— > Gteveo = Space = wlume = oid moleudar qensty depends on pial arrergement of alem| fn a melcules change “9 cpotidl pcitizn of ale, qeemeby of wndolet chee 5 nalecdlar properton Caigice, chant balgieel) depends on meleaday qearvely 4 ae * spate > change tn. pobitin of abomf in ap ape elbedly tri propertieg . Gady of phy fal, he Keli propettieg wrt. (patil areange ment gan} ina tl le Xx {eo} bide) rey wey . wed Inactive i 7 ° on active dk 4 th > ; vol oh 5 phyttel propery ize as > tp 3 fH ty Te Oe Ha Fah 0 ae q tg trang ayse obove weapound ciffag to cheaical properties ay org: melialt wat @ cloud ov ebitel orientation , clotted af rapt wet bag , sec a maleate -ap popertion of indeadel th bois by Se phanee ley to cath other Cae’) - SP ntl . molecle D = 08 hy nid aD with TL gary, + oF hyde i phar rpamide gerd planar Se conuerfina pretentation cb 2p axrengere on a place called * spolecalae xeprekertabionwedge Representabion Flyin Wedge Represented ony + Hy = win SF (od of plane cel NX a Gents iba broken wedge wedge , wae *& In wed ge formulae, Gore bond Heavy of Thick wedge attachment ; neat to chtdiwer are thown wit edge model . (ot) Front thi plane (x) aboye the clan (F) eo & Broken of dathed uedee attachment aeg fury te ob(chver (or) below th lane (a) oF tency Avon, the plane. & niomd attache ‘n flame ef papey beard ; Fine Meltiame sy 4, —e huordt ohCervey , \ 27 > Se Pe ~~ SS W “H, — | trom obcedvey Mirror ‘images icool ti sel > wen em ol} an a yea | \ ' — } i | Sit te 4 Aq a, S ; . } a) 2 Pn, Ze a @ ng ee" coe ‘| tH Bechet prajectiond Flat orejetond i Ruleg 2 ) walle drould be ¢hown in th tom of verticd line and tpovigontad bine —¢ a, cotlee (+), eating point a) cach Gas sepekorf | ¢ _ 3) 4 rnulecele lovey autyenehic combrek, cro) Uinek thould be given tp aly ty canbek. saw noch conbang om verhcal bigs. veal hah otidigabl carbon 9p should onygemt» inf. po.of- 4) rang inf 6) carbon Cheleton uuntygrmei be taken at top of vertid Gor (tf OP having road no. of hduogent) « BB Ail, chal, Ho, aol%) 9s atfathed 40 verlical bine aay ie obtehver . Dd» * herigentdl + nearer tb # 2) AU -ficcher projection! we eutipted. A et {Lt yor A ty qr rotstion “in plone of Fitcher givee anantiomer D was ; co as fo Oe ate Enamtiomert 8) Igo" in plane wt of -fucher rey identicl ’ . ¢ dented an ny oae tied contre + Lcher only tuo pf oF atomt oped exchange predic} enamored @1) diatereomet{ . Ging hired coke wndlalt, ——> enantiomer mul * « +25 Piteremer. > re my aon LL > oleae oe y wah Lee ve ag8) spabicl exchange of ony Tree #, a chivel contres produ} identical A 212, — — pe ee! c Homomer{ 8) mulud exthange of to pair at hid ceonltek pref identi heh —— at ao ferro obfdived rS near to obtaver wedge projection’ V a as J . He — 1, Hg 4 D Ethame 2 cH, = a = i 4 = 3 es exampleg +— i : Jd 7 wn 3 Bored a, CH, cH, * My souk ef plane wt? sulef ok, only ‘ny plane bak taken. 4 oH Gooy 9) ladic aid: acne tH H Sy = g Ou, eha iia ®y4) Alamine +— coou ~ wu 4 Enantomerf je wo = AF chitel Combe, opposite contign — enantiomer +, Some > = homomer. mandalic acd — ph—cH —cool{ bn a (wo ; . 4 | ott bf aia, * ’ - ol i ” o ) ZBI- cna, TET hmomeg muti gle ee thirol conlree i— ce ag TO COH . ; u Ma _ wi, Hod xy =e Mirror Imag of melo- yoo 7 Yo y tartaric addy ade hom chy - ‘cool cy Oe : oy! s 4 te 1} ae 4G ho — i A wpe ae cool] 1 H Kg rob interenvertatle with 1 fn dame ol, hey cannlt be homemerf. .°. hey are ena of eath ober.th fh é eh t ' - yg ft | Hef H a ofiy fo—| Hip ao H—-— aH, ! eu, CH, f * a oH 8 $47 Enantionenf tea" aa oth ——ny oH oy ae lL. OH Wool} C,H] ® > iq ie Wo. yb we yo—f— 7 Pay | Oy Coy a ji by pa vo cette ay enastemer oH 4 a coo{ B “pea —> jh tL ou % Hy ‘a heer 9p exchanged g p = Adenticel obtained. _oll » Aor ad g —lo_, % ~0H 9p back, bile, wali vokake uel mdeade ge ies back bevome font: vie veray Sp veft beck alter vel apport af ehh fant. ude body voi? gives Th sam on) ilontial, hen they called of “rigid sotebien’ a> ube nolewule aol won! exchange Geren chem cabled ' aigid setation ! BD) Newomann projection Repretontafion ¢ — ) ate buh along the cc bind 3) obsaver Can gee nly fiml '¢’ 8) fuente" hewn ‘in thy farm of let Rack'c’ chen hing9 §) veep three Une with wav’ of Gap ab cath 'C! 5) one th beth ssepretentakion tor confer ani ab ah : Newman'y projection OH he odipte Gauche & Gogg Fagcher— Newman) + —_— a i mobi kjed ‘into edipted, ~~ “A % oer conkivimgtion. Gh a of > Wy nr ry ri = “ Uo 4-H a ws “Se adlive tartaric 244 add 1 fs 7 or map _t sie 0 add + - Goof a" Hou Foe vt a y bot 4 oo} ull : aeae sec give eapivalent afin to Bucher 2 io " wot] ] u see Ho} —100H — ti >—a tool eH wt here nok wnat. no ef Carbon pub in vertical line Cool wall wa tt oll . y—La al sy = dew Wl H ut Spl tol cot ; ¢ rwhabe the viginal rode given chant °C akul i, Ben we gt abwe rns “Hl 1 H | . ooo H We if coll Sead Horge vepvekentation 3 ——— ) @ Wrina hung 3 tho te eC bending. in @ deed manney at end ‘yt feent/ ner carbon. hy “y clote to obcaver. 2) obcerver Can feu both neav & -fay of Carbon 4} Newey th aig = yop hee boy “if vith tat” Gparad of both ondk ormind of aged : alto a on ofthe “be aepoentaton, fer nbienotioal arly = Cou-horke tan be Ghai of Gauher aligid , sagged, anki se.= don if near ty obtelver’ 267 0” o wr fork =o" near 40 obKerver Any foe bret lel to each other eer og woere tid, oot edlipif seit toy toga] gouhe * Hou to ini Cache — Gan hehe 2 Fitcher oll ave eabptal, ceahorte fill be edtiptal n © 8 Mevo -tavtavic. add t— A cca 4 eS oH ". oll 4H 4 otf y—ty = =F = i We Ms ‘inpleene eavangement=7 ” Ww ‘oH oH Hooe se Wn ol ey u da ar" Ape, yor Cy ° 2 = sy : call de ae “4 4 lige, J aA gg > 4 es - H Ne hy f m oy Ni Hy He’ Anplane ete cavanggent ‘Snome > fucher prejettion % evey vata! Vino bak & Tn plone cChleton -gototion * amt change at-plane avrangement: wotoct] woot = hit. meee Hy cH _doilene aT = th oll rg +m wa Sent

