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    Hrms Qtof Benc Htop: Sciex Sciex X500R

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    Wulan
    The document summarizes the key features and capabilities of a QTOF mass spectrometer system. It can perform both targeted and untargeted high-resolution quantitative and qualitative analysis. The system offers high sensitivity, accuracy, and resolution for metabolite identification and biomarker discovery. It has an integrated software platform that streamlines workflows from data acquisition to processing to reporting.

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    Hrms Qtof Benc Htop: Sciex Sciex X500R

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    Wulan
    127 views6 pages
    The document summarizes the key features and capabilities of a QTOF mass spectrometer system. It can perform both targeted and untargeted high-resolution quantitative and qualitative analysis. The system offers high sensitivity, accuracy, and resolution for metabolite identification and biomarker discovery. It has an integrated software platform that streamlines workflows from data acquisition to processing to reporting.

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    The document summarizes the key features and capabilities of a QTOF mass spectrometer system. It can perform both targeted and untargeted high-resolution quantitative and qualitative analysis. The system offers high sensitivity, accuracy, and resolution for metabolite identification and biomarker discovery. It has an integrated software platform that streamlines workflows from data acquisition to processing to reporting.

    Copyright:

    © All Rights Reserved
    Download as XLSX, PDF, TXT or read online from Scribd
    Download as xlsx, pdf, or txt
    127 views6 pages

    Hrms Qtof Benc Htop: Sciex Sciex X500R

    Uploaded by

    Wulan
    The document summarizes the key features and capabilities of a QTOF mass spectrometer system. It can perform both targeted and untargeted high-resolution quantitative and qualitative analysis. The system offers high sensitivity, accuracy, and resolution for metabolite identification and biomarker discovery. It has an integrated software platform that streamlines workflows from data acquisition to processing to reporting.

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    HRMS

    QTOF
    BENC SCIEX
    11 HTOP SCIEX X500R
    The QTOF system is an accurate mass solution designed like no other with workflows for various
    levels of user. The high resolution mass spectrometer is robust enough for high sample
    throughput powerful enough for research and discovery
    Amongst the many exciting workflows you can do on the QTOF system, MRMHR is one of them.
    This means you can do the targeted quantitation you need at trace levels in a similar format to
    how you would acquire your data on a triple quadrupole system.
    One Single Integrated Interface. The OS Software Platform puts MS control, data processing
    and reporting at your fingertips. The guided workflow allows for minimal MS expertise and gets
    you to biological insights fast
    Simplified Operation. Engineered for simplicity and service accessibility-Single Injection Flow
    and an N-optic design, heated TOF, integrated calibration all with a minimized footprint

    Routine and Robust. Automated and integrated mass calibration allows enhanced stability
    while new diagnostic and tuning tools allow for more uptime.
    Libraries Enable Higher Confidence in Metabolite Identification. Get to actionable results
    quickly with user-friendly processing software and a validated biologically relevant metabolite
    library that can be expanded with other validated libraries
    Powered by OS the QTOF system presents all the data you need and would expect with and
    MRM workflow. The customizable software interface enables you to include the following and a
    lot more:
    • Retention Time - Monitor the drift of
    your analyte
    • Calculated Concentration - How much
    of your analyte is present
    • Ion Ratios - To ensure regulatory complience

    Specification

    MS type : Quadrupole-Time of Flight (QTOF) or equivalent


    High performance N-optic TOF analyzer with an effective flight path of approximately 2
    meters, six separate temperature stabilization drones heaters to ensure the system maintains
    mass accuracy even through longer runs
    The instrument should have a direct atmosphere-to-vacuum interface module with a curtain
    gas barrier for maintaining analyzer cleanliness and optimizing ion declustering and have an
    active source exhaust for the removal of gasses within the ionization source.
    The detector should be a pulse measurement with a 4-anode enhanced dynamic range
    microchannel plate detector, and a time-to-digital converter (TDC) with timestamps of leading
    digital pulses that are recorded with a single shot time resolution of 26psec
    Ionization source : Turbo Source System (Ion source with ESI twin sprayer Probe and APCI twin
    sprayer Probe), A source have combining ESI and APCI (twin channel probes) modes for
    automated calibration. Offers the same high flow characteristics as the regular Turbo ESI source
    (flowrates from 5 to 3000 mL/min) without splitting and APCI source (flowrates from 200 to
    3000mL/min)
    Sensitivity, POS TOF/MS : Using the Twin Sprayer probe in TOF-MS mode, reserpine 1pg on
    column, S/N > 750: 1 RMS
    Sensitivity, POS MS/MS Quant : Using the Twin Sprayer Probe in
    MS/MS mode, reserpine 1pg on
    column, S/N > 1750: 1 RMS
    Scan Speed, MS/MS : Up to 100Hz (100 MS/MS spectra per second)
    Resolution, MS : Equal to or grater than 42,000 (FWHM) measured on the (M+6H) charge
    isotope cluster for bovine
    insulin at m/z 956
    Mass Accuracy, Internal : Less than or equal to 0.4 ppm absolute error as demonstrated on
    m/z 813 fragment ion of Flu-Fibrinopeptide B
    Mass Accuracy Over Time, External : Less than 2 ppm RMS over 12 hours of LC-MS
    Polarity Switching : Yes (computer controlled)
    Linear Dynamic Range : Equal to or greater than 4 orders of magnitude inter-scan linear
    dynamic range without signal reduction
    Mass Range : TOF : up to 40 kDa
    Precursor ion selection : 5-2250 m/z
    Standard Ionization Source : Turbo ion source with Twin Sprayer ESI Probe and Twin Sprayer
    APCI Probe for QTQF system only
    Flow Rate : 5uL/min to 3mL/min
    Scan modes : Full scan MS and MS/MS or Product Ion Scan, Q1 scan, fixed or variable window
    Data Independent Acquisition (DIA), High resolution MRM and Information Data Acquisition
    (IDA).
    Data Independent Acquisition (DIA) window width : variable 5 – 2,250 amu, define by user.
    Data Independent Acquisition (DIA) scan speed : 200 windows per cycle
    10,835,000,000

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