USER GUIDE

NI USB-622x/625x/628x OEM
M Series USB-6221/6225/6229/6251/6255/6259/6281/6289 OEM Devices
This document provides dimensions, pinouts, and information
about the connectors, switch, LEDs, and chassis ground of the National
Instruments USB-6221 OEM, USB-6225 OEM, USB-6229 OEM,
USB-6251 OEM, USB-6255 OEM, USB-6259 OEM, USB-6281 OEM,
and USB-6289 OEM devices. It also explains how to modify the USB
device name in Microsoft Windows.

CautionThere are no product safety, electromagnetic compatibility (EMC), or

CE marking compliance claims made for the USB-622x/625x/628x OEM devices.
Conformity to any and all compliance requirements rests with the end product supplier.

Caution (USB-628x Devices) Exercise caution when placing USB-628x OEM devices inside
an enclosure. Auxiliary cooling may be necessary to keep the device under the maximum
ambient temperature rating of 45 °C, as specified in the NI 628x Specifications.

Figure 1 shows the USB-6221/6251/6281 OEM and

USB-6225/6229/6255/6259/6289 OEM devices.

USB-6221/6251/6281 USB-6225/6229/6255/6259/6289

Figure 1. USB-622x/625x/628x OEM Devices

 Refer to the NI 622x Specifications document for USB-6221/6225/6229
specifications, the NI 625x Specifications document for
USB-6251/6255/6259 specifications, and the NI 628x Specifications
document for USB-6281/6289 specifications. Refer to the M Series User
Manual for more information about USB-622x/625x/628x devices.
You can find all documentation at ni.com/manuals.

Dimensions
Figure 2 shows the dimensions of the USB-6221/6251/6281 OEM device.

NI USB-622x/625x/628x OEM User Guide 2 ni.com

 5.210 (132.33)

5.900 (149.86)
6.013 (152.74)
6.400 (162.56)
0.918 (23.32)

3.180 (80.77)

3.198 (81.22)
3.220 (81.79)
3.730 (94.74)
3.734 (94.84)
0.000 (0.00)
0.200 (5.08)
0.390 (9.91)
4X Ø 0.110 (2.79)
6.950 (176.53) 7X Ø 0.125 (3.18)
4x 6.718 (170.63)
6.270 (159.26)
6.140 (155.96) 6.140 (155.96)
5.930 (150.62)

5.290 (134.37)

0.396 (10.06)
0.304 (7.72)
0.256 (6.50)
0.304 (7.72)
0.116 (2.95) 0.200 (5.08)
0.000 (0.00)
0.200 (5.08)

2.072 (52.63)

3.296 (83.72)

6.200 (157.48)
1.057 (26.85)

1.750 (44.45)

2.300 (58.42)
2.606 (66.19)
3.080 (78.23)
0.393 (9.98)

0.436 (11.07)
0.392 (9.96)
0.362 (9.19)
0.609 (15.47)
0.162 (4.11) 0.515 (13.08)
0.062 (1.57) 0.442 (11.23)
0.000 (0.00)
2X Ø 0.140 Cutout
0.000 (0.00)

6.400 (162.56)

in Panel for LEDs

Ø 0.330 Cutout in Panel
for Power Connector

Figure 2. USB-6221/6251/6281 OEM Dimensions in Inches (Millimeters)

© National Instruments Corporation 3 NI USB-622x/625x/628x OEM User Guide

 Figure 3 shows the dimensions of the USB-6225/6229/6255/6259/6289
OEM device.

5.210 (132.33)

5.900 (149.86)
6.013 (152.74)
6.400 (162.56)
0.918 (23.32)

3.180 (80.77)

3.198 (81.22)
3.220 (81.79)
3.730 (94.74)
3.734 (94.84)
0.000 (0.00)
0.200 (5.08)
0.390 (9.91)
4X Ø 0.110 (2.79)
6.950 (176.53) 7X Ø 0.125 (3.18)
4x 6.718 (170.63)
6.270 (159.26)
6.140 (155.96) 6.140 (155.96)
5.930 (150.62)
5.839 (148.31)
5.499 (139.67) 5.290 (134.37)

