the principles of calcination method in catalyst activation.
e) Write the principles of green chemistry.

[5323]-403 2
a) Discuss impregnation method of preparation of catalyst.
b) Discuss the AES method to determine solid particle size.
c) Derive the expression for kinetics of unimolecular surface reaction.
d) Differentiate between physisorption and chemisorption.
Q6) Solve any one of the following [5]

a) The data below are for the chemisorption of hydrogen on copper powder
at 25°C. Confirm that they fit the Langmuir isotherm at low coverages.
Then find the value of K for the adsorption of equilibrium and the
adsorption volume corresponding to complete coverage.
P/Pa 25 129 253 540 1000 1593
V/cm3 0.042 0.163 0.221 0.321 0.411 0.471
b) The adsorption of a gas is described by the Langmuir isotherm with
K = 0.75 kPa-1 at 25°C. Calculate the pressure at which the fractional
surface coverage is 0.95.

[5323]-403 3
P1908 [5323]-404
M.Sc.-II PHYSICAL CHEMISTRY

CHP-413 : Biophysical Chemistry
(2013 Pattern) (Semester-IV)
1) Answers to the TWO sections should be written in separate answer books.

1) Avogadro Number N = 6.022 ×1023 mol1
2) Boltzmann Constant k = 1.38 × 1016 erg K1 molecule1
= 1.38 × 1023 JK1 molecule1
3) Planck Constant h = 6.626 × 1027 erg s
= 6.626 ×1034 J s
4) Electronic Charge e = 4.803 × 1010 esu
= 1.602 × 1019 C
5) leV = 23.06 k cal mol1
= 1.602 × 1012 erg
= 1.602 × 1019 J
= 8065.5 cm1
6) Gas Constant R = 8.314 × 107 ergK1 mol1
= 8.314 J K1 mol1
= 1.987 cal K1 mol1
7) Faraday Constant F = 96487 C equiv1
8) Speed of light c = 2.997 ×1010 cm s1
= 2.997 × 108 ms1
9) 1 cal = 4.184 × 107 erg
= 4.184 J
10) 1 amu = 1.673 × 1027 kg
11) Bohr magneton β e = 9.274 ×1024 J T1
12) Nuclear magneton β n = 5.051 × 1027 J T1
13) Mass of an electron me = 9.11 ×1031 kg
[5323]-404 1 P.T.O.
SECTION-I
a) Define genome and gene.
b) Give two functions of proteins.
c) Differentiate between RNA and DNA.

d) Write the Henderson's equation and explain the terms therein.
e) State Bragg's law.
a) Distinguish between active and passive transport.
b) Write a note on nerve impulse.
c) Explain the role of nucleic acids in cell biology.

d) Explain a method to determine molecular weight of a protein.
a) Explain the role of ATP in biological systems.
b) Write a note on DNA sequencing.
SECTION-II
a) What are extracellular and instracellular enzymes?
b) Explain the effect of concentration of enzyme and of substrate on enzyme
activity.
c) Define Circular Dichroism (CD).
d) Explain 'all or none law' applicable to all nerves.
e) Explain the role of Na+/k+ pump.
[5323]-404 2
a) Discuss the mechanism of ion transport through the cell membrane.
b) Describe the viscosity method of determination of molecular weight of
biopolymers.
c) What is enzyme inhibition? Explain the mechanism of reversible inhibition.
d) What is optical rotatory dispersion? Give the theory of ORD.

a) A polymer sample contains equal weights of molecules with molecular
weight 25000 and 35000. Calculate M n and M w .
b) 1.0 g of a polyester in 100cm3 methyl ethyl ketone required 11.5cm3 of
0.01M alcoholic KOH for neutralization. Calculate the molecular weight
of the polymer.
iiii
[5323]-404 3
P1909 [5323]-405
M.Sc.-II (Physical Chemistry)

CHP-414 : SPECIAL TOPICS IN NUCLEAR AND RADIATION
CHEMISTRY
(2013 Pattern) (Semester-IV) (New)
1) Answers to the TWO sections should be written in separate answer books.
5) Use of logarithmic table calculator is allowed.
[5323]-405 1 P.T.O.
SECTION-I
a) Enlist various man made sources of radiation.
b) Explain the term elastic scattering and inelastic scattering.
c) Define the terms radiopharmaceutical and Nuclear pharmacy.

d) Complete the following reactions by writing equation
i) 197
79 Au (n, γ ).....
ii) 3
H (α , n ).....
a) Draw and explain linear accelerator.
b) Write a note on Radiation protection.
c) Explain various natural and man made sources of radiations.

d) Explain general aspects of use of radiopharmaceuticals.
a) Evaluate Q-value for the

7
Li (p, n)7 Be reaction
Given : 7
Li = 7.01822 amu
1
H = 1.00814 amu
1
0 H = 1.008665 amu
7
Be = 7.019465 amu
b) What do you understand by the terms in-vivo and in-vitro techniques.

