Syllabus For B. Pharm. (Honours) Session: 2013-2014: Examination-2017

Syllabus for B. Pharm.
(Honours)
Session: 2013-2014
Examination- 2017
DEPARTMENT OF PHARMACY
FACULTY OF SCIENCE
UNIVERSITY OF RAJSHAHI
RAJSHAHI-6205, BANGLADESH
Published by: Department of Pharmacy, University of Rajshahi

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UNIVERSITY OF RAJSHAHI
FACULTY OF SCIENCE
DEPARTMENT OF PHARMACY
Syllabus for B. Pharm. (Honours)
Session: 2014-2017
Examination: B. Pharm. (Honours) Part-I : 2014
B. Pharm. (Honours) Part-II: 2015
B. Pharm. (Honours) Part-III: 2016
B. Pharm. (Honours) Part-IV: 2017
The B. Pharm. (Honours) courses Pharmacy consists of total 160 credits of 4000 marks (40 units) spread over four academic years. No
students shall be allowed to stay for more than two academic years in each of the 1st, 2nd and 3rd year of the program. There shall be
theoretical, practical, viva-voce, class assessment/ tutorial/ terminal/ home assignment, project/ in-plant training and related subjects.
An honours student, for obtaining the degree, shall have to pass all the examinations within 6 (six) academic years from the date of
his/ her first admission and shall not be allowed to stay for more than 2 (two) academic years in each of his/ her first, second, and third
year honours classes. The non-credit English course shall have to be passed in 4 (four) academic years from the date of his/ her
admission.
The duration of examination of the theory courses shall be 3 and 4 hours for 0.50 and 1.00 unit courses, respectively. The duration of
practical examination shall be 6-12 and 12-24 hours (4-6 hours per day) per 0.50 and 1.00 unit practical courses, respectively. For
other fractions of a unit, proportionality shall be applied.
The year-wise distribution of marks among the theory, practical, viva-voce, class assessment/ tutorial/ terminal/ home assignment,
thesis/ dissertation/ project/ in-plant training, etc. are as follows:
B. Pharm. (Honours) Part- I Examination, 2014
Course Unit Marks Credit
Theory 7 700 28
Practical 1.5 150 6
Viva 0.5 50 2
Class record 0.5 50 2
Total 9.5 950 38
Course Course Title Unit Mark Credit
101 Inorganic Pharmaceutical Chemistry-I 1 100 4
102 Organic Pharmaceutical Chemistry-1 1 100 4
103 Physical Pharmacy-I 1 100 4
104 Pharmacognosy-I 1 100 4
105 Physiology and Biochemistry-1 1 100 4
106 Pharmaceutical Microbiology and Immunology 1 100 4
107 Biostatistics and Computer Science 1 100 4
108 English (Noncredit)1 1 100 0
109 Practical2 1.5 150 6
110 Viva-Voce (General) 0.5 50 2
111 Class assessment/ tutorial/ home assignment/ attendance3 0.5 50 2
Total 9.5 950 38
B. Pharm. (Honours) Part-II Examination, 2015
Theory 7 700 28
Practical 1.5 150 6
Viva 0.5 50 2
Total 9.5 950 38
Course Course Title Unit Mark Credit
201 Inorganic Pharmaceutical Chemistry-II 1 100 4
202 Organic Pharmaceutical Chemistry-II 1 100 4
203 Physical Pharmacy-II 1 100 4
204 Pharmacognosy-II 1 100 4
205 Physiology and Biochemistry-II 1 100 4
206 Pharmacology-I 1 100 4
207 Pharmaceutical Technology-I 1 100 4
208 Practical2 1.5 150 6
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210 Class assessment/ tutorial/ home assignment/ attendance 0.5 50 2
Total 9.5 950 38
B. Pharm. (Honours) Part-III Examination, 2016

6x1 =6 600 24
Theory
3 x 0.5 = 1.5 150 6
Practical 2 200 8
Viva 0.5 50 2
Total 10.5 1050 42
Course Course Title Unit Marks Credit
301 Pharmaceutical Analysis-I 1 100 4
302 Medicinal Chemistry-I 1 100 4
303 Pharmacology-II 1 100 4
304 Biopharmaceutics-I 1 100 4
305 Pharmaceutical Engineering 1 100 4
306 Pharmaceutical Technology-II 1 100 4
307 Cosmetology 0.5 50 2
308 Hospital and Community Pharmacy 0.5 50 2
309 Quality Control, Quality Assurance & Validation 0.5 50 2
310 Practical2 2 200 8
Total 10.5 1050 42
B. Pharm. (Honours) Part-IV Examination, 2017
Theory 6x1 =6 600 24
3 x 0.5 = 1.5 150 6
Practical 2 200 8
Viva 0.5 50 2
Total 10.5 1050 42
Course No Course Title Unit Marks Credit
401 Pharmaceutical Analysis-II 1 100 4
402 Medicinal Chemistry-II 1 100 4
403 Pharmacology-III 1 100 4
404 Biopharmaceutics-II 1 100 4
405 Pharmaceutical Technology-III 1 100 4
406 Molecular Biology and Biotechnology 1 100 4
407 Organic Spectroscopy 0.5 50 2
408 Clinical Pharmacy and Pharmacy Law & Ethics 0.5 50 2
409 Pharmaceutical Marketing and Management 0.5 50 2
410 Practical2 2 200 8
Total 10.5 1050 42
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A Candidate shall not be allowed to continue the B.Pharm. Honours programmed if he/she fails to obtain the
letter grade (LG) “S” in the English course in 4(four) academic years from the date of admission. The letter grade
“S” corresponds to at least 30% marks.
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30% of the total practical marks shall be allotted for continuous laboratory assessment.
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20% of the assessment marks shall be awarded for attendance in the class on the basis of the following table:
Table: Marks on attendance
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Attendance Marks Attendance Marks Attendance Marks
95-100% 20% 90-<95% 18% 85-<90% 16%
80-<85% 14% 75-<80% 12% 70-<75% 10%
65-<70% 8% 60-<65% 6% <60% 00%
Eligibility for Examination:

Percentage of Attendance: In order to be eligible for taking up the B. Pharm. (Honours) examinations, a
candidate must have pursued a regular course of study by attending not less than 75% of the total number of
classes held (theoretical, practical, class assessment etc.) provided that the academic committee of the department
on special grounds and on such documentary evidence that may be necessary, may condone the cases of shortage
of attendance not below 60%. A candidate, appearing at the examination under the benefit of this provision shall
have to pay in addition to the examination fees, the requisite fee prescribed by the syndicate for the purpose.
Candidates having less than 60% attendance shall not be allowed to fill up the examination form.
Readmission: A candidate, who failed to appear at the examination or fails to pass the examination, may on the
approval of the relevant department be readmitted to the immediate following session in the first, second, third or
fourth year of the program. A readmitted candidate shall have to reappear at all course examinations.
Medium of Questions and Answers:
Questions shall be made in English. The medium of answers in the examination of all courses shall be either
English as directed by the department. However, a mixing of English and Bangla shall never be allowed in an
answer-script.
Award of Degree, Promotions and Improvement of Results :
(a) Award of degree: The degree of Bachelor of Science with Honours in any subject shall be awarded on the
basis of CGPA obtained by a candidate in B. Sc./B. Pharm. Honours Part-1, Part-2, Part-3 and Part-4
examinations. In order to qualify for the B. Sc./B. Pharm. Honours degree a candidate must have to obtain
within 6 (six) academic years from the date of admission :
(i) a minimum CGPA of 2.50
(ii) a minimum GPA of 2.00 in the practical courses in each of Part-1,Part-2,Part-3 and Part-4 examinations,
(iii) 144 Credits out of 160 and
(iv) “S” letter grade in English course (in 4 academic years from the date of admission).
The result shall be given in CGPA with the corresponding LG (Table of LG, GP and CP) in bracket. For
instance, in the example cited above the result is “CGPA=3.10 (B)”.
(b) Publications of results: The overall results of a successful candidate covering all examinations of four
years shall be declared on the basis of CGPA. The transcript in English shall show the course number, course
title, credit, grade and grade point of individual courses, GPA of each year, CGPA and the corresponding LG for
the overall result.
(c) Promotions: In order to be eligible for promotion from one class to the next higher Honours class, a
candidate must secure
(i) at least 2.00 GPA in each of his/her Part-1, Part-2 and Part-3 examinations,
(ii) at least 2.00 GPA in each of his/her Part-1, Part-2 and Part-3 practical and class assessment / tutorial
/ terminal / home assignment course examinations, and
(iii) (a) minimum 30 credits in his/her Part-1 examinations
(b) minimum 30 credits in his/her Part-2 examinations and 64 credits in total Part-1 and Part-2
examinations.
(c) minimum 34 credits in his/her Part-3 examinations and 102 credits in total Part-1, Part-2
Part-3 examination. (d) minimum 34 credits in his/her Part-4 examination for considering the
award of Honours degree.
(d) Course Improvement: A promoted student earning a grade less than 3.00 in individual courses shall be
allowed to improve the grades on courses, not more than 8 Credits courses including those of “F” grades, if any,
of Part-1, Part-2 and Part-3 examinations or their equivalent courses (in case of changes in the syllabus), defined
by the departmental academic committee, through the regular examination of the immediate following batch.
However, if the candidate fails to clear his/her “F” grades in the first attempt, he/she shall get a second (last)
chance in the immediate next year to clear the “F” grades. No improvement shall be allowed in practical course
examinations/ viva-voce/ class assessment/ tutorial/ terminal/ home assignment and thesis/ dissertation/ project/
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in-plant training courses. If a candidate fails to improve his/her course grade, the previous grade shall remain
valid. If a readmitted candidate fails to appear at the regular class assessment/ tutorial/ terminal/ home
assignment and thesis/ dissertation/ project/ in-plant training courses, his/her previous grades shall remain valid.
(e) Result Improvement: A candidate obtaining a CGPA of less than 3.00 at the end of the Part-4
examinations, within 5 (five) academic years, shall be allowed to improve his/her result, on up to a maximum of
4 (four) full units (16 Credits) of the Part-4 theoretical courses in the immediate next regular examination (within
six academic years from the date of admission) after publication of his/her result. The year of examination, in the
case of a result improvement, shall remain same as that of the regular examination. His/her previous grades for
practical courses/ viva-voce/class assessment/ tutorial/ terminal/ home assignment, thesis/ dissertation/ project/
in-plant training courses shall remain valid. If a candidate fails to improve CGPA, the previous results shall
remain valid.
(f) Pass Degree: Candidates failing to obtain required CGPA 2.50 and 144 Credit.
(i) For promotion in Honours Part-3 examination in 4 (four) academic years, in case of readmission in Part-3
course year, in 5 (five) academic years, with no readmission in Part-3 course year from the date of Ist year
admission. But fulfill the following Conditions.
If a candidate fails to obtain required GPA (2.00) and Credit Point (102) for promotion from Part-3 to Part-4
within 5 academic years from his/her first date of admission in First year but secured CGPA 2.00 and total Credit
Point 94 with LG of “S” in the English Course, shall be awarded Pass degree, such candidates shall not be
allowed to improve their pass degree.
or
If a candidate fails to obtain a minimum of 34 Credits and GPA (2.00) in his/her Part-4 examination also fails to
obtain 144 Credits and CGPA 2.50 within 6 academic years from his/her first date of admission in first year but
secured minimum CGPA 2.00, 128 Credits, with LG of “S” in the English Course, shall be awarded Pass degree
and such candidates shall not be allowed to improve their pass degree.
(g) Dropping out: Candidates, failing to earn the yearly required GPA after completing regular examinations
and subsequently failed again after taking readmission in 1st, 2nd or 3rd year, or to clear required “F” grades in
the stipulated period, shall be dropped out of the programme.
The Grading Systems:
(a) Credit Point (CP): The credit points achieved by an examinee for 0.50 and 1.00 unit courses shall
be 2 and 4, respectively. For other fractions of a unit, proportionality should be applied.
(b) Letter Grade (LG) and Grade Point (GP): Letter Grades, corresponding Grade Points and
Credit Points shall be awarded in accordance with provisions shown below:
Table of LG, GP and CP for credit courses
Numerical grade Letter Grade (LG) Grade Point (GP) / Credit Point (CP) /
unit unit
80% or its above A+ (A plus) 4.00 4
75% to less than 80% A (A regular) 3.75 4
70% to less than 75% A- (A minus) 3.50 4
65% to less than 70% B+ (B plus) 3.25 4
60% to less than 65% B (B regular) 3.00 4
55% to less than 60% B- (B minus) 2.75 4
50% to less than 55% C+ (C plus) 2.50 4
45% to less than 50% C (C regular) 2.25 4
40% to less than 45% D 2.00 4
Less than 40% F 0.00 0
Incomplete I -- 0
Absence from the final examination shall be considered incomplete with the letter grade “I”.
(ii) Table of LG, GP and CP for non-credit courses

Numerical grade LG GP / unit CP / unit
30% and above S 0.0 0.0
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Less than 30% U 0.0 0.0
Here S and U refer to “satisfactory” and “unsatisfactory”, respectively.
B. Pharm. (Honours) Part-I

Course: 101 (Unit – 1)
Course Title: Inorganic Pharmaceutical Chemistry-I
Full marks - 100
1. Structure of Atoms: Fundamental particles, origin of spectral lines and elementary treatment of
theories of atomic structure, quantum numbers, De-broglies relationship, Heisenburg uncertainty
principle, Pauli exclusion principle, Hund’s rule, Aufbau principle, shapes of s, p, d, f orbitals.
2. Classification of Elements: Electronic structure of atoms, modern periodic table and periodic law,
variation of periodic properties within periods and groups, ionization potential, electron affinity,
electronegativity, usefulness and limitation of periodic table.
3. The Chemical Bonds: Electronic concept of valency, different types and formation of chemical
bonds, e.g., ionic, covalent, co-ordinate covalent, metallic, hydrophobic, Vander Waal's force,
hydrogen bond, etc., concept of atomic orbital, theories of covalent bonding and hybridization.
4. Oxidation Reduction Reactions: Definition, oxidation number, equivalent weight of oxidant and
reductant, decomposition of drugs by redox reaction, ion electron method of balancing equation,
importance and determination of redox potential.
5. Co-ordination Compounds: Definition, Werner,s theory, electronic interpretation, structures of

co-ordination compounds, valence bond theory and hybridization approach.
6. Alkali, Alkaline earth metals and Halogen: Electronic configuration, Physical and chemical
properties of alkali, alkaline earth metals and halogens including their pharmaceutical applications.
7. Basic concept on acids, bases, salts and pH : Definitions, various theories of acids & bases,
classification of acids, bases & salts, strength of acids & bases, determination of strength gradient of
acids & bases.
Recommended Books:
I. S. Z. Haider : Introduction to Modern Inorganic Chemistry
II. Satya Prakash, Tuli, Basu and Madan : Advanced Inorganic Chemistry
III. R.D. Madan : Modern Inorganic Chemistry
IV. B.R. Puri and L.R. Sharma : Principles of Inorganic Chemistry
* Other Books will be indicated by respective teachers

