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    23 Perhitungan Farmakokinetika Klinik

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    Mila Dwi Putri Utami
    This document provides examples of calculating pharmacokinetic parameters and dosages for various clinical scenarios involving intravenous and oral drug administration using one-compartment models. Sample cases illustrated include intravenous bolus doses, continuous intravenous infusions, intermittent intravenous infusions, and extravascular drug administration. Practice problems are also provided involving calculating pharmacokinetic parameters and adjusting drug dosages to achieve target steady-state concentrations for new patients.

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    23 Perhitungan Farmakokinetika Klinik

    Uploaded by

    Mila Dwi Putri Utami
    96 views3 pages
    This document provides examples of calculating pharmacokinetic parameters and dosages for various clinical scenarios involving intravenous and oral drug administration using one-compartment models. Sample cases illustrated include intravenous bolus doses, continuous intravenous infusions, intermittent intravenous infusions, and extravascular drug administration. Practice problems are also provided involving calculating pharmacokinetic parameters and adjusting drug dosages to achieve target steady-state concentrations for new patients.

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    This document provides examples of calculating pharmacokinetic parameters and dosages for various clinical scenarios involving intravenous and oral drug administration using one-compartment models. Sample cases illustrated include intravenous bolus doses, continuous intravenous infusions, intermittent intravenous infusions, and extravascular drug administration. Practice problems are also provided involving calculating pharmacokinetic parameters and adjusting drug dosages to achieve target steady-state concentrations for new patients.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    96 views3 pages

    23 Perhitungan Farmakokinetika Klinik

    Uploaded by

    Mila Dwi Putri Utami
    This document provides examples of calculating pharmacokinetic parameters and dosages for various clinical scenarios involving intravenous and oral drug administration using one-compartment models. Sample cases illustrated include intravenous bolus doses, continuous intravenous infusions, intermittent intravenous infusions, and extravascular drug administration. Practice problems are also provided involving calculating pharmacokinetic parameters and adjusting drug dosages to achieve target steady-state concentrations for new patients.

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    9/10/2019

    PERHITUNGAN RUMUS
    FARMAKOKINETIKA
    KLINIK
    Nova Hasani F., S.Farm., M.Sc., Apt.

    CONTOH KASUS (IV BOLUS) CONTOH KASUS (INFUS INTRAVENA)


    • Pasien dg diagnosa complex partial seizures • Seorang pasien dg diagnosa infark
    mendapat terapi fenobarbital iv. Diketahui
    miokard dan aritmia ventrikuler akan
    parameter farmakokinetika : ke = 0,139/hari, V =
    50 L, Cssmax = 30 mg/L dan Cssmin = 25 mg/L. mendapat terapi dg lidokain.
    • Hitung dosis dan interval dosis fenobarbital iv yg • Diketahui : Css = 3,0 mg/L; V = 50 L; Cl =
    hrs diberikan pd pasien! 1,0 L/min.
    • Buat pengaturan dosisnya ! (Hitung DL
    dan dosis infus)

    1
    9/10/2019

    CONTOH KASUS (INFUS IV INTERMITTEN) CONTOH KASUS (EKSTRAVASKULAR)

    • Pasien mendapat tobramisin utk terapi • Pasien dg simple partial seizures


    sepsis intrabdomen. mendapat asam valproat.
    • Diketahui : V = 20 L, ke = 0,087 h−1 • Diket : V =12 L, ke = 0,05 h−1, Tmax = 3 h,
    • Hitung dosis tobramisin (diinfus selama 1 F = 1,0) dan Cssmax = 80 mg/L ; Cssmin =
    jam) agar tercapai Cssmax = 6 mg/L dan 50 mg/L
    Cssmin = 1 mg/L ! • Hitung dosisnya !

    CONTOH KASUS (KADAR TUNAK RATA-RATA) SOAL


    • PZ is a 35-year-old, 60-kg female with a Staphylococcus
    • Pasien aritmia mendapat terapi tablet aureus wound infection. While receiving vancomycin 1 g
    every 12 hours (infused over one hour), the steadystate
    prokainamid SR. Cl prokainamid = 24 L/h;
    peak concentration (obtained one-half hour after the end
    F = 0,85, τ = 12 h (untuk tablet SR) dan of infusion) was 35 mg/L, and the steady-state trough
    Cssave = 5 mg/L concentration (obtained immediately predose) was 15
    mg/L.
    • Hitung dosisnya ! • (A) Using one compartment IV bolus equations, compute
    the pharmacokinetic parameters for this patient.
    • (B) Using the patient-specific pharmacokinetic
    parameters calculated in part A, compute a new
    vancomycin dose that would achieve Cssmax = 30 mg/L
    and Cssmin = 7.5 mg/L.

    SOAL SOAL
    • Negamycin is a new antibiotic with an average • KL is a 65-year-old, 60-kg female being treated
    volume of distribution of 0.35 L/kg and a half-life for septic shock. Among other antibiotics, she is
    of 2 hours in patients with cystic fibrosis. being treated with tobramycin 60 mg every 8
    Compute a dosage regimen for JM, a 22-year- hours (infused over 1 hour). Steady-state serum
    old, 45-kg female cystic fibrosis patient with concentrations are: Cssmax = 7.1 mg/L, Cssmin =
    Pseudomonas aeruginosa in her sputum, that 3.1 mg/L. Using one compartment intermittent
    will achieve steady-state peak concentrations of intravenous infusion equations, compute the
    10 mg/L and trough concentrations of 0.6 mg/L pharmacokinetic parameters for this patient and
    using one-compartment model IV bolus use them to individualize the tobramycin dose to
    equations (assume that the drug is given as an achieve Cssmax = 8 mg/L and Cssmin = 1.0 mg/L.
    IV bolus).

    2
    9/10/2019

    • MM is a 54-year-old, 68-kg male being


    treated with procainamide 750-mg regular
    release capsules every 6 hours for an
    arrhythmia. The following steady-state
    concentration is available: Cssmin = 1.5
    mg/L (obtained immediately predose).
    Calculate a dose that will achieve a
    Cssmin = 2.5 mg/L.

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