ce He, Hoy i" = oA a ( An plane vel ~~, te V K€ a To tonveit thy ‘nto Eder, ctu th pleme queupf rake them back Po 2 eh a lt Js 4 Hge- 4 a = & Poy : tl Jao TaN IR! Weft Me of, > ed ty a i Lt ai He’ iy = Oat, oS - a ey ®. = =H se Cl Je * “Don rebi, @ ca FE ABIL are farmefi *y—fiw ie my Cooff 4 a Se 1 BR aw fame With inplane 100" -athation Hs sy LiL? wk, i ee Mock ¢ hearer to fet obtedver > Cee dong ec Chaletory He, (ay Hy yt w/t fient PS _Newmaam _preectiong ¢ in be G iat ay > (y > Ginple olebin gives edited entiation 4 2 = Hee Lad bind angle betes sg” ob ms a b Sted a} Menees)Molecules hauling came molecular -foyrmula Tenticaly. (Hemomevs) cameh {4 cot col vest fame bondi 4 ih Me Hl Covet Hy NH, Goyer ‘komevr cats irl ‘enaged LL chet | me tr pesthere| a . Enentiomer’ Diagereomers L funcbienal Stered itomerd mefainarf Tnkerwnvertabh ab RT. arnt aki swe ee Ce) Cenery bevver 40 a) Carey bower 20 egfrel) minor tage, ofivret ‘images, No coke ‘ cobigney eongirnaienl eqantiomer, conbimaliene} onto dtacneys (a digfenomers thy Dynawhc exgotomerf a, Sy ude EGY, aSlee ‘ornek 2— ige 19 Spall arrangement bub ei Aarne bonding cxonectivit ~> unffitedion ome i~ A -g-c-p AC BD bard connectvifp eae didber{ “enantiomers” — Handednegk y pt ikomevd ” , ° y ( pviutly called ent. ankigodes imaget 1 omy. Cupevienpolable mivror imaget stomert-ave earner, 2 enantiomers - "enantiomer are hen eo taht right hand av 21,2, ave enantiomers Bik ata, @ge $2 > 2) » pd ha Ban @ ’ C - (1 came E35 Enantiomen( # Enantiomers’ chemical iyttel bili properties depen oy ralure of environment or) madium.4 Date : aa/otfoe Enantiomers ¢— = J Adhital envicenment chiral environment Ae] homomers dit, chanical entitieg. — chincl reference : CFs yl 4 rh yo cool] i}, ise a — + Th montiomens of compl, tdi teparation Yo reference graup) fame “intend enericg alto tame ; icombric” Guemdeally eqpivedent ~ 1 0,4 ‘co, oH —~ . = H on | He H om AC £ cts th + érintiomat are’ “woprepily non=eqpivlert Be caute cote artangemsnt of. x n oppure cirection. =>et the H 4 otf i it CO ; gc Gh. e Lv : cr, 3 5 4 j rn o-} tf o- at U cay oh eS Diaketeromera : Ep fE sn hid aderence, enentiomerf Fenporary dlevep| diagtereomertc - dation thip{ * exhibif dilgerent: shal cherie propertieg al pa aH fi—t—oll Ht a => fl —ol a ey a) 4 a, tree fone mentonay wl by <1, Sn J sano tal Gm, dene + enanfiomelf are vad by kewnd ind ob ym demeih = Sn. . A i nivior lame § > oc > of> For objed, oo one mirror ‘nage ‘f potible . For avery object or meade, only one enanliomeric paiv . Hoe. eg 3 cll ‘| , 5, - to ya! ° W 4 cH, uo €nanticmerf yay > Prt, igh chy iy ! a 4 Aw A x27 | Sane b =b Auth — enantiome, are eplicely adive @r) died > th otek The PPL ‘in oppotile divechon i degree ct, rotabion copied viotalion ) Aame. e tie" locket > i Tap Bleue YY EDO aw fol > nkeq-fuperimpozable nen-mirror Dio bereomerk >— images . di dsK tot a on He, 4 Wt oH 4 olf oH on] 4 4 = 3 60/ ig bing ‘in diaztereomeric relafianehips. — — Anitomevic + be diaxtereemey dilger ‘in Weir ‘interne! energies" anitomeric. yf 4 ol] > En Btw dy 4 > diactereomer} grorshiclly of well a toregneghicay nin. spielen port onitenehic papery -diattereme! “thysiel chee, bidegicad properties ditberent ‘in achinel at well af chival medum. ‘Ly For given rnubcule ov objet, move thon one pair of diagtereomerg ave pouible h ih th ‘ th 1 > tet \ do—}—y , i Hm tpt {ip Hey of It oH cH. a, Sees th aft h Enavrtionetic pair a . - fk ql fe ql 2&1; Tam — dirttereoneric- pais . co —> two diartereomeric pair< > diatterenines ane optically achive or inachve 3 AchiralfebiralioofAod i) “yy TN non Leegeringotalle, on birror ‘imagex o. diaghereomert « > they ave apially ‘native 5 achiral. b th —F I olf J} 4 of }o—+—1) 4 H, i: 3 I = “ephlly adive ' > Ging cfeveoemitxer camlt be clesified at enantiomer or ciacteren| a, j ' eqs WN + a oH —> — enanfomert, diagtereomer are relative terme, i = cu oy ta ot cy tH, > Enartiomers, diactereament ave - mi exdudive, that meant ‘if ceresieamer, enantiomer, , they tanpit be diastterce mers and vice-vewa. —> Ak one time, bo two eresivomerh enantiomeric af well a diastereomericcHe 3 & tr CHO. 4 rr oH Al Homomer{ uy ® cag I =-\~ XY Piteamer a i D4 i 4 4 a Hod , u, 3 H 9 pf ft ° < 5) pd) ad cs a i eacac. Catach Enontiomert WY, r Cb 9pt ore make t exthanoeh d 4, “, ‘in any one tereinii of allene d a Ga Cycom, recalng ove if enarrtinmer) hs Pinder comet ke oS 10 > eee ap 9oOODD. 0 @ @ w oe o Ge» & © ) mM @. QW) Ka) — diattereomerd @ay- ' @ka- ° Mee — ” : hth * de—tane : diattereomer, My { 7 “ue Sn-anli ” Lh Rh ad of Eryhi0 threo; » ths ca My crtal — eqpiovl ze re ‘ * erro exo poe thea ny re | de 3 ak a 5 teat (| mela dive 3 4 iy ey : oH - eto helo Chom); + . ‘rtth pln. we —4 y—L— ai tH—+— ot ay tl, ative adive , a al aoe i Lp Pi Oa at 7 “ i i sa 9 dig e P oH at Aes By dia O © Atomic contre] chiral centre == Any contre oftacted to four different bganls or groups 4 calle acy or cord cmte, it mney be ,G, N,P, ete £ sere canbe| Ase cae o > PN ae / ‘* 4 Clevergenic anhe > ih cee mle cle ab uli, charge“ i) cpalial petition of Aa= {" abou] pk a rod Glesecitanjer. wid ot Ly teres Kone set conecool ; cro Ho] — 4 off +——1} th of «| At Cool “ait Geren conte P fered el > Act care A K hank Ab the tire conker af ever cenhet, tub all the ereo centres are n't chird anher . d d Soo Gee centre bubolt chital cotte a 