0.396 (10.06)
0.304 (7.72)
0.256 (6.50)
0.304 (7.72)
0.116 (2.95) 0.200 (5.08)
0.000 (0.00)
0.200 (5.08)

2.072 (52.63)

3.296 (83.72)

6.200 (157.48)
1.057 (26.85)

1.750 (44.45)

2.300 (58.42)
2.606 (66.19)
3.080 (78.23)
0.393 (9.98)

0.436 (11.07)
0.392 (9.96)
0.362 (9.19)
0.609 (15.47)
0.162 (4.11) 0.515 (13.08)
0.062 (1.57) 0.442 (11.23)
0.000 (0.00)
2X Ø 0.140 Cutout
6.400 (162.56)
0.000 (0.00)

in Panel for LEDs

Ø 0.330 Cutout in Panel
for Power Connector

Figure 3. USB-6225/6229/6255/6259/6289 OEM Dimensions in Inches (Millimeters)

NI USB-622x/625x/628x OEM User Guide 4 ni.com

I/O Connector Pinouts
Figures 4 through 9 show the connector pinouts for the USB-6221 OEM,
USB-6225 OEM, USB-6229 OEM, USB-6251 OEM, USB-6255 OEM,
USB-6259 OEM, USB-6281 OEM, and USB-6289 OEM devices.

Refer to the M Series User Manual at ni.com/manuals for more

information about USB-622x/625x/628x signals and how to connect them.

© National Instruments Corporation 5 NI USB-622x/625x/628x OEM User Guide

 Bank 0

50-Pin Digital Connector +5 V 50 49 +5 V

D GND 48 47 PFI 15
D GND 46 45 PFI 14
D GND 44 43 PFI 13
D GND 42 41 PFI 12
D GND 40 39 PFI 11
D GND 38 37 PFI 10
D GND 36 35 PFI 9
D GND 34 33 PFI 8
D GND 32 31 PFI 7
D GND 30 29 PFI 6
D GND 28 27 PFI 5
Bank 0
D GND 26 25 PFI 4
D GND 24 23 PFI 3
D GND 22 21 PFI 2
D GND 20 19 PFI 1
D GND 18 17 PFI 0
D GND 16 15 P0.7
D GND 14 13 P0.6
D GND 12 11 P0.5
D GND 10 9 P0.4
D GND 8 7 P0.3
D GND 6 5 P0.2
D GND 4 3 P0.1
D GND 2 1 P0.0

Bank 0

34-Pin Analog Connector AI GND 34 33 AI 15

AI 7 32 31 AI GND
AI 14 30 29 AI 6
AI GND 28 27 AI 13
AI 5 26 25 AI GND
AI 12 24 23 AI 4
AI GND 22 21 AI 11
AI 3 20 19 AI GND
AI 10 18 17 AI 2
AI GND 16 15 AI 9
AI 1 14 13 AI GND
AI 8 12 11 AI 0
Bank 0 AI GND 10 9 AI SENSE
AI GND 8 7 NC
AI GND 6 5 AO GND
AO 1 4 3 AO GND
AO 0 2 1 AO GND

NC = No Connect

Figure 4. USB-6221 OEM Connector Pinout

NI USB-622x/625x/628x OEM User Guide 6 ni.com

 Bank 1 Bank 0

50-Pin Analog/Digital +5 V 50 49 +5 V AI 71 50 49 AI 79
Connectors D GND 48 47 PFI 15 AI 78 48 47 AI 70
D GND 46 45 PFI 14 AI GND 46 45 AI 69
D GND 44 43 PFI 13 AI 77 44 43 AI 76
D GND 42 41 PFI 12 AI 68 42 41 AI GND
D GND 40 39 PFI 11 AI 67 40 39 AI 75
D GND 38 37 PFI 10 AI 74 38 37 AI 66
D GND 36 35 PFI 9 AI GND 36 35 AI 65
D GND 34 33 PFI 8 AI 73 34 33 AI 72
D GND 32 31 PFI 7 AI 64 32 31 AI GND
D GND 30 29 PFI 6 AI 55 30 29 AI 63
D GND 28 27 PFI 5 AI 62 28 27 AI 54
Bank 1 D GND 26 25 PFI 4 AI GND 26 25 AI 53
Bank 0 D GND 24 23 PFI 3 AI 61 24 23 AI 60
D GND 22 21 PFI 2 AI 52 22 21 AI GND
D GND 20 19 PFI 1 AI 51 20 19 AI 59
D GND 18 17 PFI 0 AI 58 18 17 AI 50
D GND 16 15 P0.7 AI GND 16 15 AI 49
D GND 14 13 P0.6 AI 57 14 13 AI 56
D GND 12 11 P0.5 AI 48 12 11 AI GND
D GND 10 9 P0.4 AI 39 10 9 AI 47
D GND 8 7 P0.3 AI 46 8 7 AI 38
D GND 6 5 P0.2 AI GND 6 5 AI 37
D GND 4 3 P0.1 AI 45 4 3 AI GND
D GND 2 1 P0.0 AI 44 2 1 AI 36

