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    Glycogen Metabolism

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    Karan Singh
    1. Glycogenolysis is the breakdown of glycogen into glucose. It involves phosphorylation by glycogen phosphorylase, debranching by glycosyl transferase, and cleavage by alpha-1,6-glucosidase. 2. Phosphorylase sequentially cleaves alpha-1,4 glycosidic bonds in glycogen, producing glucose-1-phosphate until limit dextrins remain. 3. Debranching enzyme removes 3-4 glucose fragments from limit dextrin branches and transfers them to another chain. Alpha-1,6-glucosidase then cleaves the remaining alpha-1,6 bonds to fully release glucose.

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    Glycogen Metabolism

    Uploaded by

    Karan Singh
    199 views2 pages
    1. Glycogenolysis is the breakdown of glycogen into glucose. It involves phosphorylation by glycogen phosphorylase, debranching by glycosyl transferase, and cleavage by alpha-1,6-glucosidase. 2. Phosphorylase sequentially cleaves alpha-1,4 glycosidic bonds in glycogen, producing glucose-1-phosphate until limit dextrins remain. 3. Debranching enzyme removes 3-4 glucose fragments from limit dextrin branches and transfers them to another chain. Alpha-1,6-glucosidase then cleaves the remaining alpha-1,6 bonds to fully release glucose.

    Original Description:

    Notes of Glycogen metabolism an important topic for NIPER and GPAT

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    1. Glycogenolysis is the breakdown of glycogen into glucose. It involves phosphorylation by glycogen phosphorylase, debranching by glycosyl transferase, and cleavage by alpha-1,6-glucosidase. 2. Phosphorylase sequentially cleaves alpha-1,4 glycosidic bonds in glycogen, producing glucose-1-phosphate until limit dextrins remain. 3. Debranching enzyme removes 3-4 glucose fragments from limit dextrin branches and transfers them to another chain. Alpha-1,6-glucosidase then cleaves the remaining alpha-1,6 bonds to fully release glucose.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    199 views2 pages

    Glycogen Metabolism

    Uploaded by

    Karan Singh
    1. Glycogenolysis is the breakdown of glycogen into glucose. It involves phosphorylation by glycogen phosphorylase, debranching by glycosyl transferase, and cleavage by alpha-1,6-glucosidase. 2. Phosphorylase sequentially cleaves alpha-1,4 glycosidic bonds in glycogen, producing glucose-1-phosphate until limit dextrins remain. 3. Debranching enzyme removes 3-4 glucose fragments from limit dextrin branches and transfers them to another chain. Alpha-1,6-glucosidase then cleaves the remaining alpha-1,6 bonds to fully release glucose.

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    GLYCOGENOLYSIS
    Breakdown of glycogen into glucose

    1. Phosphorylasis
    Glycogen phosphorylase cleave α 1, 4 glycosidic bonds
    sequentially (from non reducing end of glycogen) to yield
    glucose 1 phosphate, continues until 4 glucose residues remain
    on the either side of branching to form limit dextrin.
    α 1, 6-bond α 1, 4-bonds

    Glycogen
    2. Debranching
    Glycosyl tranferase removes fragments of Pi
    Glycogen Phosphorylase 1
    3-4 glucose of branch chain and transfer
    them to another chain

    Glucose-1-Phosphate

    3. Cleavage of α 1, 6-bond by α
    1-6 glucosidase activity. Release
    of a free glucose

    Limit dextrin
    4. Remaining molecule of glycogen is again
    cleaved by phosphorylase and debranching 2
    Debranching enzyme (Tranferase activity)
    enzyme to repeat the reaction 1 to 3.
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    Debranching enzyme (α 1-6 glucosidase activity) 3


    5. Isomerization Free Glucose
    By phosphoglumutase

    Further action of Phosphorylase


    4
    6. Release of phosphate group from glucose 6
    phosphate by glucose 6 phophatase in liver and Glucose-1-Phosphate
    kidney to form glucose
    Phosphoglucomutas
    e 5
    Glucose-6-Phosphate Glycolysis

    Glucose-6-Phosphatase (In Liver and Kidney only)


    6

    Glucose
    ‘The Power of Body’
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    GLYCOGENESIS
    Storage of glucose into glycogen to serve you later (when your body really needs it)

    Glucose
    ATP
    Mg2 Phosphorylation
    + Glucokinase
    ADP e

    Glucose-6-phosphate

    Phosphoglucomutas Isomerisation
    e
    Glucose-1-phosphate
    UTP
    UDP- Uridine
    UDP glucose phosphorylase Diphosphate Glucose Synthesis
    PPi
    UDP-Glucose UDP-
    _-
    Glycogenin OH
    Glycogen initiator synthasis Glyocgenin protein accept glucose
    UDP from UDPG to from glycogen primer to
    initiate glycogen synthesis
    1 2 3
    O
    Glycogen Primer Glycogen synthase
    13UDP- Transfer Glucose from UDPG to the
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    Glycogen syntheses formation to form α 1, 4 glycosidic
    UDP linkages
    1 10 16
    O

    Glucosyl 4, 6 transferase
    α 1, 4-bonds
    (Branching enzyme)

    1 7 10
    O Formation of branches in
    glycogen by glucosyl 4, 6
    11 α 1,6-bonds transferase

    16
    Further elongation of glycogen by
    glycogen synthase forming α 1, 4-
    bonds

    Branching by glucosyl 4, 6 transferase


    forming α 1, 6-bonds

    Glycogen
    The Reserve Fuel of Body

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