0,4 ” ‘ Geren atwell ak chiral centre. | toyll she Ghreo wntte 5 10 anid conbe 4 POOKY ~ pe camph ork Sterententre. PODS, > LoSSterepizome ts No Sn Cumalement wth chiral eve! omen Adi lf opt. inactive opt- active & Corp ¥\ > All] Sym. alemerity absent ‘in aitymelc indlecoleg . chiral wal hevlg Cy a diaymotric wndecele . Ouith atgymehic_ @nbe ——+ => @Juitwut oscymelric conbre 9 igh auymdic_ conte a Sascymebic decile wit attuned centre = qe Any Cingl chital cenke. dace Cool weal ote, ‘ fos . tfom “ a HOWs 4 aug inchic vnolecules, witout abymeric centre » oper cabttitaled allenee, biphenyl, piv corapourndt «alecl : a Bissyrmeric eke wih ascymebric cenle : a od, * oe q y 4 fa Beeym. melee withouk attymeric Conkle * = peegety cubiditabed allenes, (pito compde , biphenyl a 4 \aeet, XO’ / — \ Ny abe : aofowog optical fetiil 2 — —_—— Uapl REF 7 PoP Ree Al éthird aie prim “ak ptm plore plaid bahtW Rep | erontieric Leph mirror ot ~ Ff ire" plone achiral I opt ‘inactive ‘nteradion q Garg P w/ nh herd Ge of pesied bgt ~ WN dine, weak interaction cauive ao Ut Cle week J Cha “lee ce > Degree ob ang of arotalion by come Absorption] gebrachive ‘ndieek 2 fahraitive ‘ndicee of “et fe lq with 'X! are ound called “plc -totation! (08 _» Grafar Birebienges dilerent-~ Grular dicbvoium 1—- Can) Difference An absorptim of Repl & Lepl “4 2 Oh qhenomenon galled * dvudar dichroism’ cation cllet = d+ 68 s (or) CE = CODECS + alrry teh ef umf. geitlalet ‘in, all pouille eyotiel divedtions | dyodeid pedilletion’ doyibiel ot active, tight pall shou wical pram , 06d lation of effin ailolen , cid 40 be PP. famek > yandomn sy onte exdinat qt vethited only fone shoe] divedion ot pel composed with pepl, Lend + — - of AMll-O Za = = Oe ] ordinary abt tal foph — He. vic. % cradat didhroigm i piffevona an abgorption of wens scr 4 medium. © rh obs. wallidonlp of tcehf uch differnt {0 median, alle CD. rebracive ‘indiceR if different * dralar Bivebringes + — Repl, Lope “in medion called a6.cotton efbet? = CD + 6-8. CE p+eB > comps cabthance ulich sotely lone ok phriged Light called ortilly - adive’ oF chiral Cubstance’. f yotation of ppd optical aptabion (4) > Degree o dock wite votabion” 5 ah Rok shen abtoilel than Led , -> Tf tok » ro Bch, acid diredor * Deguee of relation depend on CD — ss gabflante hich qotatec ppl clock wike- "detho-d” 4 » awd * teavo- I", — 9 > — pexto ot leave can be antuered hy from eaperimentel | rot from atruckute + obgetval mt. experimerty "ddermineg the opted aul | ptcel volalioog = “plasinehe pr ‘in oppotite divecFion’ with Zame egret 5 Enantiomert yolabee of wotefion > Be optical wetabion 4 = +0" Cdetho wiakery) yy ett Cleave), Sra ” Biot 'X tas — —— epficl elation oe che Acording to thy low, OR 4 dhretly prop: = ortiocal to concn &2 length of Sol).one ct gx aptical station (4) - Specific xateien c— tench in aylet j- Length ch, polorimnstey tube ‘in din x > (I= “og c c-qilm) @ w= (cgi) 3+ optical rotation depend 0 t= 2 ) wavelength of ppl ha been § « vib etn Wi ok pL optical ato V@. ono 3) concentrabion ob Gol? « 3) Leng of pelaviegeter tube 4) -feinperabe 5) atgodation ol andscalee ‘in 2 medium > in gene pesbic avtat) repreteted of a ( ih pine Cigpide ate taken in pelavimelric tube, cone % sepleced by denail cf anid C4) sh t | hy = dxl ~~ I] Cod. vapour lomp ; A= S84 0m (0- line) certain opt -aitive compound foken ‘in 100 lengtr pdavioghic. tube coer = we gil, degeee aotahinty ahel 4 spedtic v1” 7 { 10 = = 4 mio 43, xa I fim cof ke gpasth volved geneilly nang in 64 to wet, Cor 019 Gubetamces) se optical tote alto dependt on note of selvent 0 ory Gingle cdvent » Gabstance naga! be athival .7w teat chvalily ov opt- activi didgeren! calvert « all aveilable talverty, opt-w0lD =0 f compl % optically ‘inactive « — In “4 Gingl calvemt chewy egt vel, comnpd ‘gt optic Sf, opt yokny ave zero, ie one hag te msature optical -otebion’ “n > bb ah cadfive.& criteria for optical activity on penne SS opt.activily i thyCiel propel rat K 4 thy virtue oh vet" ef ppl: 1) plegence of, ontynehic conkee det having chivol cenbiek optical active. > vivelly mbt xnpeundt ubich vidlokes thik Giteria. pub thee > Gorne enelecal even with ckid conte, opt inactive. fog y eH yatlstd ) Syn ofl Noe i} H th all wv i . ae " . d d reco tartaric atid — oft inotlive | adid Germe rolecdet uitioul chivel contre, opt active alte & a a allenet, ot gfiro cempurde NO 80 egal ot ¥ Sarmmelg Giteria + + moleadet heving | So’ a “ochre ept naive Gy" artoriotek ult? plane of Capone + "pone ob cen” clernentt enough fo tect opt: advil — veel hing lane of. ne ot! Madive- — » doth — opt active . Q | dond, pig = Hie Nat hed =A> ge peta, cl ‘nactive. t combe woleales, C\- point queep (all the ap olernenfy > cingle china absent) = wy ave clas opt adive co, d d col] > y+} — — otf { #—+—-- 4 u 4 pas - coy oS cool > A el d j io, CGAL = Gant, - 7 ~/ roo) <0 - £9) No Ly ov Ab hance opt. active ¥ chin = > "cial in be thetic proper 4 viitue of Tb, objet oF ndleae. dows non-Super ‘unpotable D mivior ‘image Ay chjett of wntlead Ching nan uperiempotable miner ‘inage, opt, adive- # cent guretien i- = pekevmigabion of Gail potition of groupe] * eenbiguration + ent qe \ 5 b Go io atoms 9% ndeaale % WeNotafin] slemendafwe :— et aes higher’ - Dok Ciel ute in Cathy chemigby) — sy Rules: - ) draw mmoleade in a fiather form ) dently betlem moet chiral Cente fem thy lower Ge 3) Ak bette raogt hivel conke, if move en. ake ¢ 9p aight of nornondabuve —Dd. conbiqrations tabt cide of father, contiquection ficchey > Wy Th mere en.ctin| a nornen~ debuve “L By ek vdekion ghvip mas be enantiomeric » diagtereorqeric or