Explain in-vivo diagnostic procedure.
[5323]-405 2
SECTION-II
a) Explain the term incineration.
b) Write products formed in radiolysis of methanol.
c) Explain the term G-value.
d) Give IAEA classification of radioactive waste.
e) What is the condition required for choosing a radioactive nuclide as
indicator for radiometric titrations.

a) Draw and describe the radiometric titrations based on absorption of
β-particles.
b) Write a note on pulse radiolysis.
c) Describe in detail the various methods for disposal of low and intermediate
level waste.
d) Write a note on premordial nucleosynthesis.

a) 20cc Na*I solution was titrated with 0.05M AgNo3. Addition of 1ml of
AgNo3 showed a loss in activity from 6,000 counts per minute to 5000
counts per two minutes. Find the amount of iodide in the solution. Back
ground counts are 60 for 2 min.
[Given : At. wts: Na = 23, I = 127, Ag = 108, N = 14 and O = 16]
b) Give a brief account on Non-homogenous kinetics.
iiii
[5323]-405 3
P1910 [5323]-406
M.Sc. - II
INORGANIC CHEMISTRY
CHI - 430 : Inorganic Polymers & Heterogeneous Catalysis
4) Use of logarithmic table and calcualtor is allowed.

a) How oxoanions plays an important role during the synthesis of zeolite?
b) What are the desired properties of heterogeneous catalyst?
c) Describe Incipient wetness method for preparation of supported metal
catalyst.
d) What is chemical reactor? Which reactor is used for ammonia synthesis?
e) Draw the sheelite structure & give its physical properties.
f) Why TiO2 is considered as good photocatalyst?
g) Draw the structures of keggins heteropolyanion.
h) Differentiate between Chemisorption & Physisorption.
i) What is Pervoskite? Explain its structure.
j) What are phosphazenes? Draw the structure of tetrameric phosphazene.

a) Discuss in detail the characteristics of zeolite framework structure.
b) Give an account of use of Bismuth molybdate in the oxidation &
ammoxidation of olefins.
c) Discuss various methods of catalyst deactivation.
d) Discuss the role of support in support metal catalyst.
[5323]-406 1 P.T.O.
Q3) Attempt the following. (any two) [10]
a) Discuss construction, working, merits & demerits of fixed bed reactor.
b) What do you mean by shape selective catalysis? How zeolites are used
as shape selective catalyst. Illustrate with suitable example.
c) Give an account of the surface characterisation methods used for
supported metal catalyst.
d) Discuss in detail heteropolyacids of Mo & W.
Q4) Write notes on (any two): [10]

a) Applications of heterogeneous catalysis in Industry.
b) S-N polymers.
c) SOD & LTA type zeolites.
d) Semiconducting oxides as photocatalyst.
zzz
[5323]-406 2
P1911 [5323]-407
M.Sc.-II (Inorganic Chemistry)

CHI - 431 : MATERIAL SCIENCE - I : INORGANIC SOLID
STATE MATERIALS
2) Draw neat diagrams wherever necessary.

a) What is diffusion? List the different types of diffusion in solids.
b) Give four important applications of composite materials.
c) What is permanent magnet?
d) Explain the classification of super conductors.
e) Define :
i) Ageing and
ii) Gelation
f) Draw the structure of wood.
g) Give the full forms of C2S and C3AF.
h) Explain classification of biomaterials.
i) Explain the composition of portland cement.
j) A piece of wood containing moisture weighed 95.3 gram and after over
drying showed constant weight of 80.5 gram. Calculate the percentage
of moisture in it.

