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Amiodarone

Indications: Wide-complex tachydysrhythmias


New-onset atrial fibrillation (conversion to sinus rhythm)
Stable monomorphic ventricular tachycardia
Polymorphic ventricular tachycardia with normal QT interval
Rate controller due to accessory pathway conduction
in pre-excited atrial arrhythmias
Preferred in: Acute myocardial infarction
Left ventricular dysfunction

• Stable patient: Amiodarone 150 mg SIVP over 10 mins


(may repeat same dose every 10 mins up to 2 gms)

• Amiodarone drip: Amiodarone 150 mg + 100 ml PNSS x 10 mins,


followed by 1 mg/min for 6 hrs, then 0.5 mg/min for the next 18 hrs
• Amiodarone 300 mg + 250 ml D5W / PNSS over 24 hours







Dopamine
ml/hr = mcg/kg/min x weight x 60 x ml (solution)
mg (stock) x 1000

1 vial = 200 mg/5 ml (40 mg/ml)

Dose range = 2 to 20 mcg/kg/min


5 to 10 mcg/kg/min
­ renal blood flow & cardiac output, positive inotropic & chronotropic
>10 mcg/kg/min
vasoconstriction and increase blood pressure







Dobutamine

ml/hr = mcg/kg/min x weight x 60 x ml (solution)


mg (stock) x 1000

1 vial = 250 mg/5 ml (50 mg/ml)

Dose range = 2 to 20 mcg/kg/min


Uses: Acute decompensated heart failure
Cardiogenic shock
Vasodilatory shock (septic shock)





Norepinephrine

ml/hr = mcg/kg/min x weight x 60 x ml (solution)


mg (stock) x 1000

1 vial = 4 mg/4 ml (1 mg/ml)

Dose range = 2 to 50 mcg/min


0.02 to 2 mcg/kg/min
Uses: Acute hypotension
Post-cardiac arrest patients
Severe sepsis and septic shock
(refractory to adequate fluid resuscitation)








Mannitol


Loading dose: 0.5 to 1.0 mg/kg x weight x 100
20

IV infusion: 1.5 to 2 g/kg over 30 to 60 mins

1 vial Mannitol = 20 mg/100 ml

Uses: Increased intracranial pressure


Increased intraocular pressure




Insulin Drip

Humulin R 100 units + 100 ml PNSS x 0.1 unit/kg/hr







Epinephrine Drip

Epinephrine 1 mg + 250 ml D5W x 15 to 150 ugtts/min


Dose = 2 – 10 mcg/min






Omeprazole Drip


Omeprazole 80 mg + 90 ml PNSS x 8 mg/hr x 10 hrs






Tramadol Drip


Tramadol 300 mg + 250 ml D5W x 24 hrs





Nalbuphine Drip


Nalbuphine 10 mg + 250 D5W x 24 hrs






Nicardipine


Nicardipine 10 mg + 90 ml PNSS x 10 ml/hr (1 mg/hr)

Titrate: 2.5 mg/hr every 5 to 15 mins
Maximum dose: 15 mg/hr






Isosorbide dinitrate (ISDN) Drip


Single concentration:

Isoket 10 mg + 90 ml PNSS x 10 ml/hr (1 mg/hr)
(10 to 50 ml/hr or 1 to 5 mg/hr)

Double concentration:
Isoket 20 mg + 80 ml PNSS x 5 ml/hr (1 mg/hr)


(5 to 25 ml/hr or 1 to 5 mg/hr)







Sodium Bicarbonate (NaHCO3)


HCO3 Deficit (mEqs) = 0.4 x kg x (24 – actual)


2


1) Give 1/2 of volume as IV bolus
2) Give 1/2 as drip: NaHCO3 (mEqs) + 250 ml PNSS x 24 hrs









Hypokalemia



K+ Deficit = (Expected K+ - Actual K+) x ICF


Intracellular fluid (ICF) = 0.4 x kg



Moderate Hypokalemia (K+ < 3.0):


40 mEqs KCl + 1000 ml PNSS x 8 hours



Severe Hypokalemia (K+ < 2.0):
10 – 20 mEqs KCl + 100 ml PNSS x 1 hr x 3 cycles

Repeat serum potassium after 3rd cycle






Hyponatremia


Expected ∆Na+ (mEq/L) = Infusate Na+ - Actual serum Na+
(TBW + 1)
Infusates: Total Body Water = kg x %
3% Hypertonic Saline = 513 mEq/L 60% adult male <65 & children
0.9% Normal Saline = 154 mEq/L 50% adult female <65 & elderly male
45% elderly female



How much to give? ml = 1000 ml x 5 mEqs x 6 hrs
Expected DNa+

Chronic hyponatremia: >48 hours of suspected hyponatremia
à 6 mEqs in 24 hours (high risk patients)


à 12 meqs in 24 hours (low risk patients)






























Hypocalcemia


Calcium gluconate 1 amp + 10 – 30 ml IV x 10 – 20 mins


(May repeat every 60 mins)

Ca2+ gluconate infusion: 0.02 – 0.08 ml/kg/hr




Hypomagnesemia



MgSO4 1 to 4 grams + 100 ml D5W or PNSS x 10 – 60 mins
MgSO4 2 grams + 50 ml PNSS x 20 mins





Levetiracetam


Levetiracetam 500 mg or 1 gram + 100 ml PNSS x 15 mins





Furosemide


Furosemide 200 mg + 100 ml PNSS x 20 mg/hr





Midazolam


Midazolam 50 mg + PNSS to make 100 ml x 3 mg/hr

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