homarnent ole ‘ Pr ts ae [ Ly rove ere Fgh ad tf 4 Hy | tls p— acbygdoory hukame ' Lg butane! ANY Gingle chiral combe mndeale' § p-L relationship * enantionpic —» No vdabion eo dexto @, Lavo) & Did entiguration’. cool} ! ~ coll wol] > 4 1 . | woH oe HW sy fa HW Hy i a \ polndic ald detafc avd th { th p-nandaltic add 4-1”Go ot} Ho cHe We wi, is Hoon of Ho] a, ay cll, cll, of p- alanine Le» de qlgeraldde love ls I lls — HH of ; Ho | Hf ol] Cright sit) "Ho i t hs ten nett hal cenke tH d- Gubane 2, 3-diol I Lebaane 4,3-dl (eat) Gneto) Hotnomeric as | Cs + Hl 1 ol 4 “off Ho cit, | Hg pebutane ad-dil |) y gahane atediol (adive) (ative) We See. ontiomers Cuo}f oH He -——-o} =_ le & p 3 ee el] coe Dome TAs kn TA peadiveT-A — deadiveT-A- oO @ 6 tomunctf enon orci .4 © —tinwmas_@ | DIA DA © ea ex Fora ampd, in a feb ch Glerenitornert , dattereomeric relationship are move than enanticmeric relahonchipe cto > 1 otf Pte tion pentane h-isiens fepanek i 3 Hf tadive) i——_}|__oy cH oth volt oa at wy Te ed Got i br bf} —-—-+# b= qlucoze oy “tr ow wa jqurodton& i— " Br Wy Hy Rs =s CAHN INGOLD - pRELOG C cp) = ah Win, = veg 5S = Ginikter (co) aa) Rules i = d dently chival comes ‘ina inclecale « 2) aded dire combe, give priority uy attached aren fotos er er cummber ( Hicpet af no - op perib) . Th tthe ave alloca, priealy betel pa af mated p-¢-T@ 6 Neeat chic conte, Y fact allachent of gp Zamne, Glee nett atoms in a pour id prioity detded 4 Nore 9p oS w2c-H W & at direl cnive, “if malliple bended Ceoulle or biph) gp are pretent, do dulglicatin) rgbiation fr decideg pier - . cos) €ee0) + NL 25 Le cata phantom pumbeit e | to further inkagek . Cow) _¢ (000) agen ae el tooo) S ewe) —c=S wey i—Se (000) i €, (000) | te 9% (00d) J Coot) >» —ceN @—> ant nN ¢¢ceo) (ove) = / (a) ce, 6) eeCH a IG GH is | & 4 (aon) (coe)28 Oe at clival cenhet, Ree Unbiq qroupy or EX ey tit [rank gobign qoupf pregent é ail move priov ity over & cenkiquted 4p a, nilike) > RA (unlike) Cele) ¥ RECT). x z (qrup) > E che Cqep) > Bank eo —> wet Ita HHS oy olf 3) Alter giving piierily forte 94 at hirall contre, bop loos prio te direction of goterver, Then fee the priorilj vit direthon,, & w— unbin of chive a - cnbiqgn of chied cone qooup auto fern ae wre gph tb pvie cents Qi, if HK xe Re LS ae abgolite eenbiqurations - Notet- on Fecher projettion, ‘beaut priory gpletem on vertical Une, anbig™s | on ior direchon . eo, = eaty n bori gontal bre, lake veverAe of ay leah griert E enbgaralion . priori direction (er covrel besigentel gps ave nate to cbtdver Becautt @tcolt eo @, > 4 © > dg od o. $ a R Eman Frome rs axis ‘och © © Coot) 4 soni] (8. @ ou, * i “ts ow * Cae eon @ oy {voll fl o I} — ay tee g, ¢ oa Gly | > Enantiome ihal 3 cool ot > & yey cel] Hy A ‘ec GP Homomer® —+ Redanine — Sedlanine tel tell i a j fo 1 ay ' athe —s Renandallic acid & mmanlallic atid oteell coll 7 We 4 O oth sega? Ena ata ditd onbe, tuo Wi exthargel gat yetully ot Eo 6, to (00°) 5 — € (o0) — t#—c=0 1 | g oy = ‘ : C—O} Sa oa ea ( fl © ® H og, ar ee fe * ed ssh n= ng : Ros Bt oes 6 fe i=] ; a [We Se fe W Sie He, ls31 @. USA ty hy ' a, SP ned Ce eee te AE al she t " oy Avot | it ay a, by e @ . th ef Sis Pe a , Oa ° Hos Hl D&O — Hemomers és a “Cool oul evel] Col) 4 c 4] Je ol Hoe thy 4 ¢ Hof& __y Hos Ry Vf ay . NH (il 4, cot 4 coot| © 5 DH Go ° o Heromerh EKE ov homomere g atom, . die ) 0” &w . “cl (ve cect} - tal 4 d d le y oH {c dd f py eed dt dy r fh h ph é@ @ @ @cet @ cool] 4-—}4& en lo fay i—+ all Coot ® \ me cnttitubion, different” —* ‘hind conde’ which 1 atlachel fo 4pf fevig ame conttitution ‘ fi tae | cerdiqn Caled" pludo cite) cents _ iy ov ot 4. : b wth ¥ coke ald ke Shown w the config of pire third Gabe — (ho a eel] (-—|8 ap Yoo ek tiff Hl cect Colt tect] el inl a chael Gnbe te — ol all wol] lo —_]¢ 4 fl g ai tt z on ti olf. Hf ot cool]‘SF d | id =F «4 2 J Hl d 4 H KR a " fd : 4 {=> 4 i Ww de z xf o BVat Os Pe Soa co00) du, Cawenekay ; gaol se A Hf Oty cH Cyt) His) ean d pO cferytio / tren = — Fo endif eal ancy. chiral conte molecule? A -_ 1h Feel we —+ Ab dino cenhet, if bog ceone vi tt different cnet ungyy inmebical kulet -— ¥ Dye vilecde tn futher fev op Bw f B p—f—p ne 4 A A Ae erythro Ht ee eh ae "enytore” ‘if converted inte -Cauwhele or nkeorann , identical mn yelakien. cbiph wil be Lame g Qn > > wep & A Bt nor Fr iad oS A 8 A Boe Ae Aw A ie A > An A s——« we. p, z d—>—8 A ® A A Wo F 4 a gt pple — C a i « A ato Ho oh rh > 8 Sy 5 thy Sy 4— 12 +R (te Hot Ho oy tly évvbyo thee i Erybiahe Threete,eH. : & 3 “tye Hl n Re a= ne tom Envy , “oll z alo de oe. ca ae ote 6 ~S ei . NA, Nt apm tree ' tien th a a * . ; ‘i tt HH ete ' ttle ' 7 a 4, te [ae nly t Cnythio reo Hey beg Xx SK to Hell pee H e a) Enythyo i ies} CH ays threo Exertifer ¢ Date + 04/0 he ertihek 1 Date osfoepot > Makh the ollosiog Dd Terpene proline (4) 3) piteleid Arabingge (2) 3) cag <- demain (0) “D ning acid meray! (1) 5 dered apsinine (2) Q Gryme chelethal (3)abe * As Gn o onfi iqerakion REG to each of the cenpound 10 8e OH > ‘ KIS L es g un 3 Ke Mo s g oy —e 4: Prado ananiney of. COO 5 4h 8 Anh i ! i ays i Ny ' ' ' ; 4 i $ non =Geapey ‘impotabl. mirvov ‘mage > are there compeurd, did 7 dred te diagrams ty inhi ur angwer 7 es * a Me snes | Minot “i Ry te OS i snize-cingtereomer meg hatter, meBotl ankt he vehizh ont Atay poe. @ These aye dostawrel wsity aired onfies rae 1 a Diottereomerf with achiral . Crane of tym) 0a-05- iu fant 4-Gp we 34 bani > ac {4 36—s onthe! like notations ¢ - a > procedure to find out notation *— = dont y ate dil conke on Te ndecale Give RL fig for cath chital cenke —* Hf, onthe cotter, Cheldoo, Selected putitions chiral centres, ean fiqurationt ‘axe same t vidi { Gke J" eettt unlite @ *w on é LN een : & & a oH f Y q a3) ag GO)“+ unfiguiaiond oendoline fur Tediatteomert :— Etuo dinensione dg—Trang 3 — aaa _— —_> en dele bord ety qroph fame Cle »oppesile Gide Tank 52 § — Diggtereomert Re aikival f cabctituee on db adil = aT —dionteraomers opt inadive « Keath i AL A ts he . 