a) What is defect? Explain different types of defects?
b) What is magnetism? Explain different types of it.
c) Explain Meissner effect. Explain different types of super conductors.
c
d) Derive the expression : X = .
T − vc
[5323]-407 1 P.T.O.
a) What is hysteresis loop? Explain with retentivity and corecitivity.
b) Draw the FCC, BCC and HCP structure in solids. Calculate number of
atoms per unit cell in each of the above.
c) What are important applications of biomaterials?
d) What is concrete? Explain different concrete mixtures used.
Q4) Write short notes on (any two) : [10]

a) Fullerence
b) Macrodefect free cement
c) Kirkendall effect
d) Pyroelectric materials
iiii
[5323]-407 2
P 1912 [5323]-408
M.Sc. - II
INORGANIC CHEMISTRY
CHI - 432 : Material Science - II (Nanomaterials)
(2013 Pattern) (Semester-IV) (4 Credits)

2) All questions carry equal marks.
3) Use of calculators allowed.
a) Define pyroelectricity. Give two examples of nanomaterials shows

pyroelectricity.
b) What is a quantum dot? Give its aspects.
c) What is meant by stokes and antistokes lines in Raman spectroscopy?
d) What is the most common magnetic nanoparticle oxide compound family?

What are the variants, and why is it used more commonly than other
compounds?
e) How gold nanoparticles are prepared? Give the chemical reaction involved
in it.
f) Give the methods for synthesis of oxide nanoparticles.
g) Give the application of nanomaterials in drug delivery.

h) What are the methods that can be used to stabilise colloidal nano-
suspensions?
i) What is photonic nanocyrstals? Give two examples.
j) Define surface plasmon band.
[5323]-408 1 P.T.O.
Q2) Answer the following (any two): [10]
a) Explain sonochemical fabrication of nanomaterials.
b) Explain various methods for carbon nanotube synthesis and give its
application in various fields.
c) Explain the mechanism of zero valent metal nanoparticle for formation

of encapsulation with suitable example.
d) How PbSe nanowire prepared? Give the chemical reaction involved in it.
a) How Raman spectroscopy is useful in characterization of nanoparticles.
b) Discuss the different applications of nanomaterials in medicinal field.
c) Explain the principle and working of SEM?

d) What is nanoporous materials? Explain different types of nanoporous
materials.
a) What are nanosensors? Explain gas sensor with suitable example.

b) Explain the magnetic properties of nanoparticles.
c) Explain optical properties of nanoparticles.
d) Explain the role of surfactant in preparation of nanomaterials. Give the

two examples of surfactant.

[5323]-408 2
P1913 [5323]-409
M.Sc.-II
INORGANIC CHEMISTRY
CHI-445 : Inorganic Chemistry : Applications in Industry,
Environment and Medicine.
1) Attempt any two sections of the following :
2) Both sections should be written in the same answer book.
4) Figures to the eight indicate full marks.
6) Use of logarithmic table or calculators is allowed.
SECTION-I
(Applications in Industry)
a) What is meant by azo dyes? Give suitable example.
b) Why animal pigment like melanin in light shows dark colour?
c) Write the composition of lithophone white pigment.
d) Draw the structure of sunset yellow and white its applications.
e) What is tining?
Q2) Answer the following (any two) : [10]

a) Discuss the different process available for electroplating of Zinc.
b) What is PVP electrode? Explain the methods for electrodeposition of
PVP on metal.
c) Explain the manufacturing process of medially metallizable azo dyes of
cobalt.
d) Explain the following physical properties of inorganic pigments.
i) Colour
ii) Oil absorption
iii) Resistant to light
iv) Dispersion
[5323]-409 1 P.T.O.
Q3) Write a note on any one : [5]
a) Brightening agents
b) Mordant dyeing
c) Electroplating of chromium on Iron metal.
SECTION-II
(Environment)
a) What is the effect of suspended solids and sediments on aquatic life?
b) Explain oil and grease removal from waste water.
c) What is power ball? How is the hydrogen liberated from power ball.
d) List the provisions of clean water act.
e) What do you understand by geothermal energy?
Q5) Answer the following (any two) : [10]

a) Explain how coliform bacterial count is useful to test pathogens from
drinking water.
b) Define PE. What is the range of PE in natural water. If a sample from
lake gave a PE = 12.5 does the lake favour oxidation?
c) Explain the sources, incidents and biochemicals effect of Hg?
d) Draw a schematic diagram of a Phosphoric Acid Cell (PAFC). What
reactions occurring at cathode and anode. Show over are reaction.

