Psychodynamic Treatment of Schizophrenia Is There
Psychodynamic Treatment of Schizophrenia Is There
Psychodynamic Treatment of Schizophrenia Is There
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EDITORIAL
1
Address for correspondence: Dr Kim T. Mueser, Medical College of Pennsylvania at Eastern Pennsylvania Psychiatric Institute,
3200 Henry Avenue, Philadelphia, Pennsylvania 19129, USA.
253
254 Editorial: Psychodynamic treatment of schizophrenia
Gunderson et a/.'s collaborative study (Gunderson et al. 1984; Stanton et al. 1984) did not suffer
from any of the shortcomings noted in the two studies previously mentioned, and employed highly
experienced psychotherapists. This study also had by far the most comprehensive assessment of
treatment outcome of all the studies described in this paper, including multiple assessments for each
outcome dimension, and stands as an example of a well-conceived and executed treatment study.
These investigators compared reality-adaptive supportive (RAS) therapy with exploratory insight-
256 Editorial: Psychodynamic treatment of schizophrenia
orientated (EIO) psychodynamic therapy. The following descriptions illustrate the differences
between the insight orientated, psychodynamic treatment and the RAS approach of attempting to
enhance practical coping skills. RAS therapy ' focused on problems in the current living situation
of the patient. In contrast to the EIO therapy, there was little attempt to explore the past and to
seek correlates between past experience and the present. Rather, the exploration of the present was
intended to identify problems that could be solved or that could be expected to recur in the future
so that more effective coping strategies could be mapped out. Another major feature of the RAS
therapy was its focus on the patient's behavior itself rather than the covert meanings behind that
behavior' (Stanton et al. 1984, p. 535). The EIO treatment was 'a form of analytic psychotherapy
adapted from that described by Frieda Fromm-Reichmann (1950) "...it was by no means
psychoanalysis... its aim is to increase insight"' (Stanton et al. 1984, p. 536).
Gunderson et al. found that psychodynamic therapy (EIO) was clearly inferior to reality-adaptive
supportive (RAS) therapy in three out of four outcome criteria: rehospitalization, vocational
adjustment, and to a lesser extent social adjustment. The two treatments did not differ in their
impact on symptoms.
Since our summary of the Gunderson et al. data is at some variance with their own summary, a
brief discussion of this discrepancy is warranted. Gunderson et al. (1984) wrote 'when one looks at
our complete array of results, the overriding impression one gets is that in most respects the EIO
(psychodynamic) and RAS patients performed similarly' (p. 582). Nevertheless, RAS-treated
patients spent significantly less time in the hospital and more time employed than their
psychodynamically treated counterparts. Furthermore, RAS patients assumed more major
household responsibilities than psychodynamically treated patients, indicating that at least one
aspect of social adjustment was superior for the RAS than EIO group. Other dimensions of social
adjustment, such as social dysfunction and social relationships, did not differ between the two
treatments, nor did any measures of symptoms. The only advantages Gunderson et al. attribute to
the psychodynamic treatment over the RAS treatment is in the area of 'ego functioning', and even
here the treatments did not differ at a statistically significant level (May, 1984) on any of the
variables measuring this construct (adaptive regression, ego weakness, and subjective experience).
Thus, our interpretation of the data differs from Gunderson et a/.'s conclusion that the two
treatments were essentially equivalent.
Karon & VandenBos (1972, 1975) reported that psychodynamic treatment was superior to
antipsychotic drug treatment. Serious methodological shortcomings limit generalizability from this
study. Although patients were randomly assigned to one of the three treatment groups, there was
a confound between therapist and treatment modality. Half of the patients in the psychodynamic-
treatment-alone group were treated by one' experienced' therapist and half of the patients receiving
psychodynamic treatment plus antipsychotics were treated by a second 'experienced' therapist. The
remaining patients receiving therapy were treated by 'inexperienced' therapists. Since only one
experienced therapist treated patients in one group, and a different experienced therapist treated
patients in the second group, the obtained interaction between therapist experience and concomitant
pharmacotherapy may simply reflect differences between the therapists. In addition, patients in the
drug-only group were transferred to a different hospital for treatment. Thus, it is impossible to
determine whether the effects noted by Karon & VandenBos resulted from different types of
treatment, different therapists, or different treatment facilities.
NATURALISTIC STUDIES
Two reports have recently been published on lengthy followups of large samples of schizophrenic
patients treated with psychodynamic therapy. Stone (1986) followed up 72 schizophrenic patients
who received an average of 12-3 months of intensive psychodynamic therapy at the New York State
Psychiatric Institute. Ten to twenty years later, more than half of the patients were substantially
dysfunctional.
McGlashan (1984a,&) reported on the outcomes for schizophrenic patients treated at Chestnut
Editorial: Psychodynamic treatment of schizophrenia 257
Lodge, a long-term private residential facility that specializes in intensive, psychoanalytic treatment.
