Arcega, Romar Rico H.

BSN-III

NAME OF THE DRUGS CLASSIFICATION MECHANISM OF ACTION INDICATION/ SIDE EFFECTS NURSING
CONTRAINDICATION CONSIDERATIONS
Generic name: GASTROINTESTINAL Locally acting INDICATION: Body as a Whole: Nausea, >Monitor for GI distress.
SULFASALAZINE AGENT; MUCOUS sulfonamide. Believed to Antiinflammatory and vomiting, bloody GI symptoms that develop
MEMBRANE AGENT; be converted by intestinal immunomodulatory diarrhea; anorexia, after a few days of
Brand name: ANTIINFLAMMATORY; microflora to properties are effective in arthralgia, rash, anemia, therapy may indicate
Azulfidine SULFONAMIDE sulfapyridine (provides controlling the S&S of oligospermia (reversible), need for dosage
antibacterial action) ulcerative colitis and blood dyscrasias, liver adjustment.
Dosage: PO 40–50 which may exert an crohn’s disease injury, infectious
mg/kg/d in 4 divided antiinflammatory effect. mononucleosis–like >Be aware that adverse
doses CONTRAINDICATION: reaction, allergic reactions generally occur
Sensitivity to reactions. within a few days to 12
sulfasalazine, other wk after start of therapy;
sulfonamides; intestinal most likely to occur in
and urinary tract patients receiving high
obstruction; pregnancy; doses.
porphyria.
>Be aware that drug may
color alkaline urine and
skin orange-yellow.

>Do not breast feed while

NAME OF THE DRUGS CLASSIFICATION MECHANISM OF ACTION INDICATION/ SIDE EFFECTS NURSING
CONTRAINDICATION CONSIDERATIONS
Generic name: HORMONES AND Immediate-acting INDICATION: CNS: Euphoria, headache, >Establish baseline and
PREDNISONE SYNTHETIC SUBSTITUTES; synthetic analog of Crohn’s disease. insomnia, confusion, continuing data regarding
ADRENAL hydrocortisone. Effect psychosis. CV: CHF, BP, I&O ratio and pattern,
Brand name: Apo- CORTICOSTEROID; depends on CONTRAINDICATION: edema. GI: Nausea, weight, fasting blood
Prednisone GLUCOCORTICOID biotransformation to Systemic fungal infections vomiting, peptic ulcer. glucose level, and sleep
prednisolone, a and known Musculoskeletal: Muscle pattern.
conversion that may be hypersensitivity; weakness, delayed wound
Dosage: PO 5–60 mg/d in impaired in patient with pregnancy (category C), healing, muscle wasting, >Monitor patient for
single or divided doses liver dysfunction. Less lactation. osteoporosis, aseptic evidence of HPA axis
mineralocorticoid activity necrosis of bone, suppression during long-
than hydrocortisone, but spontaneous fractures. term therapy by
sodium retention and Endocrine: Cushingoid determining plasma
potassium depletion can features, growth cortisol levels at weekly
occur. suppression in children, intervals.
carbohydrate intolerance,
hyperglycemia. Special >Be alert to signs of
Senses: Cataracts. hypocalcemia.
Hematologic:
Leukocytosis. Metabolic: >Be aware of previous
Hypokalemia. history of psychotic
tendencies.

NAME OF THE DRUGS CLASSIFICATION MECHANISM OF ACTION INDICATION/ SIDE EFFECTS NURSING
CONTRAINDICATION CONSIDERATIONS
Generic name: BIOLOGIC RESPONSE Adalimumab is a DNA INDICATION: Body as a Whole: >Monitor for and report
ADALIMUMAB MODIFIER; TUMOR recombinant cytokine Crohn’s disease Infections, sepsis, lupus-like syndrome
NECROSIS FACTOR that binds to tumor lymphoma, back pain,
Brand name: MODIFIER necrosis factor (TNF)- CONTRAINDICATION: fever, allergic reactions, >Monitor for and report
Humira alpha and blocks its Hypersensitivity to flu-like symptoms, promptly S&S of infection.
interaction with cell adalimumab fatigue. CNS: Headache.
Dosage: SC 40 mg every surface TNF receptors. CV: Hypertension. GI: >Monitor neurological
other wk Nausea, vomiting, status closely.
abdominal pain.
Respiratory: Upper
respiratory infection,
sinusitis. Skin: Injection
site reactions (erythema,
 itching, hemorrhage, pain,
swelling), rash, urticaria,
fixed drug reaction.
Urogenital: UTI

NAME OF THE DRUGS CLASSIFICATION MECHANISM OF ACTION INDICATION/ SIDE EFFECTS NURSING
CONTRAINDICATION CONSIDERATIONS
Generic name: IMMUNOSUPPRESSANT Precise mechanism of INDICATION: Body as a Whole: >Monitor therapeutic
AZATHIOPRINE immunosuppressant and Crohn’s disease Hypersensitivity (skin effectiveness which
antiinflammatory actions eruptions, rash, usually requires 6–8 wk of
Brand name: not determined. CONTRAINDICATION: arthralgia). GI: Nausea, therapy for patients.
Azasan Hypersensitivity to vomiting, anorexia,
azathioprine esophagitis, diarrhea, >Monitor for toxicity.
Dosage: PO 3–5 mg/kg/d steatorrhea, hepatitis Drug has a high toxic
initially, may be able to with elevations in potential.
reduce to 1–3 mg/kg/d bilirubin, alkaline
phosphatase, AST, ALT, >Monitor vital signs.
biliary stasis, toxic
hepatitis. Hematologic: >Monitor kidney function
Bone marrow depression,
thrombocytopenia, >Monitor I&O ratio.
leukopenia, anemia,
agranulocytosis, >Use protective isolation
pancytopenia. for the hospitalized
patient to reduce risk of
infections.