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Course: 102 (Unit –1)
Course Title: Organic Pharmaceutical Chemistry-I
Full marks - 100
1. General Concepts: Methods of purification, tests of purity, acids, bases, polarity of bonds,
carbonium and carbanions, hydride, protons, free-radicals, hydrogen bonding, etc.
2. Chemistry of Aliphatic Compounds: Introduction, methods of preparation, physical and chemical

properties and pharmaceutical applications of alcohols, aldehydes, ketones, hydrocarbons, ester,
ethers, amines, amides and carboxylic acids.
3. Chemistry of Aromatic Compounds:

a) Aromaticity, mechanism of orientation and substitution and resonance.
b) Preparations, reactions and pharmaceutical importance of aldehyde, amine, acid, diazonium
compounds, etc.
4. Carbohydrates:
a) Monosaccharides and Disaccharides: Nomenclature, classifications, general reactions,
configurations and pharmaceutical importance of monosaccharides and disaccharides.
b) Polysaccharides: Composition, structure, properties and pharmaceutical importance of starch and
cellulose.
Recommended Books:
I. B.S. Bahl and Arun Bahl : Advanced Organic Chemistry
II. R.T. Morrison and R.N. Boyd : Organic Chemistry
III. I.L. Finar : Organic Chemistry Vol. I & II
IV. Ashutosh Kar : Medicinal Chemistry

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Course Title: Physical Pharmacy-I
Full marks – 100
1. Properties of Gases: Gas laws, diffusion of gases, kinetic theory of gases, Van der Waal’s
equation, critical phenomena, continuity of state, principle of corresponding states and the reduced
equation of states, liquefaction of gases, uses of liquefied gas.
2. a) Thermodynamics: System, state and state functions, first law of thermodynamics, reversible,
irreversible, isothermal and adiabatic changes, enthalpy, internal energy, molar heat capacity,
second law of thermodynamics, Carnot’s cycle, entropy, Free energy, Gibb’s free energy, Gibbs-
Helmholtz equation, third law of thermodynamics.
b) Thermo chemistry: Exothermic and endothermic reactions, thermochemical equation, heat of
reaction, Laplac’s and Hess’s laws and its applications, bond energies.
3. Solutions: Units of concentration, Henry’s law and distribution law and colligative properties.
4. Phase rule: Phase, component and degree of freedom, one component system (water and sulfur),
two component systems (liquid-liquid, liquid–vapor) eutectic systems and dilution of completely
immiscible systems.
5. Ionic Equilibria : Definition, Ostwald’s dilution law, dissociation theory, ionization of water,
common-ion effect, ionization constants of acid and bases, ionization of polyprotic electrolytes,
solubility products and its application in pharmacy.
6. pH, Buffer and salt hydrolysis: Relative strengths of acids and bases, pH scale and its limitations,
pH of weak acids and bases, degree of hydrolysis and hydrolysis constant, buffer equation, buffer
capacity, buffer in pharmaceutical and biological systems, buffered isotonic solutions, methods of
adjusting tonicity and pH, application of pH, buffer and salt hydrolysis in pharmacy.
7. Chemical Equilibria: Law of mass action, criteria of chemical equilibrium, application of law of
mass action to homogenous and heterogeneous equilibrium, factors affecting equilibrium, Gibb’s
free energy change for chemical equilibria, Le-Chatelier principle and its industrial application.
Recommended Books:
I. M. M. Haque and M. A. Nawab : Principles of Physical Chemistry
II. A. Martin and J. Swarbrick : Physical Pharmacy
III. P.W. Atkins : Physical Chemistry
IV. K.K. Sharma and L.K. Sharma : A Textbook of Physical Chemistry
V. B.S. Bahl, D.G. Tuli and Arun Bahl : Essentials of Physical Chemistry
VI. N. Kundu and S.K. Jain : Physical Chemistry
VII. S. H. Maron and C.F. Prutton : Principles of Physical Chemistry

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Course Title: Pharmacognosy-I
Full marks - 100
1. Introduction: Definition, scope, historical background and relation to other disciplines.

2. Drug Literatures and Publications: Pharmacopoeia, pharmaceutical codex, formulary, index,
official, non-official, unofficial and INN drugs (new drugs).
3. Crude Drugs: A general view of their origin, distribution, cultivation, collection, drying, storage,
commerce and quality control.
4. Phytochemistry: Extraction, separation and detection of plant metabolites; basic principles of
chromatography.
5. Lipids: Definition, classification, properties and extraction of
a) Plant origin: Castor oil, coconut oil, linseed oil, olive oil, peanut oil and chaulmoogra oil.
b) Animal origin: cod liver oil, shark liver oil and halibut liver oil.
c) Waxes.
6. Carbohydrate and Related Compounds: Definition, classification, properties and biosynthesis.
a) Monosacharides and oligosaccharides: Sucrose, dextrose, glucose, fructose etc.
b) Polysaccharides and polysaccharide-containing drugs: Starch, dextrin, cellulose, etc.
c) Gums and mucilages: Tragacanth, acacia, sodium alginate, agar etc.
7. Alkaloids: Definition, nomenclature, classification, distribution, properties, test, extraction and
biosynthesis.
Study of the following alkaloidal drugs: a) areca, conium b) lupinus and c) ephedra and colchicum.
8. Phenolic Compounds and Tannins: Definition, classification, properties and tests. Study of tanin
containing drugs such as nutgall, catechu, etc.
9. Resin and Resinous Compounds: Definition, classification and properties. Study of balsam,
podophylum, jalap, canabis, capsicum, ginger, murrh, tolu balsam, benzoin etc.
Recommended Books:
I. E. P. Claus and V.E. Tylor : Pharmacognosy
II. V.E. Tylor, L.R. Brady & J.E.Robbers : Pharmacognosy
III. W.C. Evans : Trease and Evan’s Pharmacognosy
IV. Mohammed Ali : Textbook of Pharmacognosy
V. K. Raghunathan and Roma Mitra : Pharmacognosy of Indigenous Drugs Vol. I & II

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Course Title: Physiology and Biochemistry-I
Full marks – 100
1. Cell and Tissue

a) Cell: Prokaryotic and eukaryotic cells, Structure and function, cell inclusions, division of cells.
b) Tissue: Definition, classification, Characteristics, Structure and function of epithelial tissues,
Connective tissue, muscular tissue and nervous tissue.
2. I. Blood system
a) Blood : composition and function
b) Plasma: electrolytes, proteins and other organic constituents.
c) Blood cells: Formation and destruction, cell constituents, functions of different blood cells.
d) Haemoglobin: Structure and function, haemoglobinopathy, thalassemia.
e) Anaemia: Causes and classification
f) Blood coagulation and anticoagulants.
g) Blood group and transfusion
II. Lymph: Composition, function, circulation and function, lymph nodes and lymphatics.
3. Cardiovascular System
a) Heart: Structure and properties of cardiac muscles, conduction system of heart, cardiac cycle,
heart sound, cardiac out put and ECG. Control and requirement of normal heart beat.
b) Blood vessels: Type of blood vessels and their function.
c) Blood pressure (BP): Measurements and regulation of BP, control of BP (neural and
humoral).
d) Regional blood circulation: Pulmonary, hepatic, cerebral, capillary and coronary circulation.
4. Digestive System: Structure of the different parts of the alimentary tract; composition, function
and regulation of the secretion of different digestive juices; digestion and absorption of food stuffs,
movement of alimentary tract.
5. Respiratory System: Functional anatomy of the respiratory system, mechanism of respiration, lung
volumes and capacities, gaseous exchange and transport (O2 and CO2); regulation of respiration
(nervous and chemical); causes and classification of hypoxia; periodic (abnormal) breathing, Chene-
stokes breathing, Kussmal breathing and breathing at high altitude.
6. Basic Concept of Nucleic Acid: Definition, classification, structure and function of protein.
Protein, DNA, RNA. Importance of nuclic acid study, transcription and translation.
Recommended Books:
I. C.C. Chatterjee : Human Physiology Vol. I & II
II. Guyton : A Textbook of Medical Physiology
III. Chakrabarti, Ghosh and Sahana : Human Physiology
IV. W. F. Ganong : Review of Medical Physiology
V. Selim Reza : The Essentials of Human Physiology
VI. K. Meftun Ahmed : Physiology of Blood

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Course Title: Pharmaceutical Microbiology and Immunology
Full marks - 100
1. Introduction: Historical development, scope of microbiology with special reference to pharmaceutical

sciences.
2. Microscopy: Bright field, dark field, flourescence, phase contrast and electron microscopy.
Microscopic examination of microorganisms, wet mount and hanging drop techniques. Microbial
staining.
3. Industrial microbiology: Microorganisms and industry (prerequisites to practical industrial
microbiological processes, major classes of products and processes, microorganisms used in industrial
process, industrial uses of bacterial, yeast, molds etc.
4. Bacteria
a) General characteristics of bacteria.
b) General and cellular morphology - size, shape, fine structures and movement.
c) Cultivation of bacteria: Nutritional requirements, factors affecting growth, bacteriological media.
d) Reproduction and growth: Modes of cell division, normal growth cycle, growth curve, synchronous
growth and measurement of growth.
e) Pure culture and cultural characteristics: Methods of isolation, maintenance and preservation of pure
cultures, colony characteristics and characteristics of broth culture.
f) Microbial metabolisms: Introduction, biogenesis, anabolism, catabolism, metabolic versatility of
organisms, enzymes, energy production by aerobic & anaerobic processes, fermentation processes.
5. Virus:
a) Definition and general properties, classification and nomenclature, morphology, multiplication and
cultivation, viruses and human diseases, treatment of viral diseases, application of virus in life sciences
and medicine.
b) Bacteriophage: Definition, ICTV classification, morphology and replication cycle of bacteriophages,
role of phages in food fermentation.
6. Fungi, rickettsia and actinomycetes

a) Fungi- Characteristics, morphology, reproduction (sexual & asexual), cultivation, classification of
fungi, some fungi of special interest (Penicillium, Candida, Aspergillus, Rhizopus), diseases caused by
fungi, pharmaceutical importance of fungi.
b) Brief study on rickettsia and actinomycetes
7. Immunology
a) Introduction to immune response: Innate and acquired immunity, complement, self and non-self
discrimination and source and chemistry of antigen.
b) Cells involved in immune system: Macrophage and other antigen presenting cells, T cells, B cells, etc.
c) Antibody: Classification, chemistry and function.
d) Hypersensitivity: Immediate and delayed type hypersensitivity reactions.
Recommended Books:
1. M.J. Pelczar, E.C.G. Chan and N.R. Kreig : Microbiology
2. Stainer : General Microbiology
3. R. Ananthanarayan and C. K. J. Paniker : Textbook of Microbiology
4. M. R. Choudhury : Modern Medical Microbiology
5. Ivan Roitt, J. Brostoff and David Male : Immunology
6. Abul K. Abbas, A.H. Lichtman and J.S. Pober : Cellular and Molecular Immunology
7. W.H. Elliott and D.C. Elliott : Biochemistry and Molecular Biology
8. S. J. Carter : Cooper and Gunn’s Tutorial Pharmacy
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Course Title: Biostatistics and Computer Science
Full marks - 100
(Biostatistics 60 + Computer Science 40)
Biostatistics
1. Statistics: Meaning & Scope. Variables and Attributes, Collection and presentation of Statistical data,
Frequency Distribution and Graphical Representation.
2. Analysis of Statistical Data: Location, Dispersion and their measures. Skewness, Kurtosis and their
measures. Moment, Cumulants and Practical examples.
3. Probability: Concept of probability, Sample Space, Events. Union and Intersection of Events. Probability
of Events. Laws of probability. Conditional Probabilities. Bose Einstein Statistics. Bay's Theorem,
Chebysec's Inquality, and Practical examples.
4. Random Variables and Probability Distribution: Basic concepts. Discrete and continuous random
variables. Density and distribution functions. Mathematical Expectation and variance. Joint, marginal and
conditional density functions. Conditional Expectation and conditional valiance. Moments and Culnulant
generating functions. Characteristic function. Study of Binomial, Poisson, Normal and Bivariate Normal
distribution and Practical examples.
5. Bivariate Distribution: Bivariate data, Scatter Diagram, Marginal and conditional Distribution,
Correlation, Rank correlation. Partial and Multiple correlation, Contingency, Analysis and Practical
applications.
6. Linear Regression: Linear Regression for two Variables, Principle of Least Squares Method, Lines of
best fit, Residual Analysis and examples.
7. Test of Significance: Basic idea of Null hypothesis, Alternative hypothesis, Type-1 error Type-II error,
level of significance Degree of freedom, Rejection region and Acceptance region. Test of Single mean, single
variance, Two sample means and Variances. Test for 2x2 contingency tables, Independence test and Practical
examples.
Computer Science
1. Computer: History, classification and application in pharmaceutical analysis.
2. Organization of computer: A general review of INPUT/OUTPUT media and devices, functional
parts and organization of CPU, hardware, software, batch processing, RAM, ROM, maintenance, etc.
3. Operating systems: Introduction to Windows, Linux and other operating system.
4. Computer packages: Microsoft Office-Word, Power Point, Excel and Outlook; Photoshop and Internet
explorer.
5. Computer Virus: Definition, Classification, Developing an Effective anti-virus strategy, how anti-
virus software works. Brief discussion on computer worms, Adware, Spyware and trojan horse.
Recommended Books:
I. R. N. Shil and S. C. Debnath : An Introduction to the theory of Statistics
II. S. P. Gupta : Statistical Methods
III. S.C. Gupta and V.K. Kapoor : Fundamentals of Mathematical Statistics
IV. Jerrold H Zar : Biostatistical Analysis
V. Aptech : Computer Books
VI. Noel Kalicharan : An Introduction to Computer Studies
VII. H. L. Capron : Computers
VIII. Peter Norton’s : Introduction to computers
IX. Mahbubur Rahman : Office97 / 2000 / XP
Recommended Books of Biostatistics:
Anderson, A.J.B (1989) : Interpreting Data, Chapman and Hall, London.
Cramer, H. (1955) : The Elements of Probability Theory, Wiley, N. Y.
Gupta, S.C. and Kapoor, V.K.(1.001) : Fundamentals of Applied Statistics, 3rd Ed. Sultan Chand and Sons, N-Delhi, India.
Hoel, P.G. (1993) : Introductory Statistics, Wiley, N.Y. / Lipschutz, S. (1987): Probability, McGraw-Hill, N.Y.
Mosteller, F., Rourke and Thomas (197(1) : Probability with Statistical Applications, 2nd Ed., Addison-Wesley, N. Y.
Ross, S.M. (2002) : Introduction to Probability Models. 3rd 4 Academic Press, N.Y.
Yule, G. U. and Kendall, M. G. (1994) : An Introduction to the Theory of Statistics, 14th ed... Charles Griffin., London
13