a) Energy sources for the 21st century.
b) Industrial and municipal waste water treatment.
c) Atomic absorption hydride method for As.
[5323]-409 2
SECTION-III
(Applications of Metal ions in Medicine)
a) What is the full form of NSAIDS and RIDS give example of each type
of drug?
b) What are the disorders causal due to overdose of Lithium?
c) Name any three gold compounds used in crysotherapy. Which oxidation
states of gold are important in medicines.
d) Explain the binding modes of Bismuth complexes with biomolecules.
e) Give the properties of radionuclides.

a) Discuss the non associative interactions of metal complexes with DNA.
b) Explain mechanism of inhibition of H. Pylori bacterium by Bismuth.
c) Explain the binding interactions of this phenanthroline metal complexes
with DNA.
d) Explain the mechanism of action of gold complexes with the help of
sulfhydryl shuttle model.

a) Chelation therapy
b) Toxicity of vanadium
c) Second and third generation of cisplatin analogues
iiii
[5323]-409 3
P1914 [5323]-410
M.Sc. - II
ORGANIC CHEMISTRY
CHO - 450 : CHEMISTRY OF NATURAL PRODUCTS
SECTION - I
Q1) Outline the steps involved in the following synthetic sequences. [10]
a)
b)
c)
d)
Si
e) ⎯⎯
→ → ± Estrone
S1
[5323]-410 1 P.T.O.
a) Describe the evidence for the stereochemistry at Cq in Hardwickiic Acid.
b) Give evidence for the presence of following:
i) Quinoline ring
ii) Pyridove ring and presence of ArCH2NCO grouping.
c) Give evidence for the following in podophyllotoxin.
i) Presnece of lactone ring
ii) Prsence and nature of OH group

a) Give evidence to show the presence of pyrroloquinoline ring in hydroxy
comptothecin.
b) Give brief account of silyl ether protection of hydroxyl group in Taxol.
OR
a) Role of Boron mediated Diels-Aider reaction in Taxol synthesis.
b) Draw the stereostructures of any two isomers of podophyllotoxin.
SECTION - II
Q4) Suggest biogenetic schemes for the following. [10]
a) 2 Z,6E FPP ⎯⎯
→
b)
c) GGPP ⎯⎯
→
d)
e)
[5323]-410 2
a)
Complete the sequence
b)
Complete the sequence
c) Outline the steps involved inthe following conversion.
Squalene ⎯⎯
→→

a) Discuss the transamination reaction and role of pyridoxal phosphate in
biosynthesis of alkaloids.
b) Suggest the biogenetic steps for the following.
GGPP ⎯⎯
→ →
zzz
[5323]-410 3
P1915 [5323]-411
M.Sc.-II (Organic Chemistry)

CHO - 451 : ADVANCED SYNTHETIC ORGANIC CHEMISTRY
SECTION-I
Q1) Predict the products of the following : [10]
a) ?
b) ?
c) ?
d) ?
e)
?
iii) NaCN, (CF3CO)2O

iv) NaOH, H2O2
[5323]-411 1
Q2) Suggest the mechanism in any four of the following : [10]
a)
b)
c)
d)
ii) CuI, (CH3)3N

iii) H+/H2O
e)

a) Explain sonogashira coupling.
b) Organosilane in organic synthesis.
c) Discuss mechanism of Suzuki coupling.
SECTION-II
Q4) Predict the products of the following : [10]
a) ?
[5323]-411 2
b) ?
c) ?
d) ?
e) ?
Q5) Suggest the mechanism in any four of the following : [10]
a)
b)
c)
d)
e)
[5323]-411 3
a) Discuss Julia Olefination
b) Explain Witting Horner reaction
c) Discuss Ugi reaction
iiii
[5323]-411 4
[5323] - 412
M.Sc. - II
ORGANIC CHEMISTRY
CHO - 452 : Carbohydrates, Chiron Approach, Chiral Drugs and
Medicinal Chemistry

3) Answers to the two sections should be written in separate answer-books.
SECTION - I
Q1) a) Complete the following sequence from (M) to (N). [10]
Describe the role of ethyl magnessium bromide in this sequence.
b) Write a short note on “anomeric effect”.
c) Define the term ‘Eutomer’ and explain with suitable examples.
d) Write the retrosynthesis of (–) – multistriatin using hexose.
e) Write adverse effects of s- metoprolol.
[5323] -412 1 P.T.O.