7 OH 4 ty 7 ~~, vs % tank ie ai eon *Gereeqenic ne ' @ Aleren Cente dif. mp hp > diff. wit + dig. bilgi ativits > dt frank having eH S —> os oy fang for ties thomery (itfreomper), cal trang can't be given mw ‘identical conf sys 1 ae le Gp termini? > oder to diferentike Gy, vabinal — a- dattereomef . €/2 enfin nunendature ‘nheduced eins Ubgein os 8RN C0 %-Zajomenny —- to getber ame)as Rulees — Give prov -for the group at the termini boxed on 6 nomenclaluve prior thould be gen indpendenty toy erini at the termini, if Lame priority gk Bame tide ~onfiguiston | ‘ho > oppose ide - »E! ‘ez! vddionthip aluays diaktercotne rh . de * od oy d? yO q DY te on @ i e @ oO © h h th yet Fee fen : “i j yh ? : ) 5) W ee it aay On ‘> Wo a! ; a it ae tank aw fj genetly cy YZ! and trang YE! 10 wae ship Yo oy, Aang Ui ez Y may be 'E' or cil ‘ant! may be Ew 'Z! © o o Ho, H® He (Hy oa, 04 Hg CH= cH—o)] ve pwpenel oe oF spy Lea vf s- ptvp |-ene -|-0) @ @ ® Wo. D Ho. 84 ne ” Se alex rane [e ZX i4-dbonp zteukeo afanl, E-% 6 «©® ® © © ~ "Sa hat BY oer Ye D Jn 0 die rank |X _x th a weleade, more than one icolatef doutle onde protent wart cach double bend [Hang % EZ canfigureon are given " rt Se a é fio ty Ww & z 4 pat Ps SG woa zo y cguge lt / amabative clbines and —* efx tomendebne aplialh elz Config Can be qn given for ocx age yt 5 | nage olefines 7 i om a vr, A a7, VE ke az4y hls os * eee diatleromen et a oN he « x, oni Se "ts, GE he 7 m le RHE hewaleageat a anjugetel ckbinet , doulle bende , on teertical no of t-diaeveomer} =| ie told nos tf rane anpvalent dows bend. “a 4 ¥ q Sy a cne—eack, aca o OS nea; Mey \ rot applicable applicalle a f v % a 4 cae tel XX / Cat 30-60 ve ° J 7% Ne near fed aptnable neg Pee _y write 7 diaGtereomert for a.y -hepta diene . > et a Seecmenel = no-¢ T—diathreomerk =a =a%= 4 q ned H ang-hepla diene y E ee HW d) € yee ga \ a 2 eect Vv a ay fo 2 ak 3) GZ ae + ) ZF eb EA ls ial He eee pont? g orl 7H av cc 4 ri Hy —> eb-dHedl— cHedl— CHU 7 ® Gite Pak ) FEE %) 22zz a = > cex 9 22 Ser a Dec 5 ) e a M, 2d Eze a) ZEZ ug MW wa 4) EE gy Ezz—— Sy SR Br Nay Wty . fl + a, SX fT QL f3 Le AGS . WE f=” ve an : a i wer 2 NI oF ey E,z anfig® for cumabive dienet :— Se ae See nit Sub? 4 —» — orolewte muy be with od no ef camdative double bode, ‘ere fore glane a, ° toot? a We fe A _/ a, / c=cal=€ = OEE Yatec=e A a, 6 7 “ 4 wz goog ald no-of curmul chive ° ® Oy Cet oot 7 a ieee FN acacacS ye € Ss One o> t tz srant, & eA 0 fhe é > 6 ‘ve Ye Ky Yeon? Hy Sap od Oyu ae Noy Sh zeautelderime E-autabloxine ' att thy an ey ® Py c Wyae } 2 > Wh fh ee yO wh wih Q, A yen Sea oi a" PSs Ga? Z agemedbane tb expmatane aengubettiehe ©. agehengene — MeN HH We H lice A We Kei , Ralls ' © a + no CA yo 4 Tae a 1 al Be 2 il Ty We < ie aD 3 eX a at “ ou t diakteceorer 1B met Ber oe diadercomert Ge Soyteme Gerevibomerd oasbec ystems + AN OO cyten( ak “her oy non-adjace if. ented — on cylic nt pocitiont,, ath ave fame Gide 6 if siden abe ae. - pak Yo ne possible (kereoilomers i‘ yo na indeale , | 5 pum of phe ¢ > yi settee vteally goles plone Sp “Therefore , 19. genera covet possitle Slerericomat leua, than cetiqog aude packney «* Viasteveorget/ Enantiomers 2 — _ cyelo-pepane — devivatives + —s single gubttiteenl enn! | be given aycantiomeritm ¢t diatercenjerinn. sdentied en gave *tannt be given itommerk- aA 4 > An At plane of Syn fo ik it atid th cheane no enantemersé. / ™ Set Go ‘t “ sin > di subttitutien present —s dn han, ~ i not prekent-, 4 A fe UA A 8 Enantiomerk A a 4 A 8 => d-neo identical ubttitelion 1 — aBIL \ ! ‘ eo 4 Nia A Hoy A A | i EN) ame ry / { ' | ] lt ] Hood i h By ok | wiles | enantiemes Le Enantiomerg s situbitifeoh — enki I A VAN Khos | Ay 3 Werevitorner} t q 4 4 h tl = no enantiomer pe enantiomer at 2d, atrant dhant — if ie not petible * u . si Wee Uereoi lamer are by, becare of om ce. of. plane ¢f Gem. 3 cubstitabion ~ ron. identical Geren ‘tomers ee cs I ' cSNGA t 1 = ' i H ‘ & ft acrhen | eA \ t | to = “a . 8 co ANG t K \ 6 i) a | ! sritub?— a identical 5 3- differnt:x cxlic camppunds ~ tereoigorers ca ar etal veceh Geresicomerf o— auhir + 29! Hasler tydohexane — CanocrtoL) A cll He eC) diachervomes’ 4 ! mi O 3 (atid) | My > chiral sy cIootitel wil have ¢ chatderetmnerf , ouk ef. there cit, ceven dine reemerf ples chor of Sym, erly one Farvoney wsiieul! ot, cpiclly active a ‘al a a pee et ym ue ti t ¥ Mey Aes Hi bh ie asl} ‘ ce ogee Wr erenioretf* _hidyd cy alee expected he ef erenisemert = gve4. camphor if bait teee rene hitied dire conker , chenfd hove 4" hercorgrmert, ba 4 ‘k telinal ontlente, Chowk aul foo eveoiComerf , q ee te Chain the anlecale , cFereciener’ of pane [ution ten etietant. > mt o ey “wy ‘ Oe pone sitet camber ant fain 18 chained tn seluiel exiddenee, tt adeyly ce fagun, which 4 fee fan Grain. Tian t! he enantiomeric fou mk dikappearh « dy Ginn & nm Lovnene, it tren fed conficsgation ig Ue boat St ar y> F = eqpivalent chival conket, loge 90-¢{ (ieleo- Hemet aw etpeded , Lal cath, hy 8 hoo Hhereciseinel{, due te & Caintbs sruditane a Gerecitrmey 0 non eat Gant Mn ~ w 5 ( oot pay nh a op Adacuntanc aivelie » seth Geveoid vty eqpeded , tal cai with wl foo (levee goal fring, neni wy ¢ pally due to hain, bot Algal, > deals havi foo & moe than deo chiral