Bank 1 Bank 0

34-Pin Analog Connectors AI GND 34 33 AI 15 AI 43 34 33 AI 35

AI 7 32 31 AI GND AI GND 32 31 AI 34
AI 14 30 29 AI 6 AI 42 30 29 AI 41
AI GND 28 27 AI 13 AI 33 28 27 AI GND
AI 5 26 25 AI GND AI 32 26 25 AI 40
AI 12 24 23 AI 4 AI 31 24 23 AI 23
AI GND 22 21 AI 11 AI GND 22 21 AI 22
AI 3 20 19 AI GND AI 30 20 19 AI 29
AI 10 18 17 AI 2 AI 21 18 17 AI GND
AI GND 16 15 AI 9 AI 28 16 15 AI 20
AI 1 14 13 AI GND AI GND 14 13 AI 27
AI 8 12 11 AI 0 AI 19 12 11 AI GND
Bank 1
AI GND 10 9 AI SENSE AI 26 10 9 AI 18
Bank 0
AI GND 8 7 NC AI GND 8 7 AI 25
AI GND 6 5 AO GND AI 17 6 5 AI GND
AO 1 4 3 AO GND AI 24 4 3 AI 16
AO 0 2 1 AO GND AI GND 2 1 AI SENSE 2

NC = No Connect

Figure 5. USB-6225 OEM Connector Pinout

© National Instruments Corporation 7 NI USB-622x/625x/628x OEM User Guide

 Bank 1 Bank 0

50-Pin Digital Connectors +5 V 50 49 +5 V +5 V 50 49 +5 V

D GND 48 47 P0.31 D GND 48 47 PFI 15
D GND 46 45 P0.30 D GND 46 45 PFI 14
D GND 44 43 P0.29 D GND 44 43 PFI 13
D GND 42 41 P0.28 D GND 42 41 PFI 12
D GND 40 39 P0.27 D GND 40 39 PFI 11
D GND 38 37 P0.26 D GND 38 37 PFI 10
D GND 36 35 P0.25 D GND 36 35 PFI 9
D GND 34 33 P0.24 D GND 34 33 PFI 8
D GND 32 31 P0.23 D GND 32 31 PFI 7
D GND 30 29 P0.22 D GND 30 29 PFI 6
D GND 28 27 P0.21 D GND 28 27 PFI 5
Bank 1
Bank 0 D GND 26 25 P0.20 D GND 26 25 PFI 4
D GND 24 23 P0.19 D GND 24 23 PFI 3
D GND 22 21 P0.18 D GND 22 21 PFI 2
D GND 20 19 P0.17 D GND 20 19 PFI 1
D GND 18 17 P0.16 D GND 18 17 PFI 0
D GND 16 15 P0.15 D GND 16 15 P0.7
D GND 14 13 P0.14 D GND 14 13 P0.6
D GND 12 11 P0.13 D GND 12 11 P0.5
D GND 10 9 P0.12 D GND 10 9 P0.4
D GND 8 7 P0.11 D GND 8 7 P0.3
D GND 6 5 P0.10 D GND 6 5 P0.2
D GND 4 3 P0.9 D GND 4 3 P0.1
D GND 2 1 P0.8 D GND 2 1 P0.0