Q2) a) Answer any two of the following. [6]
i) Write the pharmacological activities of Ephidrine.
ii) How will you cenvert D - mannitol into (R) - Epichlorohydrin.
iii) Describe the role of oxidation studies using HIO4 in carbohydrate
chemistry.
b) Identify the intermediates formed in any two of the following sequence
of reactions and rewrite the sequence again. [4]
i)
ii)
iii)
Q3) Complete the following sequence using appropriate reagents.
Comment on optical activity of compound X formed in the sequence of

reactions.
How will you convert it into optically active (S) - Ibuprofen? [5]
[5323] -412 2
SECTION - II

a) Explain the term broad spectrum antibiotics with suitable example.
b) What is ADME in drug design?
c) What are anti metabolites?
d) Give SAR of Chloramphenicol.
e) Give an account of history of antibiotics.
Q5) a) Answer any two of the following. [6]

i) Name any two antifungal agents and explain their mode of action.
ii) Write note on protein synthesis inhibitor antibiotics.
iii) Discuss in brief antiviral agents and selective toxicity.
b) Explain the following (any two). [4]

i) Chloroquine as antimalarial agent.
ii) Macrolides as antibiotics.
iii) SAR of tetracyclins.
Q6) What are β- Lactum antibiotics? How they act as cell wall inhibitors? Give
examples of semisynthetic penicillins. [5]

[5323] -412 3
P1917 [5323]-413
M.Sc.-II
INORGANIC CHEMISTRY
CHO-453 : Designing Organic Synthesis and Asymmetric Synthesis
SECTION-I
a) What is the use of Fmoc protecting group in organic synthesis?
b) Give the synthetic equivalents to the following synthons.
O
+
CH2 COOH , CH3 C +
c) Explain the alkylation of aldehyde or ketone using enamine.

d) Use of cynide ion in umpolung of reactivity.
e) What are disadvantages of linear synthesis, explain with suitable example.
Q2) a) How will you effect the following conversions? (any two) [5]
i) ?
ii) ?
iii) ?
[5323]-413 1 P.T.O.
b) Predict the products in any two of the following : [5]
1. Na, NH3
i) Ph − C ≡ C − H → ?
2. CH3 I
3. Lindlar's Catalyst
ii) ?
iii) ?
Q3) a) Using retrosynthetic analysis, suggest suitable method to synthesis any

one of the following : [3]
i) ii)
b) Arrange the given reagents in proper order to accomplish the following

conversion. Write the structures of the intermediates. [2]
H3O+, Hg2+, CuHgLi, THF,10°C; HSCH2CH2SH, H+; C6H5CH2Br
[5323]-413 2
SECTION-II
Q4) a) Explain the following transformations with respect to stereochemical
outcome of the reaction (any two) [6]
i)
ii)
iii)
b) Name the suitable reagent for the following transformations and comment
on the formation of the product (any two) : [4]
i)
ii)
iii)
[5323]-413 3
Q5) a) Write a short note on (any two) : [6]
i) Felkin-Anh Model
ii) Sharpless Asymmetric Epoxidation
iii) Chiral Pool.
b) Predict the product/s and comment on the following transformations
(any two) : [4]
i)
?
ii)
?
iii)
?
Q6) a) Define the following terms (any one) : [2]

i) Burgi-Dunitz Trajectory
ii) Noyori-Catalyst
b) Complete the following multistep synthesis using appropriate reagents
or intermediates. [3]
iiii
[5323]-413 4
P1918 [5323]-414
M.Sc. - II
CHA - 481 : Analytical Toxicology and Food Analysis
4) Use of logarithmic tables/non programmable calculator is allowed.
SECTION - I
a) What is coma? Which system is used to classify coma?
b) Give the principle of isolation and identification of cocaine and heroin.
c) Define the terms:
i) Narcotic drugs ii) Hemp (cannabis)
d) Explain Stimulants.
e) State the principle of estimation of benzodiazepine.

a) How barbiturates are estimated? Explain procedure-C in detail.
b) State principle of determination of caffeine. Discuss procedure in detail.
c) Explain type B procedure for isolation and determination of amphetamine
from urine.
d) Write a short note on offences and penalties for narcotic and psychotropic
substances.