Of 163 schizophrenic patients treated at the Lodge for an average of over three years, two-thirds
were functioning marginally or worse 15 years later. Thus, this large sample of schizophrenics
appears to have gained little, if anything, from their intensive psychoanalytic treatment. McGlashan
concurs with this conclusion in his summary of the effects of intensive psychodynamic treatment for
schizophrenia: 'Unfortunately, we still have not improved much on Kraepelin's work. In effect,
with chronic schizophrenia, we are still just beginning to fight' (McGlashan 19836, p. 600).
Note: + / > < 0 1 0 ; *P<0-05; ** P < 0 0 1 ; *** P < 0005; '*** P < 0001.
258 Editorial: Psychodynamic treatment of schizophrenia
illness. This explanation would not explain why the correlations were negative for the
psychodynamic treatment but positive for the reality adaptive treatment. In addition, patients who
dropped out of either therapy within the first six months of treatment did not differ from patients
who remained in treatment in pre-morbid adjustment, chronicity, or two-year outcome (Stanton
et al. 1984; Katz et al. 1984), suggesting that less severely ill patients did not tend to terminate
treatment prematurely.
The hypothesis that psychodynamic therapy had deleterious effects on schizophrenics, as
evidenced by the negative correlations between months in therapy and outcome at McLean
Hospital, must be tempered by the fact that such correlations were not obtained for patients treated
at the other two sites of the study: Boston University and the Bedford Veterans Administration
Hospital. Table 3 contains the correlations between months in RAS or psychodynamic treatment
and clinical outcome for patients treated at Boston University and the VA hospital. No consistent
pattern of correlations separates the two treatments. The significant differences between months of
RAS or psychodynamic treatment and outcome for patients treated at McLean (Table 2),
contrasted with the absence of such differences at the other two hospitals (Table 3), may reflect the
fact that the two treatments were more distinguished from each other at McLean than the other two
hospitals. For example, the McLean RAS and psychodynamic therapists were more experienced
and divergent in their attitudes and practices. In addition, there was more institutional support for
the practice of psychodynamic therapy at McLean Hospital, leading the investigators to anticipate
that' the specific effects of the EIO (psychodynamic) treatment might emerge more clearly in the
McLean setting than in the other settings' (Stanton et al. 1984, p. 569). Another reason why the
correlations at the Boston University and VA hospitals may have differed from the correlations at
McLean is that the sample size of the former group was small, approximately half the size of the
McLean group. While these data are open to different interpretations, the possibility that
psychodynamic treatment provided at McLean Hospital had negative effects cannot be dismissed.
In the follow-up study reported by Stone (1986), 20 % of the patients who received psychodynamic
therapy committed suicide, approximately double the suicide rate commonly reported for
schizophrenics (Winokur & Tsuang, 1975; Drake & Cotton, 1986; Roy, 1986; Roy et al. 1986). This
high suicide rate may be further evidence for the potentially negative effects of psychodynamic
treatment for this population.
An alternative explanation for the high suicide rate in the Stone study is that many of the
individuals diagnosed as schizophrenic may have actually been psychotic depressives or bipolar
disorder patients. Although this is a possibility, diagnoses in this study were made using DSM-III
criteria. The question of diagnosis is probably more pertinent for those studies conducted prior to
DSM-III, such as Karon & VandenBos (1972, 1975). The possibility of misdiagnosis does not
change the meaning of the failure of the studies reviewed to find a beneficial effect for
psychodynamic treatment, however. The inclusion of depressives would probably have increased
the likelihood of obtaining positive results rather than decreasing it, since there is empirical support
Editorial: Psychodynamic treatment of schizophrenia 259
for the efficacy of at least some forms of psychodynamic treatment for depression (Hersen et al.
1984).
The thesis that treatments which are too intensive may have adverse effects on schizophrenic
patients is not new (Drake & Sedere, 1986). Psychoanalytic treatment of schizophrenia is usually
provided with greater intensity than other psychotherapeutic approaches. For example, the patients
in the Gunderson study (Gunderson et al. 1984) who received psychodynamic therapy spent more
than three times as much time in therapy as patients treated with reality adaptive therapy (20 v.
06 hrs/wk, respectively). However, intensive treatments do not invariably worsen the outcome of
schizophrenia. Social skills training, a highly structured and directive treatment, can produce
positive outcomes even when multiple sessions are held daily (Liberman et al. 1986).
Thus, it is clear that having frequent sessions will not necessarily lead to worse outcome. It is
possible, however, that therapy that is too emotionally intense may be harmful for at least some
schizophrenics. If psychodynamic treatment is harmful for schizophrenics, it is probably the
emotional intensity of the treatment rather than the frequency of sessions that is responsible.
shortcomings (e.g. Leff et al. 1982; Liberman et al. 1986). Clearly, additional research validating
such treatments is warranted, especially concerning the effects of interventions on outcome criteria
other than relapse rate (e.g. social and vocational adjustment). Nonetheless, the pattern of results
has been consistently positive. Despite the failure of empirical investigations to demonstrate that
psychodynamic treatment is effective for schizophrenics, and the development of other interventions
that controlled studies suggest improve outcome, psychodynamic therapy continues to be offered
as a treatment for schizophrenia. Stanton et al. (1984) noted, 'Of the many institutions approached
about possible collaboration, most of those that had the strongest identification and tradition with
the practice of intensive psychotherapy still felt they could not randomly withhold this treatment
from patients admitted to their institutions' (p. 524). Thus, psychodynamic therapy appears to
remain an influential choice in the treatment of schizophrenia.