Bank 1 Bank 0

34-Pin Analog Connectors AI GND 34 33 AI 31 AI GND 34 33 AI 15

AI 23 32 31 AI GND AI 7 32 31 AI GND
AI 30 30 29 AI 22 AI 14 30 29 AI 6
AI GND 28 27 AI 29 AI GND 28 27 AI 13
AI 21 26 25 AI GND AI 5 26 25 AI GND
AI 28 24 23 AI 20 AI 12 24 23 AI 4
AI GND 22 21 AI 27 AI GND 22 21 AI 11
AI 19 20 19 AI GND AI 3 20 19 AI GND
AI 26 18 17 AI 18 AI 10 18 17 AI 2
AI GND 16 15 AI 25 AI GND 16 15 AI 9
AI 17 14 13 AI GND AI 1 14 13 AI GND
AI 24 12 11 AI 16 AI 8 12 11 AI 0
Bank 1 AI GND 10 9 AI SENSE 2 AI GND 10 9 AI SENSE
Bank 0
AI GND 8 7 NC AI GND 8 7 NC
AI GND 6 5 AO GND AI GND 6 5 AO GND
AO 3 4 3 AO GND AO 1 4 3 AO GND
AO 2 2 1 AO GND AO 0 2 1 AO GND

NC = No Connect NC = No Connect

Figure 6. USB-6229 OEM Connector Pinout

NI USB-622x/625x/628x OEM User Guide 8 ni.com

 Bank 0

50-Pin Digital Connector +5 V 50 49 +5 V

D GND 48 47 PFI 15
D GND 46 45 PFI 14
D GND 44 43 PFI 13
D GND 42 41 PFI 12
D GND 40 39 PFI 11
D GND 38 37 PFI 10
D GND 36 35 PFI 9
D GND 34 33 PFI 8
D GND 32 31 PFI 7
D GND 30 29 PFI 6
D GND 28 27 PFI 5
Bank 0
D GND 26 25 PFI 4
D GND 24 23 PFI 3
D GND 22 21 PFI 2
D GND 20 19 PFI 1
D GND 18 17 PFI 0
D GND 16 15 P0.7
D GND 14 13 P0.6
D GND 12 11 P0.5
D GND 10 9 P0.4
D GND 8 7 P0.3
D GND 6 5 P0.2
D GND 4 3 P0.1
D GND 2 1 P0.0

Bank 0

34-Pin Analog Connector AI GND 34 33 AI 15

AI 7 32 31 AI GND
AI 14 30 29 AI 6
AI GND 28 27 AI 13
AI 5 26 25 AI GND
AI 12 24 23 AI 4
AI GND 22 21 AI 11
AI 3 20 19 AI GND
AI 10 18 17 AI 2
AI GND 16 15 AI 9
AI 1 14 13 AI GND
AI 8 12 11 AI 0
Bank 0
AI GND 10 9 AI SENSE
AI GND 8 7 APFI 0
AI GND 6 5 AO GND
AO 1 4 3 AO GND
AO 0 2 1 AO GND

Figure 7. USB-6251/6281 OEM Connector Pinout

© National Instruments Corporation 9 NI USB-622x/625x/628x OEM User Guide

 Bank 1 Bank 0

50-Pin Analog/Digital +5 V 50 49 +5 V AI 71 50 49 AI 79
Connectors D GND 48 47 PFI 15 AI 78 48 47 AI 70
D GND 46 45 PFI 14 AI GND 46 45 AI 69
D GND 44 43 PFI 13 AI 77 44 43 AI 76
D GND 42 41 PFI 12 AI 68 42 41 AI GND
D GND 40 39 PFI 11 AI 67 40 39 AI 75
D GND 38 37 PFI 10 AI 74 38 37 AI 66
D GND 36 35 PFI 9 AI GND 36 35 AI 65
D GND 34 33 PFI 8 AI 73 34 33 AI 72
D GND 32 31 PFI 7 AI 64 32 31 AI GND
D GND 30 29 PFI 6 AI 55 30 29 AI 63
D GND 28 27 PFI 5 AI 62 28 27 AI 54
Bank 1 D GND 26 25 PFI 4 AI GND 26 25 AI 53
Bank 0 D GND 24 23 PFI 3 AI 61 24 23 AI 60
D GND 22 21 PFI 2 AI 52 22 21 AI GND
D GND 20 19 PFI 1 AI 51 20 19 AI 59
D GND 18 17 PFI 0 AI 58 18 17 AI 50
D GND 16 15 P0.7 AI GND 16 15 AI 49
D GND 14 13 P0.6 AI 57 14 13 AI 56
D GND 12 11 P0.5 AI 48 12 11 AI GND
D GND 10 9 P0.4 AI 39 10 9 AI 47
D GND 8 7 P0.3 AI 46 8 7 AI 38
D GND 6 5 P0.2 AI GND 6 5 AI 37
D GND 4 3 P0.1 AI 45 4 3 AI GND
D GND 2 1 P0.0 AI 44 2 1 AI 36