a) By using gas chromatographic method a sample of barbiturate was
analysed following data is obtained.
i) Concentration of known barbiturate = 3.1 mg/ml.
ii) Peak area of drug in sample = 6.7 min.
iii) Peak area of internal standard = 5.1 min.
iv) Peak area of known drug in reference = 3.6 min.
v) Peak area of internal standard in reference barbiturate solution = 8.7 min.
Calculate concentration of barbiturate in the sample.
[5323]-414 1 P.T.O.
b) Define the terms:
i) Addict
ii) Opium
iii) Coca leaf
iv) Poppy straw
v) Medicinal Cannabis
SECTION - II

a) Give the principle of estimation of carbohydrate by Anthrone method.
b) What is peroxide value?
c) How saponification value of an oil is determined?
d) Give the composition of milk.
e) Define preservative. Give any two examples.

a) Discuss the analytical method for estimation of pectic substances by
gravimetric method.
b) Explain method for estimation of benzoic acid from food sample.
c) Explain the analytical method used for estimation of saccharin.
d) Give the principle and outline the method for estimation of protein by
Lowrys method.

a) Calculate the peroxide value of 2.30 gm ghee sample requiring 16.7 ml of
0.01 M Na2S2O3 solution, if blank reading of Na2S2O3 solution was 24.9 ml.
b) If nitrogen retained, nitrogen absorbed and nitrogen intake from protein
by rat was 1.74 mg, 1.18 mg and 8.24 mg respectively. Calculate net
protein utilization, digestibility and biological value.
zzz
[5323]-414 2
P 1919 [5323]-415
M.Sc. - II
CHA - 490 : Analytical Spectroscopy

SECTION-I
Q1) Answer the following questions: [10]
a) State and explain the principle of UPS.
b) Enlist the detectors used for X-ray method of analysis.
c) Explain the ESCA satellite peak.
d) State and explain the principle of scanning electron microscopy.
e) Give the applications of X-ray method of analysis.

a) What is scanning probe microscopy? Explain its working with neat labeled
diagram.
b) Explain the Bragg’s X-ray spectrometric method. How different order
reflections are obtained using Bragg’s equation.
c) What is analyzer? Enlist various analyzers used in ESCA. Explain
electrostatic field analyzer in detail.
d) What is X-ray fluorescence? Draw labeled diagram and discuss major
components of X-ray fluorescence method.
[5323]-415 1 P.T.O.
a) The 1 ‘S’ electron of Na ion has binding energy 1068 eV. Estimate the
work function of electron spectrometer if incient radiation is the Kα line
of Mg and kinetic energy of measured electron is 167.0 eV. (Given :
Plank constant h = 6.626×10-34 Js, λ = 1.89Å velocity of light C = 3×108
m/s).
b) Calculate the mass absorptive coefficient of an alloy which consists of
29% Ni and 37% Cu of the wavelength corresponding to Kα radiation of
copper. The mass absorptive coefficient at that wavelength is 45.0 cm2/g
for Ni and 53.0 cm2./g for Cu.
SECTION-II
Q4) Answer the following questions: [10]
a) Explain the term delayed Fluorescence.
b) What is heavy-atom effect?
c) Explain the term quantum efficiency.
d) Enlist various solvent used in NMR.
e) What is nuclear overhauser effect?

a) Give the application of photoluminescent analysis with suitable example.
b) What is 2-D NMR? Explain in brief HETCOR and cosy.
c) Explain phenomenon of an electrochemiluminescence with suitable
example.
d) Calculate the chemical shift of a particular nucleus in a 60 MHz instrument
if the reference nucleus absorbs at a magnetic flux density that is 0.074 G
greater than that at which the sample nucleus absorbs.

a) How solid sample was handled in NMR technique.
b) The 'H NMR of a compound with empirical formula C4H8O2 shows
quartet at δ 4.1, triplet at δ 1.2 and singlet at δ. 1.97. The integration of
each peak shows 2:3:3 ratio respectively. Identify the compound.

