NCM 22106 PHARMACOLOGY

ACTIVITY 3
DRUG STUDY
CARDIAC DRUGS

DRUG NAME DRUG MECHANISM OF INDICATION CONTRAINDICATION ADVERSE REACTIONS NURSING RESPONSIBILITIES
CLASSIFICATION ACTION
Generic Name ANTINEOPLASTI Through this capsules is contraindicated in mild nausea or Before
C; ALKYLATING mechanism, the drug indicated for use patients with pre- vomiting; Advise patient to report any numbness or tingling in
AGENT is metabolized into as a single agent in existing severe bone mild numbness or extremities to physician; nausea and vomiting may occur
Altretamine alkylating agents by the palliative marrow tingling; and even begin up to weeks after therapy is stopped
N-demethylation. treatment of suppression. loss of appetite;
These alkylating patients with Patients with mood changes, mild
species consequently persistent or preexisting bone dizziness; or.
Brand Name damage tumor cells recurrent ovarian marrow skin rash, itching, hair During
cancer following suppression, loss. Perform a neurologic examination regularly; question
Hexalen first-line therapy including patient about the presence of: paresthesias, hypoesthesias,
with a cisplatin neutropenia or muscle weakness, peripheral numbness, ataxia, decreased
and/or alkylating thrombocytopenia, sensations, and alterations in mood or consciousness.
agent-based should not receive
combination. altretamine until
their counts recover After
or, if therapy is Withhold medication if neurologic symptoms fail to resolve
necessary, receive a with dose reduction. Notify physician.
lower dose.

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Generic name displays a distinct Bendamustine is contraindicated in Nausea, vomiting, Before
pattern of activity, indicated for use in patients with a diarrhea, tiredness,
Bendamustine based on molecular the treatment of known headache, dizziness,
evidence for 3 chronic hypersensitivity weakness, or mouth During
Brand Name mechanisms of lymphocytic (e.g., anaphylactic sores may occur. Monitor signs of leukopenia and neutropenia (fever, sore
Treanda action: (1) p53- leukemia (CLL) and and anaphylactoid throat, signs of infection), thrombocytopenia (bruising,
dependent activation indolent B-cell reactions) nose bleeds, bleeding gums), or unusual weakness and
of DNA-damage non-Hodgkin fatigue that might be due to anemia.
stress response and lymphoma (NHL)
apoptosis, (2) that has After
inhibition of mitotic progressed during
checkpoints, and (3) or within six
induction of mitotic months of
catastrophe treatment with
rituximab or a
rituximab-
containing
regimen.

Generic name

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 Following systemic is indicated for the should not be given nausea. Before
absorption, palliative if neutrophil or diarrhea. Ensure the patient has antiemetics before first dose and is
Brand name carbonium ions are treatment of platelet counts are loss of appetite or also prescribed them regularly (for example, domperidone
rapidly formed, chronic myeloid depressed. Busulfan weight. 20mg tds and ondansetron 8mg tds);
resulting in alkylation leukaemia. should not be used constipation.
of DNA. This leads to in patients whose sores in the mouth During
breaks in the DNA disease has and throat. Weigh all patients twice daily and ensure strict fluid
molecule as well as demonstrated dry mouth. balance charts;
cross-linking of the resistanc headache.
twin strands, difficulty falling After
resulting in asleep or staying
interference of DNA asleep.
replication and
transcription of RNA

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