Combescorttitelinally - conttifalin lly — u é. Couonehial g sajna i @ é th Lb Ie aye eye yee en yy x 8 y . i cond tationally Me Ak thal cone, if coved of afew [aang] re, dl Coyne il i 5 fo oes oA nt ots A A 1s ferent (ott ! pleads fesieg wolecey hosir aan 0. thnal Cobee ll voef d cenhet « > ana wvleleh, al ditcl abel, exen one Congelivity, differnt, contt- : rh adioeally ce rnuchied toed fl i 1 “ , y wy oe tecil y—fon I 4 tfaen bo ufos) tf ito fl —ar coatl ' ely cool Gl, Gm undy Ste) enn sp sym | eneennnet chiyal deol vse: clvaleat tg / 8 b Jy Ne coy hw Hood : oman Sym Ce) ‘a cena copied y condone aniynichiol molecule 5 cunt telly une vodecslt tent gest plane of Syrimely, eahibit lenge nec — Ahereet Gomerf chiral cevbree) x tofal novel tecoicsinerf ead (ne neef th i oe oh ceneatl, ey te al 4 | Ho 1 hs ned Paley 2° cH, . th : posiany i A oi pals fooleoy ; | 4 af Pah iia ty ‘ cH, * , & nae enenrtiome tic pert -for centhabreelly cwrlyn. aay amo = ah! Coe A H oid Gerenmett = 2 4 ] A ai ne-ef enantiomeve pail =cell " pom ol flied ceil i ai) | Woe taaG te N-—p— at N-—+__ 1} ie ells +o @ Cool 4 ecell ull etl — a __| Nf ey le —— { el i 4 (144 Ho] yo! u—t—a it me a H ot e——_l fl H yp al, a 3 & © ct, é © meh detlncenes for ene evevivoiney ef woul wont nbyes ndewkt = Ba = centtitabionell eaprocbied casa fedl dine eae 2 ly trl even] & ve of The Cheenibornes polbas lane of Sypmmeby, coneyansig confitakione ty nti. tute cut ros of Geer Heerne (ey THe inde ue - ean ne ef end Conheh + _ ee eld rect dosilonaf = pla ae ee ee ae — nt ope dene ti Cemert, z fer + —alimallectas aod ro-of chiral combos -— 1 & ) alot ro: of foveritarnerf = 3 i - ailive > = y > mek ee 20 q Tartavic atid += e rece — Elon) Gio) OH NR aw etal Gereoilamu = a Vee = ates no atkive form = alam =2 necof meso fury = QB) =a ad Meee? Geveritemer heving plane of S| ive contecs. wot] 1 i—t—oy tt aot O (opt inactive) 4 I; rnlernel empensetions - Active + Coot} \ (volt Me oll! yp 4 H Hoo gd oH well i a mt a) “hea, 1 iadichlew ethane J wz wi 4 v ae AI eto, i adie, >sty yay Ne fo wee, re ananhomeri an , bub it will have ‘hoo diatercomers ale +06 fos for * 4. Yoca Sen 3 hoe — Glen — col — Ce — He CH Heamie. add old reef qereoifemerds = gaa = 0 no of active fume = 8. 3 MAD #2 col oH j——_}—a #—_}-—ot 4—_—_++——4| Ho} oT 4——ot Ho ——_}-—-H} >t y—|—on (t,t coll Ge eee Meco . j Col | cH cy \ oH 4 (et = 4 oy | /—}—!l " olf | Ip. “ #o—t—-H a H cede a t ol lye 1-1 — on { Ho. A 4 aH! Hy oll 1 o——+ H bn | oo) 6H , oH ‘ Gt GH! wall 1} 1 4) lo Lil " ae, oH to 4 eH Mo 4 u 4 —}——al (0 4 ¢ : ot Wo fl cH fl Cll oy <moleules, hoving add no. of china eng = ic atid dd) WwW bykowy ghter lige tH ay GH bao 3H stated to-ef Geveoieomerf =4 . ade {= ieee = 4-4-4 ‘ mo = a sg an oH OH cyl |__| —a Ho. h Py et SES EE o {+ | i / fot q Ht \ jo} ol , mM oH ok meee, ache - 8) Heplasic-acdd ge —at—tl ty ty —t oH by by by by om ro of Ghevdbivamer{ = al al hoof alive © a meo * od 4} — ¥__ | ot i y—}—4 \—--——4 itp ome eeecadh u “a it (sl i— oH v(eH ot} u_+— af Natt al +#—}——ol] i al 14 -o te — u i— on He} Ho——}___ if Oi at coh cy ' a $—}— a 4 ot Ho———f} | ofl i#——}__ oy oj — al to J Gel oH lof (af ‘65 —_;——-@ H 4H Sgt} wy Ho a 4—— ial fi fy V8 Ho—}@. ag yo | —__y | ————_. ait by . el de. => bh F th fallocig ara, Melo, ceepoun ds37 at ‘ 7 4 mee alt may Racemnic motificdian a ic A % | ; leA Ladic lactic aid ie geal onic ailve oa ly eoantirnel( O Cf] ' oH _ " aH u : © ' \ a ; a, \ i; " opt: pre BLA (a (%) 3 me ally * / tiomey of ommpd. optically pure: — een woof one enjanton oncgn SLA: ot Bet inactive apart Iq gta we eqeactive [pl vel pure —. ecterael corporation ta eh } nok roumic 1gin ma> Nicene havig eel nlf a axnoinky of enantmaf of Come comyd called" Racrmic modifications” > ban tho LA. ot Tn eee he * racemic Externe -couperalion of 14° tgn ee A a0] Jonttive xe opt. punt mpaurd tment info raamic, a 445g rede 010". presentafion ¢ — © Lax Keamic — ae) ept que detho gta > ‘ leva J)- La @rA @O-+ f ieee f sac O comer RJA @+a ahs facamic. medificaion \ in tolil als) J Rowermic organo faumic ome w neue € FH] Le tion cline nih ent taumaly ye! Getta) 2 Ez] + Ine a RM. ih one extil be (Lettie) developed by nile enantiomers sither oly deiho or onty leo called " gaamic canglomeraly —y ha RM. Hf Sings oyied deveepel Fi equel rect trdawfee of 40 enantiomers cf camp called "Ratenic cand (or) Rawireli: 1; i Lie, one uyital with caf dethe & 207 lov motley)ut releealy > Ih RM. Singe cog developed " uneyed ro-ef Minakeney of ond , peoude momglt " \ ESI Es| & conpemer eumic. «med cascode reado tact d=0 d=0 L=0 > gendomera wth clu Lua dan pure enenkiomer of wmpd we oie age orth mt E a we J we tater at ee ard og Hd i wrZdabo op Ty. evo Maho sa) ad sl %f Be4, ed 7 Teef cenpotiin alk ae le Plede Ptinate! B onglarerat Rano Joe deve, Jee 0) 107 coe =) wee Ww) tay peek WC pk =e gl etic pedisa ec ype fous d — Wee tgp. Fv a : Ay campo tit” of plende rowwls mpl. Some af ingl of. opt pure ceropd - : Cling encokion) — > Racemic modi Bion 1— (ered {or preparing ) A) mechani cel rmiting i Orn ern OT AG, = \eter MW ar» Racemnigatien aa of? on san) @A hy Sok eg fatemic a opt putt —gtanyertien of ent pre compl into raumic modibelien calle} "aceite! > 8A-————+6A gt pure Koceric i Benpctin GA === OA 1] 5 pacarigtiekenidy 4 9 Gontaneouk proc, vit Min enbopy. Vv dmp (Ag 2 +ve for raami¢ehon UK +Ve —+ thang in oben Cool} “- — i _— oy HH > Th mull div eenhe insta , of oly on third eambse, enhyn rnverted calle] * epimeritebin * — €pime ri) ‘involvg ‘ diagtereomoy’ ‘nt dtenvertion)34 i" tol ‘all “4 tes wt wy, 7 Hl, CF ReLA SLA —> — opl- pure compl if converted inte racemic ice, at equilibria diteqal , uf aon avnounlf ef enarnbiomen all * alsynichic fran} fevnistion ' o7/o5 [oe Racemigation + — ——— pea aE ade cf ele | ce ving ‘av rintermediatt Rocemigationg ¢— eS =} Carbene -ion ——> aol tect J > wee es OK Ye» Dyranial tn = x A wa . *. in 7 te a eocnl vr til = Racmic Re * Racemigabion * y- molecules having acidic 'c' groupe gyi tedic af ana aid [cc i z et aa sh —= aidic a "] | 3 al; gt -pure Rawmigetiony> — fo nol, aby fm fo Gea ad Gta \ " tay sym inkevmediate ©o,H Lee Lie edn Hs Erte es tote I, I, ry \ ye cul oH ny el: Ue eh ichs cet > Sheu a> Gee ~ th cymabied sy Akoladtic ail wilh't undergo vacemigalion oH = th—beool — th yg te roumitalien fi Cabome atidic proton) . 