Bank 1 Bank 0

34-Pin Analog Connectors AI GND 34 33 AI 15 AI 43 34 33 AI 35

AI 7 32 31 AI GND AI GND 32 31 AI 34
AI 14 30 29 AI 6 AI 42 30 29 AI 41
AI GND 28 27 AI 13 AI 33 28 27 AI GND
AI 5 26 25 AI GND AI 32 26 25 AI 40
AI 12 24 23 AI 4 AI 31 24 23 AI 23
AI GND 22 21 AI 11 AI GND 22 21 AI 22
AI 3 20 19 AI GND AI 30 20 19 AI 29
AI 10 18 17 AI 2 AI 21 18 17 AI GND
AI GND 16 15 AI 9 AI 28 16 15 AI 20
AI 1 14 13 AI GND AI GND 14 13 AI 27
AI 8 12 11 AI 0 AI 19 12 11 AI GND
Bank 1
AI GND 10 9 AI SENSE AI 26 10 9 AI 18
Bank 0
AI GND 8 7 APFI 0 AI GND 8 7 AI 25
AI GND 6 5 AO GND AI 17 6 5 AI GND
AO 1 4 3 AO GND AI 24 4 3 AI 16
AO 0 2 1 AO GND AI GND 2 1 AI SENSE 2

Figure 8. USB-6255 OEM Connector Pinout

NI USB-622x/625x/628x OEM User Guide 10 ni.com

 Bank 1 Bank 0

50-Pin Digital Connectors +5 V 50 49 +5 V +5 V 50 49 +5 V

D GND 48 47 P0.31 D GND 48 47 PFI 15
D GND 46 45 P0.30 D GND 46 45 PFI 14
D GND 44 43 P0.29 D GND 44 43 PFI 13
D GND 42 41 P0.28 D GND 42 41 PFI 12
D GND 40 39 P0.27 D GND 40 39 PFI 11
D GND 38 37 P0.26 D GND 38 37 PFI 10
D GND 36 35 P0.25 D GND 36 35 PFI 9
D GND 34 33 P0.24 D GND 34 33 PFI 8
D GND 32 31 P0.23 D GND 32 31 PFI 7
D GND 30 29 P0.22 D GND 30 29 PFI 6
D GND 28 27 P0.21 D GND 28 27 PFI 5
Bank 1
Bank 0 D GND 26 25 P0.20 D GND 26 25 PFI 4
D GND 24 23 P0.19 D GND 24 23 PFI 3
D GND 22 21 P0.18 D GND 22 21 PFI 2
D GND 20 19 P0.17 D GND 20 19 PFI 1
D GND 18 17 P0.16 D GND 18 17 PFI 0
D GND 16 15 P0.15 D GND 16 15 P0.7
D GND 14 13 P0.14 D GND 14 13 P0.6
D GND 12 11 P0.13 D GND 12 11 P0.5
D GND 10 9 P0.12 D GND 10 9 P0.4
D GND 8 7 P0.11 D GND 8 7 P0.3
D GND 6 5 P0.10 D GND 6 5 P0.2
D GND 4 3 P0.9 D GND 4 3 P0.1
D GND 2 1 P0.8 D GND 2 1 P0.0