[5323]-415 2
P 1920 [5323]-416
M.Sc. - II
CHA - 491 : Analytical Methods for Analysis of Fertilizers,
Detergents, Water and Polymer, Paint and Pigment

3) Draw neat diagrams wherever necessary.
4) Use of lagarithmic table, non-programmable calculator is allowed.
SECTION-I
a) What is meant by syndet? Give suitable examples.
b) List standard test methods for estimation of acidity and alkalinity.
c) What is total Nitrogen? Give principle of estimation of Nitrogen by

Kjeldahl method.
d) Explain the terms:-
i) Iodine value.
ii) Saponification value.
e) Enlist four organic pollutants found in waste water.
[5323]-416 1 P.T.O.
a) What is available and non-available phosphorus? Discuss the alkali metric
ammonium molybdophosphate method.
b) Discuss general scheme of analysis of soaps and give tests for:-
i) Total fatty acids.
ii) Anhydrous soap.
iii) Active ingredient.
c) Write a note on industrial waste water treatment.
d) Orthophosphate was determined by weighing as ammonium
phosphomolybdate (NH4)2 PO4.12MoO3. Calculate the percentage of
phosphorus and phosphorus pentoxide if, 1.673 g precipitate was
obtained from 0.328 g of sample. Given At. Wt N = 14, H = 1, P =
30.97, Mo = 95.94, O = 15.99.

a) Discuss analytical method for the determination of cyanide from waste
water.
b) Nitrogen containing fertilizer weighing 0.54 g was treated in a Kjeldahl
flask and NH3 produced was absorbed in 0.1 N H2SO4. The excess of
acid required 17 ml 0.1 N NaOH solution for neutralization. Find the
percentage of Nitrogen in the fertilizer. (Given: atomic weight of N = 14).
SECTION-II
a) Explain the role of thinner in paints.
b) How are organic pigments analysed?
c) Define degree of polymerisation.
d) Explain the terms:
i) Impact testing.
ii) Tear resistance.
With respect to polymers.
e) Distinguish between thermosetting polymers and thermoplastic polymers.
[5323]-416 2
a) Explain the characterisation of polymers by X-ray diffraction technique.
b) Write a short note on ‘end group analysis’ method for molecular weight
determination of polymers.
c) When a certain polymer sample contains 200 molecules with molecular

weight 104, 250 molecules with molecular weight 105 and 300 molecules
with molecular weight 103 and 50 molecules with molecular weight 107.
Find M n and M w for the given polymer sample.
d) Explain isolation and determination of pigments.

a) 0.846 g CTPB sample was dissolved in a mixture of ethanol and xylene
solution and was titrated with 0.295 N alcoholic potassium hydroxide
solution. The burette reading was 5.1 ml. Calculate M n and M w of the
polymer. (Given: functionality = 2).
b) Explain the optical properties of polymers.

[5323]-416 3
P1921 [5323]-417
M.Sc.-II
CHA-492 : Methods of Analysis and Applications Pollution
Monitaring and Control. Analysis of Body Fluid, Carbon
Nanostructures and Application of Nanotechnology
4) Use of logarithmic tables/non-programmable calculator is allowed.
SECTION-I
(Pollution Monitoring and Control)
a) What are the sources of SOx and NOx?
b) Give the principle of Brownian diffusion.
c) Discuss the sources of Inorganic particulate matter.
d) Give any two methods for the control of particulate matter.
e) Explain the term electrocoagulation.

a) Discuss the phenomenon of the photochemical smong.
b) Describe in detail a method used for detection of lead (Pb) in waste
water.
c) Discuss any two method for the control of particulate emissions.
d) Write a short note on wet scrubbing.

a) Outline the analytical method for estimation of Amonia (NH3)
b) Enlist adverse effects of particulate matter. Describe any two in details.
[5323]-417 1 P.T.O.
SECTION-II
(Analysis of Body Fluid)
a) What is the composition of faeces? How it is collected?
b) Give the structures of the following :
i) Retinol
ii) Vitamin D3
c) Give any two functions of liver in details.
d) Give principal of estimation of inorganic phosphate by colorimehy.
e) Give any two functions and deficiency diseases of vitamin C.

a) Discuss the chemistry of vitamin B1 with respect to structure, sources
and bio functions.
b) Explain principle, instrumentation and any two applications of radioimmuno
assary.
c) Explain the principle of fluorometry and estimation of xanthunic acid
using above technique.
d) Discuss kidney function tests in details.

a) Give a short note on estrogen and progesteron.
b) Describe 2, 6 dichlorophenot indophenot method for the estimation of
vitamin C.
SECTION-III
(Carbon Nanostructure and Applications of Nanotechnology)
a) Give the applications of quantum dots.
b) How pantide shape of nano material causes a potential health hazards?
Explain.
[5323]-417 2
c) Explain the term internal delivery.
d) List factors involved in rapid developement of sensors in modern
medicines.
e) Give the different types of biosensors.

a) Write a short note on plant and microbes as nanofactories.
b) How CNTs are fabricated.
c) Describe the applications of CNTs in fund cells and catalysts.
d) Explain the functioning of implantable devices for drug delivery.

a) Write a short note on sensing modalities.
b) Discuss the importance of material characterization in nano biotechnology.
iiii
[5323]-417 3

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Total No. of Questions :6] SEAT No.