3 Qo ° + bee be > het orf * Cxglain Ratomigalion of ° > tht tet He Rawrrigabion a ‘in alkali Lad ait | iia <0 -$-4-©> q *3 chick cet} dhongly audic, oven in Ho predotf cots unkrgo roonnia”Centocation Intermedia : cn! — examples ‘= — ee a-halo ay! bemgene in shy - + > oa 4 Conlon. Radial Tntermetiake ¢— Lattin adie a — afsiledfe age o¢—chloie oth) bemgobe.na ph 4) th | lfc he ls umbylit . ed Hy J Is # ae fh pty iy d H a LA, Rawmic * SNe Ratenitation + —_[_[—_———— By external nu? i game Leaving me wo Ne me want / ake a Ae, He ® Sy a= ie Po ry hy Racmic . gu’? =» biel 2 ty A, <0. U fo» reo Nay ee by cc bond For anantiomcly RecernicRing aa 2— Rani false ay a La Lay ae ac Sonioon, Ratormic “fe RF ia) —» tt eens eile in Raueic term, ‘it if opt ‘active . > Fatleing compl undergo datemi aban, explain 7 a stele biphenyl helaton by 9e Inferconver Jwo eqantionerg foamirn takes plate $ RAS Rawmigation + — ° 4 5 ta gts ict Cy & » BYQe a Racemigation of camphene 4 wey A + oy te Lh Nh ee " Resolution ob RM t—- Gt EL comic x cegoralion of Geantiomert fem Rom calle] “retalion), FH & goyertal ROCK of vocuntiabion yore (pentaran poe — Retalutin i — ms of votabiony 4M, alto allel opt win igen gen om gam) m tp 3 et ey — jase | +E, wash Ey =o bi opt-adivatin. Gltef * Rawmic fwichesmethede of Coparabon ;— 2 + y hand agplicllr fe veqolubiern of aly Rowmic onflsly ‘ pacenic. enfersrat] uly homachiral “Cryetell, eatly cepa and *“Tweegerf” Cforeesph) « ae es viangmagntbying glace” gir” dest patteuve” ceqarct] Racerc of Mae ng taytaiake toto opt pure encantiomert "i ule thy inatind + placrercomenic METHOD + ——— en dy aa 2S tn Ges 4a eS = =| 1 ea qf & @a eA vee am d,=4, = -4 Be > atevomenic natnd, a fe toeloh tatniqne tn Gp ra fem atomic» Sq th mato, ena-ef toemic ful convetled ‘orto dinky vatning wits opt: puht alee (ubtance Coirel rb), tell diafevormey wit be Gponalid balel on tar ghtial fede Clolobulitid, tk, bptt ok) - te Geprei dilteveomung Seconverlef nto opt Pore enankioney cf Yawemic43 Umitabiong 3 Date + offo5/og es 1) opt: pure eternal fubdance readily available . 9) dhival veherema oY eternal Gedbttance Ghoul thdevadt with boty ‘enantiomer! 9d Retalting diattereomert coualy (eperatile - Copavated diaGtereomerf pull be nal reunverfable inno enanticnerf 5) nature of iduest Sppepridk 8) enantiomer) chird reb- could have ombinentey Groups. Raven ‘ chiel x cool —o i —nl —ot — OH] =n, cool a —f20 —Ny example for; add; chiral veherencee > opt- pire tactic aid, dhic add, mandallic add, malic add, tartare aud compet - o-Calphonic aad er > &r: she x bakes — artineg 5 ait < ormounds eeated from plash . aa opt-adtive oph pure: ) Bracing —aMRerpire 3) Sy cbrire Y Quinine 5S) ebodeire 9 meorphire, OcH. HT? at-aly Helou ph ephidiene & Example 3— 4) petolubion oh ladtic add Racemic vith chiral eh - S-2-Cubarel ° & sled UA aS, A A \ Sl Ke eH as” + Oy HO" of ae Fe me 4 Rawmic a 4 oe ‘“e i He a Su 4 = (KY i x ; om ° y\y gid) —> toile phage9 = 4 5) > By ug chivel motile phage ; achiral Gabionedy phage. gph tno thirel vent, coluteditice of ena diktevert. wayyy eg: eH Ol f Fe Hall rh ef Jag Galle (ad) ‘ots phate caubulitg of e & dig to. cival ahi chever highly Celuble, cernet ou -forn cdoumn in ta begining fasting whi indie mend if alto udd ‘0 cep of ara. of raamic. ocemical thartferregion imdnod : enaynalic Syctem} ate dial - Retaatien of racemic by wing imicrooiganiem| or engynaic Cypfom cated * Godentol Aranifernahiong ? eq: @® ammonium tartare” penidilliam— « owen ertor, 5 glucan Rawmic © vo. otaly emntwmad by perialliny qfauain « Limitations ¢~ — —y or gti ena. of yoamic ig WY. > Enayynle Cytem sequives afer, racemic Yeqple —* suitable engin tut be aveilable -for reselubion 4 oT gl vent of. racemic .Wb 4) chiral melecdes witeub chivd cenbes + — vee ee ae thse! ad}, pane, pint moby, elec. ped Greveni Gomer by chang ing ay Reh. token for qenevating paid petition of atom) at ‘na mnsoade calle] ‘ Ceroogenic unit! dF troy be conte i | point, heey - any, fee an wt — + weet clit» HoH fel “4 =“ a <2 a> ¥( levangertc centre bud not @ chiral come + chive -0ts tnolecules 2— . Ay ow cate mewgeeme le I os ot Sa | ere as Vea oF S por fo for 1 tehahed ed 4 elay ed ad 0 B / eabended Fd rhe aay HE i veh to gener rod (herentlomer Saloni Any Th Ge Herengeaic unit.