Bank 1 Bank 0

34-Pin Analog Connectors AI GND 34 33 AI 31 AI GND 34 33 AI 15

AI 23 32 31 AI GND AI 7 32 31 AI GND
AI 30 30 29 AI 22 AI 14 30 29 AI 6
AI GND 28 27 AI 29 AI GND 28 27 AI 13
AI 21 26 25 AI GND AI 5 26 25 AI GND
AI 28 24 23 AI 20 AI 12 24 23 AI 4
AI GND 22 21 AI 27 AI GND 22 21 AI 11
AI 19 20 19 AI GND AI 3 20 19 AI GND
AI 26 18 17 AI 18 AI 10 18 17 AI 2
AI GND 16 15 AI 25 AI GND 16 15 AI 9
AI 17 14 13 AI GND AI 1 14 13 AI GND
AI 24 12 11 AI 16 AI 8 12 11 AI 0
Bank 1
AI GND 10 9 AI SENSE 2 AI GND 10 9 AI SENSE
Bank 0
AI GND 8 7 APFI 1 AI GND 8 7 APFI 0
AI GND 6 5 AO GND AI GND 6 5 AO GND
AO 3 4 3 AO GND AO 1 4 3 AO GND
AO 2 2 1 AO GND AO 0 2 1 AO GND

Figure 9. USB-6259/6289 OEM Connector Pinout

© National Instruments Corporation 11 NI USB-622x/625x/628x OEM User Guide

Default Counter/Timer Pinouts
By default, NI-DAQmx routes the counter/timer inputs and outputs to the
PFI pins, shown in Table 1.

Table 1. NI-DAQmx Default Counter/Timer Pins

Counter/Timer Signal Default Terminal Name

CTR 0 SRC PFI 8
CTR 0 GATE PFI 9
CTR 0 AUX PFI 10
CTR 0 OUT PFI 12
CTR 0 A PFI 8
CTR 0 Z PFI 9
CTR 0 B PFI 10
CTR 1 SRC PFI 3
CTR 1 GATE PFI 4
CTR 1 AUX PFI 11
CTR 1 OUT PFI 13
CTR 1 A PFI 3
CTR 1 Z PFI 4
CTR 1 B PFI 11
FREQ OUT PFI 14

NI USB-622x/625x/628x OEM User Guide 12 ni.com

Attaching External LEDs
USB-622x/625x/628x OEM devices have two LEDs that reflect the device
state. The green READY LED indicates when the device is powered on and
configured as a USB device. The yellow ACTIVE LED indicates USB bus
activity.

Three connectors on the device allow you to connect an external LED

circuit to the device, as shown in Figure 10. To connect an external READY
LED, use E1 as the positive connection (+3.3 V) and E2 as the negative
connection. To connect an external ACTIVE LED, use E1 as the positive
connection and E3 as the negative connection. E1 is current limited with
a 100 Ω resistor to the 3.3 V internal supply. This configuration limits
the current to approximately 16 mA into a single external LED or
approximately 8 mA each when both LEDs are lit. You also can limit this
current further by using external resistors, also shown in Figure 10.

OEM (On-Board)
3.3 V
E3
E2
100 Ω E1
E3 E2 E1

External External
READY ACTIVE
LED LED

Figure 10. Schematic for External LED Circuits

© National Instruments Corporation 13 NI USB-622x/625x/628x OEM User Guide

Power Switch
The power switch on the USB-622x/625x/628x OEM device powers the
device on and off. Figure 11 shows the pins on the power switch and
circuitry.

100 kΩ VDC Out VDC In

to Ground

3 2 1

XF1
J4/J6/J8
SW1
100 kΩ Switch
NC NC
Outer
Shell

SW1 XF1 J4/J6/J8

Power to 2 1 Power
FUSE
Device 3 Connector
100 kΩ

Figure 11. Schematic for the Power Switch

Pin 1, VDC In, is connected to VDC through the fuse (reference designator
XF1). The VDC is the voltage provided by the power supply through the
power connector (reference designator J4/J6/J81) and must be 11–30 VDC,
20 W.

Pin 2, VDC Out, provides power to the circuitry on the device. When the
switch is in the On position, the VDC power supply from pin 1 is routed to
pin 2.