Course Title: English
Full marks – 100
1. A brief introduction on the popular English language tests and implications of these tests for
higher studies. Importance of learning English.
2. IELTS and TOEFL: Practice of the different modules: Listening, Reading, Writing and
Speaking
3. GRE: Verbal Reasoning, Quantitative Reasoning and Analytical Writing
4. Functional English:
Parts of Speech, Articles, Sentence Structures, Verb, Tense, Punctuations, Structure of simple,
compound and complex sentences; Voice; Narrations; Modal verbs; Phrasal verbs; Translations.
5. Differences between American and British English.
6. Vocabulary Building: Commonly used words in pharmaceutical and health sciences,

newspapers and scientific articles; synonyms and antonyms.
7. Writing cover letter, curriculum vitae/resume, application for jobs etc.
Recommended Books:
• Raymond Murphy : Intermediate English Grammar
• Cambridge University press :Cambridge IELTS
• E Van Bemmel : IELTS to Success
• S. Ahmed : Learning English, The Easy Way
• A.J. Thomson and A.V. Martinet : A Practical English Grammar.
• J. Swales : Writing Scientific English
• Wren and Martin : English Grammar and Composition
• G.H. Vallins : Good English
• A.S. Hornby : The Teaching of Structural Words and Sentences

14

Course: 109 (Unit –1.5)
Course Title: Practical
Full marks – 150
101. Inorganic Pharmaceutical Chemistry-I (Marks-25)

Inorganic qualitative analysis of radicals of elements Na, K, Ca, Ag, Mn, Fe, Co, Mg, Al, Cu and acid radicals:
CO3, halides, citrates, SO4, SO3, NO3, etc.
102. Organic Pharmaceutical Chemistry-I (Marks-25)
Qualitative analysis of organic compounds a) Detection of elements b) Identification of functional groups c)
Determination of melting points. d) Test of purity (e) Solubility test and classification of the compound.
103. Physical Pharmacy-I (Marks-25)
(i) Laboratory procedures, safety regulations, scientific notations, plotting of data and finding of slope and
intercept.
(ii) Determination of formula and composition of a suitable hydrate (CuSO4 5H2O, NiSO4 7H2O etc)
(iii) Determination of the density of a liquid / solution by density bottle / pycnometer method.
(iv) Determination of molecular weight of substances like CHCl3, CCl4 by Victor Meyer’s method.
(v) Determination of molecular weight of organic salts by chemical method.
(vi) Determination of heats of solution of simple salts by calorimeter.
(vii) Determination of heats of solution of sparingly soluble samples in water by measuring solubility as a function
of temperature (application of Vants-Hoff equation).
(viii) Determination of distribution coefficients of benzoic acid between (i) hexane and octane (ii) ether and water.
(ix) Determination of heat of neutralization of HCl with NaOH.
(x) Preparation of primary and secondary standard solutions.
(xi) Standardization of HCl acid solution by sodium carbonate solution
(xii) Standardization of NaOH solution by potassium hydrogen phthalate / oxalic acid
(xiii) Standardization of NaOH solution by potassium hydrogen phthalate / oxalic acid
(xiv) Standardization of KMnO4 solution by sodium oxalate
104. Pharmacognosy-I (Marks-25)
a) The cell, cell contents and cell types:
(i) The cell: Some cellular organism (Cork and diatomites), Fungi, mucor or rhizomes, aspergillus, penicillin,
ergot and yeast. (ii) Cell contents: Starches and derivatives, calcium carbonate, silica.
(iii) Cell types: Parenchyma and modifications colocynth nux-vomica, endosperm, cinnamon, powder, tea,
liberated-stem, prosenchyma pericyclic fibers-jute: xylem fibers and vessels-liquorice: tracheids-pinus wood.
b) Epidermal cells and associated structures (trichomes stomata etc.), leaves of belladonna, menthe, rosemery,
sienna, Indian hemp, digitalis, etc. Seed trichomescotton and nux vomica seeds; cork, cells-cascara sagrada.
c) Study of some groups of unorganized white and off white powdered and whole drugs
i) General tests for carbohydrates. ii) Preparation examination of starches and related products.
iii) Examination of gums: Acacia, tragacanth, sterculia, agar and alginates.
d) Examination of fibers and surgical dressing
e) Study of some medicinal plants of Bangladesh
105. Physiology and Biochemistry-I (Marks-25)
a) Hematology
i) Study of compound microscope ii) Microscopically study of blood cells iii) Different types of WBC,
erythrocytes and platelets iv) Examination of hemoglobin v) Differential count of WBC vi) Total count of
RBC and WBC vii) Determination of clotting and bleeding time viii) Examination of clot under the
microscope ix) Effect of chemical agents of RBC x) Fragility test of RBC. xi) Determination of erythrocytes
sedimentation rate xii) Examination of haemin crystals
b) Histology: Histology of muscle, liver, spleen, stomach, duodenum, pancreas, lung, kidney, skin and endocrine
glands.
c)Chemical physiology:
i) Qualitative test of carbohydrates, proteins and fats ii) Qualitative and quantitative experiments on digestive
juice. iii) Examination of urine, estimation of main constituents and detection of abnormal constituents.
106. Pharmaceutical Microbiology and Immunology (Marks-25)
15
1. (a) Preparation of bacterial media b) Culture of Bacteria c) Isolation of bacteria from natural habitat d)
Identification and characterization of bacteria e) Staining of bacterial cells and spores f) Preparation of pure cultures
and its identification g) Bacterial counts h) Identification and characterization of fungus
2. (a) Isolation of pure culture by serial dilution method (b) Determination of bacterial growth curve
B. Pharm. (Honours) Part-II

Course Title: Inorganic Pharmaceutical Chemistry-II
Full marks - 100
1. General Properties, Preparation and Uses of Pharmaceutically important salts of Sodium,

Potasium, Magnasium, Calcium, Iron, Copper, Aluminium and Zinc Ions.
2. Gastrointestinal Agents: Antacids, preparations and applications (Al and Mg), protective and
adsorbents; saline cathartics; their preparations with applications.
3. Radioactive Elements: Chemistry, types, properties, their uses in pharmaceutical and medical
sciences.
4. Environmental Chemistry
a) Environmental pollutants: Gases (SO2, SO3, CO, NO, HCl, NO2 etc.), hydrocarbons, cigarettes,
smokes, suspended particulate, pesticides, gasoline and industrial waste. The detrimental effects of
pollutants.
b) Heavy metal toxicity: Mercury, arsenic, lead, iron and copper poisoning - prevention and
treatment.
5. Preparation and Application of the Followings: Fluoride, Zinc, iodine, sulfur, boric acid,
selenium and cadmium sulfides.
6. Impurities in Medicinal Substances: Source, principles, qualitative and quantitative analysis and
test of purity.
Recommended Books:
(i) A. R. Gennaro : Remington, The Science and Practice of Pharmacy
(ii) Block, Roche, Soine and Wilson : Inorganic, Medicinal and Pharmaceutical Chemistry
(iii) L. M. Atherden : Bentley and Driver’s Textbook of Pharmaceutical Chemistry
(iv) H. S. Storker and S. L. Seager : Environmental Chemistry, Air and Water Pollution
(v) A. K. De : Environmental Chemistry
(vi) Colin Baird : Environmental Chemistry

16

Course Title: Organic Pharmaceutical Chemistry-II
Full marks - 100
1. Heterocyclic Compounds
Aromaticity, general methods of preparation and properties of furan, thiophene, pyrrole, quinoline,
isoquinoline, pyridine, thiazole, imidazole, pyrimidine, indole and their pharmaceutical importance.
2. Synthesis and Applications of Drugs: Paracetamol, aspirin, phenacetin, para-amino benzoic acid
(PABA) and sulpha drugs.
3. Stereochemistry: A general concept of different types of isomerism, tautomerism, asymmetric
synthesis, Walden inversion and resolution of racemic mixture.
4. Reaction Mechanism
a) Addition reaction: Electrophilic, nucleophilic and free radical (1, 2 and 1, 4) addition.
b) Substitution reaction: Unimolecular and bimolecular.
c) Elimination reaction: Unimolecular and bimolecular.
d) Rearrangement reaction: Hoffman, Claisen, Sigmatropic and Fries rearrangement.
5. Lipids: Definition, classification, properties and pharmaceutical importance of Fats, oils and
Phospholipids
6. Proteins: Introduction, structure, acidity and basicity, isoelectric point, reactions and chemical
synthesis of amino acids. Essential and nonessential amino acids, peptide synthesis and denaturation.
Recommended Books:
(i) B.S. Bahl and Arun Bahl : Advanced Organic Chemistry
(ii) R.T. Morrison and R.N. Boyd : Organic Chemistry
(iii) I.L. Finar : Organic Chemistry Vol. I & II
(iv) O.P. Agarwal : Chemistry of Organic Natural Products Vol I & II
(v) Raj K. Bansal : Organic Reaction Mechanisms
(vi) N. Evers and D. Caldwell : The Chemistry of Drugs
(vii) Norman and Coxon : Principles of Organic Synthesis

17

Course Title: Physical Pharmacy-II
Full marks - 100
1. Properties of liquids:
a) Vaporization and vapor pressure, measurement of vapor pressure.
b) Surface tension, Clausius-Clapeyron equation, measurement, application in pharmacy;
c) Viscosity, Poiseuillies’s equation and measurement of viscosity, application in pharmacy.
2. Properties of Solids: Types of solid, band theory of solids, conductors, semiconductors,
superconductors and insulators, crystals, types of crystal including according to type of bonding,
mechnical properties of crystals, lattice energy of ionic crystals, Madelung constant and energy,
Born-Lande equation and Born-Haber cycle, space lattice, unit cells, Weiss and Miller indices,
crystal of symmetry, polymorphism and dilatometric analysis of compounds, isomorphism, crystal
defects, liquid crystal.
3. Chemical Kinetics: Rate laws and rate constants, order and molecularity, order of reactions and its
determination, integrated rate laws, half lives and shelf lives, theories of reaction rates, factors
affecting reaction rates; catalysis : types, characteristics of catalysts, promoters and catalytic
poisoning, theory of catalysis, enzyme catalysis.
4. Rheology: Newtonian and non-Newtonian systems, yield value, plastic, pseudoplastic and dilatant
flow, thixotropy. Determination of rheologic properties, viscoelasticity, psychorheology, rheologic
properties of suspension and emulsions, application in pharmacy.
5. Adsorption and Interface: Freundlich and Langmuir isotherm, BET isotherm, electrical properties
of interfaces, characteristics of adsorption, electrical double layer, Nernst and zeta potential, Gibb’s
equation, spreading, surfactants, emulgents, detergents and antifoaming agents and their uses in
pharmacy. Application of adsorption in pharmacy.
6. Electrochemistry:
a) Conductance of electrolytes, concept of E. M. F and its measurements, electrode, various types of
electrochemical cells, relation between electrical and chemical energies, oxidation-reduction systems,
solutions of electrolytes.
b) Electrochemical cells and cell reactions, Electrode and cell potentials, energies involved in
electrode processes; reference electrodes, concentration cell, stoichiometry of electrolysis.
7. Colloid: Classification, preparation, electrical and optical properties, sedimentation, Stoke’s law,
stability of colloidal dispersion, protective colloid, sensitization, dialysis, Donnan membrane
equilibrium, application and uses of colloidal preparation in pharmacy.
Recommended Books:
(i) M. M. Haque and M. A. Nawab : Principles of Physical Chemistry
(ii) A. Martin and J. Swarbrick : Physical Pharmacy
(iii) Gordon M. Barrow : Physical Chemistry
(iv) C.V.S. Subrahmanyam : Textbook of Physical Pharmaceuticals
(v) S. P. Agarwal and Rajesh Khanna : Physical Pharmacy
(vi) S. Glasstone and D. Lewis : Elements of Physical Chemistry
(vii) N. Kundu and S.K. Jain : Physical Chemistry
(viii) K. J. laidler : Chemical Kinetics

18

Course Title: Pharmacognosy-II
Full marks - 100
1. Phytochemistry and Pharmaceutical Uses of the Following Plant Constituents:

I. Glycosides and glycoside-containing drugs: Classification and biosynthesis of glycosides.
a) Phenols and phenolic glycosides.
i) Simple phenols: Vanilla and vanillin, capsicum
ii) Tannins: Galls or nutgall, hamamelis.
iii) Anthraquinone glycosides: Cascara sagrada, aloe, senna, rhubarb.
b) Saponins, cardioactive drugs and other steroids.
i) Steroidal saponin: Sarsaparilla root, ginseng, glycerhizia.
ii) Pentocyclic triterpenoid saponin.
iii) Cardioactive glycosides: Digitalis, strophanthus, squill.
iv) Cyanogenic glycoside: Wild cherry, mustard.
v) Miscellaneous isoterpenoids: Gentain, valerian root, quassia, fish berries, santonica flower, saffron.
II. Alkaloids:
a) Classification and biosynthesis of tropane, quinoline, isoquinoline and indole alkaloids.
b) Tropane: Belladona, stramonium, hyoscyamus and coca leaf.
c) Quinoline: Cinchona, cusparia bark.
d) Isoquinoline: Ipecac, opium, sanguinaria, curare.
e) Indole: Rauwolfia, nux vomica, ergot, catharanthus.
f) Imidazole: Pilocarpine.
g) Steroidal : Veretrum viride, aconite.
h) Norlupinane: Lupinus sp.
i) Purine base: Coffee, tea and cocoa.
III. Volatile oils and related terpenoids: Methods of obtaining volatile oils, chemistry, their
medicinal and commercial uses, biosynthesis of some important volatile oils.
a) Terpenes or sesquiterpenes: Turpentine, juniper, cade.
b) Alcohol’s: Coriander, sandalwood, rose.
c) Ester: Peppermint, lavender, rosemary.
d) Aldehydes: Cinnamon bark, lemon peel, lemon grass.
e) Ketones: Spearmint, caraway, dill, camphor.
f) Phenols: Clove, thyme, cinnamon leaf, ajowan
g) Ethers: Fennel, nutmeg, eucalyptus, anise, cajunut.
h) Peroxides: Chenopodium.
i) Others: Wintergreen, bitter almond.
2. Poisonous Plants and Natural Pesticides: Datura, poison hemlock, water hemlock, ipomoea,
tobacco, pyrethrum flower, derris and lonchocarpus, strychnine, neem, etc.
3. Hallucinogens: Fungi, Indian hemp.
Recommended Books:
(i) E. P. Claus and V.E. Tyler : Pharmacognosy
(ii) V.E. Tylor, L.R. Brady & J.E.Robbers : Pharmacognosy
(iii) W.C. Evans : Trease and Evan’s Pharmacognosy
(iv) Mohammed Ali : Textbook of Pharmacognosy
(v) K. Raghunathan and Roma Mitra : Pharmacognosy of Indigenous Drugs Vol. I & II
19