—s Rephumenl> of. canke trobads ult near gp Wh af c=e=e, Cee SO. unedigog regular td into along rd. ° > n dangalal ein potig tinugh bd gp called Grreqanic untl Conip > raneoddy fowing ont iad, called “be chiral ati tncleode a} oropty cubttituled allomes., Ggivowingl allyfedene eyes © tiger , adernontoidt : CaaC==c. Allene ae wr > ale boving on eof canal ub bre cubstiteentp of termini aboot tevto each other aa er - ais carnubalif olbin towing odd ro-of dh, erent cubitituerlp ot ringlome , devel qediatfeoomant, Conn! doelp a enantionert bey wy conn't wih a om china - cubltitebien pattern + — not chiral ac, pasiiianl oes , a, gold 1" 4 4 >. cade thal > “Seek @ a yt de; athial . > melee ; achiral podele ve”ay ae Yb chiral ony hire > yee No plane of" 3 pole *C," Syme. “ viiymelric indlecles a apes > eaten eine sired & Al he Cyr clement 4 —c al b abtent ; autyelrc rmalectbef 4 chiral oxi. we eee bene; ANS symm. let abut; ~ f ahi Aayrndhic nolt > ap- geome , Allene s— # tHe 7 ON, So , otfer. — + two T-tand bw The Cf pot ‘in Th Aame plane , dey to each other a al. L C= io ™ (on =e 4 , > a OK, eo “FOSS, Sn allen gp-medd, aby Joy 40 eath other, termini cobstituenly alto ~ tap to cosh i > Numer ejections forehead chil ar violecdlee : Allens: —y obkduda. hoy te Ge th inaeeuls long The cbiral arty.a. bgerlg ony orientation of gpj, Gled hovigental, vertial Gneg’ li ak meee to obtervet ae of y or 2 6 fom ony fooen dssdue! bon how 4 a7 away ae a 4 eg gel $2 cee <* —— thi & Yor chico . iH Ab dorm tat i Jom, rh raphy | A reps ont A contiquaterlly (ame dont conigurction romendlobure + WIC 2 Dake + ufos or ne gees ateaeeeee & Getty rmbvobs cong chital only & Gow nedtran projection # Give prio for neaseyt qpf (ha) ac-to Rh « bn fh OY TE + priaiky diedim 9, confsputatim nensndbaluce "&* o* Aw, . a Allene’: A H->-2 wet Nac g ee Nay a) Loe ql ily Ole,47 > @aO of enantorerf Oho ate ~ exdange of ef ot any 1) — Glutinic add che termini produts enantiomer{ .> == S48 — =n, Woop Anii biotic + angele K gpiranek + — rt then Cpa, Gimilr to allen > Fer tun Yirgf, if one atom Gemmen — fro tomnpdf - in ww tI | demi Ler to eth ie 4 membered Spiro compound Inoie @tnmen) « cm me I sn 5,3] tte Sa £ tus 1 he 5 adinetsf tpivol a3) feptene eW nomen dafure = - 3 J 2 . - e ING Pla, a = poenceetn wed a, NS OCA \ 4 chivas : Subctitabion 3 dential Sub? 5 plane of Sey WALA RXXK a _— OK ho, G pielént, ditymebic b b % A Gyn domed ebsbint, cir Attymndric pote, =, achiral —- oN > olegiqch ic . > Neamann protedtion/ onkige rations riotelien , RIC u a 7 4 } oa, ° a 4 ROSE Tepe IYO WIOKa, oe IR "iOM " one Aevnsink, rule exchange ef Jp praia sete x _, (ey KK < ‘ ow ‘ - soot Ne S teplent Qphclgad ac-dcobonic aud (abe deateony (yiro (2,2) heptane OO fan | Ss ean tly hh z £ 4 f ph > ‘ - we OKI are Gate ut Te tal-tpirax bi pyridinium Byenile a. - Loti oA a CH, ob 7 . oO f a SH > Alice oyelot kanes i O= = ay ‘ a Dh Bing a let te ech) ater yo44 -y cabltiboetle gb eroint Ler to gach ote - me lS al b i” ety aut apticd advil fon eth tay oy ae > i 4? A Noo > 5 deuegmnehic, cite. om pede G+ Aileyrnahr a. A bly manly abtent , oymeltic ~ Bag y= point Fioup - \ aL _f! b 4. hd 1k | Oe + i tts | ¢ eH : ‘ ae Ot peed R ei ena —_ ak any ont termini, mute! exchange of an praduf enortiomes,. t ol te dl ab i ue 6 A a <$% 2 peg erento] eH or ort% Apamantoi’ ; third axis 4 \aprs/oc ” ptebnabite mlecale o ft Sue. ool se Sue ee got Yet Bip 2 ghopttomers 3 ! mee ere sd & tran Ooo 7 «jal and > otalony abuk pivrtd bond pad} diff cnberaebny for biphent Tnplore arrangement of biphenyl wit pmper cob” eahibit ciactereomeritm LEN bs. a eel ae CELLS BD ay 6% ie Trang x (0? Bw wr Arank dia x ey > at inottive Ad.) my 2 (10-4 ndecult{ pot having veitiol poe Gyn 4 (aid ao be av pti rmoleul) - ~v ng (43 yo tank 4 Non-flanay cxrargement set'aded — > perpordiodat crangart of tuo thonyh Cae &) . back of board OAD —. DHey. oa plore mor NP Lote alone = de srangemenlf then, ‘in buoy | with preper Cub? echibily enantio amevifm , thab means thew rien (epevimpotatle tnivvor image, cannit thow diatteyeomeni fn . Coankiemerf Seb pattern : chiral > — Anglacy axrengenent, ‘croypective of Cb, pesfef plane of Syme tyaihival » not cheung enantiomerign - ab of plane eyangement wits pryer cub”), doveid of plane of Gyo, shew enantiemerifm - qo AO » @> @Qoy & Oyo» f Anplane Same me 2 poet sla Ab any me i patho Cubhy identi, polls O, achiral . £0 Adival, opelent 1" 5 ay a oO, QD Note’, bu poled C = diuginchic b a oO : sor’, all Sn demerit abet , Au ymebvic ¢ > peln about pivetel Bed Rot abeuF pivotal bend depen on Bae f Subly of -ovgo petition.3 > Intevenvertien of enantiomery of bien depend ony notte of Gubctitae at vepotition. TE aby are highly bulkier, ‘interconver¢ien his cathe) TF GUN ate Soll oro bulkfer, wiry aba pivotal bend fie, enont ermord Fue ‘nteranvertable , lao omy bovvier, a equilibria = abun ul ao. Us oneaalvable vacernic” Sy 1@ Blercenveren of — enantiomert tobs play via glonor TG, : bulkier culty net alloy enantiemert’ ‘ntercnverti00 . : a . ost rotenone ~ gy Lai Tou * © spot unractve b i by Facemic formg “ te opk. inathive . hee: af center wpvertien doyped, enantiomers rare be, they itare * "enantiomer. or itemef wih ate veldvable by sethictng c-chnd yotabjont called > abvapitunert”, The ¢leneneney aid 4o be “thpltoneitn’ cnfge_comendte 5 sonore: Ht s+ Ruby Grnilet to allt, i enfigurobien] . Fs hid oly am © + 4 h | ig & (iiiymehicd fo. 6 F du, he fe ie 1 @ a © o 3 e Age Fe @out, Seed klTh subttifuerdy ave Ginall or yx bulkfer, rely abouh ce band free. —s In plane, oukof. plame conformation) seadily inteyconvertable , if Subs bulkier, ae, abcul givotal bere rethicle , bigheny toler Gabilited cantove® , hich if ter. Becey Thy tonkoom® ror fram eric cmudg a 4 7 a4 4 - Gt) 4 W by vo rol? aeak givelel bend by py ea tp —~ a 4, a a fy 40° eat d= KS soe Aa 0 . ; t Loy gf. ofoh -» In Hee any one vn, vnubved eaberge of 6-CaM prediey enenkoned. 4 l fs Or eh _ ote + \Q ‘Ten - ham I GM - Ena * € boul — aller orn 3 whelhy fatter , unrerlyable ratemic, nob mite abropitorer] oh Oe > SSP HUD, oe Relalveble varemic @' v4 © eae (iy na o Wr “yee Le! adrepilamng Hae ee ot v +2 > ——s raumic “Neu as ty - sei © o- pe ‘ Se Oy ay — oO iH Se nat bt