Resources for treating schizophrenia are limited. A probable consequence of providing
schizophrenic patients with psychodynamic treatment is that they will be deprived of other
treatments which have been demonstrated to be effective, such as social skills training or some forms
of family therapy. Since psychodynamic treatment has not been demonstrated to be effective, and
more effective treatments are available, we propose a moratorium on the use of psychodynamic
treatments for schizophrenia. Indeed, if a drug had the 'efficacy profile' of psychoanalysis it would
surely not be prescribed, and no one would have the slightest qualm about relegating it to the 'dust
bin of history'. A further need for a moratorium is that clinicians who are taught to treat
schizophrenic patients with psychodynamic techniques may otherwise refrain from taking the
necessary steps to obtain training in empirically validated clinical interventions for schizophrenia.
It is possible that some schizophrenics may benefit from psychodynamic treatment, as they might
from any of the myriad of unproven pharmacological strategies such as orthomolecular treatment.
However, at present there is no data that would permit a clinician to predict which patients would
benefit. To offer such a treatment before attempting an intervention with greater empirical support
raises ethical questions. In order to provide schizophrenics with psychodynamic treatment, the
clinician must assume that he or she either practices a superior variation of therapy than has been
previously tested or is able to identify a responsive subset of patients. To our knowledge, neither
of these assumptions has been evaluated. Perhaps patients who do not appear to respond to social
skills training or certain forms of family therapy could be treated psychodynamically? This is
possible, but our preference would be to try Gunderson et al.'s 'reality-adaptive supportive'
therapy, which outperformed the more costly psychodynamic treatment.
Just as resources for patient care are limited, so are resources for research. It would be economical
to study how the theoretical constructs presumed to be modified by psychodynamic treatment are
related to outcome among schizophrenic patients before conducting further expensive outcome
studies. Gunderson et al. (1984) reported that there was a trend for schizophrenics who received
psychoanalytic treatment to have higher scores on measures of ego functioning than schizophrenics
who received reality-adaptive therapy. Despite having higher ego functioning scores, the
psychodynamically treated patients had poorer social and vocational adjustment and were
rehospitalized more frequently than patients receiving reality-adaptive treatment. If future research
found that constructs such as ego functioning or insight were predictive of poor social adjustment
and more frequent rehospitalization, the desirability of goals to improve these constructs would
need to be questioned. Determining appropriate goals for treatment will be clearer once we have a
more thorough understanding of the variables that contribute to social and vocational adjustment,
the absence of overt psychotic symptoms, and the ability to remain out of the hospital. Once such
information has been obtained it will be possible to develop specific therapeutic interventions to
address each of the factors necessary for a successful outcome.
We have proposed a moratorium on the use of psychodynamic treatments for schizophrenia. Our
intention is not to alienate dedicated practitioners, but rather encourage them to consider treatment
alternatives. The empirical evidence indicates that in order to help schizophrenics best, clinicians
need to forego their psychodynamic formulations and instead focus on building individual and
family social competence, while decreasing ambient stress. Practitioners who have been treating
Editorial: Psychodynamic treatment of schizophrenia 261
schizophrenics with insight-orientated approaches need not abandon their attempts to help such
patients. Their experience can be harnessed by focusing on patients' current problems in living and
their ability to cope with daily stresses. Descriptions of recent treatment approaches are readily
available to the interested clinician (e.g. Leff et al. 1982; Curran & Monti, 1982; Kelly, 1982;
Falloon et al. 1984; Anderson et al. 1986; Liberman et al. 1989) as are training opportunities.
Recent advances in the psychosocial treatment of schizophrenia, fuelled by a surge in funding for
schizophrenia research, make this an exciting and hopeful area in which to work. Although
clinicians tend to be slow to abandon their old methods of treating patients (Barlow, 1981; Backer
et al. 1986), we hope they will take advantage of these recent advances in order to improve the
outcome of their patients with schizophrenia.
KIM T. MUESER AND HOWARD BERENBAUM
Appreciation is extended to Terry Wiggins for assistance in conducting the literature search and to the
following persons for their comments on an earlier draft of this paper: Henry Beck, Alan S. Bellack, Anita
DeLongis, Daniel Klein, Arnold A. Lazarus, Rachel Lehr, Douglas Levinson, Robert P. Liberman, Gregory
Miller, Nina R. Schooler, George M. Simpson, Shimon Waldfogel, and William Wilson.
This study was supported by National Institute of Mental Health grants MH 3998 and MH 3836.
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