Course Title: Physiology and Biochemistry-II
Full marks - 100
1. Nervous System: Properties of nerve cells, nerve impulses and their transmission. Reflex action,
principal afferent and efferent paths of CNS. Functions of spinal cord and brain. The autonomic
nervous system. Properties of synapses and synaptic transmission.
2. Metabolism: Metabolism of fats, carbohydrates, protein and nucleoprotein. Vitamins and minerals,
their physiological properties and functions.
3. Excretory System: Structure and function of kidney, composition and formation of urine, renal
circulation, renal regulation of acid base balance, renal diseases and kidney function tests,
physiology of micturition. Artificial kidney: basic principles, method and applications.
4. Temperature Control: Heat production and heat dissipation, hypothalamus and nervous factors
involved in body temperature regulation, function of skin.
5. Endocrine Glands: Structure and function of pituitary, thyroid, parathyroid, suprarenal and
pancreas glands. Functions and regulation of secretion of hormone, disorders of abnormal hormone
secretion.
6. Reproduction: Structure and function of testis, ovary, uterus and placenta. Male and female sex
hormones and their functions. Spermatogenesis and its hormonal regulation. Menstruation cycle,
different phases and its regulation. Ovogenesis & ovulation and its control. Pregnancy and lactation
and their hormonal control.
7. Enzymes & Coenzymes :
a) Enzymes: Chemical nature, classification, enzyme kinetics, enzyme specificity, characteristics of
active sites, factors affecting enzyme activity, enzyme activation, enzyme inhibition, irreversible
inhibition of poisons and toxins, enzyme catalyst and chemotherapy.
+
b) Coenzymes: Thiamine pyrophosphate, flavin coenzyme, TH4, pentothenic acid, NAD ,
NADPH+ pyridoxal pyrophosphate, biotin, vitamin B12 coenzyme, etc.
Recommended Books:
(i) C.C. Chatterjee : Human Physiology Vol. I & II
(ii) Guyton : A Textbook of Medical Physiology
(iii) Chakrabarti, Ghosh and Sahana : Human Physiology
(iv) W. F. Ganong : Review of Medical Physiology
(v) S. Wright : Applied Physiology
(vi) Selim Reza : The Essentials of Human Physiology
(vii) Stryer : Biochemistry
(viii) Lehninger, Nelson and Coxs : Principles of Biochemistry
(ix) A.C. Dev : Fundamental of Biochemistry

20

Course Title: Pharmacology-I
Full marks - 100
1. History and Scope of Pharmacology

2. General Pharmacology: Methods of drug administration, biological half life, drug absorption,
bioavailability, distribution of drugs, protein binding, accumulation and storage in body, drug
dilution in the body fluid, metabolism of drugs and excretion. Drug allergy, idiosynchrasy, drug
toxicity and drug interaction.
3. Drugs Acting on CNS
a) Analgesic and antipyretics. (i) Non-opoids (NSAID): salicylates and congeners. (ii) Opoids:
natural and synthetic.
b) Hypnotic-sedatives: Benzodiazepines, barbiturates, etc.
c) C.N.S. stimulants: Amphetamine, caffeine, strychnine, xanthine derivatives.
4. Gastric Antacids: General consideration, chemistry, absorption, modification, distribution and
excretion. Action and adverse effects of gastric antacids. Classification of antacids-aluminums
hydroxide, aluminum carbonate, calcium carbonate, magnesium hydroxide and oxide, magnesium
carbonate, megaldrate, magnesium trisilicate, sodium bicarbonate, antacid mixtures, colloidal
bismuth, H-2 receptor antagonists (cimetidine, ranitidine and famotidine) etc.
5. Autacoids
a) Histamines: Mode of action, action on cardiovascular system, smooth muscle, gastric secretion,
anaphylactic shock, histamine-releasing drugs, allergic disorder.
b) Antihistamines: Classification, pharmacological, therapeutic uses, absorption, distributions,
excretion, adverse reactions, etc.
c) Serotonin and serotonin antagonists: Occurrence, pharmacological action, serotonin antagonist,
prostaglandins, prostacyclins and thromboxane.
d) The kinins: Kallidins and bradykinin.
6. Anesthetics: Introduction and classification.
a) Local anesthetics: general properties, chemistry and SAR, mechanism of action, pharmacological
action, clinical use and fate of cocaine, procaine, benzocaine, lignocaine, lidocaine, etc.
b) General anasthetics. (i) Inhalation anasthetics: Halothene, enflurane, methoxyflurane, nitrous
oxide, diethyl ether, cyclopropane and ethylene, etc. (ii) Intravenous anesthetics: Barbiturates,
opoids, etc.
7. Drugs Used in Haemopoietic System: (a) Anticoagulants: Heparin, warfarin, dicumarol, Na- and
K-oxalates and citrates. (b) Iron, folic acid and vitamin B12.
8. Drugs Affecting Renal Function: Osmotic diuretics, carbonic anhydrase inhibitors, potassium
sparing diuretics, high ceiling diuretics.
Recommended Books:
(i) H. P. Rang, M. M. Dale and J. M. Ritter : Pharmacology
(ii) A. Goodman Gilman, T. W. Rall, A. S. Nies and P. Taylor : Goodman and Gilman’s The Pharmacological Basis of Therapeutics Vol. – I & II
(iii) R. S. Satoskar and S. D. Bhandarkar : Pharmacology and Pharmacotherapeutics Vol. I & II
(iv) K. D. Tripathi : Essentials of Medical Pharmacology
(v) Andres Goth : Medical Pharmacology
(vi) R. A. Harvey and P. C. Champe : Lipponcott’s Illustrated Reviews Pharmacology
(vii) B. G. Katzung : Basic and Clinical Pharmacology
21

Course: 207 (Unit -1)
Course Title: Pharmaceutical Technology-I
Full marks - 100
1. Pharmaceutical Calculations: Different systems weights & measures used in pharmacy and their
conversions, weighing and measuring for large and small quantities, density & specific gravity,
strength and its units, mathematical principles and their rules (significant figures, fractions,
exponents, power and roots, logarithms and anti-logarithms), percentage preparations, dilution and
concentrations, isotonic solutions, dosage calculation for children and adult, reducing and enlarging
formulas, parts per million, milliequivalents.
2. Basic Principles of Compounding and Dispensing: Fundamental operation in compounding,
current good pharmaceutical practices in compounding and dispensing, containers and closures for
dispensed products, responding to the prescription and labeling of dispensed medications.
3. Micromeritics: Importance of particle size determination, different means of expressing particle
size, methods of particle size determination: Optical and electron microscope studies, Coulter
counter methods, laser beam technique, sieve analysis, sedimentation methods; particle shape and
surface area. Measurement of particle surface area.
4. Pharmaceutical Excipients: Chemistry, physical properties and uses of antimicrobial
preservatives, antioxidants, buffering agents, coloring agents, complexing agents, suspending
agents, emulsifying agents, flavoring agents, humectants, ointment bases, solvents and co-solvents
stiffening agents, wetting and solubilizing agents.
5. Liquid Dosage Forms: Solution and elixirs, theory of solution, different factors affecting solution
process, advantages and disadvantages, formulation and manufacturing considerations, packaging
of liquids, preservation and stability aspects and quality control systems of liquids.
6. Dispersed System
a) Properties of dispersed systems: Theoretical aspects of suspension, emulsion and colloids, surface
characteristics and zeta potential, inter-particle force, crystal growth, wetting, adsorption at solid-liquid
interface, surface and interfacial tension, flocculation and coalescence.
b) Suspension: Definition and application, advantage and disadvantages, aggregated and dispersed system,
formulation, manufacturing and stability, evaluation, rheological consideration, illustrative examples.
c) Emulsion: Definitions and applications, advantage and disadvantages, theory of emulsion, formation of
emulsion, classification of emulsifying agents, HLB values of surface active agents, formulation
manufacturing, stability and evaluation, rheological considerations.
6. Semisolids (ointments, paste, gels, etc.): Structure of skin, percutaneous absorption of drugs,
definition and classification of semisolid, classification of ointment bases, formulation and
manufacturing, rheological considerations, evaluation and quality analysis.
7. Drug Decomposition: Decomposition of drugs and pharmaceutical product, stabilization of
pharmaceutical products, accelerated stability testing.
8. Sterilization: Principle of sterilization, classification, factors affecting thermal sterilization,
sterilization by heat, gas, radiation and filtration, aseptic technique and sterility testing.
Recommended Books:
(i) A. Martin and J. Swarbrick : Physical Pharmacy
(ii) E. W. Martin : Husa’s Pharmaceutical Dispensing
(iii) E. A. Rawlins : Bentley’s Textbook of Pharmaceutics
(iv) L. Lachman, H.A. Liebernan, J.L. Kanig : The Theory and Practice of Industrial Pharmacy
(v) S. J. Carter : Cooper and Gunn’s Dispensing for Pharmaceutical Students
(vi) M. E. Aulton : Pharmaceutics, the Science of Dosage Form Design
(vii) H. C. Ansel and N. G. Popovich : Pharmaceutical Dosage Forms and Drug Delivery Systems
(viii) A. R. Gennaro : Remington, The Science and Practice of Pharmacy
22

Course: 208 (Unit – 1.5)
Full marks - 150
201. Inorganic Pharmaceutical Chemistry-II (Marks-20)

1. Quantitative analysis: (i) Estimation of iron (ferrous and ferric) in solution by titration with KMnO4/
K2Cr2O7 / Ce(IV) solution (ii) Standardization of thiosulfate solution against KMnO4/ K2Cr2O7
solution
2. Limit test for As, Pb and Hg.
3. Preparation of inorganic compounds of medicinal importance such as KMnO4, K2Cr2O7, Mohr’s
salt, FeSO4 (NH4)2SO4 6H2O etc.
202. Organic Pharmaceutical Chemistry-II (Marks-20)

1. Determination of physical constants and criteria of purity including melting point, boiling point,
refractive index, specific rotation and viscosity.
2. Identification of organic compounds: Solids and liquids, detection and identification of impurities,
tests for carbohydrates, proteins and fats.
3. Organic preparations involving typical reactions e.g. Perkin reaction, Grignard reaction, Friedel-
Craft reactions, esterification etc.
203. Physical Pharmacy-II (Marks-25)

1. Determination of viscosity of pure liquids such as glycerin, alcohol and nitrobenzene using Ostwald
viscometer.
2. Determination of viscosity coefficient of a liquid at two different temperatures and finding out the
temperature coefficient for the given liquid.
3. Determination of viscosity coefficient of the water-alcohol mixtures and comment on the structure
of the solutions.
4. Determination of viscosity coefficient of a liquid at different temperatures and estimation of the
activation parameters of viscous flow.
5. Determination of partition coefficient of (i) salicyclic acid between water and chloroform, (ii)
benzoic acid between toluene and water, (iii) iodine between methylene chloride and water
6. Determination of velocity constant of the hydrolysis of methyl/ethyl acetate catalyzed by HCl.
7. Determination of absorption isotherm of oxalic (or acetic) acid from aqueous solution by charcoal
and calculation of the constant in Freundlich’s equation.
8. Determination of the equilibrium constant of the reaction Kl +I2= KI3.
9. Determination of titration curve for the titration of a weak base with a strong acid and a strong base
with a weak acid pH metrically and hence finding their strengths.
10. Determination of solubility of a sparingly soluble salt in water by conductance measurement.
11. Determination of velocity constant for the hydrolysis of an ester in the basic medium by
conductance measurement.
12. Determination of the molecular weight of an organic solid like camphor by cryoscopy.
13. Determination of the molecular weight of a solid like naphthalene by ebullioscopy.
14. Determination of dissociation constants of some organic weak acids by potentiometric method.
15. Determination of heat of solution by solubility methods
23
204. Pharmacognosy-II (Marks-20)
1. Pharmacognostic study of a few selected powdered drugs
2. Chromatographic techniques: Analysis of plant extracts by thin layer chromatography.
3. Study of volatile oils and some volatile-oil containing drugs: Caraway, clove, cinnamon, peppermint, etc.
4. Detection of adulterants, (i.e. cotton seed, sesame-and arachis-oils) in olive oil
5. Examination of cod liver oil and detection of vitamin A in cod liver oil .
6. Extraction and isolation of anthraquinone glycosides from cascara sagrada , aloe, senna and rhubarb.
7. Isolation of lycopene from tomato.
8. Isolation of β-carotene from carrot.
9. Examination of some saponin containing drugs: Sarsaparilla, dopscorea, etc.
10. Study of few important cardio active drugs: Digitalis, strophanthus and squill.
11. Study of alkaloids and some alkaloid-containing drugs: Belladonna, strammonium, cinchona, rauwolfia, tea,
coffee, tobacco, ergot, ephedra, nux vomica and areca.
12. Isolation of lactose from cow’s milk.
13. Physical and chemical tests for honey.
14. Study of some Important medicinal and poisonous plants of Bangladesh
205. Physiology and Biochemistry-II (Marks-20)