Pin 3, 100 kΩ to Ground, connects pin 2 to ground through a 100 kΩ

resistor when the switch is in the Off position.

1 The power connector is designated as J4 on USB-6225/6255 OEM devices, J6 on USB-6221/6229 OEM devices, and J8 on
USB-6251/6259/6281/6289 OEM devices.

NI USB-622x/625x/628x OEM User Guide 14 ni.com

Connecting the USB-622x/625x/628x OEM Device to
Your Chassis
The USB-622x/625x/628x OEM device includes several plated mounting
holes that are designed for customer grounded connections, as shown in
Figure 12.

Caution Do not use the holes labeled A in Figure 12 as mounting holes.

Mounting Hole Connected A Do Not Use These

to Chassis Ground as Mounting Holes

Figure 12. Customer Mounting Holes

(USB-6225/6229/6255/6259/6289 OEM Shown)

Caution (USB-628x Devices) Exercise caution when placing USB-628x OEM devices inside
an enclosure. Auxiliary cooling may be necessary to keep the device under the maximum
ambient temperature rating of 45 °C, as specified in the NI 628x Specifications.

© National Instruments Corporation 15 NI USB-622x/625x/628x OEM User Guide

Replacing Fuses
USB-622x/625x/628x OEM devices have a replaceable T 2A 250V
(5 × 20 mm) fuse that protects the device from overcurrent through the
power connector.

(USB-628x Devices Only) USB-628x OEM devices also have a replaceable

F 2A 125V fuse that protects the device from overcurrent through the +5 V
terminal(s).

Replacement fuse information can be found in Table 2. To replace a broken

fuse in USB-622x/625x/628x OEM devices, complete the following steps.
1. Power down and unplug the device.
2. Replace the broken fuse while referring to Figure 13 for the fuse
locations.

1 T 2A 250V (5 x 20 mm) Fuse

2 F 2A 125V Fuse on USB-628x OEM Devices

Figure 13. USB-622x/625x/628x OEM Fuse Locations

NI USB-622x/625x/628x OEM User Guide 16 ni.com

Device Components
Table 2 contains information about the components used for interfacing
and interacting with the USB-622x/625x/628x OEM device.

Table 2. USB-622x/625x/628x OEM Components

Manufacturer
Component Reference Designator(s) on PCB Manufacturer Part Number
LEDs DS1 Dialight 553-0332
34-pin connectors (USB-6221/6251/6281 OEM) J1 3M N2534-6002RB
(USB-6225/6229/6255/6259/6289
OEM) J1, J2

50-pin connectors (USB-6221/6251/6281 OEM) P1 3M N2550-6002UB

(USB-6225/6229/6255/6259/6289
OEM) P1, P2

USB connector J3 AMP 787780-1

Power connector (USB-6221/6229 OEM) J6 Switchcraft 722RA
(USB-6225/6255 OEM) J4

(USB-6251/6259/6281/6289 OEM) J8

Power switch SW1 ITT Industries, E101J1A3QE2

Cannon
T 2A 250V fuse XF1 Littelfuse 218.002XP
F 2A 125V fuse (USB-6281/6289 OEM) F1 Littelfuse 0453002
68-pin (USB-6221 OEM) J8 Honda PCS-E68RLMD1+
connectors*
(USB-6225/6229/6255 OEM) J7, J8

(USB-6251/6281 OEM) J7

(USB-6259/6289 OEM) J6, J7

* Optional mass termination connectors. These are not populated by default.

© National Instruments Corporation 17 NI USB-622x/625x/628x OEM User Guide

Modifying the USB Device Name in Microsoft Windows
You can change how the USB-622x/625x/628x OEM device name appears
when users install the device in both the Found New Hardware Wizard that
appears when the device is initially installed and in the Windows Device
Manager.

Windows Vista/XP Users

Figure 14 depicts how a USB-6251 OEM device name appears in the
Found New Hardware Wizard and Windows Device Manager.

Figure 14. USB-6251 OEM Device in the Found New Hardware Wizard and
Device Manager (Windows Vista/XP)

To modify the device name in the Found New Hardware Wizard and
Windows Device Manager in Microsoft Windows Vista/XP, complete the
following steps.