Time : 3 Hours] [Max. Marks : 50

Q1) Attempt the following: [10]

b) Show that, Cv,m = 3R using equipartition theorem where Cv,m is molar

c) What is the physical significance of Δ G?

d) Sketch wavefunctions and probability densities for a particle in one

Q2) Attempt any two of the following: [10]

a) Explain the experimental evidence for Heisenburgs uncertainty principle.

b) What are colligative properties? Derive the expression for elevation in

c) Explain Bose-Einstein statistics.

d) What is meant by zero point energy? Write a note on simple harmonic

Q3) Solve any one of the following [5]

a) The moment of inertia of oxygen molecule is 1.9373×1046 kg.m2.

b) When Lithium is irradiated with light of wavelength 250 nm, the

Q4) Attempt the following: [10]

b) For a given enzyme catalyzed reaction, reaction rate constant of formation

Q5) Attempt any two of the following: [10]

concentration and x=amount of A consumed at time t.

Q6) Solve any one of the following. [5]

Time : 3 Hours] [Max. Marks : 50

Q2) Attempt any two of the following. [10]

Q5) Attempt any two of the following.

Q6) Complete the following reactions. [5]

Time : 3 Hours] [Max. Marks : 50

c) Label the stereocentres and calculate the no. of stereoisomers in the

d) Assign P/S configurational labels to the following.

Q3) Solve any four of the following: [8]

b) Comment on the optical activity of the following compound.

c) Convert Fischer projection to Newman projection as shown.

d) Assign Pro-R and Pro-S labels to HA and HB.

e) Give the stereochemical relationship between the following compounds.

a) Describe in brief hydrogenation of aromatic rings.

b) What is SRNI mechanism? Explain with suitable example.

c) Trans-2-chlorocyclohexanol gives epoxy cyclohexane in high yield on

d) Explain hyperconjugation with suitable example.

e) Give examples of ambident nucleo phile.

Q5) Suggest the mechanism (Any four): [8]

Q2) Answer any two of the following : [10]

Q3) Answer any one of the following : [5]

Q5) Answer any two of the following : [10]

Q6) Answer any one of the following : [5]

Physico - Chemical Constants

Q1) Attempt the following: [10]

a) Enthalpy can not be the criteria for spontanity? Discuss briefly.

b) What are state and path functions?

c) Show that dA =  Pdv  SdT, where A is Helmholtzs function.

d) Classical mechanics predicts specific heat of monoatomic solids is

Q2) Attempt any two of the following: [10]

a) Derive the general form of maxwells equations. How change in entropy

b) What is meant by partial molar quantities? Derive Gibbs-Duhem equation.

c) What are the experimental observations made in black body radiation

Q3) Solve any one of the following: [5]

a) Calculate the velocity of an ejected electron by a photon of wavelength

b) A sample of methane gas (4.5 g) occupies 17.16 dm3 at 360 K.

i) Calculate work done when it expands isothermally against external

ii) Calculate the work done if same expansion occurs reversibly.

Q5) Solve any two of the following: [10]

CH 3CHO → CH 3 + CHO (chain initiation)

a) Explain the experimental evidence for Heisenburgs uncertainty principle.

a) The moment of inertia of oxygen molecule is 1.9373×1046 kg.m2.

concentration and x=amount of A consumed at time t.

c) Show that dA = Pdv SdT, where A is Helmholtzs function.

a) Derive the general form of maxwells equations. How change in entropy

b) What is meant by partial molar quantities? Derive Gibbs-Duhem equation.

C2V E &] σ 9;= σ 9<=

(′ 2 1 0 2 1 0 (X,Y) (x2 y2, xy)

(′′ 2 1 0 2 1 0 (Rx,Ry) (xz,yz)

b) The spectrum of HCl shows a fundamental absorption at 2886 cm1,