1. Demonstration of the effects of temperature on toad heart.
2. Demonstration of the effect of stannous ligature on frog’s heart.
3. Demonstration of the effects of drugs on toad heart.
4. Demonstration of the effect of electrolytes (Na+, K+, Ca++ etc.) on toad heart.
5. Recording of respiration by stethograph.
6. Measurement of blood pressure (B. P.) by sphygmomanometer. Effects of physical exercise on B. P. and heart rate.
7. Effect of ptyalin of saliva on starch
8. Collection of gastric juice: Tests for gastric acidity.
9. Estimation of blood sugar in normal person.
10. Properties of frog muscle and nerve preparation.
206. Pharmacology-I (Marks-20)
1. Study of drugs acting on CNS a) CNS stimulants (strychnine/ ephedrine /amphetamine) b) CNS
depressants (barbiturate-induced sleeping time)
2. Local anesthetics a) Action of local anesthetics on human skin b) Rabbit’s corneal test for surface
anesthetics
Drug antagonism: Effects of histamine and antihistamine on guinea pig.
Study of the effects of diuretics and antidiuretics on the rate of urinary flow in dogs.
207. Pharmaceutical Technology-I (Marks-25)
1. General dispensing: Receiving a prescription and writing up in detail. b) Wrapping powdered drug: dispensing of a
sample. c) Dispensing of a prescription containing powders which form eutectic mixture. d) Dispensing of a
prescription containing efflorescent powders. e) Dispensing of a prescription containing a small dose powdered
drugs. f) Dispensing of a prescription containing hygroscopic and deliquescent powders.
2. Preparation of percent solution and calculation
3. Preparation of granular effervescent powder
4. Preparation of aromatic water
5. Preparation of syrup a) Phenobarbitone- Na syrup b) Chlorpheniramine maleate syrup c) Promethazine- HCl syrup d)
Iron syrup.
6. Preparation of suspension a) Paracetamol suspension b) Antacid suspension c) Chalk powder suspension.
7. Preparation of emulsion and identification of type of emulsion. a) Primary emulsion by dry gum method and wet gum
method b) Castor oil emulsion.
24
B. Pharm. (Honours) Part-III
Course Title: Pharmaceutical Analysis-I
Full marks- 100
1. Introduction and Techniques of Pharmaceutical Analysis.
a) Introduction: Selection of samples, selection of chemicals.
b) The Art and Science of Pharmaceutical Analysis: Choosing the tools, identification of containers,
filtration, ignition of precipitates, drying of samples, recording results.
2. Titrimetric Analysis:
a) Aqueous Acid-Base Titrations: Definitions, distribution of acid base species with pH of the medium,
acid-base titration for determination of acidic and basic pharmaceuticals.
Indicators: theories, selection and applications.
b) Oxidation-Reduction Titrations: Principles and concepts, determination involving potassium
permanganate, potassium dichromate and potassium bromide. Iodimetric determination, miscellaneous
oxidation and reduction titrations, indicators and applications.
c) Complexometric Titrations: Introduction, complexes and chelates, stability of complex ions, titrations
based on complex formation, types of complexometric titrations, techniques employed in chelometric
titration, methods of end point detection, titration selectivity and masking reagents.
d) Non-aqueous Acid Base Titrations: Theoretical considerations and principles of Bronsted-Lowry
theory of acids and bases, non aqueous solvents, titration of weak acids and weak bases, applications and
scope of non aqueous titration.
3. Determination of Moisture Content in Pharmaceutical Products: Principle and scope, physical and
chemical methods of water determination, Karl-Fischer principle, procedure, chemistry, methodology,
equipment, end point detection and limitations.
4. Separation Technique:
a) Introduction, principles, procedures and theories of column chromatography, size exclusion
chromatography and gel filtration techniques, thin layer chromatography, ion exchange chromatography,
methods of detection and applications.
b) HPLC: Introduction, theory and principle, instrumentation, characteristics of stationary and mobile
phases, reversed phase HPLC and application.
5. Instrumental Methods of Analysis:
a) Molecular absorption spectroscopy: Definition, properties and spectrum of EMR, theory, Instrument,
chromophore & auxochrome concept, solvent effect, drug identification, potency determination etc.
b) Polarimetry: Introduction, origin of optical rotation, molecular requirements for optical rotatory power,
methods used in polarimetry instrumentation and application.
Optical rotatory dispersion (ORD) and circular dichroism (CD): theory, measurement, interpretation of
curves and application of ORD and CD in pharmacy.
c) Fluorometry: Introduction, theory of fluorescence & phosphorescence, instrumentation for measuring
fluorescence, factors influencing intensity of fluorescence, comparison of fluorometry and
spectrophotometry, application of fluorometry in pharmaceutical analysis.
Recommended Books:
(i) A.H. Beckett, and J. B. Stenlake : Practical Pharmaceutical Chemistry Vol. I & II
(ii) K. A. Connors : A Textbook of Pharmaceutical Analysis
(iii) L.G. Chatten : Pharmaceutical Chemistry Vol. I & II
(iv) A.M. Knevel and F.E. DiGangi : Jenkins Quantitative Pharmaceutical Chemistry
(v) T. Higuchi and E. Brockman-Hanssen : Pharmaceutical Analysis
(vi) A. I. Vogel : Textbook of Quantitative Analysis
(vii) V. Alexeyev : Quantitative Analysis
(viii) Douglas A Skoog : Principles of Instrumental Analysis
(ix) B.K. Sharma : Instrumental Methods of Chemical Analysis
(x) R.M. Verma : Analytical Chemistry, Theory and Practice
25

Course Title: Medicinal Chemistry-I
Full marks- 100
1. Stereochemistry:
a) Geometric isomerism of alkenes and cyclic compounds, cis, trans and (E), (Z) systems of
nomenclature.
b) Conformational isomers, conformation of open chain and cyclic compounds.
c) Chirality of molecules, enantiomer, diastereomer, racemic modification, meso compound, (R)
and (S) configuration, sequence rule, and optical rotation.
d) Stereoselective and stereospecific reaction.
e) Pharmaceutical importance of stereochemistry study.
2. Name Reactions: Baeyer-Villiger reduction, Cannizzaro reaction, Clemmensen reduction, Diels
Alder reaction, Friedel-Crafts alkylation and acylation reaction, Gabriel synthesis, Gattermann-Koch
and Sandmeyer reaction, Grignard reaction, Hoffman degradation reaction, Mannich reaction,
Michael and Meerwin Pondorf-Verley reduction, Oppenauer oxidation, Perkin reaction,
Reformatsky reaction, Reimer-Tiemann reaction, Wittig and Wolf-Kishner reduction.
3. Chemistry of Natural Products :
a) Alkaloids: Occurrence, isolation, classification and properties of alkaloids, structure
determination, synthesis and physiological activities of ephedrine, nicotine, atropine and
morphine.
b) Terpenoids: Occurrence, isolation and classification, synthesis of geraniol, citral, ionones and
amyrin.
c) Vitamins: Occurrence, classification and general methods of isolation of vitamins, structure
determination, synthesis and biological functions of vit-A, vit-B and vit-C.
d) Hormones: Occurrence, classification, synthesis and functions of male & female sex hormones
and thyroid hormone.
e) Antibiotics: Occurrence, isolation, structure determination, synthesis and clinical properties of
penicillin, streptomycin, chloramphenicol and tetracycline.
f) Natural pigments: (i) Carotenoids : Occurrence, isolation, classification and properties of
carotenoids, structure determination, synthesis and physiological activities of carotenes and
carotenols
(ii) Flavonoids: Occurrence, isolation, classification and properties of flavonoids, structure
determination, synthesis and physiological activities of flavonols and isoflavones.
4. Nucleic Acid: Chemistry of nucleic acids, bases, nucleosides, nucleotides, polynucleotides,
nucleoproteins, RNA and DNA. Structure determination & synthesis of adenine, guanine, cytocine,
uracil & thymine.
Recommended Books:
(i) B.S. Bahl and Arun Bahl : Advanced Organic Chemistry
(ii) I.L. Finar : Organic Chemistry Vol. I & II
(iii) O.P. Agarwal : Chemistry of Organic Natural Products Vol. I & II
(iv) Raj K. Bansal : Organic Reaction Mechanisms
(v) Lehninger, Nelson and Coxs : Principles of Biochemistry
(vi) Alfred Burger : Medicinal Chemistry Vol. I & II

26
Course Title: Pharmacology-II
Full marks- 100
1. Mechanism of Drug Action: a) Basic concept of drug action. b) Physico-chemical nature of

drugs. c) Drug receptors. d) Binding forces in drug-receptor interaction e) Receptor and non
receptor mechanisms of drugs. f) Macromolecular nature of drug receptors. g) Relationship
between drug concentrations versus response: Concentration-effect curve and receptor binding of
agonists, competitive and irreversible antagonism, partial agonists, receptor-effector coupling and
spare receptors, other mechanisms of drug antagonism.
2. Antibiotics and Chemotherapeutic Agents: Introduction, classification, chemistry, mode of
action, structure-activity relationship, pharmacokinetics, indications, contraindications. Dose,
adverse effects and drug interactions of the following individual class of drugs: i) Sulfa drugs. ii)
Penicillins and Cephalosporins. iii) Tetracyclins, Chloramphenicol, Aminoglycosides and
Macrolides. iv) Antifungal agents. v) Antileprosy drugs. vi) Miscellaneous antibacterial agents: a)
Glycopeptide antibiotics. (b) Polymixin antibiotics. (c) Bacitracin. (d) Nitrofurantoin.
3. Cardiovascular Drugs: 1) Functioning and diseases of the heart, arrythmia, ischemia, angina
pectoris, coronary thrombosis, myocardial infarction, arteriosclerosis, atherosclerosis, hypertension
and congestive heart failure. 2) Introduction, classification, chemistry, mode of action, structure
activity relationship, pharmacokinetics, indications, contra indications, dose, adverse effects and
drug interactions of the following individual class of drugs: a) Digitalis and allied drugs b)
Antihypertensive drugs: (i) α-Blockers, Prazosin, etc. (ii) β-Blockers, Propanolol, etc. (iii) M.A.O.
inhibitors, Methyldopa, Rauwolfia alkaloids. (iv) Ca-channel blocking agents. (v) Vasodilators:
Nitrites and nitrates. 3) Diuretics: Cardiac anhydrase inhibitors, low and high ceiling diuretics,
potassium sparing diuretics and osmotic diuretics. 4) Antiarrythmic drugs: Quinidine, Procaine
amide.
4. Antidiabetic Drugs: a) Introduction and classification of diabetes. b) Hyperglycemia and
hypoglycemia. c) Introduction, classification, chemistry, mode of action, structure activity
relationship, pharmacokinetics, indications, contraindications, dose, adverse effects and drug
interaction of the following individual class of drugs: Oral hypoglycemic agents: (i) Sulfonylureas
(ii) Biguanides. Hormone preparation: insulin. Management of diabetes mellitus.
5. Drug Acting on ANS:
a) (i) Parasympathomimetic agents: Acetyl choline, Methacoline, Carbachol. (ii) Sympath-
omimetic drugs: Epinephrine, norepinephrine. (iii) Anticholinesterase agents: Physostignine,
Edrophonine. Organophosphorous compounds.
b) (i) Antimuscarinic Agents or Atropine Drugs: atropine sulfate, scopolamine hydrobromide,
homatropine hydrobromide. (ii) Drugs inhibiting adrenergic nerves and structures innervated by
them, Adrenergic blocking agents.
c) Ganglion Stimulating and Blocking Agents.
Recommended Books:
(i) H. P. Rang, M. M. Dale and J. M. Ritter : Pharmacology
(ii) A. Goodman Gilman, T. W. Rall, A. S. Nies and P. Taylor : Goodman and Gilman’s The Pharmacological Basis of Therapeutics Vol. – I & II
(iii) R. S. Satoskar and S. D. Bhandarkar : Pharmacology and Pharmacotherapeutics Vol. I & II
(iv) A. Goldstein, L. Aronow and S.M. Kalman : Principles of Drug Action, The Basis of Pharmacology
(v) M. Misbahuddin and M.R. Islam : General Principles of Pharmacology
(vi) B. G. Katzung : Basic and Clinical Pharmacology
(vii) F..H. Meyers, E. jawelz and A. Goldfien : Review of Medical Pharmacology

27
Course Title: Biopharmaceutics-I
Full marks- 100
1. Introduction to Pharmaceutics and Biopharmaceutics: Biopharmaceutics, pharmacokinetics,

