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    HBeAg Negative

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    Ahmed Gaber
    HBeAg-negative hepatitis B is a form of chronic hepatitis B infection where the virus is able to reproduce without the "e" antigen protein. Around 40% of adults with chronic hepatitis B have this form, which can be more difficult to treat. Doctors recommend treatment for patients with HBeAg-negative hepatitis B if their viral load exceeds 2,000 IU/mL, even if liver enzymes are normal. Antiviral drugs entecavir and tenofovir are most effective in lowering viral load and improving liver damage for those never treated for hepatitis B.

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    HBeAg Negative

    Uploaded by

    Ahmed Gaber
    32 views1 page
    HBeAg-negative hepatitis B is a form of chronic hepatitis B infection where the virus is able to reproduce without the "e" antigen protein. Around 40% of adults with chronic hepatitis B have this form, which can be more difficult to treat. Doctors recommend treatment for patients with HBeAg-negative hepatitis B if their viral load exceeds 2,000 IU/mL, even if liver enzymes are normal. Antiviral drugs entecavir and tenofovir are most effective in lowering viral load and improving liver damage for those never treated for hepatitis B.

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    HBeAg-Negative

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    HBeAg-negative hepatitis B is a form of chronic hepatitis B infection where the virus is able to reproduce without the "e" antigen protein. Around 40% of adults with chronic hepatitis B have this form, which can be more difficult to treat. Doctors recommend treatment for patients with HBeAg-negative hepatitis B if their viral load exceeds 2,000 IU/mL, even if liver enzymes are normal. Antiviral drugs entecavir and tenofovir are most effective in lowering viral load and improving liver damage for those never treated for hepatitis B.

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    32 views1 page

    HBeAg Negative

    Uploaded by

    Ahmed Gaber
    HBeAg-negative hepatitis B is a form of chronic hepatitis B infection where the virus is able to reproduce without the "e" antigen protein. Around 40% of adults with chronic hepatitis B have this form, which can be more difficult to treat. Doctors recommend treatment for patients with HBeAg-negative hepatitis B if their viral load exceeds 2,000 IU/mL, even if liver enzymes are normal. Antiviral drugs entecavir and tenofovir are most effective in lowering viral load and improving liver damage for those never treated for hepatitis B.

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    HBeAg-Negative Hepatitis B

    Normally, the hepatitis B virus or HBeAg antigens. But some


    (HBV) needs three proteins (also HBV, with certain mutations, are
    called antigens) in order to man- able to reproduce without the “e”
    ufacture more HBV. These are antigen. This is called HBeAg
    called the core, surface, and “e” negative hepatitis B.

    If you test positive for the “e” antibody, but


    continue to have elevated ALT and viral load
    (HBV DNA), you may have HBeAg-negative
    hepatitis B.

    Some researchers estimate that about 40% of adults with chronic


    hepatitis B have HBeAg-negative hepatitis B. This infection can
    be harder to treat. Doctors recommend treatment for HBeAg-
    negative patients if their viral load (HBV DNA) exceeds 2,000 IU/
    mL, even if their alanine aminotransferases (ALT) are normal.

    If you have never been treated for hepatitis B, research shows


    that the antivirals entecavir (Baraclude) and tenofovir (Viread)
    appear to be most effective in lowering viral load (in about 90%
    of cases) and stopping liver damage (more than 75% achieve
    normal ALTs) but only while you take the antiviral medication,
    which comes in pill form.

    Pegylated interferon, which is administered in a weekly injection


    for 48 weeks or longer, also appears to be only slightly effective
    in lowering viral load (in 19% of cases). About 59% reduced their
    liver damage and achieved normal ALT.

    People who have HBeAg-negative hepatitis


    B could have a lab test result that shows:
    • The surface antigen (HBsAg)
    • The antibody to the “e” (HBeAg) antigen
    • A moderate (2,000-20,000 IU/mL) to high viral load (HBV DNA)
    • And, possibly, elevated ALT levels.
    VERSION 4.1 • November 2013
    Alan Franciscus / Christine Kukka

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