Note You must have NI-DAQmx 8.7 or later installed on your PC.

1. Locate the OEMx.inf file in the y:\WINDOWS\inf\ directory,

where x is the random number assigned to the INF file by Windows,
and y:\ is the root directory where Windows is installed.

NI USB-622x/625x/628x OEM User Guide 18 ni.com

 Note New security updates to Microsoft Vista and NI-DAQ 8.6 or later create random INF
files for NI hardware. Windows assigns random file numbers to all INF files, which causes
the user to search through several INF files until the correct file is located.

If you want to revert back, save a copy of this file as

OEMx_original.inf in a different location.
2. Edit the device INF file by opening OEMx.inf with a text editor.
At the bottom of this file are the descriptors where Windows looks to
identify the device. Locate the two lines of text that contain in quotes
the descriptors for the device name you are modifying. Change the
descriptor on both lines to the new device name, as shown in Figure 15.

Original File

Modified File

Figure 15. INF File Descriptors Changed to “My Device” (Windows Vista/XP)

3. Save and close the INF file.

4. Go to the Windows Device Manager.
(Windows Vista) In the Device Manager, notice that the OEM device
now appears as My Device, as shown in Figure 16.
(Windows XP) In the Device Manager, right-click the OEM device under
Data Acquisition Devices, and select Uninstall. Power down the OEM
device and disconnect the USB cable from your PC.

© National Instruments Corporation 19 NI USB-622x/625x/628x OEM User Guide

 When you reconnect and power on the device, it appears as My Device in
the Found New Hardware Wizard and Windows Device Manager, as shown
in Figure 16.

Note When the device is initially installed, the Windows alert message may display the
following: Found New Hardware: M Series USB 62xx (OEM). This message appears
for a few seconds until the custom name appears and the Found New Hardware Wizard is
launched. This alert message device name cannot be changed.

Figure 16. “My Device” in the Found New Hardware Wizard and
Device Manager (Windows Vista/XP)

Note Modifying the INF file will not change the USB-622x/625x/628x OEM device name
in Measurement & Automation Explorer (MAX).

NI USB-622x/625x/628x OEM User Guide 20 ni.com

Windows 2000 Users
Figure 17 depicts how a USB-6251 OEM device name appears in the
Found New Hardware Wizard and Windows Device Manager.

Figure 17. USB-6251 OEM Device in the Found New Hardware Wizard and
Device Manager (Windows 2000)

To modify the device name in the Found New Hardware Wizard and
Windows Device Manager in Windows 2000, complete the following steps.

Note You must have NI-DAQmx 8.7 or later installed on your PC.

1. Locate the nimioxsu.inf file in the x:\WINNT\inf\ directory,

where x:\ is the root directory where Windows is installed.
If you want to revert back, save a copy of this file as
nimioxsu_original.inf in a different location.

© National Instruments Corporation 21 NI USB-622x/625x/628x OEM User Guide

 2. Edit the device INF file by opening nimioxsu.inf with a text editor.
At the bottom of this file are the descriptors where Windows looks to
identify the device. Locate the two lines of text that contain in quotes
the descriptors for the device name you are modifying. Change the
descriptor on both lines to the new device name, as shown in Figure 18.

Original File

Modified File

Figure 18. INF File Descriptors Changed to “My Device” (Windows 2000)

3. Save and close the INF file.

4. Go to the Windows Device Manager, right-click the OEM device under
Data Acquisition Devices, and select Uninstall.
5. Power down the OEM device and disconnect the USB cable from
your PC.

NI USB-622x/625x/628x OEM User Guide 22 ni.com

 When you reconnect and power on the device, it appears as My Device in
the Found New Hardware Wizard and Windows Device Manager, as shown
in Figure 19.

Note When the device is initially installed, the Windows alert message may display the
following: Found New Hardware: M Series USB 62xx (OEM). This message appears
for a few seconds until the custom name appears and the Found New Hardware Wizard is
launched. This alert message device name cannot be changed.

Figure 19. “My Device” in the Found New Hardware Wizard and
Device Manager (Windows 2000)

Note Modifying the INF file will not change the USB-622x/625x/628x OEM device name
in Measurement & Automation Explorer (MAX).

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