clinical pharmacokinetics, pharmacodynamics, toxicokinetics, measurement of drug concentrations,
interpretation of drug-plasma level curve.
2. Mathematic Fundamentals in Pharmacokinetics: Graphs, units in pharmacokinetics,
measurement and use of significant figures, units for expressing blood concentrations, statistics,
rates and orders of reactions.
3. Gastrointestinal Absorption of Drugs:
a) Route of drug administration, membrane physiology, passage of drugs across cell membranes,
gastrointestinal physiology and oral drug absorption.
b) Factors affecting drug absorption: pKa and gastrointestinal absorption, pH-partition theory and
other physicochemical factors, effects of disease states on drug absorption.
c) Dosage form consideration: Role of different dosage form like solution, suspension. tablet,
capsule, emulsion etc. on gastrointestinal absorption.
d) Dissolution and drug absorption: Dissolution process, Noyes-Whitney equation, Hixson-Crowell
Cube Root Law, factors influencing dissolution, dissolution test apparatus, in-vitro & in-vivo
correlations of dissolution, drug release patterns.
4. Distribution of Drugs:
a) Important Pharmacokinetic Parameters: Biological half-life, apparent volume of distribution,
area under the curve, absorption and elimination rate constant etc.
b) Drug-Protein Interaction: Theoretical aspect of protein-drug interaction, methods used for
protein binding, identification of drug binding sites, kinetics of protein binding, determination of
bindings sites and association constant, factors affecting protein binding, effects of protein
binding on drug distribution, elimination and pharmacological effects of drugs.
5. Drug Clearance:
a) Theoretical aspects of drug elimination, excretion and biotransformation.
b) Renal Elimination: Glomerular filtration, active tubular secretion, tubular reabsorption.
Determination of renal clearance.
c) Biotransformation of Drugs: Definition, drug biotransformation reactions, pharmacokinetics of
drugs and metabolites (Michelis-Menten equation), hepatic elimination, first pass effect, liver
excretion ratio, relation between absolute bioavailability and liver excretion, hepatic clearance-
relationship between blood flow, intrinsic clearance and hepatic clearance, hepatic clearance of a
protein bound drug (effect of protein binding on hepatic clearance).
d) Biliary excretion of drug.
6. Bioavailability and Bioequivalence: Definitions of different parameters relative to bioavailability,
purpose of bioavailability, relative and absolute to bioavailability, methods of assaying
bioavailability, criteria for bioequivalence studies, method and determination of bioavailability
7. Drug product selection on the basis of bioavailability testing.
Recommended Books:
(i) Leon Shargel and Andrew B.C. Yu : Applied Biopharmaceutics and Pharmacokinetics
(ii) Milo Gibaldi : Biopharmaceutics and Clinical Pharmacokinetics
(iii) Donald E. Cadwallader : Biopharmaceutics and Drug action
(iv) Bourne, Triggs and Eadie : Pharmacokinetics for the Non-mathematical
(v) CVS Subrahmanyam : Textbook of Physical Pharmaceutics
28
Course Title: Pharmaceutical Engineering
Full marks- 100
1. Drying: Definition, importance of drying, terminology, theory & fundamental concepts, periods of drying, constant
rate period, falling rate period, critical moisture content. equilibrium moisture content, classification : direct,
indirect, radiation, dielectric, batch and continuous, dryers, types of beds: static, moving, fluidized, pneumatic bed
systems, different drying equipments(construction, operation, merits, demerits): tray dryer, through-circulation
dryer, pneumatic conveying dryer, rotary dryer, spray dryer, tunnel dryer, steam tube rotary dryer, agitated pan
dryer, vacuum rotary dryer and freeze dryer, selection of drying equipment, preliminary dryer selection, drying
tests, final selection.
2. Filtration: Definition, importance of filtration, difference with expression, sedimentation and drying.
Classification of filters, theory of filtration, filter media, filter aids, filter thickeners, different filtration equipment
:(construction, operation, merits and demerits) the gravity nutsche, delpark industrial filter, bag filters, sand filters,
plate and frame press, recessed plate filter press, Eimco-Burwell plates and frames, Readco short cycle filter,
vertical pressure leaf filter, horizontal plate filter, industrial tubular filter, Rodney Hunt pressure filter, Moore
filter, vacu-flow suction leaf filter, string discharge filter, clarifying filters, selection of filtration equipment.
3. Centrifuges: General principles, magnitude of centrifugal force, materials of construction, critical speed.
sedimentation centrifuges, filtering centrifugal, centrifuge auxiliaries, drive mechanisms, feed and discharge lines,
feed treatment, selection of centrifugal separators.
4. Mixing:
a) Solid-Solid Mixing: Importance, fundamentals, batch homogeneity, types of solids-mixing machines: (mixing
mechanisms and operations) double cone, twin shell, horizontal drum, double-cone revolving around long axis,
ribbon, vertical screw, batch muller, continuous muller, twin rotor. Performance, characteristics, selection of
machines.
b) Paste Mixing: Definition, importance, simple blending, dispersion operations and general equipment design.
Standard types of equipment and operations, change-can mixer, change-can mixer with planetary motion,
change-can mixer with rotating turntable, troy angular mixer, duplex mixer, stationary-tank mixer, kneader,
mullers, three-roll mill, selection of process and mixer.
c) Liquid Mixing: Definition, importance, mixing equipment, axial and radial flow impellers, mechanisms, flow
patterns, impellers, flat-blade and curved blade turbines, spiral turbines, paddles, gate impellers, anchor
impellers, different fixed-mounted and portable positions, shaft lengths, baffled and unbaffled tanks, vortex
formation and its control, selection of impeller.
5. Milling: Definition, application and limitations, factors affecting milling operation, mechanisms of size reduction
process, methods of size reduction by cutter mill, roller mill, hammer mill, ball mill, vibration mill, edge runner
mill, end runner mill, fluid energy mill, hand mill, colloid mill (principle, design, operation and advantages) and
selection of a mill.
6. Air conditioning, Refrigeration & Humidity Control:
a) Air conditioning: Definition, importance, pharmaceutical application, differences between air conditioner &
air cooler, comfort zone, different types of air conditioners, selection of an air conditioner, design of an air
conditioned room, pharmaceuticals needing air conditioning.
b) Refrigeration: Definition, pharmaceutical application, refrigerators design, mechanism of cooling, refrigerants,
brine selection, pharmaceuticals needing refrigerated storage.
c) Humidity control: Terminology (psychometry, absolute humidity, relative humidity, dew point, humid heat,
humid volume, wet bulb temperature and adiabatic saturation temperature), relationship between wet bulb and
adiabatic saturation temperatures, humidifier, dehumidifier, uses of psychometric charts, measurement of
humidity and applications of humidity control.
Recommended Books :
(i) E. A. Rawlins : Bentley’s Textbook of Pharmaceutics
(ii) L. Lachman, H.A. Liebernan, J.L. Kanig : The Theory and Practice of Industrial Pharmacy
(iii) S. J. Carter : Cooper and Gunn’s Dispensing for Pharmaceutical Students
(iv) M. E. Aulton : Pharmaceutics, the Science of Dosage Form Design
(v) H. C. Ansel and N. G. Popovich : Pharmaceutical Dosage Forms and Drug Delivery Systems
(vi) A. R. Gennaro : Remington, The Science and Practice of Pharmacy
29
Course: 306 (Unit-1)
Course Title: Pharmaceutical Technology-II
Full marks- 100
1. Formulation & Manufacturing of Tablets: Manufacturing of tablets by wet granulation, dry
granulation & direct compression. Granulation of powders for tableting. Advantages and
disadvantages of different processes, processes and machineries used in tablet manufacturing.
2. Common Tableting Problems and Evaluation of Tablets: Hardness measurement, weight
variation tests, thickness and diameter, friability, disintegration time, dissolution time, mechanism of
tablet disintegration and dissolution. In-process quality control, study of common tableting
problems.
3. Tablet Coating: Definitions and classification of coating methods, advantages and disadvantages of
coated tablets. Different methods of coating: Sugar coating: different stages of sugar coating,
problems of sugar coating. Film coating: Theory of film coating, film formers, plasticizer, solvents.
Enteric coating: Enteric coating polymers, formulations of enteric coating. Dry coating
(compression coating). Comparison between sugar coating and film coating. Aqueous film coating
techniques. Modern film coating materials and coating formulations. Problems of organic and
aqueous film coating. Coating machines: Conventional coating machines, perforated coating
machines, fluidized coating machines.
4. Capsules:
a) Hard Gelatin Capsules: Definition and classification, advantages and limitations of capsule
dosage form, gelatin and its manufacture, manufacture of hard capsule shells, properties of
capsules, formulation of capsules, capsule filling machines, tooling and accessories. Problems in
capsule manufacturing, quality control methods of capsules, packaging of capsules.
b) Soft Gelatin Capsules: Definitions and classifications, advantages and limitations, properties,
formulation, manufacturing, quality control and packaging of soft capsules. Problems and remedy of
soft capsule manufacturing.
5 Microencapsulation Technology: Purpose, methods of preparation, evaluation, pharmaceutical
and biological applications of microencapsulation process.
6 Suppositories: Definition, advantages & disadvantages, Classification of suppositories,
Suppository bases, formulation of suppositories, manufacturing of suppositories, Displacement
value of testing of suppositories, Mechanism of absorption of medicaments from suppositories.
Recommended Books :
(vii) L.W. Dittert : Sprowl’s American Pharmacy

30
Course Title: Cosmetology
Full marks- 50
1. The skin and skin creams: (A) Introduction, epidermis and keratinizing system, pigmentary
system, exocrine sweat glands, hair follicles, sebaceous glands, apocrine glands, common disorders
of the skin. (B) Skin creams: Introduction, classification of skin creams, cold cream, vanishing
creams, emollient cream & lotion.
2. Hair Preparations:
(A) Hair products: Introduction, shampoos; hair setting lotions, hair tonic, conditioners.
(B) Shaving preparations: Introduction, lather shaving cream, brushless or non-lathering
cream, aerosol shaving foams, after shave preparations.
(C) Depilatories: Introduction, formulation and manufacture of chemical depilatories: perfuming,
packaging, assay and toxicities of depilatories.
3. Teeth and dental products: Physiology and common diseases of teeth; introduction, formulation
and manufacture of dentifrices, quality control of dentifrices, toothpastes, tooth powder,
mouthwash and gargles.
4. (A) Lip-products: Introduction, Lip skin, Characteristics of an ideal lip sticks, colors, pigments,
bases, perfumes antioxidants used in lipsticks, formulations, manufactures, toxicities, analysis and
quality control of lipsticks. (B) Brief study on deodorant: Introduction, perspiration and its
control, formulation, manufacture, labeling of antiperspirants, deodorants, Talcum powder,
perfume, etc.
5. Eye makeup: Introduction, formulation, manufacture and evaluations of eye shadow, mascara, eye
brow pencils, eye liners etc.
6. Nail lacquers and removers: Introduction, raw materials, formulations, manufactures and
evaluations of nail lacquers and nail lacquer removers.
7. Herbal preparations
Recommended Books:
(i) M. S. Balsam and E. Sagarin : Cosmetics, Science and Technology Vol. I & II
(ii) Pulok K. Mukherjee : Quality control of herbal drugs
(iii) M. Vimaladevi : Text book of Cosmetics
(iv) J.B. Wilkinson : Harry's cosmetology
R.J. Moore

31
Course Title: Hospital and Community Pharmacy
Full Marks - 50
1. Hospital Pharmacy:
A) Introduction: Goals, minimum standards, abilities required for a hospital pharmacist. Hospital as
an organization, classification, organizational patterns, management and administration, different
departments and services, role of a pharmacist in the hospital. Hospital pharmacy, organizational
and personnel, supportive personnel, pharmacy education, job descriptions.
B) Pharmacy and Therapeutics Committee: Description and purpose, membership and functions.
Hospital formulary, guiding principles, legal basis, principles for admission or deletion of drugs,
selection of text.
C) Investigational Use of Drugs: Description, principles involved, classification, control,
identification, role of hospital pharmacist, advisory committee.
D) Purchasing and Inventory Control: Purchasing agent, purchasing procedure, control on
purchases, storage, perishable inventory, physical inventory, perpetual inventory.
E) Control of Special Classes of Drugs: Use of samples, in-patient drug orders, out-patient
prescriptions, ward stock drugs, label symbols. Narcotics and their control, classes, procurement
and execution of order forms, dispensing, hospital narcotic regulations, new systems. Floor stock
drugs, selection, charge and non-charge, labeling, regulations concerning narcotics, inspection of
nursing drug cabinets.
F) Dispensing to In-and Out Patients: Drug distribution systems, dispensing of charge, non- floor
stock drugs, mobile dispensing unit, unit dose dispensing, new concepts. Dispensing to out patients,
locality of out-patient dispensing area, dispensing routine, record keeping. Dispensing during off-
hours, use of nursing supervisors, emergency boxes and night drug cabinets, pharmacist-on-call.
Drug charges in hospitals, pricing, break- even point pricing.
G) Manufacturing-Bulk and Sterile: Control and budget, manufacturing facility and capacity,
operating costs, quality control.
H) Drug Information Centre and Library: Physical facilities, selection of contents, methods of
dissemination, role in educational and training programmes, professional education, internal
teaching programmes, external teaching programmes.
2. Community Pharmacy:
Concept of community health care, health needs of the community, different levels of health care,
elements of primary health care. Principles of primary health care: Equitable distribution,
community participation, intersectoral coordination, appropriate technology, health manpower,
health care delivery at different levels, community pharmacy in dealing with communicable diseases
problem, nutritional problems, environmental sanitation problems and indigenous systems of
medicine, development of community pharmacy infrastructure, participation of non-governmental
voluntary health agencies.
Recommended Books:
(i) W.E. Hassan : Hospital Pharmacy
(ii) Pratibha Nand and R.K. Khar : A Textbook of Hospital and Clinical Pharmacy
(iii) Anees Ahmed Siddiqul and M. Ali : Hospital and Clinical Pharmacy
(iv) Rashid, Khabiruddin and Hyder : Textbook of Community Medicine and Public Health
(v) Selim Reza : The Essentials of Community Medicine
(vi) K. Park : Textbook of Preventive and Social Medicine
(vii) A. R. Gennaro : Remington, The Science and Practice of Pharmacy

32
Course: 309 (Unit - 0.5)
Course Title: Quality control, Quality Assurance & Validation
Full marks- 50
1. Introduction: Importance of pharmaceutical analysis in the quality control of drugs, sources of

quality variation, control of quality variation. Set up of a quality control laboratory for
pharmaceutical analysis, personnel, equipment, environments, etc. Types of specifications,
sampling, testing program and methods.
2. In Process Quality Assurance Method: Concept of quality assurance, selection and testing of
major raw materials input. Methods of drug sampling, statistical quality control of major
categories of dosage forms, QA activities, GMP.
3. Pharmaceutical Validation:
i. Pharmaceutical room and equipment validation: Importance and process of room and
equipment validation.
ii. Pharmaceutical process validation: Importance, type of process validation, validation of
dissolution process, mixing process, granulation process, tablet compression process, tablet
coating process, capsule filling process, injection vial filling process.
iii. Pharmaceutical analytical method validation: Importance, linearity, accuracy, precision, limit
of detection, limit of quantification, heat sensitivity and system suitability.
4. Management of Quality Assurance: Quality management consideration, quality motivation,
total quality management.
5. International standard organization and BSTI (DA) policies for quality in pharmaceutical
industries.
6. Concept of Statistical Quality Control: Normal frequency distribution, Q.C. charts, sampling
and sampling plan, binomial distribution, tests of significance, consumer acceptance testing,
analysis of variance (ANOVA) and experimental design, bio-availability and crossover design,
regression correlation, Wilcoxon rank sum test
7. Quality of packaging materials.
8. Quality of analytical methodologies, automated continuous system for assay procedure,
associated activities.
9. Quality control of herbal drugs: safety & toxicity profile, development of standardization
parameters, extraction, pharmacological screening, quality assurance and stability study of
herbal drugs.
Recommended Books
(i) M. Shah Nawaz Khan : Assurance of Quality Pharmaceuticals
(ii) Pulok K. Mukherjee : Quality control of herbal drugs

33
Full marks- 200
1. Analytical Pharmacy: (Marks –40)
I. Assay of acetyl salicylic acid in aspirin tablets.
II. Assay of sodium salicylate tablets
III. Determination of potency of penicillin tablets.
IV. Non- aqueous assay of phenobarbitone tablets.
V. Determination of calcium in solid & liquid dosage form by complexometric titration.
VI. Assay of promethazine hydrochloride.
VII. Assay of methamphetamine hydrochloride
VIII. Assay of aluminum hydroxide gel.
IX. Assay of milk of magnesia
X. Assay of magnesium and aluminum from antacid preparation.
XI. Determination of iodine value, saponification value, acid value and R.M. value of oils and fats.
2. Medicinal Chemistry: (Marks –40)
Synthesis of drug and drug intermediates: a) Paracetamol b) Benzocaine c) Aspirin d) Phenacetin
e) PABA (Para amino-benzoic acid f) Meta Nitro-benzaldehyde g) Ethyl para hydroxy-benzoate h)
Para Amino phenol i) Methyl salicylate.
3. Pharmacology-II: (Marks –40)
I. Estimation of blood glucose by enzymatic method.
II. Estimation of blood glucose by chemical method.
III. Estimation of aspirin after oral administration by UV spectrophotometric method.
IV. Estimation of aspirin after oral administration by calorimetric method.
V. Estimation of plasma protein by enzymatic method.
VI. Estimation of plasma protein by burette method.
VII. Estimation of blood uric acid level by enzymatic method.
VIII. Estimation of Paracetamol after oral administration by UV/Visible spectrophotometric method.
IX. Handling of experimental animals: mice and rat.
X. Different routes of administration of drugs in experimental animals.
XI. Assay of serum SGOT and SGPT activities in mice and rat.
XII. Assay of serum alkaline phosphatase activity
XIII. Isolation and determination of cholesterol content of biological samples.
4. Pharmaceutical Engineering & Technology: (Marks –40)
I. Formulation and compounding of different syrups.
II. Formulation and compounding of different suspensions.
III. Formulation and compounding of different emulsions.
IV. Formulation and compounding of ointments.
V. Study of different compounds of a 16- station rotary tablet press.
VI. Formulation and manufacturing of antihistamine tablets.
VII. Formulation and manufacturing of dispersible aspirin tablet.
5. Biopharmaceutics-I: (Marks –40)
I. Tablet weight variation test.
II. Tablet hardness test.
III. Tablet friability test.
IV. Tablet disintegration test.
V. Tablet dissolution test.
VI. Leakage test of packaging of tablets / capsules.
VII. Capsule weight variation test
VIII. Determination of binding sites and association constant.
34
B. Pharm. (Honours) Part-IV
Course Title: Pharmaceutical Analysis-II
Full Marks – 100
1. Conductometry: Principle, important laws, definition & relations, mobility of ions governing
forces, applications. kohlrausch’s Law, apparatus and measurements, experimental details of
conductometric titration, high frequency titration, application and limitations.
2. Potentiometry: Terminology, potentiometer, principle, various half cells & electrodes, relation pH
to potential, types and curves of potentiometric titration, methods, applications and advantages.
3. Amperometry: Definition, classification, theory, technique and applications of amperometric
titration, titration curve shapes, factor affection current flow during analysis.
4. Polarographic Analysis: Principle, component of polarogram, Ilkovic equation, diffusion current,
factor affecting diffusion current and half wave potential, quantitative analysis and applications.
plarographic maxima supprissor, oxygen wave, supporting electrolyte.
5. Coulometry: Definition, principle, coulometers, current efficiency, background current, various
types of coulometric analysis, detection of end-points , advantages, applications and
chronopotentiometry.
6. Gas Chromatography: Introduction and principles GLC & GSC, theoretical consideration,
component of instruments, column technology, detectors, analytical application of gas
chromatography.
7. X-ray Crystallography: Generation and properties of X-ray, diffraction of X-ray by crystals,
Bragg's equation, X-ray diffraction methods, powder diffraction patterns, methods of
measurement, analysis, indexing of X-ray reflections and determination of space groups, Fourier
and Patterson syntheses and application of X-ray analysis in pharmacy.
8. Radiochemical Methods of Analysis: Origin and nature of radioactive isotopes, natural and
induced radioactivity, radioactive decay, different type of radiation, radiation detection and their
measurement, principles of Geiger-Muller, Scintillation and proportion counters, radio- activation
analysis, isotope dilution analysis, characterization, methodology and use of radiometric titrations
in pharmaceutical research.
9. a) Bioassay: Prerequisites and development, errors in bioassay and how to overcome them.
Statistical design of bioassay.
b) Principles of Microbiological Analysis (diffusion method) of the Following Drugs:
(i) Microbiological Assay: Antibiotics, vitamins, sulfa drugs
(ii) Microbial counts: Antacids and water.
Recommended Books:
(i) Gurdeep R. Chatwal and Sham K. Anand : Instrumental Methods of Chemical Analysis
(ii) A.H. Beckett, and J. B. Stenlake : Practical Pharmaceutical Chemistry Vol. I & II
(iii) K. A. Connors : A Textbook of Pharmaceutical Analysis
(iv) L.G. Chatten : Pharmaceutical Chemistry Vol. I & II
(v) Douglas A Skoog : Principles of Instrumental Analysis
(vi) B.K. Sharma : Instrumental Methods of Chemical Analysis

35
Course Title: Medicinal Chemistry -II
Full Marks – 100
1. Drug Design and Discovery:

(i) Drug design: Definition, purposes and factors governing of drug design, Interpretation of SAR of
small molecules (sulfa drugs), Design of pharmaceutical dosage forms.
(ii) Drug discovery: Discovery of new drugs without leads, Lead discovery strategies, Requirements
for identification of lead compounds, Principle and development of rational drug design
(Cimetidine) and Role of biotechnology in drug design.
(iii) Drug Development: Objectives, Pharmacophore, Patterns and SAR of drug development from
natural sources, Modification synthetic analogues (Variation of Substituents, Bioisosterism,
Homologation, Chain Branching and Ring variation).
(iv) Drug Design for Pharmacokinetics Problems: Metabolic blockers, Prodrugs, Sentry drugs,
‘Search and destroy’ drugs, Self-destruct drugs, Drug distribution and survival of drugs.
(v) Introduction of Computational Molecular Modeling of Drug Design: a) Quantitative
Structure Activity Relationships (QSAR): Physicochemical properties (hydrophobicity, electronic
effects, steric factors, solvent accessible surface area etc), Application of QSAR ( Hansch
equation, Hammett relationships) on biological systems.
2. Combinatorial Chemistry and Rapid Parallel Syntheses:
(i) Introduction, various drug discovery processes, design, diversity, expression, methods &
techniques, and applications of combinatorial syntheses on drug discovery.
(ii) Solid phase syntheses: Introduction, various linkers, solid phase peptide synthesis (SPPS):
principle, mechanism and application; heterocyclic synthesis.
(iii) Liquid phase combinatorial synthesis, Dendrimer: supported combinatorial chemistry.
3. Biosynthetic Pathways of Natural Products:
(i) Alkaloids–I (ii) Terpenoids (iii) Flavonoids (iv) Vitamins (v) Eicosanoids
4. Chemistry, Synthesis and Therapeutic Uses of the Following Drugs:
(i) Psychotropic drugs : TCA compounds, MAOIs, Phenothiazine derivatives.
(ii) Antineoplastic drugs : Alkylating agents, Antimetabolites, Plant products.
(iii) Sedatives & Hypnotic agents : Benzodiazepines, Barbiturates.
(iv) Antihistaminics : H1 and H2 antagonists.
(v) NSAIDs : Indomethacin, Ibupropen, Naproxen and Probenecid.
(vi) Antipyretic Analgesics : Phenacetin, Phenylbutazone, Mefenamic Acid.
(vii) Cardiovascular Drugs : Hydralazine , Propranolol, Procainamide, Prenylamine.
(viii) Local Anaesthetics : Benzocaine, Procaine , Lignocaine.
(ix) Antimalarials : Chloroquine, Pamaquine, Trimethoprim.
(x) Diuretics : Chlorothiazide , Acetazolamide , Triamterene.
(xi) Non-steroidal Oestrogens : Stilbesterol, Hexestrol, Dienestrol.
Recommended Books:
i. Wilson and Gisvolds : Textbook of Organic, Medicinal and Pharmaceutical Chemistry
ii. Ashutosh Kar : Medicinal Chemistry
iii. Graham L. Patrick : An Introduction to Medicinal Chemistry
iv. Alfred Burger : Medicinal Chemistry Vol. I & II
v. E. J. Ariens : Drug Designs Vol. I, II & III
vi. O.P. Agarwal : Chemistry of Organic Natural Products Vol. I & II
vii. W.O. Foye : Principles of Medicinal Chemistry

36
Course Title: Pharmacology-III
Full marks- 100
1. Molecular Mechanism of Drug Action: Signaling mechanisms and drug action: Regulation of
gene expression by intracellular receptors, Ligand regulated transmembrane enzymes, Ligand gated
channels, G-proteins and secondary messengers, such as cyclic-AMP, calcium and
phosphoinositides and cyclic-GMP interplay among signaling mechanisms.
2. Drug Metabolism: Various pathway of drug metabolism, metabolism of various group of drugs,
factors affecting drug metabolism with special emphasis on aging, methods of studying drug
metabolism, new aspects of drug metabolism.cytochrome p-450, induction and inhibition
3. Psychotropic Drugs: Theories of psychosis, Classification, mode of action, SAR, pharmacological
actions, indications, toxicities and contraindications of chlorpromazine, TCA, MAO inhibitors, etc.
4. Hormonal Drugs: Biochemistry and mode of action of hormones. Hormones as drugs. Selective
serotonic uprke inhibitor. Types of chemical signal, Rule of hormone, mechanism of hormone
action, Interaction between hormones, hormone therapy. bioidentical hormones, hormones
replacement therapy, Risk, benefits and alternative of hormone replacement therapy.
5. Enzymes in Therapy: General properties of enzymes and their mode of actions, activators,
inhibitors and cofactors, enzymatic basis of drug action. Enzymes of pharmaceutical importance,
their production, preparation, formation, use and assay methods. fibrinolytic drugs, LHD.
6. Anticancer Agents: (a) Alkylating agents: Nitrogen mustard, alkyl sulphonates and nitrosoureas.
(b) Anti-metabolites: (i) Folic acid analog (ii) Pyrimidine analog (iii) Purine analog and related
inhibitors. (c) Natural products: (i) Vinca alkaloids (ii) Antibiotics (iii) Miscellaneous agents (metal
complexes, radioisotopes, hormones, etc.)
7. Pharmacological Studies of Various Groups of Drugs:
I. Drugs used in the treatment of tuberculosis: (a) Chemotherapeutics: INH, para-aminosalicylic
acid, ethambutol, pyrazinamide, etc. (b) Antibiotics: gentamicin, rifampicin, streptomycin, etc.
II. Antidiarrhoeal agents: ORS, tetracycline, streptomycin, sulfonamide, loperamide and spasmodic
drugs, etc.
III. Anti-fertility drugs: Oral contraceptives, mechanical barriers, implants, foams, etc.
IV. Drugs used in Acquired Immune Deficiency Syndrome (AIDS)
8. Toxicology:
a) Principles, evaluation in animals, determination of LD10, LD50, ED50, therapeutic index, etc.
b) Adverse drug reactions, causes of adverse reactions, factors affecting side effects of drugs.
c) Drug allergy, tests for prediction of drug allergy.
Recommended Books:
(i) Wilson and Gisvolds : Textbook of Organic, Medicinal and Pharmaceutical Chemistry
(ii) A. Goldstein and L. Aronow : Principles of Drug Action, The Basis of Pharmacology
(iii) R. A. Harvey and P. C. Champe : Lipponcott’s Illustrated Reviews Pharmacology
(iv) R. S. Satoskar and S. D. Bhandarkar : Pharmacology and Pharmacotherapeutics Vol. I & II
(v) Craig and Stitzel : Modern Pharmacology
(vi) Laurence and Bennett : Clinical Pharmacology
(vii) Davidson : Principles and Practice of Medicine
(viii) S. Vincent, T. Devita, S. Hellman and S.A. Rosenberg : Cancer, Principles and Practices of Oncology
(ix) Pratti : Anticancer Drugs

37
Course Title: Biopharmaceutics-II
Full marks- 100
1. Compartmental Analysis: Introduction:

a) One compartment open model, determination of plasma concentration from one compartment
open model, calculation of apparent volume of distribution, calculation of K from urinary
excretion data.
b) Multiple-Compartment models: (i) Two compartment open model, method of residuals,
apparent volumes of distributions, drug in tissue compartment, elimination rate constant (ii)
Three compartment open model: method of residuals, determination of area under curve,
apparent volumes of distribution, elimination rate constant.
2. Pharmacokinetics of Drug Absorption: Zero order absorption model, first order absorption
model, determination of absorption rate constants from oral absorption data: method of residuals
Wagner Nelson method, determination of ka from two comportment oral absorption data, Loo
Riegelman method.
3. Multiple Dosage Regimens (MDR): Drug accumulation, repetitive intravenous injection, multiple
oral dosage regimens, loading dose and determination of bioavailability and bio-equivalency from
MDR.
4. Intravenous Infusion: One compartment model drugs, two compartment model drugs, infusion
plus loading dose.
5. Dosage Adjustment in Renal Disease:
a) Pharmacokinetic considerations, general approaches for dose adjustment in renal disease, dose
adjustment based on drug clearance, method based on changes in the elimination rate constant,
measurement of glomerular filtration rate (GER), calculation of creatinine clearance from serum
creatinine concentration. Dose adjustment based on Nomogram. Giusti Hayton method, Wagner
method.
b) Extracorporeal removal of drugs, dialysis.
6. Relationship between pharmacokinetic and therapeutic responses: Pharmacokinetics and
pharmacodynamics, relation of dose to pharmacologic effect, relation between dose and duration of
activity, effect of dose and elimination half-life on the duration of activity, rate of drug absorption
and pharmacodynamic response, drug tolerance and physical dependency, drug distribution and
pharmacologic response,
7. Impact of drug product quality and Biopharmaceutics on clinical efficacy: Risks from
medicines, drug product quality, Good Manufacturing Practices(GMP), cGMP; drug manufacturing
requirements, Scale-up and post-approval changes (SUPAC), postmarketing surveillance.
Recommended Books:
(i) Leon Shargel and Andrew B.C. Yu : Applied Biopharmaceutics and Pharmacokinetics
(ii) Milo Gibaldi : Biopharmaceutics and Clinical Pharmacokinetics
(iii) Donald E. Cadwallader : Biopharmaceutics and Drug action
(iv) Bourne, Triggs and Eadie : Pharmacokinetics for the Non-mathematical
(v) CVS Subrahmanyam : Textbook of Physical Pharmaceutics

38
Course: 405/ Unit-1
Subject: Pharmaceutical Technology-III
Full Marks – 100
1) Compaction and Compression of Powder: Physics of tablet compression, different stages of

tablet compression, effect of compression force on tablet properties, strength of tablet, factors
affecting the strength of tablet, mechanism of bonding to tablets, problems associated with large
scale manufacturing of tablet.
2) Sustained Release Drug Delivery Systems: Definition, advantages and limitations of SR dosage
forms, principle of SR dosage forms, classification and types of SR dosage forms, methods of
obtaining SR effects of drugs, formulation and manufacturing of SR matrix tablets, release
mechanism of drug, sustained action oral liquids, parenteral sustained action dosage form, pellets,
dose calculation for SR dosage forms, in vitro and in vivo evaluation of sustained action dosage
form.
3) Aerosol Science and Technology: Definition and classifications of aerosols, advantages and
disadvantages of aerosols, propellants for aerosol manufacturing, components of aerosol
formulations, systems of aerosol, container, valves and actuators for aerosols, manufacturing of
aerosols, metered dose inhalers and dry powder inhalers, testing and quality assurance of aerosols.
4) Design and Operation of Clean Rooms: Source of contamination, classification of clean rooms,
air flow systems conventional flow, unidirectional flow, laminar air flow units, air filtration
mechanisms, fibrous filters and HEPA filters, temperature and humidity control, building design,
construction and use, personnel, protective clothing, cleaning and disinfection, commissioning tests
of clean and aseptic rooms, routine monitoring tests, the operation of clean and aseptic rooms, key
factors in clean room operations.
5) i) Parenteral Products: Definition and classification of parenteral products, formulation
considerations, vehicles and additives, containers, manufacturing consideration, environment,
manufacturing techniques, raw materials and machines, quality control of parenteral products.
ii) Ophthalmic Products : Anatomy of eye and adrena, absorption of drugs in the eye,
classification of ophthalmic products, formulation, vehicles and additives, manufacturing
consideration, environment, manufacturing techniques, ocular drug delivery system, quality control
of ophthalmic products.
6) Packaging Technology: Purpose of packaging, properties of packaging materials, factors
influencing choice of package, advantages and disadvantages of different packaging materials, glass
and glass containers, metal and metal containers, plastic and plastic containers, films foils and
laminates, rubber based materials, closures, tamper resistant packaging, testing and quality
assurance of packaging materials, different packaging machines and accessories, organization of
packaging line and labeling.
Recommended Books :

39
B.Pharm. (Honours) Part-IV
Course Title: Molecular Biology and Biotechnology
Full Marks-100
Molecular Biology:
1. Introduction to Cell: Differences between prokaryotic cells and eukaryotic cells, structure and
functions of mitochondria, and chloroplasts, cytoskeleton, cell development and differentiation.
2. Nucleic Acid: Structure, classification, isolation and purification of nucleic acid, detection and
quantification of DNA, chemical and enzymatic hydrolysis and hybridization.
3. Central Dogma of Molecular Biology:
a) Replication: DNA replication, DNA polymerases, types of DNA replication, and inhibitors of
replication.
b) Transcription: RNA synthesis and mRNA processing (post-transnational modification of mRNA,
promoters, enhancers and transcriptional factor) in bacteria and yeast, inhibitors of transcription.
c) Genetic code: Characteristic feature of genetic code, Wooble hypothesis with experimental
evidence, initiation and termination codon.
d) Translation: Structure of Ribosome, mechanism of translation, (protein synthesis), post-
transnational modification, inhibitors of translation.
4. Proteins: Structures of proteins, important domains and their functions, conformational changes of
protein, denaturation and renaturation of protein, synthesis of protein and protein sequencing.
5. Mutation: Types of mutation, molecular mechanism of mutation, site specific mutagenesis, mutation hot spot,
DNA repair mechanism, inheritant mutational diseases.
6. Techniques in Molecular Biology: Polymerase chain reaction (PCR), DNA sequencing techniques, Southern,
Northern and Western blotting, agarose gel electrophoresls, SDS- PAGE, RT-PCR, In vitro kinase assay and
microarray analysis.
Biotechnology:
1. General Introduction: Definition and historical perspective, scope, potential and
achievements, Pharmacist and biotechnology, GMP compliance and Biopharmaceutical
facilities.
2. Fermentation Technology: General consideration: Introduction and historical perspectives; the
fermentation process and optimization; Improvement of microbial strain-Mutations,
recombination, protoplast fusion; Structure and types of fermenters. Fermentation of industrial
products- antibiotics, vitamins and amino acids.
3. Recombinant DNA technology: Basic principle, cutting and rejoining of DNA molecules,
restriction endonuclease, ligase and other enzymes used in gene cloning, cloning of particular
fragment of gene in different vector, expression in the recombinant DNA molecules,
cDNA library construction, pharmaceutical application of recombinant DNA technology.
4. Gene Therapy: Ex vivo versus in vivo therapy, potential target diseases for gene therapy, gene
transfer method, non-viral gene transfer.
Recommended Books:
(i) De Robertis : Cell and Molecular Biology
(ii) Stefen Surzycki : Human Molecular Biology
(iii) W.H. Elliott and Daphne C. Elliott : Biochemistry and Molecular Biology
(iv) P.C. Turner and M.R.H. White : Instant Notes in Molecular Biology
(v) S.P. Vyas and V.K. Dixit : Pharmaceutical Biotechnology
(vi) K. Sambamurthy and A. Kar : Pharmaceutical Biotechnology
(vii) W. Crueger and A. Crueger : Biotechnology, A Textbook of Industrial Microbiology
(viii) Harvey Lodish : Molecular cell Biology
40
Course: 407 (Unit-0.5)
Course Title: Organic Spectroscopy
Full marks- 50
1. Ultra violet and visible spectroscopy: Definition, Lambert’s law, Beer’s Law, Instrument,
Electronic Transition, Transition probability, Chromophore concept, Auxochrome, Absorption &
Intensity shift, Absorption bands, Solvent effects, Absorption maxima calculation using Woodward-
Fieser rules, Importance in structure determination and application of ultra-violet and visible
spectroscopy.
2. Infra-red spectroscopy: Molecular vibration and their types, Hook’s law of vibrational frequency,
Fundamental vibration, Number of fundamental vibration, Overtone, Factors influencing vibrational
frequency, Instrument, Sampling techniques, Precautions in running IR spectra, Finger point region,
Importance of Finger point region and IR spectra in structure determination and application of IR
spectroscopy.
3. Nuclear Magnetic Resonance Spectroscopy: 1H-NMR spectroscopy: introduction & theory,

relaxation process, instrumentation, chemical shift, spin-spin coupling, different spin systems,
coupling constants, spin-spin decoupling, long range coupling, Fourier transform NMR, 13C NMR:
introduction, theory, use of NMR to study drugs in pharmacy.
4. Mass Spectroscopy: Introduction, theory, instrumentation, mass spectrum, determination of

molecular formula, ionization technique, recognition of molecular ion, fragmentation process, high
resolution MS, applications of MS in pharmacy.
Recommended Books:
(i) D. L. Pavia, G. M. Lampman and G.S. Kriz : Introduction to Spectroscopy
(ii) Y. R. Sharma : Elementary Organic Spectroscopy
(iii) Douglas A Skoog : Principles of Instrumental Analysis
(iv) B.K. Sharma : Instrumental Methods of Chemical Analysis
(v) Gurdeep R. Chatwal and Sham K. Anand : Instrumental Methods of Chemical Analysis
(vi) L.G. Chatten : Pharmaceutical Chemistry Vol. I & II
(vii) Willard, Merritt, Dean and Scattle : Instrumental Methods of Analysis

41
Course: 408 (Unit - 0.5)
Course Title: Clinical Pharmacy and Pharmacy Law & Ethics
Full Marks – 50
Clinical Pharmacy:
1. Introduction to Clinical Pharmacy Practice: Functions and scope. Status of clinical pharmacy in
Bangladesh.
2. Modern Dispensing aspects: Patient compliance, reasons and importance of non-compliance. Role
of pharmacists in improving patient compliance and instructions for the use of some common drugs.
3. Drug abuse, drug addiction, drug habituation, drug dependence, drug over-dose and draw back of
self-medication
4. a) Diagnosis and routine tests for diagnosis, common sources of laboratory errors and role of
pharmacists.
b) Physiological parameters and interpretation of clinical laboratory tests:
(i) Blood chemistry, (ii) Hematology (iii) Urinalysis (iv) Stool, Sputum and CSF examination
5. Manifestations and pathophysiology of the following diseases:
(a) Essential hypertension, (b) Diabetes, (c) Asthma, (d) Osteoporosis, (e) Hepatitis, (f) Anemia,
(g) Rheumatoid arthritis (h) Osteoporosis.
6. Drug Interaction: Introduction, mechanism of drug interaction, drug-drug interaction with reference
to analgesics, diuretics, cardiovascular drugs, gastrointestinal agents, vitamins and hypoglycemic
agents. Drug-food interaction.
7. Adverse Drug Reactions (ADRs): Definition, importance, drug-induced diseases and teratogenicity.
8. Clinical Toxicity: Poisons, toxins of animal origin, role of poison centers, poisoning incidence,
analysis of poisoning situation, sources and assessment of poison exposure, general treatment of
poisoning. Symptoms and management of poisoning cases with pesticides, fumigants, solvents,
vapors, food toxins and heavy metal poison. Snake poisons, venoms.
Pharmacy Law and Ethics:

1. Law, ethics, forensic pharmacy, ordinance, act, etc.
2. A brief description of the following acts:
a) Drugs act 1940. b) Poison act 1952. c) Pharmacy act and pharmacy ordinance 1976. d)
Narcotic act. e) Drug control ordinance 1982. f) Pharmacists code of ethics. g) Drug and
Cosmetics Act and Rules
3. National Drug Policy (NDP) 2005
Recommended Books:
(i) Pratibha Nand and R.K. Khar : A Textbook of Hospital and Clinical Pharmacy
(ii) Anees Ahmed Siddiqul and M. Ali : Hospital and Clinical Pharmacy
(iii) J. Marshal and K. Bangert : Clinical Biochemistry
(iv) A. R. Gennaro : Remington, The Science and Practice of Pharmacy
(v) Lloyd Y. Young and M.A. Koda : Applied Therapeutics
(vi) S.C. Sahajan and J. B. K. Narang : Forensic Pharmacy and Ethics
(vii) B. M. Mithal : Textbook of Forensic Pharmacy

42
Course: 409 / Unit-0.5
Subject: Pharmaceutical Marketing and Management
Full Marks - 50
1. Introduction of Management: Definition, Importance, Level of Management, Function.

2. Personnel Management:
a) Definition, scope, importance, behavioral science and personnel management.
b) Motivation, moral and job satisfaction.
c) Education, training, management development and performance evaluation.
d) Means of achieving harmonious industrial relation collective bargaining, joint consultation worker
council, arbitration, and industrial democracy.
3. Production Management: Definition, scope, importance and application of management,

techniques and principles to production management, production planning and quality control.
4. Materials Management:
a) Purchasing: Formulating effective buying policies, determination of needs and desires of patrons, selecting
the sources of supply, determination the terms of purchase, receiving, marketing and stocking goods.
b) Inventory control: Methods of inventory control, selection of optimum method, effect of
inventory control.
5. Risks Management
6. Pharmaceutical Marketing:
a) Promotion: Objectives, classification, developing a promotional plan, promotion strategy, budget
and executing the program. Steps of implantation of advertising, types (display, direct mail, etc.)
and preparation of advertisement. Personal selling and evaluation of promotion (general and
specialized method).
b) Pricing: General consideration, pricing method, prescription pricing and professional fees.
c) Channel of distribution
d) Forecasing of sales
7. Management of Community Pharmacy and Governmental Pharmacy.
Recommended Books:
(i) R. M. Mehta : Pharmaceutical Industrial Management
(ii) Kotler Armstrong : Principles of Marketing
(iii) V.S. Ramaswamy : Marketing Management
(iv) F.D. Sturdivant and L.W. Stern : Managerial Analysis in Marketing
(v) Robert E. Stevens : Strategic Marketing Plan Master Guide

43
Full Marks – 200
1. Pharmaceutical Analysis-II: (Marks-35)

Pharmaceutical analysis of drugs using spectrophotometer, flourometer, polarimeter, thin-layer
chromatography, gas-liquid chromatography polarography, non-aqueous titration, pH meter, etc.
2. Medicinal Chemistry-II: (Marks-30)

Synthesis of at least two important members of the following groups of drugs: sulphonamides,
antimalarials, antibiotics, barbiturates, adrenergic agents, antihistamines and antineoplastic agents.
3. Pharmacology-III: (Marks-30)
Estimation of glucose in blood in normal condition and after administration of insulin; biological assay
of digitalis, histamine and insulin; microbiological assay of antibiotics and vitamins; spectrophotometric
estimation of blood pigments; toxicity test of some selected drugs like, phenobarbitone, nikethamide,
some antineoplastic drugs, pilocarpine, etc.
4. Biopharmaceutics-II: (Marks-35)
Evaluation of drugs and drug products (pharmacokinetics); measurement of viscosity of emulsion;
quality control of sterile medicaments such as ophthalmic solution.
5. Pharmaceutical Technology-III: (Marks-35)

Preparation of water for injection, preparation of injection of (a) procaine and adrenaline (b) procaine
with benzylpenicillin; studies on the formulation problems of vitamins with minerals; formulation of
prolonged acting dosage forms.
6. Molecular Biology & Biotechnology: (Marks –35)

a) Isolation of plasmid DNA from bacteria.
b) Estimation of DNA, RNA and oligonucleotides
c) Agarose-gel electrophoresis of nucleic acids
d) Determination of bacterial drug resistance by disk diffusion method.
e) Estimation of protein concentration by Lowry method
<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<

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Syllabus for B. Pharm.

Published by: Department of Pharmacy, University of Rajshahi

B. Pharm. (Honours) Part-III Examination, 2016

Eligibility for Examination:

(ii) Table of LG, GP and CP for non-credit courses

B. Pharm. (Honours) Part-I

5. Co-ordination Compounds: Definition, Werner,s theory, electronic interpretation, structures of

* Other Books will be indicated by respective teachers

B. Pharm. (Honours) Part-I

2. Chemistry of Aliphatic Compounds: Introduction, methods of preparation, physical and chemical

3. Chemistry of Aromatic Compounds:

* Other Books will be indicated by respective teachers

B. Pharm. (Honours) Part-I

* Other Books will be indicated by respective teachers

B. Pharm. (Honours) Part-I

1. Introduction: Definition, scope, historical background and relation to other disciplines.

* Other Books will be indicated by respective teachers

B. Pharm. (Honours) Part-I

1. Cell and Tissue

* Other Books will be indicated by respective teachers

B. Pharm. (Honours) Part-I

1. Introduction: Historical development, scope of microbiology with special reference to pharmaceutical

6. Fungi, rickettsia and actinomycetes

B. Pharm. (Honours) Part-I

B. Pharm. (Honours) Part-I

3. GRE: Verbal Reasoning, Quantitative Reasoning and Analytical Writing

5. Differences between American and British English.

6. Vocabulary Building: Commonly used words in pharmaceutical and health sciences,

7. Writing cover letter, curriculum vitae/resume, application for jobs etc.

* Other Books will be indicated by respective teachers

B. Pharm. (Honours) Part-I

101. Inorganic Pharmaceutical Chemistry-I (Marks-25)

B. Pharm. (Honours) Part-II

1. General Properties, Preparation and Uses of Pharmaceutically important salts of Sodium,

* Other Books will be indicated by respective teachers

B. Pharm. (Honours) Part-II

* Other Books will be indicated by respective teachers

B. Pharm. (Honours) Part-II

* Other Books will be indicated by respective teachers

B. Pharm. (Honours) Part-II

1. Phytochemistry and Pharmaceutical Uses of the Following Plant Constituents:

B. Pharm. (Honours) Part-II

* Other Books will be indicated by respective teachers

B. Pharm. (Honours) Part-II

1. History and Scope of Pharmacology

B. Pharm. (Honours) Part-II

B. Pharm. (Honours) Part-II

201. Inorganic Pharmaceutical Chemistry-II (Marks-20)

202. Organic Pharmaceutical Chemistry-II (Marks-20)

203. Physical Pharmacy-II (Marks-25)

205. Physiology and Biochemistry-II (Marks-20)

B. Pharm. (Honours) Part-III

* Other Books will be indicated by respective teachers

1. Mechanism of Drug Action: a) Basic concept of drug action. b) Physico-chemical nature of

* Other Books will be indicated by respective teachers

1. Introduction to Pharmaceutics and Biopharmaceutics: Biopharmaceutics, pharmacokinetics,

* Other Books will be indicated by respective teachers

* Other Books will be indicated by respective teachers

* Other Books will be indicated by respective teachers